MX354687B - Composicion farmaceutica que comprende (1r,4r)-6´-fluoro-n,n-dimet il-4-fenil-4´,9´-dihidro-3´h-espiro[ciclohexano-1,1´-pirano-[3,4, b]indol]-4-amina y un derivado de acido propionico. - Google Patents

Composicion farmaceutica que comprende (1r,4r)-6´-fluoro-n,n-dimet il-4-fenil-4´,9´-dihidro-3´h-espiro[ciclohexano-1,1´-pirano-[3,4, b]indol]-4-amina y un derivado de acido propionico.

Info

Publication number
MX354687B
MX354687B MX2014013148A MX2014013148A MX354687B MX 354687 B MX354687 B MX 354687B MX 2014013148 A MX2014013148 A MX 2014013148A MX 2014013148 A MX2014013148 A MX 2014013148A MX 354687 B MX354687 B MX 354687B
Authority
MX
Mexico
Prior art keywords
pyrano
indol
spiro
dihydro
cyclohexane
Prior art date
Application number
MX2014013148A
Other languages
English (en)
Other versions
MX2014013148A (es
Inventor
Linz Klaus
Schiene Klaus
Frosch Stefanie
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2014013148A publication Critical patent/MX2014013148A/es
Publication of MX354687B publication Critical patent/MX354687B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se refiere a una composición farmacéutica que comprende un primer principio farmacológicamente activo, que se selecciona de (1r,4r)-fluoro-6´N,N-dimetil-4-fenil-4´,9´-dihidro-3 ´H-espiro-[ciclohexano-1,1´-pirano-[3,4,b]-indol]-4-amina y las sales fisiológicamente aceptables de la misma, y un segundo principio farmacológicamente activo, que es un derivado de ácido propiónico seleccionado del grupo que consiste de ibuprofeno, naproxeno, cetoprofeno, flurbiprofeno, fenoprofeno, fenbufeno, suprofeno, pirprofeno, indoprofeno, ácido tiaprofénico, oxaprozina, ibuproxam, flunoxaprofeno, alminoprofeno, naproxcinod, y las sales fisiológicamente aceptables de los mismos.
MX2014013148A 2012-05-18 2013-05-16 Composicion farmaceutica que comprende (1r,4r)-6´-fluoro-n,n-dimet il-4-fenil-4´,9´-dihidro-3´h-espiro[ciclohexano-1,1´-pirano-[3,4, b]indol]-4-amina y un derivado de acido propionico. MX354687B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12003935 2012-05-18
PCT/EP2013/001466 WO2013170967A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative

Publications (2)

Publication Number Publication Date
MX2014013148A MX2014013148A (es) 2015-01-19
MX354687B true MX354687B (es) 2018-03-15

Family

ID=48468206

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014013148A MX354687B (es) 2012-05-18 2013-05-16 Composicion farmaceutica que comprende (1r,4r)-6´-fluoro-n,n-dimet il-4-fenil-4´,9´-dihidro-3´h-espiro[ciclohexano-1,1´-pirano-[3,4, b]indol]-4-amina y un derivado de acido propionico.

Country Status (23)

Country Link
US (2) US9320729B2 (es)
EP (1) EP2849745B1 (es)
JP (1) JP6116674B2 (es)
CN (1) CN104284659A (es)
AU (1) AU2013262073B2 (es)
BR (1) BR112014028571A2 (es)
CA (1) CA2873656A1 (es)
CY (1) CY1119786T1 (es)
DK (1) DK2849745T3 (es)
EA (1) EA028200B1 (es)
ES (1) ES2658216T3 (es)
HK (1) HK1204942A1 (es)
HR (1) HRP20171693T1 (es)
HU (1) HUE035112T2 (es)
IL (1) IL235655B (es)
LT (1) LT2849745T (es)
MX (1) MX354687B (es)
NO (1) NO2849745T3 (es)
PL (1) PL2849745T3 (es)
PT (1) PT2849745T (es)
RS (1) RS56771B1 (es)
SI (1) SI2849745T1 (es)
WO (1) WO2013170967A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130310435A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol
US9320729B2 (en) 2012-05-18 2016-04-26 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative
US9855286B2 (en) 2012-05-18 2018-01-02 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component
US20130310385A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants
EP3247352B1 (en) 2015-01-23 2020-06-24 Grünenthal GmbH Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function

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Also Published As

Publication number Publication date
LT2849745T (lt) 2018-01-25
IL235655A0 (en) 2015-01-29
JP2015516447A (ja) 2015-06-11
AU2013262073B2 (en) 2018-01-18
SI2849745T1 (en) 2018-03-30
US10076510B2 (en) 2018-09-18
DK2849745T3 (en) 2017-12-04
ES2658216T3 (es) 2018-03-08
HK1204942A1 (en) 2015-12-11
MX2014013148A (es) 2015-01-19
US20130324581A1 (en) 2013-12-05
IL235655B (en) 2018-08-30
EA028200B1 (ru) 2017-10-31
HUE035112T2 (en) 2018-05-02
BR112014028571A2 (pt) 2017-06-27
US20160199349A1 (en) 2016-07-14
EP2849745A1 (en) 2015-03-25
JP6116674B2 (ja) 2017-04-19
NO2849745T3 (es) 2018-03-31
RS56771B1 (sr) 2018-04-30
CA2873656A1 (en) 2013-11-21
CN104284659A (zh) 2015-01-14
CY1119786T1 (el) 2018-06-27
EP2849745B1 (en) 2017-11-01
PT2849745T (pt) 2018-02-07
US9320729B2 (en) 2016-04-26
HRP20171693T1 (hr) 2017-12-15
AU2013262073A1 (en) 2015-01-22
PL2849745T3 (pl) 2018-04-30
EA201401266A1 (ru) 2016-05-31
WO2013170967A1 (en) 2013-11-21

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