RS56771B1 - Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’-dihidro-3’h-spiro[cikloheksan-1,1’-pirano-[3,4,b]indol]-4-amin i ibuprofen - Google Patents

Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’-dihidro-3’h-spiro[cikloheksan-1,1’-pirano-[3,4,b]indol]-4-amin i ibuprofen

Info

Publication number
RS56771B1
RS56771B1 RS20180056A RSP20180056A RS56771B1 RS 56771 B1 RS56771 B1 RS 56771B1 RS 20180056 A RS20180056 A RS 20180056A RS P20180056 A RSP20180056 A RS P20180056A RS 56771 B1 RS56771 B1 RS 56771B1
Authority
RS
Serbia
Prior art keywords
pyrano
indol
ibuprofen
spiro
dihydro
Prior art date
Application number
RS20180056A
Other languages
English (en)
Inventor
Stefanie Frosch
Klaus Linz
Klaus Schiene
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of RS56771B1 publication Critical patent/RS56771B1/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RS20180056A 2012-05-18 2013-05-16 Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’-dihidro-3’h-spiro[cikloheksan-1,1’-pirano-[3,4,b]indol]-4-amin i ibuprofen RS56771B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12003935 2012-05-18
PCT/EP2013/001466 WO2013170967A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative
EP13723672.5A EP2849745B1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and ibuprofen

Publications (1)

Publication Number Publication Date
RS56771B1 true RS56771B1 (sr) 2018-04-30

Family

ID=48468206

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20180056A RS56771B1 (sr) 2012-05-18 2013-05-16 Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’-dihidro-3’h-spiro[cikloheksan-1,1’-pirano-[3,4,b]indol]-4-amin i ibuprofen

Country Status (23)

Country Link
US (2) US9320729B2 (sr)
EP (1) EP2849745B1 (sr)
JP (1) JP6116674B2 (sr)
CN (1) CN104284659A (sr)
AU (1) AU2013262073B2 (sr)
BR (1) BR112014028571A2 (sr)
CA (1) CA2873656A1 (sr)
CY (1) CY1119786T1 (sr)
DK (1) DK2849745T3 (sr)
EA (1) EA028200B1 (sr)
ES (1) ES2658216T3 (sr)
HK (1) HK1204942A1 (sr)
HR (1) HRP20171693T1 (sr)
HU (1) HUE035112T2 (sr)
IL (1) IL235655B (sr)
LT (1) LT2849745T (sr)
MX (1) MX354687B (sr)
NO (1) NO2849745T3 (sr)
PL (1) PL2849745T3 (sr)
PT (1) PT2849745T (sr)
RS (1) RS56771B1 (sr)
SI (1) SI2849745T1 (sr)
WO (1) WO2013170967A1 (sr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130310385A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants
US9855286B2 (en) 2012-05-18 2018-01-02 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component
US20130310435A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol
US9320729B2 (en) 2012-05-18 2016-04-26 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative
DK3247352T3 (da) 2015-01-23 2020-09-07 Gruenenthal Gmbh Cebranopadol til behandling af smerter hos individer med forringet lever- og/eller forringet nyrefunktion

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Also Published As

Publication number Publication date
SI2849745T1 (en) 2018-03-30
US9320729B2 (en) 2016-04-26
US20130324581A1 (en) 2013-12-05
DK2849745T3 (en) 2017-12-04
BR112014028571A2 (pt) 2017-06-27
PL2849745T3 (pl) 2018-04-30
IL235655A0 (en) 2015-01-29
WO2013170967A1 (en) 2013-11-21
HRP20171693T1 (hr) 2017-12-15
CN104284659A (zh) 2015-01-14
EP2849745A1 (en) 2015-03-25
IL235655B (en) 2018-08-30
MX2014013148A (es) 2015-01-19
US20160199349A1 (en) 2016-07-14
HK1204942A1 (en) 2015-12-11
JP6116674B2 (ja) 2017-04-19
CY1119786T1 (el) 2018-06-27
CA2873656A1 (en) 2013-11-21
PT2849745T (pt) 2018-02-07
EA201401266A1 (ru) 2016-05-31
LT2849745T (lt) 2018-01-25
EP2849745B1 (en) 2017-11-01
US10076510B2 (en) 2018-09-18
AU2013262073B2 (en) 2018-01-18
AU2013262073A1 (en) 2015-01-22
MX354687B (es) 2018-03-15
ES2658216T3 (es) 2018-03-08
NO2849745T3 (sr) 2018-03-31
HUE035112T2 (en) 2018-05-02
EA028200B1 (ru) 2017-10-31
JP2015516447A (ja) 2015-06-11

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