EA201401266A1 - Фармацевтическая композиция, которая содержит (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амин и производное пропионовой кислоты - Google Patents

Фармацевтическая композиция, которая содержит (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амин и производное пропионовой кислоты

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Publication number
EA201401266A1
EA201401266A1 EA201401266A EA201401266A EA201401266A1 EA 201401266 A1 EA201401266 A1 EA 201401266A1 EA 201401266 A EA201401266 A EA 201401266A EA 201401266 A EA201401266 A EA 201401266A EA 201401266 A1 EA201401266 A1 EA 201401266A1
Authority
EA
Eurasian Patent Office
Prior art keywords
spiro
dihydro
fluoro
dimethyl
amine
Prior art date
Application number
EA201401266A
Other languages
English (en)
Other versions
EA028200B1 (ru
Inventor
Штефани Фрош
Клаус Линц
Клаус Шине
Original Assignee
Грюненталь Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA201401266A1 publication Critical patent/EA201401266A1/ru
Publication of EA028200B1 publication Critical patent/EA028200B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Изобретение относится к фармацевтической композиции, содержащей первый фармакологически активный компонент, который выбирают из (1r,4r)-6'-фтор-N,N-диметил-4-фенил-4',9'-дигидро-3'Н-спиро[циклогексан-1,1'-пирано[3,4,b]индол]-4-амина и его физиологически приемлемых солей, и второй фармакологически активный компонент, который представляет собой производное пропионовой кислоты, выбранное из группы, состоящей из ибупрофена, напроксена, кетопрофена, флурбипрофена, фенопрофена, фенбуфена, супрофена, пирпрофена, индопрофена, тиапрофеновой кислоты, оксапрозина, ибупроксама, флуноксапрофена, альминопрофена, напроксцинода, и их физиологически приемлемых солей.
EA201401266A 2012-05-18 2013-05-16 ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, КОТОРАЯ СОДЕРЖИТ (1r,4r)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО-3'H-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО[3,4,b]ИНДОЛ]-4-АМИН И ПРОИЗВОДНОЕ ПРОПИОНОВОЙ КИСЛОТЫ, ВЫБРАННОЕ ИЗ ГРУППЫ, СОСТОЯЩЕЙ ИЗ ИБУПРОФЕНА И ЕГО ФИЗИОЛОГИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ, И НАБОР, СОДЕРЖАЩИЙ УКАЗАННЫЕ СОЕДИНЕНИЯ EA028200B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12003935 2012-05-18
EP12003935.9 2012-05-18
PCT/EP2013/001466 WO2013170967A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative

Publications (2)

Publication Number Publication Date
EA201401266A1 true EA201401266A1 (ru) 2016-05-31
EA028200B1 EA028200B1 (ru) 2017-10-31

Family

ID=48468206

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201401266A EA028200B1 (ru) 2012-05-18 2013-05-16 ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, КОТОРАЯ СОДЕРЖИТ (1r,4r)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО-3'H-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО[3,4,b]ИНДОЛ]-4-АМИН И ПРОИЗВОДНОЕ ПРОПИОНОВОЙ КИСЛОТЫ, ВЫБРАННОЕ ИЗ ГРУППЫ, СОСТОЯЩЕЙ ИЗ ИБУПРОФЕНА И ЕГО ФИЗИОЛОГИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ, И НАБОР, СОДЕРЖАЩИЙ УКАЗАННЫЕ СОЕДИНЕНИЯ

Country Status (23)

Country Link
US (2) US9320729B2 (ru)
EP (1) EP2849745B1 (ru)
JP (1) JP6116674B2 (ru)
CN (1) CN104284659A (ru)
AU (1) AU2013262073B2 (ru)
BR (1) BR112014028571A2 (ru)
CA (1) CA2873656A1 (ru)
CY (1) CY1119786T1 (ru)
DK (1) DK2849745T3 (ru)
EA (1) EA028200B1 (ru)
ES (1) ES2658216T3 (ru)
HK (1) HK1204942A1 (ru)
HR (1) HRP20171693T1 (ru)
HU (1) HUE035112T2 (ru)
IL (1) IL235655B (ru)
LT (1) LT2849745T (ru)
MX (1) MX354687B (ru)
NO (1) NO2849745T3 (ru)
PL (1) PL2849745T3 (ru)
PT (1) PT2849745T (ru)
RS (1) RS56771B1 (ru)
SI (1) SI2849745T1 (ru)
WO (1) WO2013170967A1 (ru)

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US10022353B2 (en) 2015-01-23 2018-07-17 Grünenthal GmbH Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function

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Also Published As

Publication number Publication date
US20160199349A1 (en) 2016-07-14
ES2658216T3 (es) 2018-03-08
HUE035112T2 (en) 2018-05-02
PL2849745T3 (pl) 2018-04-30
RS56771B1 (sr) 2018-04-30
NO2849745T3 (ru) 2018-03-31
PT2849745T (pt) 2018-02-07
CN104284659A (zh) 2015-01-14
HK1204942A1 (en) 2015-12-11
SI2849745T1 (en) 2018-03-30
AU2013262073A1 (en) 2015-01-22
US10076510B2 (en) 2018-09-18
US20130324581A1 (en) 2013-12-05
CA2873656A1 (en) 2013-11-21
CY1119786T1 (el) 2018-06-27
IL235655A0 (en) 2015-01-29
BR112014028571A2 (pt) 2017-06-27
HRP20171693T1 (hr) 2017-12-15
JP6116674B2 (ja) 2017-04-19
IL235655B (en) 2018-08-30
DK2849745T3 (en) 2017-12-04
MX2014013148A (es) 2015-01-19
EP2849745B1 (en) 2017-11-01
WO2013170967A1 (en) 2013-11-21
EA028200B1 (ru) 2017-10-31
US9320729B2 (en) 2016-04-26
EP2849745A1 (en) 2015-03-25
JP2015516447A (ja) 2015-06-11
AU2013262073B2 (en) 2018-01-18
MX354687B (es) 2018-03-15
LT2849745T (lt) 2018-01-25

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