KR102046668B1 - 암 대상자의 예후를 결정하기 위한 방법 및 핵산 - Google Patents

암 대상자의 예후를 결정하기 위한 방법 및 핵산 Download PDF

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KR102046668B1
KR102046668B1 KR1020147003119A KR20147003119A KR102046668B1 KR 102046668 B1 KR102046668 B1 KR 102046668B1 KR 1020147003119 A KR1020147003119 A KR 1020147003119A KR 20147003119 A KR20147003119 A KR 20147003119A KR 102046668 B1 KR102046668 B1 KR 102046668B1
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KR20140044385A (ko
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조에른 르윈
마누엘 크리스핀
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에피제노믹스 아게
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020147003119A 2011-07-08 2012-07-09 암 대상자의 예후를 결정하기 위한 방법 및 핵산 Active KR102046668B1 (ko)

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US201161505919P 2011-07-08 2011-07-08
US61/505,919 2011-07-08
PCT/EP2012/063436 WO2013007702A1 (en) 2011-07-08 2012-07-09 Methods and nucleic acids for determining the prognosis of a cancer subject

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KR20140044385A KR20140044385A (ko) 2014-04-14
KR102046668B1 true KR102046668B1 (ko) 2019-11-19

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US (4) US10626462B2 (https=)
EP (1) EP2729579B1 (https=)
JP (1) JP6397762B2 (https=)
KR (1) KR102046668B1 (https=)
CN (2) CN108048573A (https=)
AU (1) AU2012282528B2 (https=)
BR (1) BR112014000443B1 (https=)
CA (1) CA2840149C (https=)
DK (1) DK2729579T3 (https=)
EA (1) EA034232B1 (https=)
ES (1) ES2654561T3 (https=)
HR (1) HRP20180001T1 (https=)
HU (1) HUE036036T2 (https=)
IL (1) IL230303B (https=)
LT (1) LT2729579T (https=)
MX (1) MX358117B (https=)
NO (1) NO2729579T3 (https=)
PH (1) PH12014500063A1 (https=)
SI (1) SI2729579T1 (https=)
WO (1) WO2013007702A1 (https=)
ZA (1) ZA201400089B (https=)

Cited By (1)

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KR102404750B1 (ko) 2021-10-14 2022-06-07 주식회사 엔도믹스 세포 유리 dna를 이용한 대장암 진단을 위한 메틸화 마커 유전자 및 이의 용도

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US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
CA2951141C (en) * 2014-06-04 2021-11-30 Quest Diagnostics Investments Incorporated Methylated markers for colorectal cancer
CN104745575B (zh) * 2014-08-08 2019-03-12 博诚研究中心 用于检测细胞增殖性异常或疾病程度分级的基因组合物及其用途
EP3766986B1 (en) 2014-12-31 2022-06-01 Guardant Health, Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
CN106148501A (zh) * 2015-04-23 2016-11-23 博诚研究中心 一种检测Septin9基因甲基化的试剂盒及其应用
US20180187246A1 (en) * 2015-07-15 2018-07-05 Universiteit Gent Probes and a methylation in situ hybridization assay
JP6897970B2 (ja) * 2015-09-08 2021-07-07 国立大学法人山口大学 大腸腫瘍の有無を検査する方法
US11566284B2 (en) 2016-08-10 2023-01-31 Grail, Llc Methods of preparing dual-indexed DNA libraries for bisulfite conversion sequencing
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CN107385056A (zh) * 2017-08-10 2017-11-24 上海时代基因医学科技有限公司 一种检测SEPT9基因不同Cpg岛甲基化的试剂盒及应用
WO2019076949A1 (en) * 2017-10-18 2019-04-25 Deutsches Krebsforschungszentrum MEANS AND METHODS FOR CLASSIFYING COLORECTAL CANCERS
WO2019108568A1 (en) * 2017-11-29 2019-06-06 The Regents Of The University Of Michigan Compositions and methods for characterizing cancer
CN108796080B (zh) * 2018-06-06 2022-06-07 苏州唯善生物科技有限公司 用于结直肠癌诊断、检测或筛查的引物和探针组
CN109055552A (zh) * 2018-08-23 2018-12-21 北京迈基诺基因科技股份有限公司 检测Septin9基因启动子是否甲基化的方法及其专用成套试剂
CN112195243A (zh) * 2020-09-22 2021-01-08 北京华大吉比爱生物技术有限公司 一种检测多基因甲基化的试剂盒及其应用
CN114561452A (zh) * 2022-03-10 2022-05-31 天津市人民医院 mSEPT9作为预测结直肠癌患者术后复发风险标志物及用于评价化疗方案有效性的应用
KR102559496B1 (ko) * 2022-04-26 2023-07-25 연세대학교 산학협력단 핵산의 메틸화 여부 확인용 조성물 및 핵산의 메틸화 여부를 확인하는 방법
CN115248313A (zh) * 2022-08-03 2022-10-28 中山市人民医院 肠癌外周血免疫细胞m5C标志物的应用
CN115029462B (zh) * 2022-08-10 2022-11-08 中国农业科学院农业质量标准与检测技术研究所 一种动植物疫病的核酸标准物质、形貌模拟方法及其应用
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Cited By (2)

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Publication number Priority date Publication date Assignee Title
KR102404750B1 (ko) 2021-10-14 2022-06-07 주식회사 엔도믹스 세포 유리 dna를 이용한 대장암 진단을 위한 메틸화 마커 유전자 및 이의 용도
WO2023063562A1 (ko) * 2021-10-14 2023-04-20 주식회사 엔도믹스 세포 유리 dna를 이용한 대장암 진단을 위한 메틸화 마커 유전자 및 이의 용도

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US20150031021A1 (en) 2015-01-29
MX2014000116A (es) 2014-03-27
US12110558B2 (en) 2024-10-08
EA201400117A1 (ru) 2014-06-30
JP6397762B2 (ja) 2018-09-26
CA2840149C (en) 2021-10-26
ES2654561T3 (es) 2018-02-14
MX358117B (es) 2018-08-06
HUE036036T2 (hu) 2018-06-28
US20200308656A1 (en) 2020-10-01
HRP20180001T1 (hr) 2018-03-09
ZA201400089B (en) 2022-03-30
BR112014000443B1 (pt) 2021-03-23
EA034232B1 (ru) 2020-01-20
CA2840149A1 (en) 2013-01-17
SI2729579T1 (en) 2018-07-31
IL230303B (en) 2018-05-31
AU2012282528B2 (en) 2017-04-13
CN103732759A (zh) 2014-04-16
US11261499B2 (en) 2022-03-01
EP2729579A1 (en) 2014-05-14
NO2729579T3 (https=) 2018-03-03
WO2013007702A1 (en) 2013-01-17
DK2729579T3 (en) 2018-01-08
JP2014520520A (ja) 2014-08-25
LT2729579T (lt) 2018-02-26
US20250101527A1 (en) 2025-03-27
KR20140044385A (ko) 2014-04-14
US10626462B2 (en) 2020-04-21
CN108048573A (zh) 2018-05-18
EP2729579B1 (en) 2017-10-04
PH12014500063A1 (en) 2014-02-17
US20220243277A1 (en) 2022-08-04
AU2012282528A1 (en) 2014-01-23
BR112014000443A2 (pt) 2017-02-14

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