KR102011339B1 - 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자 - Google Patents

아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자 Download PDF

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KR102011339B1
KR102011339B1 KR1020137016342A KR20137016342A KR102011339B1 KR 102011339 B1 KR102011339 B1 KR 102011339B1 KR 1020137016342 A KR1020137016342 A KR 1020137016342A KR 20137016342 A KR20137016342 A KR 20137016342A KR 102011339 B1 KR102011339 B1 KR 102011339B1
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cyp
disease
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KR20130124515A (ko
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알렉산더 헤그먼스
브루스 더블유. 펜스크
댄 제이. 트리패니어
마크 디. 아벨
신 스기야마
대런 알. 유레
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콘트라빌 파마슈티컬스, 인코퍼레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
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    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
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KR1020137016342A 2010-12-15 2011-12-14 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자 Active KR102011339B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42357610P 2010-12-15 2010-12-15
US61/423,576 2010-12-15
PCT/CA2011/050773 WO2012079172A1 (en) 2010-12-15 2011-12-14 Cyclosporine analogue molecules modified at amino acid 1 and 3

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KR1020187037529A Division KR20190002731A (ko) 2010-12-15 2011-12-14 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자

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KR20130124515A KR20130124515A (ko) 2013-11-14
KR102011339B1 true KR102011339B1 (ko) 2019-08-16

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KR1020137016342A Active KR102011339B1 (ko) 2010-12-15 2011-12-14 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자
KR1020187037529A Ceased KR20190002731A (ko) 2010-12-15 2011-12-14 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자
KR1020207007384A Active KR102305423B1 (ko) 2010-12-15 2011-12-14 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자

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KR1020207007384A Active KR102305423B1 (ko) 2010-12-15 2011-12-14 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자

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US (2) US9200038B2 (enExample)
EP (2) EP2651965B1 (enExample)
JP (3) JP6144627B2 (enExample)
KR (3) KR102011339B1 (enExample)
CN (2) CN107496902B (enExample)
AU (1) AU2011342284C1 (enExample)
BR (1) BR112013014890B1 (enExample)
CA (1) CA2821009C (enExample)
DK (1) DK2651965T3 (enExample)
ES (1) ES2705750T3 (enExample)
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WO2016112321A1 (en) 2015-01-08 2016-07-14 Allergan, Inc. Cyclosporin derivatives wherein the mebmt sidechain has been cyclized
CN118324867A (zh) * 2016-05-17 2024-07-12 美国科技环球有限公司 新型环孢菌素衍生物及其用途
EP3551034A1 (en) 2016-12-07 2019-10-16 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
WO2018106928A1 (en) 2016-12-08 2018-06-14 Contravir Pharmaceuticals, Inc. Treatment and prevention of hbv diseases by cyclosporine analogue molecules modified at amino acides 1 and 3
WO2018112255A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with an immunosuppressant
AR111464A1 (es) 2017-04-14 2019-07-17 Contravir Pharmaceuticals Inc Terapia combinada para el tratamiento de infecciones virales
EP3612540A1 (en) 2017-04-20 2020-02-26 Rising Tide Foundation Triphenylphosphonium-tethered tetracycyclines for use in treating cancer
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ES2990218T3 (es) * 2018-08-22 2024-11-29 Bacainn Biotherapeutics Ltd Composiciones de ciclosporina y métodos de uso
US12594275B2 (en) 2019-02-07 2026-04-07 The Regents Of The University Of California Immunophilin binding agents and uses thereof
CN115427060A (zh) 2020-02-19 2022-12-02 海必恩制药公司 环孢菌素类似物用于治疗纤维化的用途
AU2021227230A1 (en) * 2020-02-25 2022-09-08 Hepion Pharmaceuticals, Inc. Use of cyclosporine analogues for treating cancer
TW202144378A (zh) * 2020-03-26 2021-12-01 大陸商睿諾醫療科技（上海）有限公司 親環蛋白抑制劑及其用途
IL296586B1 (en) 2020-03-26 2026-04-01 Farsight Medical Tech Shanghai Co Ltd Cyclophilin inhibitors and their uses
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CN113173974B (zh) * 2021-03-18 2024-09-06 北京大学深圳研究生院 环孢素衍生物的合成方法
CN115677533B (zh) * 2021-07-30 2023-12-05 沈阳化工研究院有限公司 一种4-庚基苯甲腈的制备方法
IT202300001116A1 (it) * 2023-01-25 2024-07-25 Indena Spa Processo per la preparazione di un intermedio utile per la sintesi di voclosporina
CN121219307A (zh) * 2023-06-02 2025-12-26 睿诺医疗科技（上海）有限公司 亲环蛋白抑制剂及其用途
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