KR101954322B1 - Ｃ－ｍｅｔ 조절제를 사용하는 방법 - Google Patents

Ｃ－ｍｅｔ 조절제를 사용하는 방법 Download PDF

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Publication number
KR101954322B1
KR101954322B1 KR1020177020220A KR20177020220A KR101954322B1 KR 101954322 B1 KR101954322 B1 KR 101954322B1 KR 1020177020220 A KR1020177020220 A KR 1020177020220A KR 20177020220 A KR20177020220 A KR 20177020220A KR 101954322 B1 KR101954322 B1 KR 101954322B1
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Prior art keywords
quinolin
cyclopropane
methyloxy
bis
fluorophenyl
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Korean (ko)
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KR20170087966A (ko
Inventor
다나 티. 아프타브
토마스 뮐러
아아론 웨이츠만
제이메스 홀랜드
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엑셀리시스, 인코포레이티드
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020177020220A 2009-08-07 2010-08-06 Ｃ－ｍｅｔ 조절제를 사용하는 방법 Active KR101954322B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23238209P 2009-08-07 2009-08-07
US61/232,382 2009-08-07
PCT/US2010/044749 WO2011017639A1 (en) 2009-08-07 2010-08-06 Methods of using c-met modulators

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020127006111A Division KR101761380B1 (ko) 2009-08-07 2010-08-06 Ｃ－ｍｅｔ 조절제를 사용하는 방법

Publications (2)

Publication Number Publication Date
KR20170087966A KR20170087966A (ko) 2017-07-31
KR101954322B1 true KR101954322B1 (ko) 2019-03-05

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KR1020177020220A Active KR101954322B1 (ko) 2009-08-07 2010-08-06 Ｃ－ｍｅｔ 조절제를 사용하는 방법
KR1020127006111A Active KR101761380B1 (ko) 2009-08-07 2010-08-06 Ｃ－ｍｅｔ 조절제를 사용하는 방법

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Country Status (17)

Country Link
US (5) US20120282179A1 (enExample)
EP (1) EP2461810A1 (enExample)
JP (3) JP5933435B2 (enExample)
KR (2) KR101954322B1 (enExample)
CN (2) CN107325048A (enExample)
AU (2) AU2010279234B2 (enExample)
BR (1) BR112012002759A2 (enExample)
CA (2) CA2770100C (enExample)
EA (2) EA024563B1 (enExample)
GE (2) GEP20156310B (enExample)
HK (1) HK1246291A1 (enExample)
IL (2) IL217889A (enExample)
MX (2) MX356176B (enExample)
NZ (2) NZ624643A (enExample)
UA (2) UA108618C2 (enExample)
WO (1) WO2011017639A1 (enExample)
ZA (1) ZA201200842B (enExample)

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CA2752421C (en) 2009-03-21 2013-08-06 Ning Xi Amino ester derivatives, salts thereof and methods of use
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JP2013501731A (ja) 2013-01-17
IL238849A (en) 2017-11-30
EP2461810A1 (en) 2012-06-13
US20190151302A1 (en) 2019-05-23
UA108618C2 (uk) 2015-05-25
CA2770100C (en) 2021-04-20
JP2016106141A (ja) 2016-06-16
KR101761380B1 (ko) 2017-07-25
CN102647985A (zh) 2012-08-22
WO2011017639A1 (en) 2011-02-10
IL217889A (en) 2015-06-30
JP6317775B2 (ja) 2018-04-25
AU2017200269B2 (en) 2019-02-07
CN107325048A (zh) 2017-11-07
US11433064B2 (en) 2022-09-06
US20120282179A1 (en) 2012-11-08
KR20170087966A (ko) 2017-07-31
BR112012002759A2 (pt) 2019-09-24
UA119316C2 (uk) 2019-06-10
EA201500300A1 (ru) 2015-10-30
EA024563B1 (ru) 2016-09-30
NZ624643A (en) 2015-11-27
US20230181559A1 (en) 2023-06-15
CA2770100A1 (en) 2011-02-10
HK1246291A1 (zh) 2018-09-07
NZ598055A (en) 2014-05-30
US10736886B2 (en) 2020-08-11
MX2012001654A (es) 2012-03-14
ZA201200842B (en) 2012-11-28
JP2017082007A (ja) 2017-05-18

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