KR101912401B1 - 다중화된 생화학적 분석에서의 시그널 인코딩 및 디코딩 - Google Patents
다중화된 생화학적 분석에서의 시그널 인코딩 및 디코딩 Download PDFInfo
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- KR101912401B1 KR101912401B1 KR1020147023833A KR20147023833A KR101912401B1 KR 101912401 B1 KR101912401 B1 KR 101912401B1 KR 1020147023833 A KR1020147023833 A KR 1020147023833A KR 20147023833 A KR20147023833 A KR 20147023833A KR 101912401 B1 KR101912401 B1 KR 101912401B1
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
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- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
- G06F17/10—Complex mathematical operations
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- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
- G06F17/10—Complex mathematical operations
- G06F17/11—Complex mathematical operations for solving equations, e.g. nonlinear equations, general mathematical optimization problems
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Theoretical Computer Science (AREA)
- Evolutionary Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Data Mining & Analysis (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Evolutionary Computation (AREA)
- Public Health (AREA)
- Software Systems (AREA)
- Artificial Intelligence (AREA)
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- Computer Vision & Pattern Recognition (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261594480P | 2012-02-03 | 2012-02-03 | |
| US61/594,480 | 2012-02-03 | ||
| US201261703093P | 2012-09-19 | 2012-09-19 | |
| US61/703,093 | 2012-09-19 | ||
| PCT/US2013/024509 WO2013116780A1 (en) | 2012-02-03 | 2013-02-01 | Signal encoding and decoding in multiplexed biochemical assays |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187030476A Division KR102145677B1 (ko) | 2012-02-03 | 2013-02-01 | 다중화된 생화학적 분석에서의 시그널 인코딩 및 디코딩 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140127282A KR20140127282A (ko) | 2014-11-03 |
| KR101912401B1 true KR101912401B1 (ko) | 2018-10-26 |
Family
ID=48905921
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147023833A Active KR101912401B1 (ko) | 2012-02-03 | 2013-02-01 | 다중화된 생화학적 분석에서의 시그널 인코딩 및 디코딩 |
| KR1020187030476A Active KR102145677B1 (ko) | 2012-02-03 | 2013-02-01 | 다중화된 생화학적 분석에서의 시그널 인코딩 및 디코딩 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187030476A Active KR102145677B1 (ko) | 2012-02-03 | 2013-02-01 | 다중화된 생화학적 분석에서의 시그널 인코딩 및 디코딩 |
Country Status (7)
| Country | Link |
|---|---|
| US (10) | US8838394B2 (enExample) |
| EP (6) | EP2809813B1 (enExample) |
| JP (1) | JP6255353B2 (enExample) |
| KR (2) | KR101912401B1 (enExample) |
| CN (3) | CN107326085B (enExample) |
| BR (1) | BR112014019168B1 (enExample) |
| WO (1) | WO2013116780A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014019168B1 (pt) | 2012-02-03 | 2021-10-05 | California Institute Of Technology | Método capaz de detectar de forma não degenerada presença ou ausência de analitos em um único volume de amostra e método de detecção da presença ou ausência de cada analito dentre uma pluralidade de analitos |
| CN104662172B (zh) | 2012-08-03 | 2018-07-06 | 加州理工学院 | Pcr中具有减少的硬件和要求的多重化和定量 |
| EP4570924A3 (en) | 2013-01-24 | 2025-09-03 | California Institute of Technology | Chromophore-based characterization and detection methods |
| US10077475B2 (en) | 2013-01-24 | 2018-09-18 | California Institute Of Technology | FRET-based analytes detection and related methods and systems |
| KR101789079B1 (ko) | 2014-09-22 | 2017-10-24 | 건국대학교 산학협력단 | 마이크로알엔에이 검지를 위한 핵산 다중 접합체 및 그 제조방법 |
| WO2016120396A1 (en) * | 2015-01-29 | 2016-08-04 | Instituut Voor Tropische Geneeskunde | Combined plasmodium-rna virus detection method |
| US10429294B2 (en) | 2015-04-02 | 2019-10-01 | University Of Washington | Optical painting and fluorescence-activated sorting of adherent cells |
| WO2017112025A2 (en) | 2015-10-05 | 2017-06-29 | The University Of North Carolina At Chapel Hill | Decoding methods for multiplexing assays and associated fluidic devices, kits, and solid supports |
| WO2017173035A1 (en) | 2016-04-01 | 2017-10-05 | Chromacode Inc. | Competitive probes for engineering signal generation |
| CN109923613B (zh) * | 2016-06-02 | 2023-07-04 | Seegene株式会社 | 利用信号变化量数据集的样品内的目标分析物质检测方法 |
| US10066263B2 (en) | 2016-06-17 | 2018-09-04 | California Institute Of Technology | Nucleic acid reactions and related methods and compositions |
| JP6846636B2 (ja) * | 2017-02-28 | 2021-03-24 | パナソニックIpマネジメント株式会社 | 核酸検出用オリゴヌクレオチド |
| EP3645749B1 (en) * | 2017-06-28 | 2022-03-02 | Chromacode, Inc. | Multiplexed fluorometric measurements with droplet pcr systems |
| JP2019154246A (ja) * | 2018-03-08 | 2019-09-19 | 株式会社リコー | プローブセット、及びそれを用いた核酸検出方法 |
| CN112424377A (zh) | 2018-04-17 | 2021-02-26 | 克罗玛科德公司 | 用于多重分析的方法和系统 |
| WO2019236447A1 (en) * | 2018-06-04 | 2019-12-12 | ChromaCode, Inc. | Methods for watermarking and identifying chemical compositions |
| US12203129B2 (en) * | 2018-07-03 | 2025-01-21 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
| CN112805392A (zh) * | 2018-07-11 | 2021-05-14 | 克罗玛科德公司 | 多重生化反应中分析物的定量方法 |
| USD975312S1 (en) | 2020-02-14 | 2023-01-10 | Beckman Coulter, Inc. | Reagent cartridge |
| CN115851890A (zh) * | 2022-10-08 | 2023-03-28 | 江苏圣极基因科技有限公司 | 基于数字pcr技术的多重核酸定量检测方法 |
| KR20250159770A (ko) * | 2024-05-03 | 2025-11-11 | 대한민국(질병관리청장) | 호흡기증후군 원인병원체 동시 검출용 병원체 특이 프로브 세트 및 이의 용도 |
| WO2025235889A1 (en) * | 2024-05-10 | 2025-11-13 | Guardant Health, Inc. | Methods involving multiplexed pooled pcr |
| WO2026019326A1 (en) | 2024-07-18 | 2026-01-22 | Biomiris Capital Group B.V. | Probe-resolved melting curve analysis for identifying microorganisms in clinical samples |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030148544A1 (en) | 2001-06-28 | 2003-08-07 | Advanced Research And Technology Institute, Inc. | Methods of preparing multicolor quantum dot tagged beads and conjugates thereof |
| US20070178485A1 (en) | 2005-09-01 | 2007-08-02 | El-Deiry Wafik S | Molecular beacons, methods and kits for detecting DNA damage response |
| US20080124705A1 (en) | 2003-04-30 | 2008-05-29 | Kramer Fred R | Homogeneous multiplex screening assays and kits |
Family Cites Families (157)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0232967B1 (en) | 1986-01-10 | 1993-04-28 | Amoco Corporation | Competitive homogeneous assay |
| US5618711A (en) | 1986-08-22 | 1997-04-08 | Hoffmann-La Roche Inc. | Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase |
| US6127155A (en) | 1986-08-22 | 2000-10-03 | Roche Molecular Systems, Inc. | Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents |
| US5079351A (en) | 1986-11-26 | 1992-01-07 | Cetus Corporation | Oligonucleotides and kits for detection of htlvi and htlvii viruses by hybridization |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| EP0519338B1 (en) | 1991-06-20 | 1996-08-28 | F. Hoffmann-La Roche Ag | Improved methods for nucleic acid amplification |
| EP0675966B1 (en) | 1992-02-19 | 2004-10-06 | The Public Health Research Institute Of The City Of New York, Inc. | Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US5948360A (en) * | 1994-07-11 | 1999-09-07 | Tekmar Company | Autosampler with robot arm |
| CN1100258C (zh) | 1995-02-02 | 2003-01-29 | 中外制药株式会社 | 以调节化学发光为手段分析被分析物的方法 |
| KR19990008052A (ko) | 1995-04-25 | 1999-01-25 | 마이클 피 노바 | 기억 장치를 갖는 원격적으로 프로그램 가능한 매트릭스 및 이의 용도 |
| ATE196322T1 (de) | 1995-05-05 | 2000-09-15 | Perkin Elmer Corp | Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay |
| US5882856A (en) | 1995-06-07 | 1999-03-16 | Genzyme Corporation | Universal primer sequence for multiplex DNA amplification |
| US5773258A (en) | 1995-08-25 | 1998-06-30 | Roche Molecular Systems, Inc. | Nucleic acid amplification using a reversibly inactivated thermostable enzyme |
| US20050112637A1 (en) | 1995-09-08 | 2005-05-26 | Chatterjee Deb K. | Mutant DNA polymerases and uses thereof |
| US5981180A (en) | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
| US6007994A (en) | 1995-12-22 | 1999-12-28 | Yale University | Multiparametric fluorescence in situ hybridization |
| EP0929694A4 (en) | 1996-03-15 | 2002-05-02 | Penn State Res Found | DETECTION OF TUMOR-RELATED EXTRACELLULAR NUCLEIC ACID USING PLASMA OR BLOOD SERUM USING NUCLEIC ACID AMPLIFICATION TESTS |
| PT938320E (pt) | 1996-03-26 | 2010-09-22 | Michael S Kopreski | Método que permite a utilização de arn extracelular extraído de plasma ou de soro para detectar, monitorizar ou avaliar o cancro |
| US6174670B1 (en) | 1996-06-04 | 2001-01-16 | University Of Utah Research Foundation | Monitoring amplification of DNA during PCR |
| US5834203A (en) | 1997-08-25 | 1998-11-10 | Applied Spectral Imaging | Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardwire therefore |
| US6632526B1 (en) | 1997-10-14 | 2003-10-14 | Luminex Corporation | Precision fluorescently dyed particles and methods of making and using same |
| US6235480B1 (en) | 1998-03-13 | 2001-05-22 | Promega Corporation | Detection of nucleic acid hybrids |
| AU3555599A (en) | 1998-04-13 | 1999-11-01 | Luminex Corporation | Liquid labeling with fluorescent microparticles |
| DE69940430D1 (de) * | 1998-06-24 | 2009-04-02 | Illumina Inc | Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel |
| AU762728B2 (en) | 1998-07-02 | 2003-07-03 | Gen-Probe Incorporated | Molecular torches |
| US6642062B2 (en) | 1998-09-03 | 2003-11-04 | Trellis Bioinformatics, Inc. | Multihued labels |
| JP2002542793A (ja) | 1999-04-22 | 2002-12-17 | ザ アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ | 多蛍光fishによる遺伝子発現パターンのアッセイ法 |
| DE60035691T2 (de) | 1999-07-23 | 2008-04-30 | Forensic Science Service Ltd. | Verfahren zur Erkennung von Einzel-Nukleotid-Polymorphismen |
| DE60030145T2 (de) | 1999-10-22 | 2008-01-10 | PHRI Properties, Inc., Newark | Nachweisverfahren für kurze sequenzvarianten |
| US20040053230A1 (en) | 2001-03-07 | 2004-03-18 | Schaffer Michael Edward | Real time quantitative pcr with intercalating dye for single and multiplex target dna |
| DE60143974D1 (de) | 2000-03-29 | 2011-03-10 | Lgc Ltd | Hybridisierungsprobe und Methode zum schnellen Nachweis und zur schnellen Unterscheidung von Sequenzen |
| US6734420B2 (en) | 2000-04-06 | 2004-05-11 | Quantum Dot Corporation | Differentiable spectral bar code methods and systems |
| US20030064366A1 (en) * | 2000-07-07 | 2003-04-03 | Susan Hardin | Real-time sequence determination |
| US7608683B2 (en) * | 2000-08-09 | 2009-10-27 | The Regents Of The University Of California | Stress proteins and peptides and methods of use thereof |
| CA2314398A1 (en) * | 2000-08-10 | 2002-02-10 | Edward Shipwash | Microarrays and microsystems for amino acid analysis and protein sequencing |
| US20020128228A1 (en) * | 2000-12-01 | 2002-09-12 | Wen-Jen Hwu | Compositions and methods for the treatment of cancer |
| US20020142345A1 (en) | 2000-12-22 | 2002-10-03 | Nelsen Anita J. | Methods for encoding and decoding complex mixtures in arrayed assays |
| AU2002324422A1 (en) * | 2001-02-21 | 2002-12-23 | Amnis Corporation | Method and apparatus for labeling and analyzing cellular components |
| CA2439402A1 (en) | 2001-03-02 | 2002-09-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pcr method |
| WO2003002979A2 (en) * | 2001-06-28 | 2003-01-09 | Illumina, Inc. | Multiplex decoding of array sensors with microspheres |
| US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
| EP1288308A1 (en) | 2001-08-28 | 2003-03-05 | Roche Diagnostics GmbH | A method for the determination of multiple analytes |
| US6852491B2 (en) | 2001-09-04 | 2005-02-08 | Abbott Laboratories | Amplification and detection reagents for HIV-1 |
| US20030134320A1 (en) | 2002-01-15 | 2003-07-17 | Myriad Genetics, Incorporated | Method system and computer program product for quality assurance in detecting biochemical markers |
| EP1426448A1 (en) | 2002-12-03 | 2004-06-09 | bioMérieux BV | Method for lowering the effects of sequence variations in a diagnostic hybridization assay, probe for use in the assay and assay |
| WO2004087950A2 (en) | 2003-04-04 | 2004-10-14 | Roche Diagnostics Gmbh | Improved system for multi color real time pcr |
| US7070786B2 (en) | 2003-06-06 | 2006-07-04 | Centocor, Inc. | RSV proteins, antibodies, compositions, methods and uses |
| US20050053950A1 (en) | 2003-09-08 | 2005-03-10 | Enrique Zudaire Ubani | Protocol and software for multiplex real-time PCR quantification based on the different melting temperatures of amplicons |
| US20050064435A1 (en) | 2003-09-24 | 2005-03-24 | Xing Su | Programmable molecular barcodes |
| TWI232934B (en) | 2003-11-19 | 2005-05-21 | Ind Tech Res Inst | A biochip containing splitable reaction confinement and method for producing same and application thereof |
| JP2007534308A (ja) | 2003-11-19 | 2007-11-29 | アレロジック・バイオサイエンシズ・コーポレーション | 複数のフルオロフォアで標識したオリゴヌクレオチド |
| ATE431433T1 (de) * | 2004-03-24 | 2009-05-15 | Applied Biosystems Llc | Ligation und amplifikationsreaktionen zur bestimmung von zielmolekülen |
| AU2005230833B2 (en) | 2004-04-01 | 2011-04-14 | Bio-Rad Laboratories, Inc. | Quantitative amplification with a labeled probe and 3' to 5' exonuclease activity |
| ES2527426T3 (es) | 2004-05-07 | 2015-01-23 | Cepheid | Detección combinada de agentes biológicos |
| US7575864B2 (en) | 2004-05-27 | 2009-08-18 | E.I. Du Pont De Nemours And Company | Method for the direct detection of diagnostic RNA |
| DE102004043870B4 (de) | 2004-09-10 | 2009-11-19 | Eppendorf Ag | Verfahren zur Erweiterung des dynamischen Erfassungsbereich bei Mikroarrays |
| US7671184B2 (en) | 2004-09-24 | 2010-03-02 | Universitact Bern | Molecular beacons |
| AU2005295298B2 (en) | 2004-10-18 | 2011-07-14 | Brandeis University | Primers, probes and methods for nucleic acid amplification |
| CA2587085C (en) | 2004-10-27 | 2017-08-08 | Cepheid | Closed-system multi-stage nucleic acid amplification reactions |
| US20060246475A1 (en) | 2005-01-21 | 2006-11-02 | Third Wave Technologies | Compositions and methods for increased dynamic range detection of nucleic acids |
| US7951078B2 (en) * | 2005-02-03 | 2011-05-31 | Maren Theresa Scheuner | Method and apparatus for determining familial risk of disease |
| US8168602B2 (en) * | 2005-02-17 | 2012-05-01 | Dana-Farber Cancer Institute, Inc. | Compositions, kits and methods for identification, assessment, prevention and therapy of cancer |
| US7709249B2 (en) | 2005-04-01 | 2010-05-04 | 3M Innovative Properties Company | Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector |
| US7507575B2 (en) | 2005-04-01 | 2009-03-24 | 3M Innovative Properties Company | Multiplex fluorescence detection device having removable optical modules |
| US7919244B2 (en) | 2005-06-16 | 2011-04-05 | Biotools Biotechnological & Medical Laboratories, S.A. | Nucleic acid detection method involving the direct generation of a measurable signal |
| US8067208B2 (en) | 2005-06-30 | 2011-11-29 | Roche Molecular Systems, Inc. | Probes and methods for hepatitis C virus typing using multidimensional probe analysis |
| JP2009506759A (ja) | 2005-09-01 | 2009-02-19 | コーベット ライフ サイエンス ピーティーワイ リミテッド | 核酸の増幅、定量化、及び同定の方法。 |
| CN1936019B (zh) * | 2005-10-18 | 2013-01-30 | 厦门大学 | 用于多重实时核酸扩增检测的探针编码方法 |
| JP5537034B2 (ja) | 2005-12-23 | 2014-07-02 | ナノストリング テクノロジーズ,インコーポレーテッド | ナノレポーターならびにその作製方法および使用方法 |
| US8986926B2 (en) | 2005-12-23 | 2015-03-24 | Nanostring Technologies, Inc. | Compositions comprising oriented, immobilized macromolecules and methods for their preparation |
| WO2007080583A2 (en) | 2006-01-10 | 2007-07-19 | Applied Spectral Imaging Ltd. | Methods and systems for analyzing biological samples |
| US8455184B2 (en) | 2006-04-18 | 2013-06-04 | The United States Of America As Represented By The Secretary Of The Air Force | Differential multiplexing with pattern recognition |
| JP2009538123A (ja) | 2006-04-19 | 2009-11-05 | アプライド バイオシステムズ, エルエルシー | ゲル非含有ビーズベースの配列決定のための試薬、方法およびライブラリー |
| ES2620398T3 (es) | 2006-05-22 | 2017-06-28 | Nanostring Technologies, Inc. | Sistemas y métodos para analizar nanoindicadores |
| WO2007137291A1 (en) | 2006-05-23 | 2007-11-29 | Molecular Detection, Inc. | Ambient temperature stable kits for molecular diagnostics |
| EP2041318A2 (en) | 2006-06-26 | 2009-04-01 | Blood Cell Storage, Inc. | Device and method for extraction and analysis of nucleic acids from biological samples |
| WO2008005248A2 (en) * | 2006-06-30 | 2008-01-10 | Canon U.S. Life Sciences, Inc. | Real-time pcr in micro-channels |
| US8048626B2 (en) | 2006-07-28 | 2011-11-01 | California Institute Of Technology | Multiplex Q-PCR arrays |
| US8187541B2 (en) * | 2006-09-18 | 2012-05-29 | California Institute Of Technology | Apparatus for detecting target molecules and related methods |
| WO2008054595A2 (en) | 2006-09-28 | 2008-05-08 | The Regents Of The University Of California | Drug controlled molecular tags |
| WO2008052774A2 (en) | 2006-10-31 | 2008-05-08 | Noxxon Pharma Ag | Methods for detection of a single- or double-stranded nucleic acid molecule |
| US9201063B2 (en) | 2006-11-16 | 2015-12-01 | General Electric Company | Sequential analysis of biological samples |
| WO2008067567A2 (en) | 2006-11-30 | 2008-06-05 | Gen-Probe Incorporated | Quantitative method employing adjustment of pre-defined master calibration curves |
| KR101433208B1 (ko) | 2006-12-13 | 2014-08-22 | 루미넥스 코포레이션 | 실시간으로 pcr의 다중 분석을 위한 시스템과 방법 |
| CA2580589C (en) * | 2006-12-19 | 2016-08-09 | Fio Corporation | Microfluidic detection system |
| WO2008109636A1 (en) | 2007-03-05 | 2008-09-12 | University Of Utah Research Foundation | Methods and compositions related to nucleic acid detection |
| WO2008118998A2 (en) | 2007-03-27 | 2008-10-02 | Primera Biosystems Inc. | Method for multiplex detection and quantitation of nucleic acids |
| WO2008124847A2 (en) | 2007-04-10 | 2008-10-16 | Nanostring Technologies, Inc. | Methods and computer systems for identifying target-specific sequences for use in nanoreporters |
| WO2009003493A2 (en) | 2007-07-03 | 2009-01-08 | Dako Denmark A/S | Mhc multimers, methods for their generation, labeling and use |
| EP2193356B1 (en) | 2007-08-29 | 2014-07-23 | Eppendorf Ag | Device and method for radiometric measurement of a plurality of samples |
| WO2009036514A2 (en) | 2007-09-20 | 2009-03-26 | Molecular Plant Breeding Nominees Ltd | Method of amplifying nucleic acid |
| WO2009081967A1 (ja) | 2007-12-26 | 2009-07-02 | Arkray, Inc. | 標的核酸配列の増幅方法およびそれに用いるプローブ |
| EP2116614A1 (en) | 2008-05-06 | 2009-11-11 | Qiagen GmbH | Simultaneous detection of multiple nucleic acid sequences in a reaction |
| EA201170088A1 (ru) * | 2008-06-25 | 2011-10-31 | Бейлор Рисёч Инститьют | Транскрипционная сигнатура крови инфекции mycobacterium tuberculosis |
| GB0812862D0 (en) | 2008-07-14 | 2008-08-20 | Lumora Ltd | Nucleic acid amplification |
| WO2010013017A1 (en) | 2008-07-31 | 2010-02-04 | Oxitec Limited | Multiplex amplification and detection |
| EP2315844A1 (en) | 2008-08-08 | 2011-05-04 | Smiths Detection Inc. | Detection algorithm for pcr assay |
| US8519115B2 (en) | 2008-08-14 | 2013-08-27 | Nanostring Technologies, Inc. | Stable nanoreporters |
| US8951939B2 (en) | 2011-07-12 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Digital assays with multiplexed detection of two or more targets in the same optical channel |
| US9921154B2 (en) | 2011-03-18 | 2018-03-20 | Bio-Rad Laboratories, Inc. | Multiplexed digital assays |
| GB0821457D0 (en) * | 2008-11-24 | 2008-12-31 | Trillion Genomics Ltd | Oligonucleotides |
| WO2010063732A1 (en) | 2008-12-01 | 2010-06-10 | Biotype Ag | Novel combination of fluorescent dyes for the detection of nucleic acids |
| CN102301005A (zh) | 2008-12-17 | 2011-12-28 | 生命技术公司 | 用于检测等位基因变体的方法、组合物和试剂盒 |
| US8361738B2 (en) * | 2009-03-06 | 2013-01-29 | California Institute Of Technology | Methods for quantitative target detection and related devices and systems |
| US8039215B2 (en) | 2009-03-10 | 2011-10-18 | Roche Molecular Systems, Inc. | Multiplex quantitative nucleic acid amplification and melting assay |
| CN101570782B (zh) * | 2009-03-20 | 2012-01-11 | 曹际娟 | 乳制品中8种致病菌检测试剂盒及其检测方法 |
| FI20095514A0 (fi) * | 2009-05-07 | 2009-05-07 | Expression Analytics Oy | Menetelmä, laitteisto ja tietokoneohjelmatuote PCR-tuotteiden kvantifioimiseksi |
| EP2430187A2 (en) | 2009-05-12 | 2012-03-21 | Abacus Diagnostica OY | Method for detecting nucleic acids |
| CN102449166B (zh) | 2009-05-26 | 2013-12-04 | 厦门大学 | 一种单管检测多个单核苷酸变异或单核苷酸多态性的方法 |
| US8691504B2 (en) | 2009-05-26 | 2014-04-08 | Xiamen University | Method for detecting variations in nucleic acid sequences |
| EP2280080A1 (en) | 2009-07-31 | 2011-02-02 | Qiagen GmbH | Method of normalized quantification of nucleic acids using anchor oligonucleotides and adapter oligonucleotides |
| EP3375890B1 (en) | 2009-09-10 | 2020-01-22 | DiaSorin S.p.A. | Methods and devices for determining a crosstalk correction in nucleic acid amplification |
| US9447457B2 (en) | 2009-09-24 | 2016-09-20 | Seegene, Inc. | Detection of target nucleic acid sequences by cyclic exonucleolytic reactions |
| US8962251B2 (en) | 2009-10-08 | 2015-02-24 | Medical Service Consultation International, Llc | Methods and compositions for identifying sulfur and iron modifying bacteria |
| WO2011047087A2 (en) | 2009-10-13 | 2011-04-21 | Nanostring Technologies, Inc. | Protein detection via nanoreporters |
| US9752187B2 (en) | 2009-12-11 | 2017-09-05 | Nucleix | Categorization of DNA samples |
| US9220743B2 (en) | 2010-01-22 | 2015-12-29 | Nuovo Biologics, Llc | Pan-antiviral peptides for protein kinase inhibition |
| WO2011100541A2 (en) | 2010-02-11 | 2011-08-18 | Nanostring Technologies, Inc. | Compositions and methods for the detection of small rnas |
| EP4435111A1 (en) | 2010-02-12 | 2024-09-25 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| EP2547795B1 (en) | 2010-03-16 | 2015-01-14 | Nanostring Technologies, Inc | Compositions and methods for the detection of genomic features |
| CA2799200A1 (en) | 2010-05-19 | 2011-11-24 | Qiagen Gaithersburg, Inc. | Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids |
| CN102985566B (zh) | 2010-06-30 | 2015-06-17 | 简.探针公司 | 使用分析物和过程控制信号的单次读取确定而鉴定含分析物的样品的方法和设备 |
| US8877464B2 (en) | 2010-07-29 | 2014-11-04 | Roche Molecular Systems, Inc. | Qualitative and quantitative detection of microbial nucleic acids |
| US10024796B2 (en) | 2010-10-29 | 2018-07-17 | President And Fellows Of Harvard College | Nucleic acid nanostructure barcode probes |
| JP6063395B2 (ja) | 2011-01-20 | 2017-01-18 | ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーション | デジタル測定を実施するための方法およびシステム |
| US20150140554A1 (en) | 2011-02-03 | 2015-05-21 | Richard O. Snyder | Detection Methods for Target DNA |
| JP2014509865A (ja) | 2011-03-18 | 2014-04-24 | バイオ−ラッド・ラボラトリーズ・インコーポレーテッド | シグナルの組合せ使用による多重化デジタルアッセイ |
| WO2012129115A2 (en) | 2011-03-18 | 2012-09-27 | University Of South Florida | Materials and methods for profiling micrornas |
| US9758834B2 (en) | 2011-03-28 | 2017-09-12 | Nanostring Technologies, Inc. | Compositions and methods for diagnosing cancer |
| CA2839705A1 (en) | 2011-06-24 | 2012-12-27 | Nanostring Technologies, Inc. | Multivariate diagnostic assays and methods for using same |
| US10196681B2 (en) | 2011-10-06 | 2019-02-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US8858623B2 (en) | 2011-11-04 | 2014-10-14 | Valtech Cardio, Ltd. | Implant having multiple rotational assemblies |
| CN102559868B (zh) * | 2011-11-28 | 2014-11-05 | 厦门大学 | 一种单管定性并定量检测多个目标核酸序列的方法 |
| EP2794928B1 (en) * | 2011-12-22 | 2019-02-20 | President and Fellows of Harvard College | Compositions and methods for analyte detection |
| BR112014019168B1 (pt) | 2012-02-03 | 2021-10-05 | California Institute Of Technology | Método capaz de detectar de forma não degenerada presença ou ausência de analitos em um único volume de amostra e método de detecção da presença ou ausência de cada analito dentre uma pluralidade de analitos |
| WO2014004609A2 (en) | 2012-06-27 | 2014-01-03 | University Of Medicine & Dentistry Of New Jersey | Rapid assays for t-cell activation by rna measurements using flow cytometry |
| CN104662172B (zh) | 2012-08-03 | 2018-07-06 | 加州理工学院 | Pcr中具有减少的硬件和要求的多重化和定量 |
| GB201218909D0 (en) | 2012-10-22 | 2012-12-05 | Univ Singapore | Assay for the parallel detection of biological material based on PCR |
| EP4570924A3 (en) | 2013-01-24 | 2025-09-03 | California Institute of Technology | Chromophore-based characterization and detection methods |
| CN105339505B (zh) | 2013-03-12 | 2021-08-10 | 生命技术公司 | 基于通用报告体的基因分型方法和材料 |
| EP2873740A1 (en) | 2013-11-19 | 2015-05-20 | Oncodiag | Methods for the surveillance, diagnosis and screening of bladder cancer |
| US9670530B2 (en) | 2014-01-30 | 2017-06-06 | Illumina, Inc. | Haplotype resolved genome sequencing |
| WO2015147370A1 (en) | 2014-03-28 | 2015-10-01 | Seegene, Inc. | Detection of target nucleic acid sequences using different detection temperatures |
| US10801067B2 (en) | 2014-05-09 | 2020-10-13 | Eurofins Lifecodexx Gmbh | Detection of DNA that originates from a specific cell-type and related methods |
| EP3274476B1 (en) | 2015-03-25 | 2023-06-07 | The General Hospital Corporation | Digital analysis of circulating tumor cells in blood samples |
| EP3800249B1 (en) | 2016-02-10 | 2022-06-22 | The Regents of The University of Michigan | Detection of nucleic acids |
| WO2017173035A1 (en) | 2016-04-01 | 2017-10-05 | Chromacode Inc. | Competitive probes for engineering signal generation |
| US10066263B2 (en) | 2016-06-17 | 2018-09-04 | California Institute Of Technology | Nucleic acid reactions and related methods and compositions |
| KR102288461B1 (ko) | 2016-10-24 | 2021-08-11 | 온테라 인크. | 시료 내 폴리뉴클레오타이드 서열의 분포 분율 |
| EP3645749B1 (en) | 2017-06-28 | 2022-03-02 | Chromacode, Inc. | Multiplexed fluorometric measurements with droplet pcr systems |
| US20190112636A1 (en) | 2017-10-16 | 2019-04-18 | ChromaCode, Inc. | Methods and compositions for nucleic acid detection |
| WO2019169043A1 (en) | 2018-02-28 | 2019-09-06 | ChromaCode, Inc. | Molecular targets for fetal nucleic acid analysis |
| US12203129B2 (en) | 2018-07-03 | 2025-01-21 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030148544A1 (en) | 2001-06-28 | 2003-08-07 | Advanced Research And Technology Institute, Inc. | Methods of preparing multicolor quantum dot tagged beads and conjugates thereof |
| US20080124705A1 (en) | 2003-04-30 | 2008-05-29 | Kramer Fred R | Homogeneous multiplex screening assays and kits |
| US20070178485A1 (en) | 2005-09-01 | 2007-08-02 | El-Deiry Wafik S | Molecular beacons, methods and kits for detecting DNA damage response |
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