KR101810799B1 - 의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도 - Google Patents
의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도 Download PDFInfo
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| US8021847B2 (en) | 2004-06-02 | 2011-09-20 | Proxy Life Science Holdings, Inc. | Microvesicle-based compositions and methods |
| JP2008501336A (ja) * | 2004-06-02 | 2008-01-24 | ソースフアーム・インコーポレイテツド | Rnaを含有する微小胞およびそのための方法 |
| EP1871809A2 (en) * | 2005-04-22 | 2008-01-02 | Morphotek, Inc. | Antibodies with immune effector activity and that internalize in endosialin-positive cells |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| CN103820562B (zh) | 2005-08-01 | 2015-05-13 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| JP2009507918A (ja) | 2005-09-12 | 2009-02-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | Bcl2関連癌の診断及び療法のための組成物及び方法 |
| EP1969147B1 (en) | 2006-01-05 | 2014-07-30 | The Ohio State University Research Foundation | microRNA-based methods for the diagnosis of stomach cancer |
| ES2553442T3 (es) | 2006-01-05 | 2015-12-09 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| US7670840B2 (en) | 2006-01-05 | 2010-03-02 | The Ohio State University Research Foundation | Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors |
| DK3517151T3 (da) * | 2006-03-09 | 2021-07-12 | Aethlon Medical Inc | Ekstrakorporal fjernelse af mikrovesikulære partikler |
| EP2369011A1 (en) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Microrna fingerprints during human megakaryocytopoiesis |
| EP2041317A4 (en) | 2006-07-13 | 2009-10-14 | Univ Ohio State Res Found | METHODS AND COMPOSITIONS BASED ON MICRO-RNA FOR THE DIAGNOSIS AND TREATMENT OF COLON CANCER RELATED DISEASES |
| EP2061907B1 (en) | 2006-09-19 | 2011-11-23 | The Ohio State University Research Foundation | Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 |
| US8252538B2 (en) | 2006-11-01 | 2012-08-28 | The Ohio State University | MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma |
| WO2008094545A2 (en) | 2007-01-31 | 2008-08-07 | The Ohio State University Research Foundation | Mic orna-based methods and compositions for the treatment of acute myeloid leukemia |
| CA2682726C (en) * | 2007-04-05 | 2017-05-09 | Morphotek, Inc. | Methods for inhibiting the binding of endosialin to ligands |
| AU2008248319B2 (en) * | 2007-04-30 | 2013-09-05 | The Ohio State University Research Foundation | Methods for differentiating pancreatic cancer from normal pancreatic function and/or chronic pancreatitis |
| ES2537349T3 (es) | 2007-06-08 | 2015-06-05 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para determinar un subtipo de carcinoma hepatocelular |
| CN101918424A (zh) | 2007-06-15 | 2010-12-15 | 俄亥俄州立大学研究基金会 | 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白 |
| CN101809169B (zh) | 2007-07-31 | 2013-07-17 | 俄亥俄州立大学研究基金会 | 通过靶向dnmt3a和dnmt3b恢复甲基化的方法 |
| EP2653561B1 (en) | 2007-08-03 | 2016-03-02 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| US20100255514A1 (en) * | 2007-08-16 | 2010-10-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| CA2733672C (en) | 2007-08-16 | 2018-09-11 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| EP3028708A1 (en) | 2007-08-22 | 2016-06-08 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| EP2212440A4 (en) * | 2007-10-11 | 2011-04-06 | Univ Ohio State Res Found | METHOD AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF ADENOCARCINOMES OF DISHES |
| CA2703707A1 (en) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (fhit) interaction and uses thereof |
| US20120058492A1 (en) * | 2008-01-25 | 2012-03-08 | Hansabiomed Ou | Method and a Kit To Detect Malignant Tumors and Provide a Prognosis |
| WO2011009104A1 (en) * | 2009-07-16 | 2011-01-20 | The General Hospital Corporation | Nucleic acid analysis |
| CN102027129B (zh) * | 2008-02-28 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物 |
| CA2716906A1 (en) * | 2008-02-28 | 2009-09-03 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis, prognosis and treatment of gastric cancer |
| US11266736B2 (en) | 2008-04-17 | 2022-03-08 | Vin De Bona Trading Company Pte Ltd | Method of painting micro vesicles |
| EP2307028B1 (en) | 2008-06-11 | 2013-10-02 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| JP2012500389A (ja) * | 2008-08-12 | 2012-01-05 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 多発性脊髄腫の診断、予後および治療のためのマイクロrnaに基づく組成物および方法 |
| CN102203295A (zh) * | 2008-09-03 | 2011-09-28 | 约翰霍普金斯大学 | 胰腺肿瘤发生的通路及遗传性胰腺癌基因 |
| WO2010028288A2 (en) | 2008-09-05 | 2010-03-11 | Aueon, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| US9487837B2 (en) * | 2008-10-06 | 2016-11-08 | Morehouse School Of Medicine | Exosome-mediated diagnosis of hepatitis virus infections and diseases |
| US20110301221A1 (en) * | 2008-10-10 | 2011-12-08 | Swedish Health Services | Diagnosis, prognosis and treatment of glioblastoma multiforme |
| US7888035B2 (en) | 2008-10-30 | 2011-02-15 | Caris Mpi, Inc. | Methods for assessing RNA patterns |
| WO2010056337A2 (en) | 2008-11-12 | 2010-05-20 | Caris Mpi, Inc. | Methods and systems of using exosomes for determining phenotypes |
| GB0822836D0 (en) * | 2008-12-15 | 2009-01-21 | Oxford Biomedica Ltd | Method |
| EP2202522A1 (en) * | 2008-12-23 | 2010-06-30 | Universiteit Leiden | Methods for immobilizing microvesicles, means and methods for detecting them, and uses thereof |
| WO2011006119A2 (en) | 2009-07-09 | 2011-01-13 | The Scripps Research Institute | Gene expression profiles associated with chronic allograft nephropathy |
| EP2475988B1 (en) | 2009-09-09 | 2018-11-14 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| US20130029339A1 (en) | 2009-09-09 | 2013-01-31 | The General Hospital Corporation | Use of microvesicles in analyzing kras mutations |
| US20120309640A1 (en) * | 2009-10-08 | 2012-12-06 | Torti Frank M | Diagnostic and Prognostic Markers for Cancer |
| WO2011063324A2 (en) * | 2009-11-20 | 2011-05-26 | The General Hospital Corporation | Microfluidic systems for isolating microvesicles |
| AU2010321555B2 (en) | 2009-11-23 | 2015-10-15 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| CA2782284A1 (en) * | 2009-11-30 | 2011-06-03 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Methods and systems for isolating, storing, and analyzing vesicles |
| US9315802B2 (en) | 2009-12-30 | 2016-04-19 | Quest Diagnostics Investments Incorporated | RNA isolation from soluble urine fractions |
| EP2370599B1 (en) | 2010-01-19 | 2015-01-21 | Verinata Health, Inc | Method for determining copy number variations |
| US20120100548A1 (en) | 2010-10-26 | 2012-04-26 | Verinata Health, Inc. | Method for determining copy number variations |
| JP2011149859A (ja) * | 2010-01-22 | 2011-08-04 | Igaku Seibutsugaku Kenkyusho:Kk | 食道癌マーカー |
| US20130052647A1 (en) * | 2010-02-10 | 2013-02-28 | Marianna Goldrick | Methods for fractionating and processing microparticles from biological samples and using them for biomarker discovery |
| EP2415877A3 (en) * | 2010-02-17 | 2012-02-15 | Deutsches Krebsforschungszentrum | Means and methods for diagnosing pancreatic cancer |
| EP2542696B1 (en) | 2010-03-01 | 2016-09-28 | Caris Life Sciences Switzerland Holdings GmbH | Biomarkers for theranostics |
| WO2011107962A1 (en) | 2010-03-03 | 2011-09-09 | Consiglio Nazionale Delle Ricerche | Increase of myeloid microvesicles in the cerebrospinal fluid as biomarker of microglia/macrophage activation in neurological disorders |
| JP2013526852A (ja) | 2010-04-06 | 2013-06-27 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス | 疾患に対する循環バイオマーカー |
| WO2011128900A2 (en) * | 2010-04-15 | 2011-10-20 | Hadasit Medical Research Services And Development Ltd. | Early detection and staging of colorectal cancer using a panel of micro rnas |
| CN103154236B (zh) | 2010-05-12 | 2016-08-31 | 再生医学Tx有限责任公司 | 生物活性肾细胞 |
| WO2011140662A1 (en) * | 2010-05-13 | 2011-11-17 | The Royal Institution For The Advancement Of Learning / Mcgill University | Cux1 signature for determination of cancer clinical outcome |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| WO2011146632A1 (en) | 2010-05-18 | 2011-11-24 | Gene Security Network Inc. | Methods for non-invasive prenatal ploidy calling |
| US12545960B2 (en) | 2010-05-18 | 2026-02-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9376679B2 (en) | 2010-05-26 | 2016-06-28 | Micromedmark Biotech Co. Ltd. | Microvesicles carrying small interfering RNAs, preparation methods and uses thereof |
| EP2578236B1 (en) | 2010-05-26 | 2016-03-30 | Micromedmark Biotech Co., Ltd | PREPARATION OF MICROVESICLE-siRNA COMPLEXES AND USE THEREOF IN AIDS TREATMENT |
| WO2011156734A2 (en) | 2010-06-11 | 2011-12-15 | Hitachi Chemical Co., Ltd. | Method of characterizing vascular diseases |
| WO2011156763A1 (en) * | 2010-06-11 | 2011-12-15 | Hitachi Chemical Co., Ltd. | Methods for characterizing kidney function |
| BR112013000024B1 (pt) * | 2010-07-01 | 2021-11-23 | Aeon Medix Inc | Composição para entregar um agente anticancer e método para preparação de microvesículas carregadas com um agente anticâncer, a partir de protoplastos de células bacterianas |
| US8980549B2 (en) | 2010-08-01 | 2015-03-17 | Ramot At Tel Aviv University Ltd. | MicroRNA patterns for the diagnosis, prognosis and treatment of melanoma |
| WO2012020308A2 (en) * | 2010-08-13 | 2012-02-16 | The University Court Of The University Of Glasgow | Cellular and molecular therapies |
| CA2808417A1 (en) * | 2010-08-18 | 2012-02-23 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| AU2011293355A1 (en) * | 2010-08-24 | 2013-03-14 | Bio Dx, Inc. | Defining diagnostic and therapeutic targets of conserved free floating fetal DNA in maternal circulating blood |
| WO2012031008A2 (en) | 2010-08-31 | 2012-03-08 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| WO2012071096A2 (en) * | 2010-09-03 | 2012-05-31 | The Johns Hopkins University | Arid1a and ppp2r1a mutations in cancer |
| EP2619329B1 (en) | 2010-09-24 | 2019-05-22 | The Board of Trustees of The Leland Stanford Junior University | Direct capture, amplification and sequencing of target dna using immobilized primers |
| WO2012051622A2 (en) * | 2010-10-15 | 2012-04-19 | The General Hospital Corporation | Microvesicle-based assays |
| WO2012054975A1 (en) * | 2010-10-28 | 2012-05-03 | Clinical Genomics Pty. Ltd. | Method of microvesicle enrichment |
| CN107823706B (zh) | 2010-11-10 | 2022-02-01 | 因瑞金公司 | 用于器官增强的注射制剂 |
| CA2817111C (en) * | 2010-11-10 | 2019-03-05 | Exosome Diagnostics, Inc. | Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom |
| ES2606146T3 (es) | 2010-11-12 | 2017-03-22 | The Ohio State University Research Foundation | Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal |
| US20130295590A1 (en) * | 2010-11-15 | 2013-11-07 | The Regents Of The University Of Colorado, A Body Corporate | Foxa1 as a marker for invasive bladder cancer |
| CN103313706A (zh) | 2010-11-15 | 2013-09-18 | 俄亥俄州立大学研究基金会 | 控制释放粘膜粘合系统 |
| EP3081651A1 (en) * | 2010-11-24 | 2016-10-19 | Yale University | Compositions and methods for diagnosing and treating diseases and disorders associated with d-dt |
| CN103608466B (zh) | 2010-12-22 | 2020-09-18 | 纳特拉公司 | 非侵入性产前亲子鉴定方法 |
| WO2012092490A1 (en) * | 2010-12-30 | 2012-07-05 | Quest Diagnostics Investments Incorporated | Diagnosis of prostate cancer |
| US20130017964A1 (en) * | 2011-01-11 | 2013-01-17 | Croce Carlo M | Methods to Identify Chronic Lymphocytic Leukemia Disease Progression |
| WO2012100023A1 (en) * | 2011-01-19 | 2012-07-26 | Thomas Jefferson University | Detection of pancreatic ductal adenocarcinoma |
| CA2826111A1 (en) * | 2011-01-31 | 2012-08-09 | Esoterix Genetic Laboratories, Llc | Methods for enriching microparticles or nucleic acids in a complex mixture using size exclusion filtration |
| CA2821355A1 (en) * | 2011-01-31 | 2012-08-09 | Esoterix Genetic Laboratories, Llc | Methods for enriching microparticles or nucleic acids using binding molecules |
| EP2484779A1 (en) * | 2011-02-03 | 2012-08-08 | Medizinische Hochschule Hannover | Device and method for analysis of kidney failure |
| RU2671980C2 (ru) | 2011-02-09 | 2018-11-08 | Натера, Инк. | Способы неинвазивного пренатального установления плоидности |
| SG183579A1 (en) * | 2011-02-11 | 2012-09-27 | Agency Science Tech & Res | Methods of detecting therapeutic exosomes |
| WO2012112865A2 (en) * | 2011-02-17 | 2012-08-23 | Cornell University | Compositions and methods to prevent cell transformation and cancer metastasis |
| US8664192B2 (en) | 2011-03-07 | 2014-03-04 | The Ohio State University | Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer |
| WO2012135814A2 (en) * | 2011-03-31 | 2012-10-04 | University Of Houston | Microrna29a,b,c as a tumor suppressor and sensitizing agent for chemotherapy |
| WO2012135844A2 (en) * | 2011-04-01 | 2012-10-04 | Cornell University | Circulating exosomes as diagnostic/prognostic indicators and therapeutic targets of melanoma and other cancers |
| RU2626540C2 (ru) | 2011-04-18 | 2017-07-28 | Диамир, Ллс | Способы обнаружения патологических изменений в органе или системе органов |
| CA2835641C (en) * | 2011-05-11 | 2019-05-28 | Exosome Diagnostics, Inc. | Nucleic acid extraction from heterogeneous biological materials |
| CN103782174A (zh) * | 2011-06-07 | 2014-05-07 | 卡里斯生命科学卢森堡控股有限责任公司 | 用于癌症的循环生物标志物 |
| JP5823031B2 (ja) | 2011-06-10 | 2015-11-25 | 日立化成株式会社 | 小胞捕捉デバイスおよびそれを用いるための方法 |
| US20140275211A1 (en) * | 2011-06-21 | 2014-09-18 | Alnylam Pharmaceuticals, Inc. | Assays and methods for determining activity of a therapeutic agent in a subject |
| US20150018227A1 (en) * | 2011-08-05 | 2015-01-15 | University Of Louisville Research Foundation, Inc. | Microrna biomarkers |
| WO2013023132A1 (en) | 2011-08-10 | 2013-02-14 | Wake Forest University Health Sciences | Diagnostic and prognostic markers for cancer |
| WO2013023376A1 (en) | 2011-08-18 | 2013-02-21 | Ming-Chung Jiang | Microvesicle membrane protein and application thereof |
| EP3492606B1 (en) * | 2011-08-22 | 2023-10-04 | Exosome Diagnostics, Inc. | Urine biomarkers |
| US9939442B2 (en) * | 2011-09-08 | 2018-04-10 | The Regents Of The University Of California | Salivary biomarkers for gastric cancer detection |
| RU2014115999A (ru) * | 2011-09-22 | 2015-10-27 | Универсидад Де Лос Андес | Способ мониторинга, диагностики и/или прогнозирования острого повреждения почек на ранней стадии |
| WO2013048734A1 (en) * | 2011-09-28 | 2013-04-04 | Tufts Medical Center, Inc. | Treatment and prevention of cardiovascular disease with cell derived lipid vesicles, microvesicles and exosomes |
| EP2766500A4 (en) | 2011-10-14 | 2015-10-14 | Univ Ohio State | METHOD AND MATERIALS IN CONNECTION WITH EGG CANCER |
| US10378060B2 (en) | 2011-10-14 | 2019-08-13 | Dana-Farber Cancer Institute, Inc. | ZNF365/ZFP365 biomarker predictive of anti-cancer response |
| FR2981662A1 (fr) * | 2011-10-20 | 2013-04-26 | Assist Publ Hopitaux De Paris | Methode de quantification de marqueurs renaux par dosage urinaire. |
| AU2011320021B2 (en) * | 2011-10-26 | 2018-02-22 | Clinical Genomics Pty. Ltd. | Method of microvesicle enrichment |
| WO2013063439A1 (en) * | 2011-10-27 | 2013-05-02 | University Of Louisville Research Foundation, Inc. | Characterizing melanoma |
| WO2013067048A1 (en) * | 2011-10-31 | 2013-05-10 | The Ohio State University | Materials and methods related to mir-221 and hepatocellular carcinoma |
| US10174361B2 (en) | 2011-11-10 | 2019-01-08 | Exosome Diagnostics, Inc. | Cerebrospinal fluid assay |
| AU2012352265B2 (en) | 2011-12-13 | 2017-02-16 | Ohio State Innovation Foundation | Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis |
| ITRM20110685A1 (it) | 2011-12-23 | 2013-06-24 | Internat Ct For Genetic En Gineering And | Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci |
| US8859202B2 (en) | 2012-01-20 | 2014-10-14 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| WO2013119602A1 (en) | 2012-02-06 | 2013-08-15 | President And Fellows Of Harvard College | Arrdc1-mediated microvesicles (armms) and uses thereof |
| US20150152474A1 (en) * | 2012-03-09 | 2015-06-04 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarker compositions and methods |
| WO2013148147A1 (en) | 2012-03-26 | 2013-10-03 | The U.S.A., As Represented By The Secretary Dept. Of Health And Human Services | Dna methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms |
| CN103374625B (zh) * | 2012-04-27 | 2016-04-13 | 中国科学院上海生命科学研究院 | 先天性心脏病相关基因dlc1及其应用 |
| US9334498B2 (en) | 2012-05-10 | 2016-05-10 | Uab Research Foundation | Methods and compositions for modulating MIR-204 activity |
| WO2013176765A1 (en) * | 2012-05-21 | 2013-11-28 | The Penn State Research Foundation | Compositions and methods relating to dennd1a variant 2 and polycystic ovary syndrome |
| WO2013184905A1 (en) | 2012-06-06 | 2013-12-12 | Myriad Genetics, Inc. | Hereditary cancer genes |
| WO2014004424A1 (en) | 2012-06-26 | 2014-01-03 | Temple University - Of The Commonwealth System Of Higher Education | Method for detecting injury to the brian |
| CA2877721A1 (en) | 2012-06-27 | 2014-01-03 | Berg Llc | Use of markers in the diagnosis and treatment of prostate cancer |
| US20140018299A1 (en) * | 2012-07-10 | 2014-01-16 | Banyan Biomarkers, Inc. | Method and device to detect, monitor and promote neural regeneration and improvement of cognitive function in a subject suffering from neural injury |
| US20150176073A1 (en) * | 2012-07-18 | 2015-06-25 | Exosome Diagnostics, Inc. | Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions |
| CA2879337C (en) * | 2012-07-19 | 2021-11-30 | Atlantic Cancer Research Institute | Method for the isolation of microvesicles |
| WO2014028862A1 (en) | 2012-08-17 | 2014-02-20 | Cornell University | Use of dna in circulating exosomes as a diagnostic marker for metastasic disease |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| US12590965B2 (en) | 2012-08-23 | 2026-03-31 | Cedars-Sinai Medical Center | Palmitoyl protein biomarkers in purified extracellular vesicles for early identification of clinically significant prostate cancer |
| CN104995311A (zh) | 2012-08-30 | 2015-10-21 | 外来体诊断公司 | 用于核酸测定的对照 |
| WO2014041087A1 (en) | 2012-09-12 | 2014-03-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Muscle secretome and uses thereof |
| WO2014055775A1 (en) | 2012-10-03 | 2014-04-10 | Exosome Diagnostics, Inc. | Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions |
| TWI485159B (zh) * | 2012-10-11 | 2015-05-21 | Ming Chung Jiang | 一個微泡膜蛋白及其應用 |
| DK2906717T3 (en) | 2012-10-11 | 2019-04-01 | Vin De Bona Trading Company Pte Ltd | PROCEDURE FOR PAINTING MICROVESICS |
| WO2014062218A1 (en) * | 2012-10-16 | 2014-04-24 | University Of Southern California | Colorectal cancer dna methylation markers |
| EP4170031A1 (en) * | 2012-10-23 | 2023-04-26 | Caris Science, Inc. | Aptamers and uses thereof |
| US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
| SI2912165T1 (sl) | 2012-10-24 | 2019-11-29 | Inregen | Populacije ledvičnih celic in njihova uporaba |
| EP2916853B1 (en) * | 2012-11-09 | 2020-05-06 | Velin-Pharma A/S | Compositions for pulmonary delivery |
| US20150292030A1 (en) * | 2012-11-27 | 2015-10-15 | Board Of Regents, The University Of Texas System | Methods of characterizing and treating molecular subset of muscle-invasive bladder cancer |
| EP2746406B1 (en) | 2012-12-18 | 2017-08-23 | Samsung Electronics Co., Ltd. | Composition and kit for diagnosing breast cancer including miRNAs within vesicle, and method of diagnosing breast cancer using the same |
| AU2013361323B2 (en) * | 2012-12-19 | 2018-09-06 | Caris Science, Inc. | Compositions and methods for aptamer screening |
| CN110106229B (zh) | 2013-01-03 | 2023-03-28 | 外来体诊断公司 | 用于分离微囊泡的方法 |
| EP2959016A4 (en) * | 2013-02-21 | 2016-10-12 | Toma Biosciences Inc | METHOD, COMPOSITIONS AND NUCLEIC ACID ANALYSIS KITS |
| WO2014132244A1 (en) * | 2013-02-28 | 2014-09-04 | The Chinese University Of Hong Kong | Maternal plasma transcriptome analysis by massively parallel rna sequencing |
| US10793913B2 (en) * | 2013-03-08 | 2020-10-06 | City Of Hope | Methods and compositions for treatment of breast cancer |
| WO2014160032A1 (en) * | 2013-03-13 | 2014-10-02 | University Of Louisville Research Foundation, Inc. | Exosome-associated rna as a diagnostic marker |
| WO2014159662A1 (en) * | 2013-03-13 | 2014-10-02 | University Of Miami | Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids |
| US12558316B2 (en) | 2013-03-13 | 2026-02-24 | University Of Miami | Methods and compositions for the treatment of epidermolysis bullosa |
| BR112015023275B1 (pt) | 2013-03-15 | 2022-06-21 | Board Of Regents, The University Of Texas System | Método in vitro de detecção de biomarcador de câncer |
| KR101473557B1 (ko) | 2013-03-29 | 2014-12-24 | 포항공과대학교 산학협력단 | 원심력을 이용한 세포유래 인공 마이크로베시클 제조 장치 |
| CN105431552B (zh) * | 2013-04-12 | 2020-03-03 | 香港中文大学 | 多组学标记在预测糖尿病中的用途 |
| EP2986326B1 (en) * | 2013-04-15 | 2018-09-05 | Cedars-Sinai Medical Center | Methods for detecting cancer metastasis |
| WO2014182330A1 (en) | 2013-05-06 | 2014-11-13 | Hitachi Chemical Company Ltd | Devices and methods for capturing target molecules |
| EP2999967B1 (en) * | 2013-05-21 | 2020-05-20 | NX Pharmagen | Use of tenascin-c as an extracellular marker of tumor-derived microparticles |
| US10071170B2 (en) | 2013-06-24 | 2018-09-11 | Ablbio | Antibody-drug conjugate having improved stability and use thereof |
| CN103272248B (zh) * | 2013-06-28 | 2016-03-30 | 上海市内分泌代谢病研究所 | miR-15b在制备糖尿病诊疗制剂中的应用 |
| US10338061B2 (en) * | 2013-07-12 | 2019-07-02 | Young Ah Kwon | Method for diagnosis of diseases using morphological characteristics of luterial |
| CA2920429C (en) * | 2013-08-06 | 2021-11-16 | Exosome Diagnostics, Inc. | Urine biomarker cohorts, gene expression signatures, and methods of use thereof |
| KR20150043937A (ko) | 2013-10-15 | 2015-04-23 | 삼성전자주식회사 | 개체의 간암 진단용 조성물, 개체의 간암 진단하는 방법 및 개체의 간암 진단에 필요한 정보를 얻는 방법 |
| CA2926092A1 (en) * | 2013-10-24 | 2015-04-30 | Nanosomix, Inc. | Biomarkers and diagnostic methods for alzheimer's disease and other neurodegenerative disorders |
| ES2923942T3 (es) * | 2013-11-06 | 2022-10-03 | Us Health | Procedimiento para el subtipado de tipos de linfoma por medio de perfiles de expresión |
| CN105917005B (zh) | 2013-11-18 | 2020-09-11 | 迪阿米尔有限责任公司 | 使用来自体液的miRNA检测和监控帕金森病(PD)的方法 |
| CA2930083A1 (en) | 2013-11-19 | 2015-05-28 | The Penn State Research Foundation | Compositions and methods for prophylaxis and/or therapy of disorders that correlate with dennd1a variant 2 |
| US9921223B2 (en) * | 2013-12-04 | 2018-03-20 | Board Of Regents, The University Of Texas System | Analysis of genomic DNA, RNA, and proteins in exosomes for diagnosis and theranosis |
| JP6128621B2 (ja) * | 2013-12-04 | 2017-05-17 | 国立研究開発法人産業技術総合研究所 | マイクロベシクルに対する核酸アプタマー |
| CN111729090A (zh) * | 2013-12-20 | 2020-10-02 | 通用医疗公司 | 与循环肿瘤细胞相关的方法和测定法 |
| US10590384B2 (en) | 2014-01-14 | 2020-03-17 | Luterion Co., Ltd. | Luterial and method for isolating and culturing the same |
| WO2015108342A1 (ko) * | 2014-01-14 | 2015-07-23 | 최원철 | 루테리알의 형태특성을 이용한 암 예방제 또는 항암제의 스크리닝 방법 |
| HK1231516A1 (zh) * | 2014-01-14 | 2017-12-22 | 崔元哲 | Luterial和用於其分离及培养的方法 |
| US20160346334A1 (en) * | 2014-02-05 | 2016-12-01 | Stc.Unm | Exosomes as a therapeutic for cancer |
| US10941446B2 (en) | 2014-03-12 | 2021-03-09 | Icahn School Of Medicine At Mount Sinai | Method for identifying kidney allograft recipients at risk for chronic injury |
| EP3125907A4 (en) * | 2014-04-01 | 2017-11-29 | Cornell University | Use of double-stranded dna in exosomes: a novel biomarker in cancer detection |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| CA2945962C (en) | 2014-04-21 | 2023-08-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US11104951B2 (en) | 2014-05-22 | 2021-08-31 | The Scripps Research Institute | Molecular signatures for distinguishing liver transplant rejections or injuries |
| US10443100B2 (en) | 2014-05-22 | 2019-10-15 | The Scripps Research Institute | Gene expression profiles associated with sub-clinical kidney transplant rejection |
| US11268085B2 (en) | 2014-05-27 | 2022-03-08 | Exosome Diagnostics, Inc. | Methods for isolating microvesicles and extracting nucleic acids from biological samples |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| BR112016029634A2 (pt) | 2014-06-18 | 2017-10-24 | Nat Cancer Ct | kit, dispositivo e método para a detecção de câncer de fígado |
| CN113444783B (zh) | 2014-06-26 | 2024-04-09 | 西奈山伊坎医学院 | 通过分析预示性基因集诊断亚临床和临床的急性排异的方法 |
| CA3084920C (en) | 2014-07-09 | 2023-02-28 | Exosome Diagnostics, Inc. | Methods for isolating microvesicles and extracting nucleic acids from biological samples |
| EP3998273A1 (en) * | 2014-07-17 | 2022-05-18 | The Trustees Of The University Of Pennsylvania | Methods for using exosomes to monitor transplanted organ status |
| AU2015301150A1 (en) | 2014-08-05 | 2017-02-23 | Ymir Genomics Llc | Methods for the isolation of extracellular vesicles and other bioparticles from urine and other biofluids |
| US20170298352A1 (en) * | 2014-09-30 | 2017-10-19 | Research Institute at Nationwide Children's Hospit al | Compositions and methods for treating hepatic fibrosis |
| US10260067B2 (en) * | 2014-10-01 | 2019-04-16 | The Brigham And Women's Hospital, Inc. | Enhancing dermal wound healing by downregulating microRNA-26a |
| US11397182B2 (en) | 2014-10-07 | 2022-07-26 | Cornell University | Methods for prognosing and preventing metastatic liver disease |
| CN104535766B (zh) * | 2014-10-30 | 2016-04-13 | 中国人民解放军总医院第一附属医院 | 外周血exosome来源的肝癌诊断和预后标志物及其应用 |
| US9816080B2 (en) | 2014-10-31 | 2017-11-14 | President And Fellows Of Harvard College | Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs) |
| US10266895B2 (en) | 2014-11-05 | 2019-04-23 | Hitachi Chemical Company Ltd. | Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease |
| EP3218521B1 (en) | 2014-11-12 | 2019-12-25 | Hitachi Chemical Co., Ltd. | Method for diagnosing organ injury |
| WO2016081699A1 (en) * | 2014-11-19 | 2016-05-26 | Boyer Thomas G | Novel peptide activator of cyclin c-dependent kinase 8 (cdk8) |
| CN104372004B (zh) * | 2014-12-04 | 2018-04-27 | 广东医学院 | 一个与心肌梗死易感相关的miR-27a基因单核苷酸多态位点的检测方法及其应用 |
| CN104404044B (zh) * | 2014-12-04 | 2018-04-27 | 广东医学院 | 与心肌梗死易感相关的anril基因外显子区单核苷酸多态位点的检测方法及其应用 |
| US10539566B2 (en) | 2014-12-08 | 2020-01-21 | Berg Llc | Use of markers including filamin A in the diagnosis and treatment of prostate cancer |
| EP3034623A1 (en) * | 2014-12-18 | 2016-06-22 | Centro de Investigación Biomédica en Red (CIBER) | Method for predicting response to continuous positive air pressure treatment |
| CN107429226A (zh) | 2015-01-06 | 2017-12-01 | 株式会社露太利温 | luterion及其分离和培养方法 |
| EP3287137B1 (en) * | 2015-03-12 | 2021-05-05 | Mitsui Chemicals, Inc. | Method for disrupting exosomes, exosome disruption kit, and method for separating exosomes derived from normal cells |
| JP2016192906A (ja) * | 2015-03-31 | 2016-11-17 | シスメックス株式会社 | 乳がんに関する情報の取得方法、ならびに乳がんに関する情報を取得するためのマーカー及び乳がん検出用キット |
| US11971402B2 (en) | 2015-04-24 | 2024-04-30 | Cornell University | Methods and reagents for determination and treatment of organotropic metastasis |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| EP3307890A1 (en) | 2015-06-10 | 2018-04-18 | Board of Regents, The University of Texas System | Use of exosomes for the treatment of disease |
| DE112016003948T5 (de) | 2015-08-31 | 2018-05-09 | City Of Sapporo | Molekulare verfahren zum beurteilen einer urothelialen erkrankung |
| KR102087373B1 (ko) * | 2015-09-11 | 2020-03-10 | 주식회사 압타머사이언스 | 비소세포성 폐암 진단용 단백질 바이오마커 패널 및 이를 이용한 비소세포성 폐암 진단 방법 |
| US20190250147A1 (en) * | 2015-10-13 | 2019-08-15 | The Trustees Of The University Of Pennsylvania | Methods for using enriched exosomes as a platform for monitoring organ status |
| US20180321258A1 (en) * | 2015-11-06 | 2018-11-08 | The Trustees Of Columbia University In The City Of New York | Exosomal Protein Profiling for Detection of Cardiac Transplant Rejection |
| WO2017087866A1 (en) | 2015-11-20 | 2017-05-26 | Grand Valley State University | Nato3 mutant polypeptides and uses thereof |
| CN105296488B (zh) * | 2015-12-02 | 2018-05-01 | 中国人民解放军第三军医大学第三附属医院 | 超声微泡介导的siRNA干扰GRK4在靶向调节尿钠排泄及血压水平中的应用 |
| US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
| CN105505918B (zh) * | 2016-01-12 | 2018-03-02 | 广州赛哲生物科技股份有限公司 | 一种血清外泌体中rna的提取方法 |
| US11753682B2 (en) | 2016-03-07 | 2023-09-12 | Father Flanagan's Boys'Home | Noninvasive molecular controls |
| US11149313B2 (en) | 2016-03-21 | 2021-10-19 | Diamir, Llc | Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases |
| RU2760913C2 (ru) | 2016-04-15 | 2021-12-01 | Натера, Инк. | Способы выявления рака легкого |
| US20190093172A1 (en) * | 2016-04-15 | 2019-03-28 | Exosome Diagnostics, Inc. | Plasma-based detection of anaplastic lymphoma kinase (alk) nucleic acids and alk fusion transcripts and uses thereof in diagnosis and treatment of cancer |
| WO2017181161A1 (en) | 2016-04-15 | 2017-10-19 | Predicine, Inc. | Systems and methods for detecting genetic alterations |
| CN109072277A (zh) * | 2016-04-19 | 2018-12-21 | 凸版印刷株式会社 | 癌化可能性的评价方法及试剂盒 |
| CN109642229A (zh) | 2016-05-13 | 2019-04-16 | 外来体诊断公司 | 从生物液体分离细胞外囊泡和共分离无细胞dna的自动和手动方法 |
| US11123372B2 (en) | 2016-07-29 | 2021-09-21 | Prokidney | Bioactive renal cells for the treatment of chronic kidney disease |
| EP4115891A1 (en) | 2016-08-05 | 2023-01-11 | The Research Foundation for The State University of New York | Keratin 17 as a biomarker for bladder cancer |
| US10914748B2 (en) | 2016-09-08 | 2021-02-09 | UNIVERSITé LAVAL | Erythrocyte-derived extracellular vesicles as a biomarker for clinically assessing Parkinson's disease |
| US11174503B2 (en) | 2016-09-21 | 2021-11-16 | Predicine, Inc. | Systems and methods for combined detection of genetic alterations |
| AU2017335084B2 (en) | 2016-09-30 | 2023-06-29 | Ilias Biologics Inc. | Compositions containing protein loaded exosome and methods for preparing and delivering the same |
| US11730823B2 (en) | 2016-10-03 | 2023-08-22 | President And Fellows Of Harvard College | Delivery of therapeutic RNAs via ARRDC1-mediated microvesicles |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| CN110191962A (zh) | 2016-10-21 | 2019-08-30 | 外来体诊断公司 | 外来体相关核酸的测序和分析 |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| CN107058468B (zh) * | 2016-11-03 | 2020-09-01 | 中国人民解放军陆军军医大学 | 一种通过循环microRNA-369-3p表达水平预测急性高山病发病风险的试剂盒 |
| CN107058472B (zh) * | 2016-11-03 | 2020-10-27 | 中国人民解放军陆军军医大学 | 一种通过四种血浆microRNA联合诊断急性高山病的诊断试剂盒 |
| CN107058475B (zh) * | 2016-11-03 | 2020-10-27 | 中国人民解放军陆军军医大学 | 一种联合miR-676、miR-181b和miR-193b诊断急性高山病的试剂盒 |
| CN107058469B (zh) * | 2016-11-03 | 2020-09-01 | 中国人民解放军陆军军医大学 | 一种通过循环microRNA-449b-3p表达水平预测急性高山病发病风险的试剂盒 |
| CN107058471B (zh) * | 2016-11-03 | 2020-09-01 | 中国人民解放军陆军军医大学 | 一种通过四种microRNA生物标志物联合预测急性高山病发病风险的试剂盒 |
| WO2018089541A1 (en) | 2016-11-08 | 2018-05-17 | Cedars-Sinai Medical Center | Methods for diagnosing cancer |
| EP3538069B1 (en) | 2016-11-09 | 2025-09-03 | Benedetta Bussolati | Extracellular vesicles from stem cells for use in a treatment of chronic kidney diseases |
| JP7280823B2 (ja) * | 2016-11-30 | 2023-05-24 | エクソサム ダイアグノスティクス,インコーポレイティド | 非小細胞肺癌患者由来のエクソソームrna及び無細胞dnaを使用して血漿中の変異を検出するための方法と組成物 |
| WO2018106648A1 (en) * | 2016-12-05 | 2018-06-14 | The Penn State Research Foundation | Lipid-based probes for extracellular isolation |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| KR101942197B1 (ko) | 2016-12-28 | 2019-01-24 | 주식회사 엠디헬스케어 | 세균 메타게놈 분석을 통한 전립선질환 진단 방법 |
| EP3562959A2 (en) | 2017-01-02 | 2019-11-06 | Exosome Diagnostics, Inc. | Methods to distinguish rna and dna in a combined preparation |
| CN108300783A (zh) * | 2017-01-11 | 2018-07-20 | 上海易毕恩基因科技有限公司 | 用于筛选肠癌和/或胃癌的基因标志物的方法、用该方法筛选的基因标志物及其用途 |
| JP6797427B2 (ja) * | 2017-01-12 | 2020-12-09 | テオリアサイエンス株式会社 | 被検者が膵臓癌に罹患している可能性を試験する方法 |
| JP6873460B2 (ja) * | 2017-01-12 | 2021-05-19 | テオリアサイエンス株式会社 | 被検者が膵臓癌に罹患している可能性を試験する方法 |
| WO2018143896A1 (en) * | 2017-02-02 | 2018-08-09 | Agency For Science, Technology And Research | Ovarian cancer biomarker |
| KR101944665B1 (ko) * | 2017-02-24 | 2019-02-01 | 주식회사 엠디헬스케어 | 세균 메타게놈 분석을 통한 만성폐쇄성기도질환 진단 방법 |
| KR101940446B1 (ko) * | 2017-02-24 | 2019-01-18 | 주식회사 엠디헬스케어 | 미생물 메타게놈 분석을 통한 난소암 진단방법 |
| CN106906287B (zh) * | 2017-03-10 | 2020-10-27 | 北京昊源生物医学科技有限公司 | Prima1基因在制备椎间盘退行性疾病诊断试剂中的应用 |
| CN110462064A (zh) * | 2017-04-18 | 2019-11-15 | 深圳华大生命科学研究院 | 基于外泌体核酸进行微生物检测的方法及其应用 |
| CN110520140A (zh) * | 2017-04-19 | 2019-11-29 | 菲格内有限责任公司 | 成纤维细胞衍生的外泌体刺激血管生成 |
| US11891664B2 (en) | 2017-05-17 | 2024-02-06 | Exosome Diagnostics, Inc. | Methods of detecting renal transplant rejection using microvesicle nucleic acid biomarkers |
| MX2019014578A (es) | 2017-06-21 | 2020-12-01 | Timothy A Bertram | Celulas renales bioactivas inmunoprivilegiadas para el tratamiento de enfermedad renal. |
| WO2019008414A1 (en) * | 2017-07-05 | 2019-01-10 | Datar Rajan | GENE EXPRESSION ANALYSIS BASED ON EXOSOMES FOR THE CARE OF CANCER |
| CN111133106A (zh) | 2017-07-12 | 2020-05-08 | 外来体诊断公司 | 用于分离和富集生物流体来源的细胞外囊泡的方法及其使用方法 |
| US11345957B2 (en) | 2017-07-18 | 2022-05-31 | Exosome Diagnostics, Inc. | Methods of treating glioblastoma in a subject informed by exosomal RNA signatures |
| US10781487B2 (en) | 2017-07-24 | 2020-09-22 | Diamir, Llc | miRNA-based methods for detecting and monitoring aging |
| EP3672582B1 (en) | 2017-08-22 | 2026-04-15 | Cedars-Sinai Medical Center | Compositions and methods for treating cancer |
| WO2019055337A1 (en) * | 2017-09-13 | 2019-03-21 | Children's Hospital Medical Center | ROLE OF EXOSOMES, EXTRACELLULAR VESICLES IN THE REGULATION OF METABOLIC HOMÉOSTASIE |
| EP3684383A4 (en) * | 2017-09-20 | 2021-07-14 | Molecular Stethoscope, Inc. | METHODS AND SYSTEMS FOR DETECTION OF TISSUE DISORDERS |
| KR102243415B1 (ko) | 2017-09-27 | 2021-04-22 | ㈜로제타엑소좀 | 크기 배제 크로마토그래피를 이용한 세포밖 소포체의 분석 방법 및 이의 용도 |
| KR102109921B1 (ko) * | 2017-09-27 | 2020-05-12 | ㈜로제타엑소좀 | 크기 배제 크로마토그래피를 이용한 세포밖 소포체의 순도 분석 방법 |
| WO2019066501A1 (ko) * | 2017-09-27 | 2019-04-04 | ㈜로제타엑소좀 | 크기 배제 크로마토그래피를 이용한 세포밖 소포체의 분석 방법 및 이의 용도 |
| EP3695227A4 (en) * | 2017-10-11 | 2021-09-29 | Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center | NETRIN G1 AS A BIOMARKER TO INCREASE TUMOR TREATMENT EFFECTIVENESS |
| CN107858430B (zh) * | 2017-11-20 | 2019-01-04 | 武汉迈特维尔生物科技有限公司 | 一种用于诊断预示Her-2过表达型乳腺癌骨转移的基因诊断试剂盒 |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| ES2724215B2 (es) * | 2018-03-01 | 2020-04-14 | Univ Alcala Henares | Microvesículas endoteliales con efecto microbicida |
| WO2019178317A1 (en) | 2018-03-14 | 2019-09-19 | Children's Medical Center Corporation | Platform for assessment of the transcytosis of extracellular vesicles across endothelial barriers and uses thereof |
| EP3546946A1 (en) * | 2018-03-29 | 2019-10-02 | Rüdiger Lange | Method of diagnosing heart muscle damage |
| EP3775258A4 (en) | 2018-03-28 | 2022-01-26 | Board of Regents, The University of Texas System | IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES |
| JP7088572B2 (ja) * | 2018-04-05 | 2022-06-21 | ゲノム アンド カンパニー | 抗がんおよび免疫増強用新規ターゲット |
| US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
| CA3095198A1 (en) | 2018-04-16 | 2019-10-24 | Icahn School Of Medicine At Mount Sinai | Method and kits for prediction of acute rejection and renal allograft loss using pre-transplant transcriptomic signatures in recipient blood |
| WO2019236123A1 (en) * | 2018-06-04 | 2019-12-12 | Memorial Sloan Kettering Cancer Center | Methods of detecting cancer via assessment of extracellular vesicle- mediated horizontal transfer of dna: rna hybrids |
| WO2019236853A1 (en) | 2018-06-06 | 2019-12-12 | Exosome Diagnostics, Inc. | Methods for developing urine biomarkers and for detecting bladder cancer |
| CN108588224A (zh) * | 2018-06-14 | 2018-09-28 | 大连医科大学附属第医院 | 一种用于嗜铬细胞瘤/副神经节瘤早期诊断和术前评估的生物标志物及其应用 |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| WO2020037135A1 (en) | 2018-08-15 | 2020-02-20 | Charlesworth M Cristine | Methods and materials for identifying and treating membranous nephropathy |
| CN110872624A (zh) * | 2018-08-29 | 2020-03-10 | 深圳大学 | 一种结直肠癌标志物及其应用 |
| US12447179B2 (en) | 2018-08-31 | 2025-10-21 | Prokidney | Compositions comprising cell-delivered vesicles and uses thereof |
| CN110885830A (zh) * | 2018-09-07 | 2020-03-17 | 安徽华大医学检验所有限公司 | Fn1基因突变及其应用 |
| AU2019343188A1 (en) | 2018-09-21 | 2021-05-20 | Aufbau Medical Innovations Limited | Compositions and methods for glaucoma |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020106853A1 (en) | 2018-11-20 | 2020-05-28 | Exosome Diagnostics, Inc. | Compositions and methods for internal controls of microvesicle isolations |
| KR102178922B1 (ko) * | 2018-11-26 | 2020-11-13 | 순천향대학교 산학협력단 | 당뇨병성 신증 진단을 위한 마이크로RNA let-7 또는 마이크로RNA-150 바이오마커 및 이의 용도 |
| RU2709651C1 (ru) * | 2018-11-29 | 2019-12-19 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ дифференциальной диагностики глиом на основании анализа экспрессии генов и микро-рнк |
| CN109402262B (zh) * | 2018-12-18 | 2022-01-25 | 上海交通大学医学院附属上海儿童医学中心 | 辅助诊断神经母细胞瘤的PCR检测试剂盒及检测miR-199a-3p表达水平的方法 |
| EP3921325A4 (en) * | 2019-02-08 | 2022-11-23 | Board of Regents, The University of Texas System | ISOLATION AND DETECTION OF AN EXOSOME-ASSOCIATED MICROBIOME FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES |
| CA3137525A1 (en) * | 2019-04-23 | 2020-10-29 | Children's Medical Center Corporation | Use of rab7 gtpase (rab7) inhibitors in enhancing permeability of the blood brain barrier (bbb) |
| EP3969914B1 (en) * | 2019-05-16 | 2025-06-11 | Academia Sinica | Lama2, plxdc2 and mll4 as novel biomarkers for prediabetes and diabetes |
| US12097222B2 (en) | 2019-06-06 | 2024-09-24 | Spiritus Therapeutics, Inc. | Methods for attenuating viral infection and for treating lung injury |
| US11607428B2 (en) | 2019-06-06 | 2023-03-21 | Spiritus Therapeutics, Inc. | Mesenchymal stem cell-derived extracellular vesicles and uses thereof for treating and diagnosing fibrotic diseases |
| WO2020247675A1 (en) * | 2019-06-06 | 2020-12-10 | Spiritus Therapeutics, Inc. | Methods for attenuating viral infection and for treating lung injury |
| US12305235B2 (en) | 2019-06-06 | 2025-05-20 | Natera, Inc. | Methods for detecting immune cell DNA and monitoring immune system |
| CN110412299B (zh) * | 2019-09-05 | 2022-11-04 | 四川大学华西第二医院 | Hectd3自身抗体检测试剂在制备肺癌筛查试剂盒中的用途 |
| CN112535726B (zh) * | 2019-09-05 | 2023-09-12 | 南京安吉生物科技有限公司 | 一种肿瘤标志物aquaporin 2蛋白及其应用 |
| EP4031676A4 (en) | 2019-09-19 | 2023-10-25 | Mayo Foundation for Medical Education and Research | Methods and materials for identifying and treating membranous nephropathy |
| WO2021062196A1 (en) | 2019-09-26 | 2021-04-01 | President And Fellows Of Harvard College | Minimal arrestin domain containing protein 1 (arrdc1) constructs |
| CN110609141A (zh) * | 2019-09-30 | 2019-12-24 | 中山大学孙逸仙纪念医院 | Gltscr1前列腺癌预后检测试剂及其试剂盒 |
| CN110791560B (zh) * | 2019-11-06 | 2021-09-14 | 中国医学科学院医药生物技术研究所 | 一种用于阿尔茨海默病诊断和/或治疗的miRNA标志物 |
| CN110954701B (zh) * | 2019-12-18 | 2023-07-21 | 重庆医科大学 | 一种肝纤维化或肝硬化的诊断试剂盒 |
| EP4117702A4 (en) | 2020-03-06 | 2024-03-13 | Mayo Foundation for Medical Education and Research | Methods and materials for identifying and treating membranous nephropathy |
| CA3172199A1 (en) * | 2020-03-18 | 2021-09-23 | Michael Nerenberg | Systems and methods of detecting a risk of alzheimer's disease using a circulating-free mrna profiling assay |
| WO2021243206A1 (en) | 2020-05-29 | 2021-12-02 | Exosome Diagnostics, Inc. | Use of microvesicle signature for the diagnosis and treatment of kidney transplant rejection |
| CN113777314A (zh) * | 2020-06-09 | 2021-12-10 | 首都医科大学附属北京世纪坛医院 | 尿液踝蛋白1及其多肽片段在烧伤中的应用 |
| CN113913423B (zh) * | 2020-07-09 | 2026-04-21 | 上海吉凯基因医学科技股份有限公司 | 人cfap65基因的用途及相关产品 |
| EP4194856A4 (en) | 2020-08-06 | 2024-12-11 | LSI Medience Corporation | METHOD OF DIAGNOSING BLADDER CANCER |
| CN116057185A (zh) | 2020-08-15 | 2023-05-02 | 雷杰纳荣制药公司 | 治疗具有编码降钙素受体(calcr)的变体核酸分子的受试者的肥胖症 |
| WO2022064162A1 (en) * | 2020-09-22 | 2022-03-31 | The Secretary Of State For Defence Dstl | Apparatus, kits and methods for predicting the development of sepsis |
| CN112415199B (zh) * | 2020-11-20 | 2023-09-08 | 四川大学华西医院 | Cetp检测试剂在制备肺癌筛查试剂盒中的用途 |
| US20220073992A1 (en) * | 2020-11-24 | 2022-03-10 | Hossein Abdul Tehrani Abdul Tehrani | Diagnosis of chronic kidney disease (ckd) and its subgroups |
| CN112458104A (zh) * | 2020-12-04 | 2021-03-09 | 哈尔滨医科大学 | 与非综合征型唇腭裂相关的突变的n4bp2基因及其应用 |
| CN113005146A (zh) * | 2021-03-10 | 2021-06-22 | 香港理工大学深圳研究院 | 一种重组质粒及其构建方法、重组影像系统与应用 |
| CN113281515B (zh) * | 2021-05-14 | 2024-12-13 | 青岛大学附属医院 | 一种tipe3免疫组织化学检测试剂盒及其使用方法和应用 |
| EP4370712A1 (en) * | 2021-07-16 | 2024-05-22 | Exosome Diagnostics, Inc. | Methods of detecting sjögren's syndrome using salivary exosomes |
| CN113564252B (zh) * | 2021-07-22 | 2022-09-02 | 中国医学科学院北京协和医院 | 甲基化酶mettl3的新用途 |
| CN113717930A (zh) * | 2021-09-07 | 2021-11-30 | 复旦大学附属华山医院 | 携带fbn1突变的颅颈动脉夹层特异诱导多能干细胞系 |
| CN113866413B (zh) * | 2021-09-29 | 2023-05-30 | 上海市同济医院 | 一种结直肠癌诊断标志物及其应用 |
| CN113995840B (zh) * | 2021-10-12 | 2022-07-05 | 武汉大学中南医院 | Tifa抑制剂在制备用于治疗和/或预防脓毒症急性肾损伤的药物中的应用 |
| KR20240099216A9 (ko) * | 2021-10-26 | 2025-12-10 | 오하이오 스테이트 이노베이션 파운데이션 | 슈반 세포로의 표적화 전달을 위한 설계자 세포외 소낭 |
| CN113789388B (zh) * | 2021-11-15 | 2022-03-25 | 苏州艾米森生物科技有限公司 | 一种食管癌基因甲基化水平检测试剂及其应用 |
| CN113913522B (zh) * | 2021-11-18 | 2023-03-10 | 武汉艾米森生命科技有限公司 | 子宫内膜癌检测的试剂及试剂盒 |
| CN114231643B (zh) * | 2022-01-07 | 2023-07-07 | 新疆畜牧科学院畜牧研究所 | 影响鄂尔多斯细毛羊羊毛纤维直径变异系数性状的分子标记、获得方法及其特异性引物对和应用 |
| CN116656810B (zh) * | 2022-02-18 | 2024-08-16 | 武汉艾米森生命科技有限公司 | 胰腺癌的生物标志物、核酸产品和试剂盒 |
| AU2023221644A1 (en) | 2022-02-18 | 2024-09-12 | Bio-Techne Corporation | Use of microvesicle signatures in the identification and treatment of renal disorders |
| CN115786501B (zh) * | 2022-07-02 | 2023-06-16 | 武汉大学 | 一种与结直肠癌早期筛查和辅助诊断相关的增强子功能位点及其应用 |
| WO2024014580A1 (ko) * | 2022-07-13 | 2024-01-18 | 이왕재바이오연구소 주식회사 | 엑소좀에서 발현되는 바이오 마커를 이용하는 인공지능 기반 암 진단용 정보제공 방법 |
| WO2024054572A1 (en) | 2022-09-07 | 2024-03-14 | Exosome Diagnostics, Inc. | Methods of detecting sjögren's syndrome using salivary exosomes |
| CN115927591A (zh) * | 2022-11-03 | 2023-04-07 | 广州市金域转化医学研究院有限公司 | 用于非tsc1/tsc2突变结节性硬化症的生物标志物及其应用 |
| JP2026503289A (ja) * | 2023-01-12 | 2026-01-28 | ザ ジェネラル ホスピタル コーポレイション | がんにおける薬剤耐性の予測およびモニタリングのための細胞外小胞(ev)の分子解析 |
| CN116219017B (zh) * | 2023-02-17 | 2024-04-30 | 安徽同科生物科技有限公司 | 生物标志物在制备卵巢癌诊断和/或预后的产品中的应用 |
| CN116859049A (zh) * | 2023-04-20 | 2023-10-10 | 中国科学院基础医学与肿瘤研究所(筹) | 用于结直肠癌诊断的肿瘤标志物及基于核酸适体的检测方法 |
| KR20260025789A (ko) | 2023-06-22 | 2026-02-24 | 폰다치오네 디 렐리조네 에 디 쿨토 "카사 솔리에보 델라 소페렌차" - 오페라 디 산 피오 다 피에트렐치나 | 비전이성 여성 유방암의 예후 예측 방법 |
| CN119570732A (zh) * | 2023-09-05 | 2025-03-07 | 中国科学院基础医学与肿瘤研究所(筹) | 胞质体囊泡的制备方法及其应用 |
| CN117092354B (zh) * | 2023-10-18 | 2023-12-29 | 亿航(苏州)生物医药有限公司 | 一种用于识别脑源性细胞的细胞外囊泡的蛋白标志物 |
| CN120366450B (zh) * | 2023-11-21 | 2026-04-10 | 首都医科大学附属北京世纪坛医院 | 检测slamf8的物质在制备用于筛查和诊断前列腺癌的产品中的应用和检测试剂盒 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005121369A2 (en) * | 2004-06-02 | 2005-12-22 | Sourcepharm, Inc. | Rna-containing microvesicles and methods therefor |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639611A (en) | 1988-12-12 | 1997-06-17 | City Of Hope | Allele specific polymerase chain reaction |
| US5219727A (en) | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| US5840867A (en) * | 1991-02-21 | 1998-11-24 | Gilead Sciences, Inc. | Aptamer analogs specific for biomolecules |
| CA2074214C (en) | 1991-07-23 | 2000-02-22 | Will Bloch | Improvements in the in situ pcr |
| US5582981A (en) | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
| CZ168194A3 (en) * | 1992-11-12 | 1994-12-15 | Biomeasure | Opioid peptides |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| GB9306053D0 (en) * | 1993-03-24 | 1993-05-12 | Nycomed Pharma As | Method and assay |
| US5639606A (en) | 1993-04-06 | 1997-06-17 | The University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| US5547859A (en) | 1993-08-02 | 1996-08-20 | Goodman; Myron F. | Chain-terminating nucleotides for DNA sequencing methods |
| US5556773A (en) | 1993-08-06 | 1996-09-17 | Yourno; Joseph | Method and apparatus for nested polymerase chain reaction (PCR) with single closed reaction tubes |
| US6759217B2 (en) * | 1996-03-26 | 2004-07-06 | Oncomedx, Inc. | Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer |
| US6607898B1 (en) * | 1996-03-26 | 2003-08-19 | Oncomedx, Inc. | Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum |
| US6794135B1 (en) * | 1996-03-26 | 2004-09-21 | Oncomedx, Inc. | Method for detection of 5T4 RNA in plasma or serum |
| DE69739909D1 (de) * | 1996-03-26 | 2010-07-29 | Michael S Kopreski | Methoden aus plasma oder serum extrahierte extrazelluraere rna zur diagnoseüberwachung oder evaluation von krebs verwenden |
| EP1164203B1 (en) | 1996-11-06 | 2007-10-10 | Sequenom, Inc. | DNA Diagnostics based on mass spectrometry |
| US6994960B1 (en) | 1997-05-28 | 2006-02-07 | The Walter And Eliza Hall Institute Of Medical Research | Nucleic acid diagnostics based on mass spectrometry or mass separation and base specific cleavage |
| US6004755A (en) | 1998-04-07 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Quantitative microarray hybridizaton assays |
| AU768810B2 (en) | 1998-07-20 | 2004-01-08 | Century Technology, Inc. | Gene sequence variances with utility in determining the treatment of disease |
| FR2788780B1 (fr) * | 1999-01-27 | 2001-03-30 | Ap Cells Inc | Procede de preparation de vesicules membranaires |
| GB9927320D0 (en) * | 1999-11-18 | 2000-01-12 | Chiron Spa | Exosome separation |
| JP2003520843A (ja) | 2000-01-28 | 2003-07-08 | エムアイピー・テクノロジーズ・エービー | 分子を認識および触媒するための官能性モノマー |
| US6812023B1 (en) | 2000-04-27 | 2004-11-02 | Anosys, Inc. | Methods of producing membrane vesicles |
| US6913879B1 (en) | 2000-07-10 | 2005-07-05 | Telechem International Inc. | Microarray method of genotyping multiple samples at multiple LOCI |
| US6525154B1 (en) * | 2000-07-20 | 2003-02-25 | The Regents Of The University Of California | Molecular imprinting for the recognition of peptides in aqueous solution |
| US6794447B1 (en) * | 2000-07-28 | 2004-09-21 | Taylor Made Golf Co., Inc. | Golf balls incorporating nanocomposite materials |
| JP2004535765A (ja) * | 2000-12-07 | 2004-12-02 | カイロン コーポレイション | 前立腺癌においてアップレギュレートされた内因性レトロウイルス |
| US6902896B2 (en) * | 2001-05-11 | 2005-06-07 | Regents Of The University Of Minnesota | Intron associated with myotonic dystrophy type 2 and methods of use |
| US6696271B2 (en) | 2001-08-23 | 2004-02-24 | The Regents Of The University Of California | Frozen tissue microarray technology for analysis of RNA, DNA, and proteins |
| WO2003023065A1 (en) | 2001-09-06 | 2003-03-20 | Syngenta Participations Ag | Dna methylation patterns |
| US7671010B2 (en) * | 2002-08-30 | 2010-03-02 | The Board Of Regents Of The University Of Texas System | Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer |
| US20030162190A1 (en) | 2001-11-15 | 2003-08-28 | Gorenstein David G. | Phosphoromonothioate and phosphorodithioate oligonucleotide aptamer chip for functional proteomics |
| EP1483372A2 (en) * | 2002-03-14 | 2004-12-08 | Anosys, Inc. | Functionalization of t cell derived vesicles and use thereof for the preparation of immunogenic pharmaceutical compositions |
| CA2489360C (en) | 2002-06-26 | 2013-01-29 | Cold Spring Harbor Laboratory | Methods and compositions for determining methylation profiles |
| WO2004020667A1 (en) | 2002-09-02 | 2004-03-11 | Pamgene B.V. | Novel integrated microarray analysis |
| US7141371B2 (en) | 2002-09-06 | 2006-11-28 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Methods for detecting and localizing DNA mutations by microarray |
| WO2005020784A2 (en) * | 2003-05-23 | 2005-03-10 | Mount Sinai School Of Medicine Of New York University | Surrogate cell gene expression signatures for evaluating the physical state of a subject |
| WO2004108770A1 (en) * | 2003-05-30 | 2004-12-16 | Rensselaer Polytechnic Institute | Low odor chain transfer agents for controlled radical polymerization |
| EP1498144A1 (en) * | 2003-07-15 | 2005-01-19 | Universite Pierre Et Marie Curie Paris Vi | Extracellular vesicles from non-pathogenic amoebae useful as vehicle for transferring a molecule of interest to an eukaryotic cell |
| US7384589B2 (en) | 2003-08-01 | 2008-06-10 | Lawrence Livermore National Security, Llc | Nanoscale molecularly imprinted polymers and method thereof |
| US20050095218A1 (en) * | 2003-10-29 | 2005-05-05 | The Procter & Gamble Company | Personal care composition containing a detersive surfactant, an antidandruff component, and ketoamide surfactants |
| CA2453198A1 (en) * | 2004-01-07 | 2005-07-07 | Wei-Ping Min | Quantification and generation of immune suppressive exosomes |
| ES2425749T3 (es) | 2004-03-31 | 2013-10-17 | The General Hospital Corporation | Método para determinar la respuesta del cáncer a tratamientos dirigidos al receptor del factor de crecimiento epidérmico |
| US8021847B2 (en) * | 2004-06-02 | 2011-09-20 | Proxy Life Science Holdings, Inc. | Microvesicle-based compositions and methods |
| US20060116321A1 (en) * | 2004-07-01 | 2006-06-01 | Robbins Paul D | Immunosuppressive exosomes |
| EA200700813A1 (ru) * | 2004-10-07 | 2008-10-30 | Ананда Чакрабарти | Транспортирующие вещества, производные купредоксина и способы их применения |
| US20060223072A1 (en) * | 2005-03-31 | 2006-10-05 | Boyes Barry E | Methods of using a DNase I-like enzyme |
| WO2006113590A2 (en) | 2005-04-15 | 2006-10-26 | Cedars-Sinai Medical Center | Flow-cytometric heteroduplex analysis for detection of genetic alterations |
| CA2612183C (en) * | 2005-06-28 | 2015-08-11 | Genentech, Inc. | Egfr and kras mutations |
| WO2007015174A2 (en) * | 2005-07-08 | 2007-02-08 | Exothera L.L.C. | Exosome-specific ligands, their preparartion and uses |
| CA2615617A1 (en) * | 2005-07-19 | 2007-01-25 | The Board Of Trustees Of The University Of Illinois | Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof |
| DK3517151T3 (da) * | 2006-03-09 | 2021-07-12 | Aethlon Medical Inc | Ekstrakorporal fjernelse af mikrovesikulære partikler |
| WO2007127848A1 (en) * | 2006-04-26 | 2007-11-08 | University Of Louisville Research Foundation, Inc | Isolation of membrane vesicles from biological fluids and methods of using same |
| US9085778B2 (en) * | 2006-05-03 | 2015-07-21 | VL27, Inc. | Exosome transfer of nucleic acids to cells |
| CN101085349B (zh) * | 2006-06-09 | 2011-05-25 | 项雯华 | 囊泡导向的免疫细胞及其在制备抗肿瘤药物上的应用 |
| US20080287669A1 (en) * | 2007-05-16 | 2008-11-20 | Braman Jeffrey C | Methods and compositions for identifying compounds useful in nucleic acid purification |
| CA2676113C (en) * | 2007-07-25 | 2014-07-08 | University Of Louisville Research Foundation, Inc. | Exosome-associated microrna as a diagnostic marker |
| CA2733672C (en) * | 2007-08-16 | 2018-09-11 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| US20100255514A1 (en) * | 2007-08-16 | 2010-10-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| EP2610342B1 (en) * | 2007-09-14 | 2016-05-04 | The Ohio State University Research Foundation | MiRNA Expression in Human Peripheral Blood Microvesicles and uses Thereof |
| US8617806B2 (en) * | 2008-01-25 | 2013-12-31 | Hansabiomed Ou | Method to measure and characterize microvesicles in the human body fluids |
| US20120142001A1 (en) * | 2008-02-01 | 2012-06-07 | Exosome Diagnostics, Inc. | Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom |
| US20100008978A1 (en) * | 2008-05-09 | 2010-01-14 | The Regents Of The University Of California | Nanoparticles effective for internalization into cells |
| WO2009147519A1 (en) * | 2008-06-06 | 2009-12-10 | Centre National De La Recherche Scientifique - Cnrs- | Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna |
| WO2010056337A2 (en) * | 2008-11-12 | 2010-05-20 | Caris Mpi, Inc. | Methods and systems of using exosomes for determining phenotypes |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005121369A2 (en) * | 2004-06-02 | 2005-12-22 | Sourcepharm, Inc. | Rna-containing microvesicles and methods therefor |
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