JP5676277B2 - 医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用 - Google Patents

医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用 Download PDF

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JP5676277B2
JP5676277B2 JP2010545256A JP2010545256A JP5676277B2 JP 5676277 B2 JP5676277 B2 JP 5676277B2 JP 2010545256 A JP2010545256 A JP 2010545256A JP 2010545256 A JP2010545256 A JP 2010545256A JP 5676277 B2 JP5676277 B2 JP 5676277B2
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microvesicles
cells
rna
exosomes
nucleic acid
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ヨハン カール オロフ スコッグ
ヨハン カール オロフ スコッグ
サンドラ オー． ブレークフィールド
サンドラ オー． ブレークフィールド
デニス ブラウン
デニス ブラウン
ケビン シー． ミランダ
ケビン シー． ミランダ
レイルアタ エム． ルッソ
レイルアタ エム． ルッソ
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ザ ジェネラル ホスピタル コーポレイション
ザ ジェネラル ホスピタル コーポレイション
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JP2010545256A 2008-02-01 2009-02-02 医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用 Active JP5676277B2 (ja)

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US2553608P 2008-02-01 2008-02-01
US61/025,536 2008-02-01
US10029308P 2008-09-26 2008-09-26
US61/100,293 2008-09-26
PCT/US2009/032881 WO2009100029A1 (en) 2008-02-01 2009-02-02 Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions

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JP2014261849A Division JP6322132B2 (ja) 2008-02-01 2014-12-25 医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用

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JP2011510663A JP2011510663A (ja) 2011-04-07
JP2011510663A5 JP2011510663A5 (https=) 2012-03-22
JP5676277B2 true JP5676277B2 (ja) 2015-02-25

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JP2014261849A Active JP6322132B2 (ja) 2008-02-01 2014-12-25 医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用
JP2017245712A Pending JP2018088922A (ja) 2008-02-01 2017-12-22 医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用

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JP2017245712A Pending JP2018088922A (ja) 2008-02-01 2017-12-22 医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用

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US (9) US20110053157A1 (https=)
EP (6) EP2245199B1 (https=)
JP (3) JP5676277B2 (https=)
KR (3) KR101810799B1 (https=)
CN (2) CN102084000B (https=)
AU (1) AU2009212543B2 (https=)
BR (1) BRPI0907050B1 (https=)
CA (1) CA2713909C (https=)
DK (1) DK2245199T3 (https=)
ES (3) ES2703363T3 (https=)
SG (2) SG10201609507TA (https=)
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Families Citing this family (356)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8021847B2 (en) 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
JP2008501336A (ja) * 2004-06-02 2008-01-24 ソースフアーム・インコーポレイテツド Ｒｎａを含有する微小胞およびそのための方法
EP1871809A2 (en) * 2005-04-22 2008-01-02 Morphotek, Inc. Antibodies with immune effector activity and that internalize in endosialin-positive cells
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
CN103820562B (zh) 2005-08-01 2015-05-13 俄亥俄州立大学研究基金会 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物
JP2009507918A (ja) 2005-09-12 2009-02-26 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション Ｂｃｌ２関連癌の診断及び療法のための組成物及び方法
EP1969147B1 (en) 2006-01-05 2014-07-30 The Ohio State University Research Foundation microRNA-based methods for the diagnosis of stomach cancer
ES2553442T3 (es) 2006-01-05 2015-12-09 The Ohio State University Research Foundation Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón
US7670840B2 (en) 2006-01-05 2010-03-02 The Ohio State University Research Foundation Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors
DK3517151T3 (da) * 2006-03-09 2021-07-12 Aethlon Medical Inc Ekstrakorporal fjernelse af mikrovesikulære partikler
EP2369011A1 (en) 2006-03-20 2011-09-28 The Ohio State University Research Foundation Microrna fingerprints during human megakaryocytopoiesis
EP2041317A4 (en) 2006-07-13 2009-10-14 Univ Ohio State Res Found METHODS AND COMPOSITIONS BASED ON MICRO-RNA FOR THE DIAGNOSIS AND TREATMENT OF COLON CANCER RELATED DISEASES
EP2061907B1 (en) 2006-09-19 2011-11-23 The Ohio State University Research Foundation Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181
US8252538B2 (en) 2006-11-01 2012-08-28 The Ohio State University MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma
WO2008094545A2 (en) 2007-01-31 2008-08-07 The Ohio State University Research Foundation Mic orna-based methods and compositions for the treatment of acute myeloid leukemia
CA2682726C (en) * 2007-04-05 2017-05-09 Morphotek, Inc. Methods for inhibiting the binding of endosialin to ligands
AU2008248319B2 (en) * 2007-04-30 2013-09-05 The Ohio State University Research Foundation Methods for differentiating pancreatic cancer from normal pancreatic function and/or chronic pancreatitis
ES2537349T3 (es) 2007-06-08 2015-06-05 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Métodos para determinar un subtipo de carcinoma hepatocelular
CN101918424A (zh) 2007-06-15 2010-12-15 俄亥俄州立大学研究基金会 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白
CN101809169B (zh) 2007-07-31 2013-07-17 俄亥俄州立大学研究基金会 通过靶向dnmt3a和dnmt3b恢复甲基化的方法
EP2653561B1 (en) 2007-08-03 2016-03-02 The Ohio State University Research Foundation Ultraconserved regions encoding ncRNAs
US20100255514A1 (en) * 2007-08-16 2010-10-07 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
CA2733672C (en) 2007-08-16 2018-09-11 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
EP3028708A1 (en) 2007-08-22 2016-06-08 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias
EP2212440A4 (en) * 2007-10-11 2011-04-06 Univ Ohio State Res Found METHOD AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF ADENOCARCINOMES OF DISHES
CA2703707A1 (en) 2007-10-26 2009-04-30 The Ohio State University Research Foundation Methods for identifying fragile histidine triad (fhit) interaction and uses thereof
US20120058492A1 (en) * 2008-01-25 2012-03-08 Hansabiomed Ou Method and a Kit To Detect Malignant Tumors and Provide a Prognosis
WO2011009104A1 (en) * 2009-07-16 2011-01-20 The General Hospital Corporation Nucleic acid analysis
CN102027129B (zh) * 2008-02-28 2014-03-12 俄亥俄州立大学研究基金会 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物
CA2716906A1 (en) * 2008-02-28 2009-09-03 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis, prognosis and treatment of gastric cancer
US11266736B2 (en) 2008-04-17 2022-03-08 Vin De Bona Trading Company Pte Ltd Method of painting micro vesicles
EP2307028B1 (en) 2008-06-11 2013-10-02 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy
JP2012500389A (ja) * 2008-08-12 2012-01-05 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 多発性脊髄腫の診断、予後および治療のためのマイクロｒｎａに基づく組成物および方法
CN102203295A (zh) * 2008-09-03 2011-09-28 约翰霍普金斯大学 胰腺肿瘤发生的通路及遗传性胰腺癌基因
WO2010028288A2 (en) 2008-09-05 2010-03-11 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
US9487837B2 (en) * 2008-10-06 2016-11-08 Morehouse School Of Medicine Exosome-mediated diagnosis of hepatitis virus infections and diseases
US20110301221A1 (en) * 2008-10-10 2011-12-08 Swedish Health Services Diagnosis, prognosis and treatment of glioblastoma multiforme
US7888035B2 (en) 2008-10-30 2011-02-15 Caris Mpi, Inc. Methods for assessing RNA patterns
WO2010056337A2 (en) 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
GB0822836D0 (en) * 2008-12-15 2009-01-21 Oxford Biomedica Ltd Method
EP2202522A1 (en) * 2008-12-23 2010-06-30 Universiteit Leiden Methods for immobilizing microvesicles, means and methods for detecting them, and uses thereof
WO2011006119A2 (en) 2009-07-09 2011-01-13 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
EP2475988B1 (en) 2009-09-09 2018-11-14 The General Hospital Corporation Use of microvesicles in analyzing nucleic acid profiles
US20130029339A1 (en) 2009-09-09 2013-01-31 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
US20120309640A1 (en) * 2009-10-08 2012-12-06 Torti Frank M Diagnostic and Prognostic Markers for Cancer
WO2011063324A2 (en) * 2009-11-20 2011-05-26 The General Hospital Corporation Microfluidic systems for isolating microvesicles
AU2010321555B2 (en) 2009-11-23 2015-10-15 The Ohio State University Materials and methods useful for affecting tumor cell growth, migration and invasion
CA2782284A1 (en) * 2009-11-30 2011-06-03 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods and systems for isolating, storing, and analyzing vesicles
US9315802B2 (en) 2009-12-30 2016-04-19 Quest Diagnostics Investments Incorporated RNA isolation from soluble urine fractions
EP2370599B1 (en) 2010-01-19 2015-01-21 Verinata Health, Inc Method for determining copy number variations
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
JP2011149859A (ja) * 2010-01-22 2011-08-04 Igaku Seibutsugaku Kenkyusho:Kk 食道癌マーカー
US20130052647A1 (en) * 2010-02-10 2013-02-28 Marianna Goldrick Methods for fractionating and processing microparticles from biological samples and using them for biomarker discovery
EP2415877A3 (en) * 2010-02-17 2012-02-15 Deutsches Krebsforschungszentrum Means and methods for diagnosing pancreatic cancer
EP2542696B1 (en) 2010-03-01 2016-09-28 Caris Life Sciences Switzerland Holdings GmbH Biomarkers for theranostics
WO2011107962A1 (en) 2010-03-03 2011-09-09 Consiglio Nazionale Delle Ricerche Increase of myeloid microvesicles in the cerebrospinal fluid as biomarker of microglia/macrophage activation in neurological disorders
JP2013526852A (ja) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
WO2011128900A2 (en) * 2010-04-15 2011-10-20 Hadasit Medical Research Services And Development Ltd. Early detection and staging of colorectal cancer using a panel of micro rnas
CN103154236B (zh) 2010-05-12 2016-08-31 再生医学Tx有限责任公司 生物活性肾细胞
WO2011140662A1 (en) * 2010-05-13 2011-11-17 The Royal Institution For The Advancement Of Learning / Mcgill University Cux1 signature for determination of cancer clinical outcome
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
WO2011146632A1 (en) 2010-05-18 2011-11-24 Gene Security Network Inc. Methods for non-invasive prenatal ploidy calling
US12545960B2 (en) 2010-05-18 2026-02-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US9376679B2 (en) 2010-05-26 2016-06-28 Micromedmark Biotech Co. Ltd. Microvesicles carrying small interfering RNAs, preparation methods and uses thereof
EP2578236B1 (en) 2010-05-26 2016-03-30 Micromedmark Biotech Co., Ltd PREPARATION OF MICROVESICLE-siRNA COMPLEXES AND USE THEREOF IN AIDS TREATMENT
WO2011156734A2 (en) 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Method of characterizing vascular diseases
WO2011156763A1 (en) * 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Methods for characterizing kidney function
BR112013000024B1 (pt) * 2010-07-01 2021-11-23 Aeon Medix Inc Composição para entregar um agente anticancer e método para preparação de microvesículas carregadas com um agente anticâncer, a partir de protoplastos de células bacterianas
US8980549B2 (en) 2010-08-01 2015-03-17 Ramot At Tel Aviv University Ltd. MicroRNA patterns for the diagnosis, prognosis and treatment of melanoma
WO2012020308A2 (en) * 2010-08-13 2012-02-16 The University Court Of The University Of Glasgow Cellular and molecular therapies
CA2808417A1 (en) * 2010-08-18 2012-02-23 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
AU2011293355A1 (en) * 2010-08-24 2013-03-14 Bio Dx, Inc. Defining diagnostic and therapeutic targets of conserved free floating fetal DNA in maternal circulating blood
WO2012031008A2 (en) 2010-08-31 2012-03-08 The General Hospital Corporation Cancer-related biological materials in microvesicles
WO2012071096A2 (en) * 2010-09-03 2012-05-31 The Johns Hopkins University Arid1a and ppp2r1a mutations in cancer
EP2619329B1 (en) 2010-09-24 2019-05-22 The Board of Trustees of The Leland Stanford Junior University Direct capture, amplification and sequencing of target dna using immobilized primers
WO2012051622A2 (en) * 2010-10-15 2012-04-19 The General Hospital Corporation Microvesicle-based assays
WO2012054975A1 (en) * 2010-10-28 2012-05-03 Clinical Genomics Pty. Ltd. Method of microvesicle enrichment
CN107823706B (zh) 2010-11-10 2022-02-01 因瑞金公司 用于器官增强的注射制剂
CA2817111C (en) * 2010-11-10 2019-03-05 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
ES2606146T3 (es) 2010-11-12 2017-03-22 The Ohio State University Research Foundation Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal
US20130295590A1 (en) * 2010-11-15 2013-11-07 The Regents Of The University Of Colorado, A Body Corporate Foxa1 as a marker for invasive bladder cancer
CN103313706A (zh) 2010-11-15 2013-09-18 俄亥俄州立大学研究基金会 控制释放粘膜粘合系统
EP3081651A1 (en) * 2010-11-24 2016-10-19 Yale University Compositions and methods for diagnosing and treating diseases and disorders associated with d-dt
CN103608466B (zh) 2010-12-22 2020-09-18 纳特拉公司 非侵入性产前亲子鉴定方法
WO2012092490A1 (en) * 2010-12-30 2012-07-05 Quest Diagnostics Investments Incorporated Diagnosis of prostate cancer
US20130017964A1 (en) * 2011-01-11 2013-01-17 Croce Carlo M Methods to Identify Chronic Lymphocytic Leukemia Disease Progression
WO2012100023A1 (en) * 2011-01-19 2012-07-26 Thomas Jefferson University Detection of pancreatic ductal adenocarcinoma
CA2826111A1 (en) * 2011-01-31 2012-08-09 Esoterix Genetic Laboratories, Llc Methods for enriching microparticles or nucleic acids in a complex mixture using size exclusion filtration
CA2821355A1 (en) * 2011-01-31 2012-08-09 Esoterix Genetic Laboratories, Llc Methods for enriching microparticles or nucleic acids using binding molecules
EP2484779A1 (en) * 2011-02-03 2012-08-08 Medizinische Hochschule Hannover Device and method for analysis of kidney failure
RU2671980C2 (ru) 2011-02-09 2018-11-08 Натера, Инк. Способы неинвазивного пренатального установления плоидности
SG183579A1 (en) * 2011-02-11 2012-09-27 Agency Science Tech & Res Methods of detecting therapeutic exosomes
WO2012112865A2 (en) * 2011-02-17 2012-08-23 Cornell University Compositions and methods to prevent cell transformation and cancer metastasis
US8664192B2 (en) 2011-03-07 2014-03-04 The Ohio State University Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer
WO2012135814A2 (en) * 2011-03-31 2012-10-04 University Of Houston Microrna29a,b,c as a tumor suppressor and sensitizing agent for chemotherapy
WO2012135844A2 (en) * 2011-04-01 2012-10-04 Cornell University Circulating exosomes as diagnostic/prognostic indicators and therapeutic targets of melanoma and other cancers
RU2626540C2 (ru) 2011-04-18 2017-07-28 Диамир, Ллс Способы обнаружения патологических изменений в органе или системе органов
CA2835641C (en) * 2011-05-11 2019-05-28 Exosome Diagnostics, Inc. Nucleic acid extraction from heterogeneous biological materials
CN103782174A (zh) * 2011-06-07 2014-05-07 卡里斯生命科学卢森堡控股有限责任公司 用于癌症的循环生物标志物
JP5823031B2 (ja) 2011-06-10 2015-11-25 日立化成株式会社 小胞捕捉デバイスおよびそれを用いるための方法
US20140275211A1 (en) * 2011-06-21 2014-09-18 Alnylam Pharmaceuticals, Inc. Assays and methods for determining activity of a therapeutic agent in a subject
US20150018227A1 (en) * 2011-08-05 2015-01-15 University Of Louisville Research Foundation, Inc. Microrna biomarkers
WO2013023132A1 (en) 2011-08-10 2013-02-14 Wake Forest University Health Sciences Diagnostic and prognostic markers for cancer
WO2013023376A1 (en) 2011-08-18 2013-02-21 Ming-Chung Jiang Microvesicle membrane protein and application thereof
EP3492606B1 (en) * 2011-08-22 2023-10-04 Exosome Diagnostics, Inc. Urine biomarkers
US9939442B2 (en) * 2011-09-08 2018-04-10 The Regents Of The University Of California Salivary biomarkers for gastric cancer detection
RU2014115999A (ru) * 2011-09-22 2015-10-27 Универсидад Де Лос Андес Способ мониторинга, диагностики и/или прогнозирования острого повреждения почек на ранней стадии
WO2013048734A1 (en) * 2011-09-28 2013-04-04 Tufts Medical Center, Inc. Treatment and prevention of cardiovascular disease with cell derived lipid vesicles, microvesicles and exosomes
EP2766500A4 (en) 2011-10-14 2015-10-14 Univ Ohio State METHOD AND MATERIALS IN CONNECTION WITH EGG CANCER
US10378060B2 (en) 2011-10-14 2019-08-13 Dana-Farber Cancer Institute, Inc. ZNF365/ZFP365 biomarker predictive of anti-cancer response
FR2981662A1 (fr) * 2011-10-20 2013-04-26 Assist Publ Hopitaux De Paris Methode de quantification de marqueurs renaux par dosage urinaire.
AU2011320021B2 (en) * 2011-10-26 2018-02-22 Clinical Genomics Pty. Ltd. Method of microvesicle enrichment
WO2013063439A1 (en) * 2011-10-27 2013-05-02 University Of Louisville Research Foundation, Inc. Characterizing melanoma
WO2013067048A1 (en) * 2011-10-31 2013-05-10 The Ohio State University Materials and methods related to mir-221 and hepatocellular carcinoma
US10174361B2 (en) 2011-11-10 2019-01-08 Exosome Diagnostics, Inc. Cerebrospinal fluid assay
AU2012352265B2 (en) 2011-12-13 2017-02-16 Ohio State Innovation Foundation Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
ITRM20110685A1 (it) 2011-12-23 2013-06-24 Internat Ct For Genetic En Gineering And Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci
US8859202B2 (en) 2012-01-20 2014-10-14 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis
WO2013119602A1 (en) 2012-02-06 2013-08-15 President And Fellows Of Harvard College Arrdc1-mediated microvesicles (armms) and uses thereof
US20150152474A1 (en) * 2012-03-09 2015-06-04 Caris Life Sciences Switzerland Holdings Gmbh Biomarker compositions and methods
WO2013148147A1 (en) 2012-03-26 2013-10-03 The U.S.A., As Represented By The Secretary Dept. Of Health And Human Services Dna methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms
CN103374625B (zh) * 2012-04-27 2016-04-13 中国科学院上海生命科学研究院 先天性心脏病相关基因dlc1及其应用
US9334498B2 (en) 2012-05-10 2016-05-10 Uab Research Foundation Methods and compositions for modulating MIR-204 activity
WO2013176765A1 (en) * 2012-05-21 2013-11-28 The Penn State Research Foundation Compositions and methods relating to dennd1a variant 2 and polycystic ovary syndrome
WO2013184905A1 (en) 2012-06-06 2013-12-12 Myriad Genetics, Inc. Hereditary cancer genes
WO2014004424A1 (en) 2012-06-26 2014-01-03 Temple University - Of The Commonwealth System Of Higher Education Method for detecting injury to the brian
CA2877721A1 (en) 2012-06-27 2014-01-03 Berg Llc Use of markers in the diagnosis and treatment of prostate cancer
US20140018299A1 (en) * 2012-07-10 2014-01-16 Banyan Biomarkers, Inc. Method and device to detect, monitor and promote neural regeneration and improvement of cognitive function in a subject suffering from neural injury
US20150176073A1 (en) * 2012-07-18 2015-06-25 Exosome Diagnostics, Inc. Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions
CA2879337C (en) * 2012-07-19 2021-11-30 Atlantic Cancer Research Institute Method for the isolation of microvesicles
WO2014028862A1 (en) 2012-08-17 2014-02-20 Cornell University Use of dna in circulating exosomes as a diagnostic marker for metastasic disease
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US12590965B2 (en) 2012-08-23 2026-03-31 Cedars-Sinai Medical Center Palmitoyl protein biomarkers in purified extracellular vesicles for early identification of clinically significant prostate cancer
CN104995311A (zh) 2012-08-30 2015-10-21 外来体诊断公司 用于核酸测定的对照
WO2014041087A1 (en) 2012-09-12 2014-03-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Muscle secretome and uses thereof
WO2014055775A1 (en) 2012-10-03 2014-04-10 Exosome Diagnostics, Inc. Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions
TWI485159B (zh) * 2012-10-11 2015-05-21 Ming Chung Jiang 一個微泡膜蛋白及其應用
DK2906717T3 (en) 2012-10-11 2019-04-01 Vin De Bona Trading Company Pte Ltd PROCEDURE FOR PAINTING MICROVESICS
WO2014062218A1 (en) * 2012-10-16 2014-04-24 University Of Southern California Colorectal cancer dna methylation markers
EP4170031A1 (en) * 2012-10-23 2023-04-26 Caris Science, Inc. Aptamers and uses thereof
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
SI2912165T1 (sl) 2012-10-24 2019-11-29 Inregen Populacije ledvičnih celic in njihova uporaba
EP2916853B1 (en) * 2012-11-09 2020-05-06 Velin-Pharma A/S Compositions for pulmonary delivery
US20150292030A1 (en) * 2012-11-27 2015-10-15 Board Of Regents, The University Of Texas System Methods of characterizing and treating molecular subset of muscle-invasive bladder cancer
EP2746406B1 (en) 2012-12-18 2017-08-23 Samsung Electronics Co., Ltd. Composition and kit for diagnosing breast cancer including miRNAs within vesicle, and method of diagnosing breast cancer using the same
AU2013361323B2 (en) * 2012-12-19 2018-09-06 Caris Science, Inc. Compositions and methods for aptamer screening
CN110106229B (zh) 2013-01-03 2023-03-28 外来体诊断公司 用于分离微囊泡的方法
EP2959016A4 (en) * 2013-02-21 2016-10-12 Toma Biosciences Inc METHOD, COMPOSITIONS AND NUCLEIC ACID ANALYSIS KITS
WO2014132244A1 (en) * 2013-02-28 2014-09-04 The Chinese University Of Hong Kong Maternal plasma transcriptome analysis by massively parallel rna sequencing
US10793913B2 (en) * 2013-03-08 2020-10-06 City Of Hope Methods and compositions for treatment of breast cancer
WO2014160032A1 (en) * 2013-03-13 2014-10-02 University Of Louisville Research Foundation, Inc. Exosome-associated rna as a diagnostic marker
WO2014159662A1 (en) * 2013-03-13 2014-10-02 University Of Miami Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids
US12558316B2 (en) 2013-03-13 2026-02-24 University Of Miami Methods and compositions for the treatment of epidermolysis bullosa
BR112015023275B1 (pt) 2013-03-15 2022-06-21 Board Of Regents, The University Of Texas System Método in vitro de detecção de biomarcador de câncer
KR101473557B1 (ko) 2013-03-29 2014-12-24 포항공과대학교 산학협력단 원심력을 이용한 세포유래 인공 마이크로베시클 제조 장치
CN105431552B (zh) * 2013-04-12 2020-03-03 香港中文大学 多组学标记在预测糖尿病中的用途
EP2986326B1 (en) * 2013-04-15 2018-09-05 Cedars-Sinai Medical Center Methods for detecting cancer metastasis
WO2014182330A1 (en) 2013-05-06 2014-11-13 Hitachi Chemical Company Ltd Devices and methods for capturing target molecules
EP2999967B1 (en) * 2013-05-21 2020-05-20 NX Pharmagen Use of tenascin-c as an extracellular marker of tumor-derived microparticles
US10071170B2 (en) 2013-06-24 2018-09-11 Ablbio Antibody-drug conjugate having improved stability and use thereof
CN103272248B (zh) * 2013-06-28 2016-03-30 上海市内分泌代谢病研究所 miR-15b在制备糖尿病诊疗制剂中的应用
US10338061B2 (en) * 2013-07-12 2019-07-02 Young Ah Kwon Method for diagnosis of diseases using morphological characteristics of luterial
CA2920429C (en) * 2013-08-06 2021-11-16 Exosome Diagnostics, Inc. Urine biomarker cohorts, gene expression signatures, and methods of use thereof
KR20150043937A (ko) 2013-10-15 2015-04-23 삼성전자주식회사 개체의 간암 진단용 조성물, 개체의 간암 진단하는 방법 및 개체의 간암 진단에 필요한 정보를 얻는 방법
CA2926092A1 (en) * 2013-10-24 2015-04-30 Nanosomix, Inc. Biomarkers and diagnostic methods for alzheimer's disease and other neurodegenerative disorders
ES2923942T3 (es) * 2013-11-06 2022-10-03 Us Health Procedimiento para el subtipado de tipos de linfoma por medio de perfiles de expresión
CN105917005B (zh) 2013-11-18 2020-09-11 迪阿米尔有限责任公司 使用来自体液的miRNA检测和监控帕金森病(PD)的方法
CA2930083A1 (en) 2013-11-19 2015-05-28 The Penn State Research Foundation Compositions and methods for prophylaxis and/or therapy of disorders that correlate with dennd1a variant 2
US9921223B2 (en) * 2013-12-04 2018-03-20 Board Of Regents, The University Of Texas System Analysis of genomic DNA, RNA, and proteins in exosomes for diagnosis and theranosis
JP6128621B2 (ja) * 2013-12-04 2017-05-17 国立研究開発法人産業技術総合研究所 マイクロベシクルに対する核酸アプタマー
CN111729090A (zh) * 2013-12-20 2020-10-02 通用医疗公司 与循环肿瘤细胞相关的方法和测定法
US10590384B2 (en) 2014-01-14 2020-03-17 Luterion Co., Ltd. Luterial and method for isolating and culturing the same
WO2015108342A1 (ko) * 2014-01-14 2015-07-23 최원철 루테리알의 형태특성을 이용한 암 예방제 또는 항암제의 스크리닝 방법
HK1231516A1 (zh) * 2014-01-14 2017-12-22 崔元哲 Luterial和用於其分离及培养的方法
US20160346334A1 (en) * 2014-02-05 2016-12-01 Stc.Unm Exosomes as a therapeutic for cancer
US10941446B2 (en) 2014-03-12 2021-03-09 Icahn School Of Medicine At Mount Sinai Method for identifying kidney allograft recipients at risk for chronic injury
EP3125907A4 (en) * 2014-04-01 2017-11-29 Cornell University Use of double-stranded dna in exosomes: a novel biomarker in cancer detection
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
CA2945962C (en) 2014-04-21 2023-08-29 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US11268085B2 (en) 2014-05-27 2022-03-08 Exosome Diagnostics, Inc. Methods for isolating microvesicles and extracting nucleic acids from biological samples
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
BR112016029634A2 (pt) 2014-06-18 2017-10-24 Nat Cancer Ct kit, dispositivo e método para a detecção de câncer de fígado
CN113444783B (zh) 2014-06-26 2024-04-09 西奈山伊坎医学院 通过分析预示性基因集诊断亚临床和临床的急性排异的方法
CA3084920C (en) 2014-07-09 2023-02-28 Exosome Diagnostics, Inc. Methods for isolating microvesicles and extracting nucleic acids from biological samples
EP3998273A1 (en) * 2014-07-17 2022-05-18 The Trustees Of The University Of Pennsylvania Methods for using exosomes to monitor transplanted organ status
AU2015301150A1 (en) 2014-08-05 2017-02-23 Ymir Genomics Llc Methods for the isolation of extracellular vesicles and other bioparticles from urine and other biofluids
US20170298352A1 (en) * 2014-09-30 2017-10-19 Research Institute at Nationwide Children's Hospit al Compositions and methods for treating hepatic fibrosis
US10260067B2 (en) * 2014-10-01 2019-04-16 The Brigham And Women's Hospital, Inc. Enhancing dermal wound healing by downregulating microRNA-26a
US11397182B2 (en) 2014-10-07 2022-07-26 Cornell University Methods for prognosing and preventing metastatic liver disease
CN104535766B (zh) * 2014-10-30 2016-04-13 中国人民解放军总医院第一附属医院 外周血exosome来源的肝癌诊断和预后标志物及其应用
US9816080B2 (en) 2014-10-31 2017-11-14 President And Fellows Of Harvard College Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
EP3218521B1 (en) 2014-11-12 2019-12-25 Hitachi Chemical Co., Ltd. Method for diagnosing organ injury
WO2016081699A1 (en) * 2014-11-19 2016-05-26 Boyer Thomas G Novel peptide activator of cyclin c-dependent kinase 8 (cdk8)
CN104372004B (zh) * 2014-12-04 2018-04-27 广东医学院 一个与心肌梗死易感相关的miR-27a基因单核苷酸多态位点的检测方法及其应用
CN104404044B (zh) * 2014-12-04 2018-04-27 广东医学院 与心肌梗死易感相关的anril基因外显子区单核苷酸多态位点的检测方法及其应用
US10539566B2 (en) 2014-12-08 2020-01-21 Berg Llc Use of markers including filamin A in the diagnosis and treatment of prostate cancer
EP3034623A1 (en) * 2014-12-18 2016-06-22 Centro de Investigación Biomédica en Red (CIBER) Method for predicting response to continuous positive air pressure treatment
CN107429226A (zh) 2015-01-06 2017-12-01 株式会社露太利温 luterion及其分离和培养方法
EP3287137B1 (en) * 2015-03-12 2021-05-05 Mitsui Chemicals, Inc. Method for disrupting exosomes, exosome disruption kit, and method for separating exosomes derived from normal cells
JP2016192906A (ja) * 2015-03-31 2016-11-17 シスメックス株式会社 乳がんに関する情報の取得方法、ならびに乳がんに関する情報を取得するためのマーカー及び乳がん検出用キット
US11971402B2 (en) 2015-04-24 2024-04-30 Cornell University Methods and reagents for determination and treatment of organotropic metastasis
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
EP3307890A1 (en) 2015-06-10 2018-04-18 Board of Regents, The University of Texas System Use of exosomes for the treatment of disease
DE112016003948T5 (de) 2015-08-31 2018-05-09 City Of Sapporo Molekulare verfahren zum beurteilen einer urothelialen erkrankung
KR102087373B1 (ko) * 2015-09-11 2020-03-10 주식회사 압타머사이언스 비소세포성 폐암 진단용 단백질 바이오마커 패널 및 이를 이용한 비소세포성 폐암 진단 방법
US20190250147A1 (en) * 2015-10-13 2019-08-15 The Trustees Of The University Of Pennsylvania Methods for using enriched exosomes as a platform for monitoring organ status
US20180321258A1 (en) * 2015-11-06 2018-11-08 The Trustees Of Columbia University In The City Of New York Exosomal Protein Profiling for Detection of Cardiac Transplant Rejection
WO2017087866A1 (en) 2015-11-20 2017-05-26 Grand Valley State University Nato3 mutant polypeptides and uses thereof
CN105296488B (zh) * 2015-12-02 2018-05-01 中国人民解放军第三军医大学第三附属医院 超声微泡介导的siRNA干扰GRK4在靶向调节尿钠排泄及血压水平中的应用
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
CN105505918B (zh) * 2016-01-12 2018-03-02 广州赛哲生物科技股份有限公司 一种血清外泌体中rna的提取方法
US11753682B2 (en) 2016-03-07 2023-09-12 Father Flanagan's Boys'Home Noninvasive molecular controls
US11149313B2 (en) 2016-03-21 2021-10-19 Diamir, Llc Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases
RU2760913C2 (ru) 2016-04-15 2021-12-01 Натера, Инк. Способы выявления рака легкого
US20190093172A1 (en) * 2016-04-15 2019-03-28 Exosome Diagnostics, Inc. Plasma-based detection of anaplastic lymphoma kinase (alk) nucleic acids and alk fusion transcripts and uses thereof in diagnosis and treatment of cancer
WO2017181161A1 (en) 2016-04-15 2017-10-19 Predicine, Inc. Systems and methods for detecting genetic alterations
CN109072277A (zh) * 2016-04-19 2018-12-21 凸版印刷株式会社 癌化可能性的评价方法及试剂盒
CN109642229A (zh) 2016-05-13 2019-04-16 外来体诊断公司 从生物液体分离细胞外囊泡和共分离无细胞dna的自动和手动方法
US11123372B2 (en) 2016-07-29 2021-09-21 Prokidney Bioactive renal cells for the treatment of chronic kidney disease
EP4115891A1 (en) 2016-08-05 2023-01-11 The Research Foundation for The State University of New York Keratin 17 as a biomarker for bladder cancer
US10914748B2 (en) 2016-09-08 2021-02-09 UNIVERSITé LAVAL Erythrocyte-derived extracellular vesicles as a biomarker for clinically assessing Parkinson's disease
US11174503B2 (en) 2016-09-21 2021-11-16 Predicine, Inc. Systems and methods for combined detection of genetic alterations
AU2017335084B2 (en) 2016-09-30 2023-06-29 Ilias Biologics Inc. Compositions containing protein loaded exosome and methods for preparing and delivering the same
US11730823B2 (en) 2016-10-03 2023-08-22 President And Fellows Of Harvard College Delivery of therapeutic RNAs via ARRDC1-mediated microvesicles
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
CN110191962A (zh) 2016-10-21 2019-08-30 外来体诊断公司 外来体相关核酸的测序和分析
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
CN107058468B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过循环microRNA-369-3p表达水平预测急性高山病发病风险的试剂盒
CN107058472B (zh) * 2016-11-03 2020-10-27 中国人民解放军陆军军医大学 一种通过四种血浆microRNA联合诊断急性高山病的诊断试剂盒
CN107058475B (zh) * 2016-11-03 2020-10-27 中国人民解放军陆军军医大学 一种联合miR-676、miR-181b和miR-193b诊断急性高山病的试剂盒
CN107058469B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过循环microRNA-449b-3p表达水平预测急性高山病发病风险的试剂盒
CN107058471B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过四种microRNA生物标志物联合预测急性高山病发病风险的试剂盒
WO2018089541A1 (en) 2016-11-08 2018-05-17 Cedars-Sinai Medical Center Methods for diagnosing cancer
EP3538069B1 (en) 2016-11-09 2025-09-03 Benedetta Bussolati Extracellular vesicles from stem cells for use in a treatment of chronic kidney diseases
JP7280823B2 (ja) * 2016-11-30 2023-05-24 エクソサム ダイアグノスティクス，インコーポレイティド 非小細胞肺癌患者由来のエクソソームｒｎａ及び無細胞ｄｎａを使用して血漿中の変異を検出するための方法と組成物
WO2018106648A1 (en) * 2016-12-05 2018-06-14 The Penn State Research Foundation Lipid-based probes for extracellular isolation
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
KR101942197B1 (ko) 2016-12-28 2019-01-24 주식회사 엠디헬스케어 세균 메타게놈 분석을 통한 전립선질환 진단 방법
EP3562959A2 (en) 2017-01-02 2019-11-06 Exosome Diagnostics, Inc. Methods to distinguish rna and dna in a combined preparation
CN108300783A (zh) * 2017-01-11 2018-07-20 上海易毕恩基因科技有限公司 用于筛选肠癌和/或胃癌的基因标志物的方法、用该方法筛选的基因标志物及其用途
JP6797427B2 (ja) * 2017-01-12 2020-12-09 テオリアサイエンス株式会社 被検者が膵臓癌に罹患している可能性を試験する方法
JP6873460B2 (ja) * 2017-01-12 2021-05-19 テオリアサイエンス株式会社 被検者が膵臓癌に罹患している可能性を試験する方法
WO2018143896A1 (en) * 2017-02-02 2018-08-09 Agency For Science, Technology And Research Ovarian cancer biomarker
KR101944665B1 (ko) * 2017-02-24 2019-02-01 주식회사 엠디헬스케어 세균 메타게놈 분석을 통한 만성폐쇄성기도질환 진단 방법
KR101940446B1 (ko) * 2017-02-24 2019-01-18 주식회사 엠디헬스케어 미생물 메타게놈 분석을 통한 난소암 진단방법
CN106906287B (zh) * 2017-03-10 2020-10-27 北京昊源生物医学科技有限公司 Prima1基因在制备椎间盘退行性疾病诊断试剂中的应用
CN110462064A (zh) * 2017-04-18 2019-11-15 深圳华大生命科学研究院 基于外泌体核酸进行微生物检测的方法及其应用
CN110520140A (zh) * 2017-04-19 2019-11-29 菲格内有限责任公司 成纤维细胞衍生的外泌体刺激血管生成
US11891664B2 (en) 2017-05-17 2024-02-06 Exosome Diagnostics, Inc. Methods of detecting renal transplant rejection using microvesicle nucleic acid biomarkers
MX2019014578A (es) 2017-06-21 2020-12-01 Timothy A Bertram Celulas renales bioactivas inmunoprivilegiadas para el tratamiento de enfermedad renal.
WO2019008414A1 (en) * 2017-07-05 2019-01-10 Datar Rajan GENE EXPRESSION ANALYSIS BASED ON EXOSOMES FOR THE CARE OF CANCER
CN111133106A (zh) 2017-07-12 2020-05-08 外来体诊断公司 用于分离和富集生物流体来源的细胞外囊泡的方法及其使用方法
US11345957B2 (en) 2017-07-18 2022-05-31 Exosome Diagnostics, Inc. Methods of treating glioblastoma in a subject informed by exosomal RNA signatures
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
EP3672582B1 (en) 2017-08-22 2026-04-15 Cedars-Sinai Medical Center Compositions and methods for treating cancer
WO2019055337A1 (en) * 2017-09-13 2019-03-21 Children's Hospital Medical Center ROLE OF EXOSOMES, EXTRACELLULAR VESICLES IN THE REGULATION OF METABOLIC HOMÉOSTASIE
EP3684383A4 (en) * 2017-09-20 2021-07-14 Molecular Stethoscope, Inc. METHODS AND SYSTEMS FOR DETECTION OF TISSUE DISORDERS
KR102243415B1 (ko) 2017-09-27 2021-04-22 ㈜로제타엑소좀 크기 배제 크로마토그래피를 이용한 세포밖 소포체의 분석 방법 및 이의 용도
KR102109921B1 (ko) * 2017-09-27 2020-05-12 ㈜로제타엑소좀 크기 배제 크로마토그래피를 이용한 세포밖 소포체의 순도 분석 방법
WO2019066501A1 (ko) * 2017-09-27 2019-04-04 ㈜로제타엑소좀 크기 배제 크로마토그래피를 이용한 세포밖 소포체의 분석 방법 및 이의 용도
EP3695227A4 (en) * 2017-10-11 2021-09-29 Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center NETRIN G1 AS A BIOMARKER TO INCREASE TUMOR TREATMENT EFFECTIVENESS
CN107858430B (zh) * 2017-11-20 2019-01-04 武汉迈特维尔生物科技有限公司 一种用于诊断预示Her-2过表达型乳腺癌骨转移的基因诊断试剂盒
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
ES2724215B2 (es) * 2018-03-01 2020-04-14 Univ Alcala Henares Microvesículas endoteliales con efecto microbicida
WO2019178317A1 (en) 2018-03-14 2019-09-19 Children's Medical Center Corporation Platform for assessment of the transcytosis of extracellular vesicles across endothelial barriers and uses thereof
EP3546946A1 (en) * 2018-03-29 2019-10-02 Rüdiger Lange Method of diagnosing heart muscle damage
EP3775258A4 (en) 2018-03-28 2022-01-26 Board of Regents, The University of Texas System IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES
JP7088572B2 (ja) * 2018-04-05 2022-06-21 ゲノム アンド カンパニー 抗がんおよび免疫増強用新規ターゲット
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
CA3095198A1 (en) 2018-04-16 2019-10-24 Icahn School Of Medicine At Mount Sinai Method and kits for prediction of acute rejection and renal allograft loss using pre-transplant transcriptomic signatures in recipient blood
WO2019236123A1 (en) * 2018-06-04 2019-12-12 Memorial Sloan Kettering Cancer Center Methods of detecting cancer via assessment of extracellular vesicle- mediated horizontal transfer of dna: rna hybrids
WO2019236853A1 (en) 2018-06-06 2019-12-12 Exosome Diagnostics, Inc. Methods for developing urine biomarkers and for detecting bladder cancer
CN108588224A (zh) * 2018-06-14 2018-09-28 大连医科大学附属第医院 一种用于嗜铬细胞瘤/副神经节瘤早期诊断和术前评估的生物标志物及其应用
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
WO2020037135A1 (en) 2018-08-15 2020-02-20 Charlesworth M Cristine Methods and materials for identifying and treating membranous nephropathy
CN110872624A (zh) * 2018-08-29 2020-03-10 深圳大学 一种结直肠癌标志物及其应用
US12447179B2 (en) 2018-08-31 2025-10-21 Prokidney Compositions comprising cell-delivered vesicles and uses thereof
CN110885830A (zh) * 2018-09-07 2020-03-17 安徽华大医学检验所有限公司 Fn1基因突变及其应用
AU2019343188A1 (en) 2018-09-21 2021-05-20 Aufbau Medical Innovations Limited Compositions and methods for glaucoma
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
WO2020106853A1 (en) 2018-11-20 2020-05-28 Exosome Diagnostics, Inc. Compositions and methods for internal controls of microvesicle isolations
KR102178922B1 (ko) * 2018-11-26 2020-11-13 순천향대학교 산학협력단 당뇨병성 신증 진단을 위한 마이크로RNA let-7 또는 마이크로RNA-150 바이오마커 및 이의 용도
RU2709651C1 (ru) * 2018-11-29 2019-12-19 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ дифференциальной диагностики глиом на основании анализа экспрессии генов и микро-рнк
CN109402262B (zh) * 2018-12-18 2022-01-25 上海交通大学医学院附属上海儿童医学中心 辅助诊断神经母细胞瘤的PCR检测试剂盒及检测miR-199a-3p表达水平的方法
EP3921325A4 (en) * 2019-02-08 2022-11-23 Board of Regents, The University of Texas System ISOLATION AND DETECTION OF AN EXOSOME-ASSOCIATED MICROBIOME FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
CA3137525A1 (en) * 2019-04-23 2020-10-29 Children's Medical Center Corporation Use of rab7 gtpase (rab7) inhibitors in enhancing permeability of the blood brain barrier (bbb)
EP3969914B1 (en) * 2019-05-16 2025-06-11 Academia Sinica Lama2, plxdc2 and mll4 as novel biomarkers for prediabetes and diabetes
US12097222B2 (en) 2019-06-06 2024-09-24 Spiritus Therapeutics, Inc. Methods for attenuating viral infection and for treating lung injury
US11607428B2 (en) 2019-06-06 2023-03-21 Spiritus Therapeutics, Inc. Mesenchymal stem cell-derived extracellular vesicles and uses thereof for treating and diagnosing fibrotic diseases
WO2020247675A1 (en) * 2019-06-06 2020-12-10 Spiritus Therapeutics, Inc. Methods for attenuating viral infection and for treating lung injury
US12305235B2 (en) 2019-06-06 2025-05-20 Natera, Inc. Methods for detecting immune cell DNA and monitoring immune system
CN110412299B (zh) * 2019-09-05 2022-11-04 四川大学华西第二医院 Hectd3自身抗体检测试剂在制备肺癌筛查试剂盒中的用途
CN112535726B (zh) * 2019-09-05 2023-09-12 南京安吉生物科技有限公司 一种肿瘤标志物aquaporin 2蛋白及其应用
EP4031676A4 (en) 2019-09-19 2023-10-25 Mayo Foundation for Medical Education and Research Methods and materials for identifying and treating membranous nephropathy
WO2021062196A1 (en) 2019-09-26 2021-04-01 President And Fellows Of Harvard College Minimal arrestin domain containing protein 1 (arrdc1) constructs
CN110609141A (zh) * 2019-09-30 2019-12-24 中山大学孙逸仙纪念医院 Gltscr1前列腺癌预后检测试剂及其试剂盒
CN110791560B (zh) * 2019-11-06 2021-09-14 中国医学科学院医药生物技术研究所 一种用于阿尔茨海默病诊断和/或治疗的miRNA标志物
CN110954701B (zh) * 2019-12-18 2023-07-21 重庆医科大学 一种肝纤维化或肝硬化的诊断试剂盒
EP4117702A4 (en) 2020-03-06 2024-03-13 Mayo Foundation for Medical Education and Research Methods and materials for identifying and treating membranous nephropathy
CA3172199A1 (en) * 2020-03-18 2021-09-23 Michael Nerenberg Systems and methods of detecting a risk of alzheimer's disease using a circulating-free mrna profiling assay
WO2021243206A1 (en) 2020-05-29 2021-12-02 Exosome Diagnostics, Inc. Use of microvesicle signature for the diagnosis and treatment of kidney transplant rejection
CN113777314A (zh) * 2020-06-09 2021-12-10 首都医科大学附属北京世纪坛医院 尿液踝蛋白1及其多肽片段在烧伤中的应用
CN113913423B (zh) * 2020-07-09 2026-04-21 上海吉凯基因医学科技股份有限公司 人cfap65基因的用途及相关产品
EP4194856A4 (en) 2020-08-06 2024-12-11 LSI Medience Corporation METHOD OF DIAGNOSING BLADDER CANCER
CN116057185A (zh) 2020-08-15 2023-05-02 雷杰纳荣制药公司 治疗具有编码降钙素受体(calcr)的变体核酸分子的受试者的肥胖症
WO2022064162A1 (en) * 2020-09-22 2022-03-31 The Secretary Of State For Defence Dstl Apparatus, kits and methods for predicting the development of sepsis
CN112415199B (zh) * 2020-11-20 2023-09-08 四川大学华西医院 Cetp检测试剂在制备肺癌筛查试剂盒中的用途
US20220073992A1 (en) * 2020-11-24 2022-03-10 Hossein Abdul Tehrani Abdul Tehrani Diagnosis of chronic kidney disease (ckd) and its subgroups
CN112458104A (zh) * 2020-12-04 2021-03-09 哈尔滨医科大学 与非综合征型唇腭裂相关的突变的n4bp2基因及其应用
CN113005146A (zh) * 2021-03-10 2021-06-22 香港理工大学深圳研究院 一种重组质粒及其构建方法、重组影像系统与应用
CN113281515B (zh) * 2021-05-14 2024-12-13 青岛大学附属医院 一种tipe3免疫组织化学检测试剂盒及其使用方法和应用
EP4370712A1 (en) * 2021-07-16 2024-05-22 Exosome Diagnostics, Inc. Methods of detecting sjögren's syndrome using salivary exosomes
CN113564252B (zh) * 2021-07-22 2022-09-02 中国医学科学院北京协和医院 甲基化酶mettl3的新用途
CN113717930A (zh) * 2021-09-07 2021-11-30 复旦大学附属华山医院 携带fbn1突变的颅颈动脉夹层特异诱导多能干细胞系
CN113866413B (zh) * 2021-09-29 2023-05-30 上海市同济医院 一种结直肠癌诊断标志物及其应用
CN113995840B (zh) * 2021-10-12 2022-07-05 武汉大学中南医院 Tifa抑制剂在制备用于治疗和/或预防脓毒症急性肾损伤的药物中的应用
KR20240099216A9 (ko) * 2021-10-26 2025-12-10 오하이오 스테이트 이노베이션 파운데이션 슈반 세포로의 표적화 전달을 위한 설계자 세포외 소낭
CN113789388B (zh) * 2021-11-15 2022-03-25 苏州艾米森生物科技有限公司 一种食管癌基因甲基化水平检测试剂及其应用
CN113913522B (zh) * 2021-11-18 2023-03-10 武汉艾米森生命科技有限公司 子宫内膜癌检测的试剂及试剂盒
CN114231643B (zh) * 2022-01-07 2023-07-07 新疆畜牧科学院畜牧研究所 影响鄂尔多斯细毛羊羊毛纤维直径变异系数性状的分子标记、获得方法及其特异性引物对和应用
CN116656810B (zh) * 2022-02-18 2024-08-16 武汉艾米森生命科技有限公司 胰腺癌的生物标志物、核酸产品和试剂盒
AU2023221644A1 (en) 2022-02-18 2024-09-12 Bio-Techne Corporation Use of microvesicle signatures in the identification and treatment of renal disorders
CN115786501B (zh) * 2022-07-02 2023-06-16 武汉大学 一种与结直肠癌早期筛查和辅助诊断相关的增强子功能位点及其应用
WO2024014580A1 (ko) * 2022-07-13 2024-01-18 이왕재바이오연구소 주식회사 엑소좀에서 발현되는 바이오 마커를 이용하는 인공지능 기반 암 진단용 정보제공 방법
WO2024054572A1 (en) 2022-09-07 2024-03-14 Exosome Diagnostics, Inc. Methods of detecting sjögren's syndrome using salivary exosomes
CN115927591A (zh) * 2022-11-03 2023-04-07 广州市金域转化医学研究院有限公司 用于非tsc1/tsc2突变结节性硬化症的生物标志物及其应用
JP2026503289A (ja) * 2023-01-12 2026-01-28 ザ ジェネラル ホスピタル コーポレイション がんにおける薬剤耐性の予測およびモニタリングのための細胞外小胞（ｅｖ）の分子解析
CN116219017B (zh) * 2023-02-17 2024-04-30 安徽同科生物科技有限公司 生物标志物在制备卵巢癌诊断和/或预后的产品中的应用
CN116859049A (zh) * 2023-04-20 2023-10-10 中国科学院基础医学与肿瘤研究所(筹) 用于结直肠癌诊断的肿瘤标志物及基于核酸适体的检测方法
KR20260025789A (ko) 2023-06-22 2026-02-24 폰다치오네 디 렐리조네 에 디 쿨토 "카사 솔리에보 델라 소페렌차" - 오페라 디 산 피오 다 피에트렐치나 비전이성 여성 유방암의 예후 예측 방법
CN119570732A (zh) * 2023-09-05 2025-03-07 中国科学院基础医学与肿瘤研究所(筹) 胞质体囊泡的制备方法及其应用
CN117092354B (zh) * 2023-10-18 2023-12-29 亿航(苏州)生物医药有限公司 一种用于识别脑源性细胞的细胞外囊泡的蛋白标志物
CN120366450B (zh) * 2023-11-21 2026-04-10 首都医科大学附属北京世纪坛医院 检测slamf8的物质在制备用于筛查和诊断前列腺癌的产品中的应用和检测试剂盒
CN117965433B (zh) * 2024-03-29 2024-07-19 四川大学华西第二医院 一种提高体外精子存活率和活性的方法、产品及应用
WO2025244068A1 (ja) * 2024-05-21 2025-11-27 学校法人関西医科大学 ヌクレオチド鎖の捕集方法、捕集用メンブレンフィルター、捕集用メンブレンフィルターユニット、及び捕集用キット
CN119530137B (zh) * 2024-12-03 2025-08-05 复旦大学附属妇产科医院 一种精子损伤修复模型及其建立方法
CN119291204B (zh) * 2024-12-13 2025-03-25 成都市第三人民医院 一种用于胃液外泌体的标志物、检测试剂、试剂盒及应用
CN119709984B (zh) * 2024-12-27 2025-08-15 梅州市人民医院(梅州市医学科学院) Nlrc3在制备诊断、筛查或评估冠状动脉粥样硬化性心脏病产品中的应用
CN119955936A (zh) * 2025-01-16 2025-05-09 浙江大学 Gabrr1作为肿瘤标记物和靶分子的应用
CN121137154B (zh) * 2025-10-11 2026-04-21 中南大学湘雅医院 一种突变基因在预测肺癌免疫治疗相关血小板减少中的应用

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639611A (en) 1988-12-12 1997-06-17 City Of Hope Allele specific polymerase chain reaction
US5219727A (en) 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction
US5840867A (en) * 1991-02-21 1998-11-24 Gilead Sciences, Inc. Aptamer analogs specific for biomolecules
CA2074214C (en) 1991-07-23 2000-02-22 Will Bloch Improvements in the in situ pcr
US5582981A (en) 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
CZ168194A3 (en) * 1992-11-12 1994-12-15 Biomeasure Opioid peptides
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
GB9306053D0 (en) * 1993-03-24 1993-05-12 Nycomed Pharma As Method and assay
US5639606A (en) 1993-04-06 1997-06-17 The University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5547859A (en) 1993-08-02 1996-08-20 Goodman; Myron F. Chain-terminating nucleotides for DNA sequencing methods
US5556773A (en) 1993-08-06 1996-09-17 Yourno; Joseph Method and apparatus for nested polymerase chain reaction (PCR) with single closed reaction tubes
US6759217B2 (en) * 1996-03-26 2004-07-06 Oncomedx, Inc. Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
US6607898B1 (en) * 1996-03-26 2003-08-19 Oncomedx, Inc. Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum
US6794135B1 (en) * 1996-03-26 2004-09-21 Oncomedx, Inc. Method for detection of 5T4 RNA in plasma or serum
DE69739909D1 (de) * 1996-03-26 2010-07-29 Michael S Kopreski Methoden aus plasma oder serum extrahierte extrazelluraere rna zur diagnoseüberwachung oder evaluation von krebs verwenden
EP1164203B1 (en) 1996-11-06 2007-10-10 Sequenom, Inc. DNA Diagnostics based on mass spectrometry
US6994960B1 (en) 1997-05-28 2006-02-07 The Walter And Eliza Hall Institute Of Medical Research Nucleic acid diagnostics based on mass spectrometry or mass separation and base specific cleavage
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
AU768810B2 (en) 1998-07-20 2004-01-08 Century Technology, Inc. Gene sequence variances with utility in determining the treatment of disease
FR2788780B1 (fr) * 1999-01-27 2001-03-30 Ap Cells Inc Procede de preparation de vesicules membranaires
GB9927320D0 (en) * 1999-11-18 2000-01-12 Chiron Spa Exosome separation
JP2003520843A (ja) 2000-01-28 2003-07-08 エムアイピー・テクノロジーズ・エービー 分子を認識および触媒するための官能性モノマー
US6812023B1 (en) 2000-04-27 2004-11-02 Anosys, Inc. Methods of producing membrane vesicles
US6913879B1 (en) 2000-07-10 2005-07-05 Telechem International Inc. Microarray method of genotyping multiple samples at multiple LOCI
US6525154B1 (en) * 2000-07-20 2003-02-25 The Regents Of The University Of California Molecular imprinting for the recognition of peptides in aqueous solution
US6794447B1 (en) * 2000-07-28 2004-09-21 Taylor Made Golf Co., Inc. Golf balls incorporating nanocomposite materials
JP2004535765A (ja) * 2000-12-07 2004-12-02 カイロン コーポレイション 前立腺癌においてアップレギュレートされた内因性レトロウイルス
US6902896B2 (en) * 2001-05-11 2005-06-07 Regents Of The University Of Minnesota Intron associated with myotonic dystrophy type 2 and methods of use
US6696271B2 (en) 2001-08-23 2004-02-24 The Regents Of The University Of California Frozen tissue microarray technology for analysis of RNA, DNA, and proteins
WO2003023065A1 (en) 2001-09-06 2003-03-20 Syngenta Participations Ag Dna methylation patterns
US7671010B2 (en) * 2002-08-30 2010-03-02 The Board Of Regents Of The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
US20030162190A1 (en) 2001-11-15 2003-08-28 Gorenstein David G. Phosphoromonothioate and phosphorodithioate oligonucleotide aptamer chip for functional proteomics
EP1483372A2 (en) * 2002-03-14 2004-12-08 Anosys, Inc. Functionalization of t cell derived vesicles and use thereof for the preparation of immunogenic pharmaceutical compositions
CA2489360C (en) 2002-06-26 2013-01-29 Cold Spring Harbor Laboratory Methods and compositions for determining methylation profiles
WO2004020667A1 (en) 2002-09-02 2004-03-11 Pamgene B.V. Novel integrated microarray analysis
US7141371B2 (en) 2002-09-06 2006-11-28 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for detecting and localizing DNA mutations by microarray
WO2005020784A2 (en) * 2003-05-23 2005-03-10 Mount Sinai School Of Medicine Of New York University Surrogate cell gene expression signatures for evaluating the physical state of a subject
WO2004108770A1 (en) * 2003-05-30 2004-12-16 Rensselaer Polytechnic Institute Low odor chain transfer agents for controlled radical polymerization
EP1498144A1 (en) * 2003-07-15 2005-01-19 Universite Pierre Et Marie Curie Paris Vi Extracellular vesicles from non-pathogenic amoebae useful as vehicle for transferring a molecule of interest to an eukaryotic cell
US7384589B2 (en) 2003-08-01 2008-06-10 Lawrence Livermore National Security, Llc Nanoscale molecularly imprinted polymers and method thereof
US20050095218A1 (en) * 2003-10-29 2005-05-05 The Procter & Gamble Company Personal care composition containing a detersive surfactant, an antidandruff component, and ketoamide surfactants
CA2453198A1 (en) * 2004-01-07 2005-07-07 Wei-Ping Min Quantification and generation of immune suppressive exosomes
ES2425749T3 (es) 2004-03-31 2013-10-17 The General Hospital Corporation Método para determinar la respuesta del cáncer a tratamientos dirigidos al receptor del factor de crecimiento epidérmico
US8021847B2 (en) * 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
JP2008501336A (ja) * 2004-06-02 2008-01-24 ソースフアーム・インコーポレイテツド Ｒｎａを含有する微小胞およびそのための方法
US20060116321A1 (en) * 2004-07-01 2006-06-01 Robbins Paul D Immunosuppressive exosomes
EA200700813A1 (ru) * 2004-10-07 2008-10-30 Ананда Чакрабарти Транспортирующие вещества, производные купредоксина и способы их применения
US20060223072A1 (en) * 2005-03-31 2006-10-05 Boyes Barry E Methods of using a DNase I-like enzyme
WO2006113590A2 (en) 2005-04-15 2006-10-26 Cedars-Sinai Medical Center Flow-cytometric heteroduplex analysis for detection of genetic alterations
CA2612183C (en) * 2005-06-28 2015-08-11 Genentech, Inc. Egfr and kras mutations
WO2007015174A2 (en) * 2005-07-08 2007-02-08 Exothera L.L.C. Exosome-specific ligands, their preparartion and uses
CA2615617A1 (en) * 2005-07-19 2007-01-25 The Board Of Trustees Of The University Of Illinois Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof
DK3517151T3 (da) * 2006-03-09 2021-07-12 Aethlon Medical Inc Ekstrakorporal fjernelse af mikrovesikulære partikler
WO2007127848A1 (en) * 2006-04-26 2007-11-08 University Of Louisville Research Foundation, Inc Isolation of membrane vesicles from biological fluids and methods of using same
US9085778B2 (en) * 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
CN101085349B (zh) * 2006-06-09 2011-05-25 项雯华 囊泡导向的免疫细胞及其在制备抗肿瘤药物上的应用
US20080287669A1 (en) * 2007-05-16 2008-11-20 Braman Jeffrey C Methods and compositions for identifying compounds useful in nucleic acid purification
CA2676113C (en) * 2007-07-25 2014-07-08 University Of Louisville Research Foundation, Inc. Exosome-associated microrna as a diagnostic marker
CA2733672C (en) * 2007-08-16 2018-09-11 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
US20100255514A1 (en) * 2007-08-16 2010-10-07 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
EP2610342B1 (en) * 2007-09-14 2016-05-04 The Ohio State University Research Foundation MiRNA Expression in Human Peripheral Blood Microvesicles and uses Thereof
US8617806B2 (en) * 2008-01-25 2013-12-31 Hansabiomed Ou Method to measure and characterize microvesicles in the human body fluids
US20120142001A1 (en) * 2008-02-01 2012-06-07 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
US20100008978A1 (en) * 2008-05-09 2010-01-14 The Regents Of The University Of California Nanoparticles effective for internalization into cells
WO2009147519A1 (en) * 2008-06-06 2009-12-10 Centre National De La Recherche Scientifique - Cnrs- Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna
WO2010056337A2 (en) * 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes

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