KR101723378B1 - 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제 - Google Patents

암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제 Download PDF

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KR101723378B1
KR101723378B1 KR1020157014221A KR20157014221A KR101723378B1 KR 101723378 B1 KR101723378 B1 KR 101723378B1 KR 1020157014221 A KR1020157014221 A KR 1020157014221A KR 20157014221 A KR20157014221 A KR 20157014221A KR 101723378 B1 KR101723378 B1 KR 101723378B1
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South Korea
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pyridin
methyl
pyrrolo
yloxy
piperazin
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KR20150065947A (ko
Inventor
밀란 브룬코
훙 딩
조지 도허티
스티븐 엘모어
리사 하스볼드
로라 헥사머
아론 알. 쿤저
샤오훙 쑹
앤드류 제이. 사우어스
제라드 설리반
즈-푸 타오
게리 티. 왕
러 왕
시루 왕
마이클 웬트
로버트 맨타이
토드 엠. 한센
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애브비 아일랜드 언리미티드 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
KR1020157014221A 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제 Active KR101723378B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18120309P 2009-05-26 2009-05-26
US61/181,203 2009-05-26
PCT/US2010/036198 WO2010138588A2 (en) 2009-05-26 2010-05-26 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020117030916A Division KR101659583B1 (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020177008201A Division KR20170037683A (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제

Publications (2)

Publication Number Publication Date
KR20150065947A KR20150065947A (ko) 2015-06-15
KR101723378B1 true KR101723378B1 (ko) 2017-04-06

Family

ID=42677657

Family Applications (8)

Application Number Title Priority Date Filing Date
KR1020157014221A Active KR101723378B1 (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
KR1020197033737A Pending KR20190130676A (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
KR1020197020313A Abandoned KR20190086591A (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
KR1020237028352A Pending KR20230128571A (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
KR1020187032920A Active KR102001418B1 (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
KR1020177008201A Abandoned KR20170037683A (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
KR1020117030916A Active KR101659583B1 (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
KR1020187011857A Active KR101920202B1 (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제

Family Applications After (7)

Application Number Title Priority Date Filing Date
KR1020197033737A Pending KR20190130676A (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
KR1020197020313A Abandoned KR20190086591A (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
KR1020237028352A Pending KR20230128571A (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
KR1020187032920A Active KR102001418B1 (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
KR1020177008201A Abandoned KR20170037683A (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
KR1020117030916A Active KR101659583B1 (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
KR1020187011857A Active KR101920202B1 (ko) 2009-05-26 2010-05-26 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제

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EP (4) EP3656771A1 (enExample)
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AU (1) AU2010254160C1 (enExample)
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CA (4) CA2929347A1 (enExample)
CL (1) CL2011002949A1 (enExample)
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US8580794B2 (en) 2013-11-12
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