CN102448959B - 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂 - Google Patents

用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂 Download PDF

Info

Publication number
CN102448959B
CN102448959B CN201080023068.1A CN201080023068A CN102448959B CN 102448959 B CN102448959 B CN 102448959B CN 201080023068 A CN201080023068 A CN 201080023068A CN 102448959 B CN102448959 B CN 102448959B
Authority
CN
China
Prior art keywords
methyl
pyridin
sulfonyl
pyrrolo
piperazin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201080023068.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN102448959A (zh
Inventor
M.布伦科
丁宏
G.多赫蒂
S.埃尔莫尔
L.哈斯沃尔德
L.赫克萨尔默
A.R.昆策
宋晓宏
A.J.索尔斯
G.萨利文
陶志福
G.T.王
王乐
王锡禄
M.温德特
R.曼泰
T.M.汉森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Inc
Original Assignee
Abbott Laboratories
AbbVie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42677657&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102448959(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Laboratories, AbbVie Inc filed Critical Abbott Laboratories
Priority to CN201510215766.6A priority Critical patent/CN104906100A/zh
Priority to CN201910261444.3A priority patent/CN109897038B/zh
Priority to CN201910270919.5A priority patent/CN109966294A/zh
Priority to CN201510165051.4A priority patent/CN104876927B/zh
Publication of CN102448959A publication Critical patent/CN102448959A/zh
Application granted granted Critical
Publication of CN102448959B publication Critical patent/CN102448959B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
CN201080023068.1A 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂 Active CN102448959B (zh)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201510215766.6A CN104906100A (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
CN201910261444.3A CN109897038B (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
CN201910270919.5A CN109966294A (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
CN201510165051.4A CN104876927B (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18120309P 2009-05-26 2009-05-26
US61/181203 2009-05-26
PCT/US2010/036198 WO2010138588A2 (en) 2009-05-26 2010-05-26 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Related Child Applications (4)

Application Number Title Priority Date Filing Date
CN201910261444.3A Division CN109897038B (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
CN201510215766.6A Division CN104906100A (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
CN201510165051.4A Division CN104876927B (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
CN201910270919.5A Division CN109966294A (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂

Publications (2)

Publication Number Publication Date
CN102448959A CN102448959A (zh) 2012-05-09
CN102448959B true CN102448959B (zh) 2015-06-17

Family

ID=42677657

Family Applications (5)

Application Number Title Priority Date Filing Date
CN201080023068.1A Active CN102448959B (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
CN201910270919.5A Pending CN109966294A (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
CN201510165051.4A Active CN104876927B (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
CN201510215766.6A Pending CN104906100A (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
CN201910261444.3A Active CN109897038B (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂

Family Applications After (4)

Application Number Title Priority Date Filing Date
CN201910270919.5A Pending CN109966294A (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
CN201510165051.4A Active CN104876927B (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
CN201510215766.6A Pending CN104906100A (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
CN201910261444.3A Active CN109897038B (zh) 2009-05-26 2010-05-26 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂

Country Status (43)

Country Link
US (1) US8580794B2 (enExample)
EP (5) EP2435432B3 (enExample)
JP (9) JP5747025B2 (enExample)
KR (8) KR101723378B1 (enExample)
CN (5) CN102448959B (enExample)
AR (2) AR076705A1 (enExample)
AU (1) AU2010254160C1 (enExample)
BR (2) BRPI1014359B1 (enExample)
CA (4) CA2929347A1 (enExample)
CL (1) CL2011002949A1 (enExample)
CO (1) CO6480950A2 (enExample)
CR (2) CR20170019A (enExample)
CY (2) CY1117423T1 (enExample)
DK (1) DK2435432T6 (enExample)
DO (1) DOP2011000367A (enExample)
EC (1) ECSP11011554A (enExample)
ES (1) ES2546294T7 (enExample)
FI (1) FI2435432T6 (enExample)
HK (1) HK1215576A1 (enExample)
HR (1) HRP20151001T4 (enExample)
HU (2) HUE027698T2 (enExample)
IL (6) IL319747A (enExample)
LT (1) LTC2435432I2 (enExample)
ME (1) ME02205B (enExample)
MX (2) MX339469B (enExample)
MY (1) MY155645A (enExample)
NL (1) NL300873I2 (enExample)
NO (1) NO2017023I2 (enExample)
NZ (1) NZ595708A (enExample)
PE (1) PE20120345A1 (enExample)
PH (1) PH12015500297B1 (enExample)
PL (1) PL2435432T6 (enExample)
PT (1) PT2435432E (enExample)
RS (1) RS54234B2 (enExample)
RU (3) RU2573832C2 (enExample)
SG (2) SG175253A1 (enExample)
SI (1) SI2435432T2 (enExample)
SM (1) SMT201500225B (enExample)
TW (3) TWI537269B (enExample)
UA (1) UA106079C2 (enExample)
UY (3) UY32668A (enExample)
WO (1) WO2010138588A2 (enExample)
ZA (1) ZA201108616B (enExample)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
DK2376480T3 (en) * 2008-12-05 2016-09-12 Abbvie Inc Sulfonamide derivatives AS BCL-2-selective apoptosis inducing agents for the treatment of cancer and immune diseases
SG172391A1 (en) * 2009-01-19 2011-07-28 Abbott Lab Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CA2929347A1 (en) * 2009-05-26 2010-12-02 Milan Bruncko (hetero)aryl substituted sulfonyl-2-(1h-pyrrolo[2,3-b]pyridine-5-oxy)benzamide compounds and their use as apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) * 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
TWI520960B (zh) * 2010-05-26 2016-02-11 艾伯維有限公司 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑
NZ772688A (en) 2010-06-03 2022-09-30 Pharmacyclics Llc The use of inhibitors of bruton’s tyrosine kinase (btk)
TWI535712B (zh) 2010-08-06 2016-06-01 阿斯特捷利康公司 化合物
SG10201801794WA (en) 2010-10-29 2018-04-27 Abbvie Inc Solid dispersions containing an apoptosis-inducing agent
UA113500C2 (xx) * 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
MY165884A (en) 2010-11-23 2018-05-18 Abbvie Ireland Unlimited Co Methods of treatment using selective bcl-2 inhibitors
KR101923364B1 (ko) * 2010-11-23 2018-11-30 애브비 인코포레이티드 아폽토시스­유도제의 염 및 결정형
CN104557646B (zh) 2011-02-15 2017-08-29 宇部兴产株式会社 生产芳基硫五氟化物的工业方法
CN102241649A (zh) * 2011-07-08 2011-11-16 陈飞 3-四氢呋喃甲醇的制备方法
US8940737B2 (en) 2011-10-14 2015-01-27 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WO2013185202A1 (en) * 2012-06-14 2013-12-19 Beta Pharma Canada Inc Apoptosis inducers
AU2013293087B2 (en) 2012-07-24 2017-08-31 Pharmacyclics Llc Mutations associated with resistance to inhibitors of Bruton's tyrosine kinase (BTK)
ES2677480T3 (es) * 2012-08-13 2018-08-02 Abbvie Inc. Agentes que inducen apoptosis
MX2015002947A (es) 2012-09-07 2015-09-23 Genentech Inc Terapia de combinacion de un anticuerpo ant-cd20 tipo ii con un inhibidor blc-2 selectivo.
LT6064B (lt) 2012-10-15 2014-08-25 Vilniaus Universitetas Fluorinti benzensulfonamidai kaip karboanhidrazės inhibitoriai
KR102229478B1 (ko) 2012-11-01 2021-03-18 인피니티 파마슈티칼스, 인코포레이티드 Pi3 키나아제 동형단백질 조절인자를 사용하는 암의 치료
US20150283142A1 (en) * 2013-03-15 2015-10-08 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
AR095265A1 (es) 2013-03-13 2015-09-30 Abbvie Inc Procesos para la preparación de un agente inductor de la apoptosis
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
AU2014251028A1 (en) * 2013-04-08 2015-11-05 Janssen Pharmaceutica Nv Ibrutinib combination therapy
TWI594975B (zh) 2013-04-24 2017-08-11 第一三共股份有限公司 二羧酸化合物
US9238652B2 (en) 2014-03-04 2016-01-19 Abbvie Inc. Processes for the preparation of an apoptosis-inducing agent
EP3139942B1 (en) 2014-05-05 2019-12-18 Bioventures, Llc COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS
EP3177144A4 (en) 2014-07-22 2018-01-24 Bioventures, LLC. Compositions and methods for selectively depleting senescent cells
CN104163798A (zh) * 2014-07-29 2014-11-26 苏州康润医药有限公司 3-氨基-8-三氟甲基喹啉的合成方法
RS62713B1 (sr) 2014-08-11 2022-01-31 Acerta Pharma Bv Terapeutske kombinacije btk inhibitora i bcl-2 inhibitora
RS60906B1 (sr) 2014-10-06 2020-11-30 Vertex Pharma Modulatori regulatora transmembranske provodljivosti za cističnu fibrozu
US10195213B2 (en) 2015-03-13 2019-02-05 Unity Biotechnology, Inc. Chemical entities that kill senescent cells for use in treating age-related disease
JP6910339B2 (ja) 2015-07-07 2021-07-28 ジェネンテック， インコーポレイテッド 抗ｈｅｒ２抗体−薬物複合体とｂｃｌ−２阻害剤の併用療法
WO2017063572A1 (zh) * 2015-10-13 2017-04-20 苏州晶云药物科技有限公司 细胞凋亡诱导剂的新晶型及其制备方法
WO2017096303A2 (en) 2015-12-04 2017-06-08 Portola Pharmaceuticals, Inc. Cerdulatinib for treating hematological cancers
US11001582B2 (en) 2016-03-10 2021-05-11 Assia Chemical Industries Ltd. Solid state forms of Venetoclax and processes for preparation of Venetoclax
US11027021B2 (en) 2016-03-15 2021-06-08 Seagen Inc. Combinations of PBD-based antibody drug conjugates with Bcl-2 inhibitors
ES3057783T3 (en) 2016-03-15 2026-03-04 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases
US11013698B2 (en) 2016-03-15 2021-05-25 Oryzon Genomics S.A. Combinations of LSD1 inhibitors for the treatment of hematological malignancies
ES2946970T3 (es) 2016-03-31 2023-07-28 Vertex Pharma Regulador de conductancia transmembrana de moduladores de fibrosis quística
CN109152933B (zh) * 2016-04-21 2022-12-02 生物风险投资有限责任公司 诱导抗细胞凋亡bcl-2家族蛋白的降解的化合物及其用途
RU2744358C2 (ru) * 2016-08-05 2021-03-05 Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган N-(фенилсульфонил) бензамиды и родственные соединения в качестве ингибиторов bcl-2
WO2018041248A1 (zh) * 2016-09-01 2018-03-08 北京赛林泰医药技术有限公司 Bcl-2选择性抑制剂及其制备和用途
LT3519401T (lt) 2016-09-30 2021-11-25 Vertex Pharmaceuticals Incorporated Cistinės fibrozės transmembraninio laidumo reguliavimo moduliatorius, farmacinės kompozicijos, gydymo būdai ir moduliatoriaus gamybos būdas
CN106749233B (zh) * 2016-11-24 2020-04-21 中山大学 一类磺酰胺衍生物及其应用
WO2018102725A1 (en) 2016-12-01 2018-06-07 Arvinas, Inc. Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders
PT3551622T (pt) 2016-12-09 2020-11-12 Vertex Pharma Modulador do regulador da condutância transmembrana da fibrose quística, composições farmacêuticas, métodos de tratamento e processo de fabrico do modulador
WO2018127130A1 (en) * 2017-01-07 2018-07-12 Shanghai Fochon Pharmaceutical Co., Ltd. Compounds as bcl-2-selective apoptosis-inducing agents
TWI773730B (zh) 2017-02-22 2022-08-11 瑞典商阿斯特捷利康公司 治療性樹枝狀聚合物
WO2018167652A1 (en) * 2017-03-13 2018-09-20 Laurus Labs Limited Process for preparation of amorphous form of venetoclax
MX391501B (es) 2017-04-18 2025-03-21 Fochon Pharmaceuticals Ltd Agentes inductores de apoptosis
CN107089981A (zh) * 2017-04-24 2017-08-25 杭州科耀医药科技有限公司 一种BCL‑2抑制剂Venetoclax的合成方法
US11253509B2 (en) 2017-06-08 2022-02-22 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
EP3626241B1 (en) * 2017-06-26 2025-04-23 Shenzhen TargetRx, Inc. Deuterated n-benzenesulfonylbenzamide compound for inhibiting bcl-2 protein and composition and use thereof
WO2019018395A1 (en) 2017-07-17 2019-01-24 Vertex Pharmaceuticals Incorporated METHODS OF TREATING CYSTIC FIBROSIS
CN110891608A (zh) 2017-07-26 2020-03-17 豪夫迈·罗氏有限公司 用BET抑制剂和Bcl-2抑制剂进行的组合疗法
JP2020528061A (ja) 2017-07-26 2020-09-17 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ＢＥＴ阻害剤、Ｂｃｌ−２阻害剤及び抗ＣＤ２０抗体を用いた併用療法
TWI799435B (zh) 2017-08-02 2023-04-21 美商維泰克斯製藥公司 製備化合物之製程
SG11202001553UA (en) 2017-08-23 2020-03-30 Newave Pharmaceutical Inc Condensed heterocyclic derivatives as bcl-2 inhibitors for the treatment of neoplastic diseases
US10654829B2 (en) 2017-10-19 2020-05-19 Vertex Pharmaceuticals Incorporated Crystalline forms and compositions of CFTR modulators
CN108037196B (zh) * 2017-11-23 2020-06-23 中山奕安泰医药科技有限公司 一种3-硝基-4-[[(四氢-2h-吡喃-4-基)甲基]氨基]苯磺酰胺的检测方法
CA3085006A1 (en) 2017-12-08 2019-06-13 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
CA3087261A1 (en) 2018-01-10 2019-07-18 Recurium Ip Holdings, Llc Benzamide compounds
EP3743069B1 (en) 2018-01-22 2025-08-06 BioVentures, LLC Bcl-2 proteins degraders for cancer treatment
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
CN112135631A (zh) 2018-02-16 2020-12-25 艾伯维公司 用于癌症治疗的选择性bcl-2抑制剂与抗pd-1或抗pd-l1抗体的组合
TW202002952A (zh) 2018-03-15 2020-01-16 美商艾伯維有限公司 用於治療胰臟癌之abbv-621與抗癌劑之組合
CN111868059B (zh) * 2018-03-30 2021-12-03 正大天晴药业集团股份有限公司 三氟甲基取代的磺酰胺类选择性bcl-2抑制剂
US11414439B2 (en) 2018-04-13 2022-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
CN112437772B (zh) * 2018-04-29 2023-11-21 百济神州有限公司 Bcl-2抑制剂
EP3788035B1 (en) 2018-05-04 2024-08-07 Alexion Pharmaceuticals, Inc. Solid forms of cerdulatinib
US12084423B2 (en) 2018-05-18 2024-09-10 Bioventures, Llc Piperlongumine analogues and uses thereof
WO2020023435A1 (en) 2018-07-24 2020-01-30 Albany Molecular Research, Inc. Venetoclax basic salts and processes for the purification of venetoclax
TW202023568A (zh) 2018-07-30 2020-07-01 瑞典商阿斯特捷利康公司 用於治療癌症之組合療法
EA202091963A1 (ru) * 2018-07-31 2021-05-13 Эсентейдж Фарма (Сучжоу) Ко., Лтд. СИНЕРГИЧЕСКИЙ ПРОТИВООПУХОЛЕВЫЙ ЭФФЕКТ ИНГИБИТОРА Bcl-2 В СОЧЕТАНИИ С РИТУКСИМАБОМ И/ИЛИ БЕНДАМУСТИНОМ ИЛИ ИНГИБИТОРА Bcl-2 В СОЧЕТАНИИ С CHOP
TWI752335B (zh) 2018-07-31 2022-01-11 大陸商蘇州亞盛藥業有限公司 Bcl-2抑制劑與MDM2抑制劑的組合產品及其在預防及/或治療疾病中的用途
CN114522167A (zh) 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
TWI725488B (zh) 2018-07-31 2021-04-21 大陸商蘇州亞盛藥業有限公司 Bcl-2抑制劑與化療藥的組合產品及其在預防及/或治療疾病中的用途
US12220419B2 (en) 2018-08-22 2025-02-11 Newave Pharmaceutical Inc. BCL-2 inhibitors
CA3117849A1 (en) * 2018-10-29 2020-05-07 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Trifluoromethyl-substituted sulfonamide as bcl-2-selective inhibitor
CN109320516A (zh) * 2018-11-30 2019-02-12 重庆三圣实业股份有限公司 一种维奈妥拉中间体的制备方法及其产品
CN109438441A (zh) * 2018-11-30 2019-03-08 重庆三圣实业股份有限公司 一种维奈妥拉的制备方法及其产品
WO2020140005A2 (en) 2018-12-29 2020-07-02 Newave Pharmaceutical Inc. Bcl-2 inhibitors
WO2020232214A1 (en) 2019-05-14 2020-11-19 Abbvie Inc. Treating acute myeloid leukemia (aml) with mivebresib, a bromodomain inhibitor
WO2020234445A1 (en) 2019-05-23 2020-11-26 F. Hoffmann-La Roche Ag Combination therapy with a bet inhibitor and a bcl-2 inhibitor
EP3978494A4 (en) * 2019-05-24 2023-04-19 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. METHYL AND TRFLUOROMETHYL CONTAINING DISUBSTITUTED SULFONAMIDE SELECTIVE BCL-2 INHIBITORS
ES3061133T3 (en) 2019-08-26 2026-03-31 Arvinas Operations Inc Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders
WO2021037933A1 (en) 2019-08-28 2021-03-04 Astrazeneca Ab Combination of azd2811 nanoparticles, 5-azacitidine and venetoclax for use in the treatment of cancer
CN112661751B (zh) * 2019-10-16 2024-06-14 南京天印健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
CN114929689B (zh) * 2019-10-28 2024-08-27 百济神州有限公司 Bcl-2抑制剂
WO2021110102A1 (en) * 2019-12-02 2021-06-10 Beigene, Ltd. Methods of cancer treatment using bcl-2 inhibitor
US12552784B2 (en) 2019-12-27 2026-02-17 Newave Pharmaceutical Inc. 1H-pyrrolo[2,3-b]pyridine derivatives as BCL-2 inhibitors for the treatment of neoplastic and autoimmune diseases
US12286430B2 (en) 2020-04-15 2025-04-29 Beigene, Ltd. Bcl-2 inhibitor
EP4129998A4 (en) * 2020-04-29 2024-05-01 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Crystal of trifluoromethyl/chloro disubstituted sulfonamide selective bcl-2 inhibitor
CN111848607B (zh) * 2020-07-22 2023-03-17 长沙创新药物工业技术研究院有限公司 一种新型bcl-2/bcl-xl抑制剂、药物组合物及用途
CN114057728A (zh) * 2020-08-06 2022-02-18 北京诺诚健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
CN114073703B (zh) * 2020-08-21 2022-12-30 苏州亚盛药业有限公司 用于治疗非酒精性脂肪肝炎的组合物和方法
WO2022089463A1 (zh) * 2020-10-28 2022-05-05 杭州和正医药有限公司 Bcl-2蛋白凋亡诱导剂及应用
CN114736203A (zh) * 2021-01-07 2022-07-12 南京天印健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
EP4308092A4 (en) * 2021-03-19 2025-01-22 Eil Therapeutics, Inc. Compounds having ((3-nitrophenyl)sulfonyl)acetamide as bcl-2 inhibitors
WO2022218311A1 (en) * 2021-04-13 2022-10-20 Appicine Therapeutics (Hk) Limited Modulators of bcl-2 or bcl-2/bcl-xl and uses thereof
CN117377672A (zh) 2021-06-04 2024-01-09 正大天晴药业集团股份有限公司 三氟甲基取代的磺酰胺类化合物的磷酸酯
CN118215660A (zh) * 2021-08-31 2024-06-18 百济神州有限公司 Bcl-2抑制剂的固体形式、其制备方法及用途
IT202100025976A1 (it) 2021-10-06 2023-04-06 Univ Degli Studi Di Perugia Combinazione di principi attivi per il trattamento della leucemia acuta mieloide (LAM) con mutazione della nucleofosmina (NPM1)
WO2023107606A1 (en) 2021-12-09 2023-06-15 University Of Florida Research Foundation, Incorporated Bcl-xl/bcl-2 dual degraders for treatment of cancers
WO2024012557A1 (en) * 2022-07-15 2024-01-18 Berrybio (Hong Kong) Limited Anti-apoptotic bcl-2 family protein degraders, pharmaceutical compositions, and therapeutic applications
KR20250079128A (ko) * 2022-07-21 2025-06-04 베이진 스위찰랜드 게엠베하 Bcl-2 저해제를 사용한 다발성 골수종의 치료 방법
CN115260191B (zh) * 2022-09-29 2022-12-27 上海睿跃生物科技有限公司 哌啶类化合物及其制备方法和应用
KR102598137B1 (ko) 2022-11-24 2023-11-06 율촌화학 주식회사 고차단성 생분해 필름 및 이의 제조방법
EP4421075A1 (en) 2023-02-27 2024-08-28 KRKA, d.d., Novo mesto Process for the preparation of venetoclax and intermediates used therein

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024636A2 (en) * 2000-09-20 2002-03-28 Abbott Laboratories N-acylsulfonamide apoptosis promoters
CN1906183A (zh) * 2003-11-13 2007-01-31 艾博特公司 N－酰基磺酰胺细胞程序死亡促进剂

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2579596B1 (fr) * 1985-03-26 1987-11-20 Inst Nat Sante Rech Med (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
GB9110625D0 (en) * 1991-05-16 1991-07-03 Glaxo Group Ltd Chemical compounds
BR9307570A (pt) * 1992-12-02 1999-05-25 Pfizer Diéteres de catecol como inibidores seletivos de pdeiv
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
PT1019385E (pt) 1995-09-15 2004-06-30 Upjohn Co N-oxidos de aminoaril-oxazolidinona
JP3409029B2 (ja) * 1997-10-03 2003-05-19 メルク フロスト カナダ アンド カンパニー Ｐｄｅｉｖ阻害剤としてのアリールチオフェン誘導体
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
PT1094816E (pt) 1998-07-06 2009-03-10 Bristol Myers Squibb Co Sulfonamidas bifenílicas duplamente antagonistas receptores de angiotensina e endotelina
DE19830430A1 (de) * 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
GB9918037D0 (en) 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
MXPA02006474A (es) 1999-12-28 2002-11-29 Eisai Co Ltd Compuestos heterociclicos que contienen sulfonamida.
GB2361003A (en) * 2000-04-07 2001-10-10 Astrazeneca Ab Novel compounds
US6720338B2 (en) 2000-09-20 2004-04-13 Abbott Laboratories N-acylsulfonamide apoptosis promoters
US20020055631A1 (en) 2000-09-20 2002-05-09 Augeri David J. N-acylsulfonamide apoptosis promoters
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
IL158985A0 (en) 2001-06-06 2004-05-12 Lilly Co Eli Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents
US20030059489A1 (en) 2001-09-24 2003-03-27 Canolio Inc. Genital lubricating compositions and uses thereof
US20030134853A1 (en) * 2001-09-26 2003-07-17 Priestley Eldon Scott Compounds useful for treating hepatitis C virus
FR2836914B1 (fr) * 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
GB0215650D0 (en) * 2002-07-05 2002-08-14 Cyclacel Ltd Bisarylsufonamide compounds
US6995787B2 (en) 2002-08-21 2006-02-07 Adams Steven L Sports projectile and camera apparatus
WO2005024636A1 (ja) 2003-09-04 2005-03-17 Hitachi Ulsi Systems Co., Ltd. 半導体装置
US7642260B2 (en) 2003-11-13 2010-01-05 Abbott Laboratories, Inc. Apoptosis promoters
US7767684B2 (en) 2003-11-13 2010-08-03 Abbott Laboratories Apoptosis promoters
US8614318B2 (en) 2003-11-13 2013-12-24 Abbvie Inc. Apoptosis promoters
US7973161B2 (en) * 2003-11-13 2011-07-05 Abbott Laboratories Apoptosis promoters
PL1737850T3 (pl) 2004-04-19 2008-02-29 Symed Labs Ltd Nowy sposób wytwarzania linezolidu i związków pokrewnych
BRPI0511070A (pt) * 2004-06-17 2007-11-27 Infinity Pharmaceuticals Inc compostos e processos para inibição da interação de proteìnas bcl com parceiros de ligação
WO2006008754A1 (en) 2004-07-20 2006-01-26 Symed Labs Limited Novel intermediates for linezolid and related compounds
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
EP1804823A4 (en) 2004-09-29 2010-06-09 Amr Technology Inc NEW CYCLOSPORIN ANALOGUE AND ITS PHARMACEUTICAL APPLICATIONS
EP2757099B1 (en) 2005-05-12 2017-08-23 AbbVie Bahamas Limited Apoptosis promoters
US8624027B2 (en) 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
BRPI0610828A2 (pt) * 2005-05-16 2010-07-27 Irm Llc compostos e composições como inibidores de proteìna quinase
TW200716636A (en) 2005-05-31 2007-05-01 Speedel Experimenta Ag Heterocyclic spiro-compounds
DK2395004T3 (en) 2005-06-22 2016-03-21 Plexxikon Inc Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors
US7514068B2 (en) 2005-09-14 2009-04-07 Concert Pharmaceuticals Inc. Biphenyl-pyrazolecarboxamide compounds
US20070115787A1 (en) * 2005-11-23 2007-05-24 Seagate Technology Llc Planar optical device for generating optical nanojets
CN101534904B (zh) * 2006-09-05 2013-11-06 Abbvie公司 治疗血小板过量的bcl抑制剂
US8796267B2 (en) 2006-10-23 2014-08-05 Concert Pharmaceuticals, Inc. Oxazolidinone derivatives and methods of use
WO2008064116A2 (en) 2006-11-16 2008-05-29 Abbott Laboratories Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection
MX2009008465A (es) 2007-02-15 2009-08-20 Hoffmann La Roche Nuevas 2-aminooxazolinas como ligandos de taar1.
US8536157B2 (en) 2007-04-13 2013-09-17 The University Of Melbourne Non-steroidal compounds
KR20100105802A (ko) 2007-04-19 2010-09-29 콘서트 파마슈티컬즈, 인크. 중수소화된 모르폴리닐 화합물
US7531685B2 (en) 2007-06-01 2009-05-12 Protia, Llc Deuterium-enriched oxybutynin
WO2009035598A1 (en) 2007-09-10 2009-03-19 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
US20090118238A1 (en) 2007-09-17 2009-05-07 Protia, Llc Deuterium-enriched alendronate
US20090088416A1 (en) 2007-09-26 2009-04-02 Protia, Llc Deuterium-enriched lapaquistat
US20090082471A1 (en) 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched fingolimod
US20090137457A1 (en) 2007-10-02 2009-05-28 Concert Pharmaceuticals, Inc. Pyrimidinedione derivatives
US20090098118A1 (en) * 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
US20090105338A1 (en) 2007-10-18 2009-04-23 Protia, Llc Deuterium-enriched gabexate mesylate
EP2212298B1 (en) 2007-10-18 2013-03-27 Concert Pharmaceuticals Inc. Deuterated etravirine
AU2008317375B2 (en) 2007-10-26 2013-02-28 Concert Pharmaceuticals, Inc. Deuterated darunavir
US8168784B2 (en) * 2008-06-20 2012-05-01 Abbott Laboratories Processes to make apoptosis promoters
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
UA108193C2 (uk) 2008-12-04 2015-04-10 Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
DK2376480T3 (en) 2008-12-05 2016-09-12 Abbvie Inc Sulfonamide derivatives AS BCL-2-selective apoptosis inducing agents for the treatment of cancer and immune diseases
WO2010077740A2 (en) 2008-12-09 2010-07-08 Cytokine Pharmasciences, Inc. Novel antiviral compounds, compositions, and methods of use
US20120094963A1 (en) 2008-12-23 2012-04-19 of Queen Elizabeth near Dublin Targeting prodrugs and compositions for the treatment of gastrointestinal diseases
NZ593594A (en) 2009-01-19 2013-08-30 Abbvie Inc Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
SG172391A1 (en) 2009-01-19 2011-07-28 Abbott Lab Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
CA2929347A1 (en) * 2009-05-26 2010-12-02 Milan Bruncko (hetero)aryl substituted sulfonyl-2-(1h-pyrrolo[2,3-b]pyridine-5-oxy)benzamide compounds and their use as apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
TWI520960B (zh) * 2010-05-26 2016-02-11 艾伯維有限公司 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024636A2 (en) * 2000-09-20 2002-03-28 Abbott Laboratories N-acylsulfonamide apoptosis promoters
CN1906183A (zh) * 2003-11-13 2007-01-31 艾博特公司 N－酰基磺酰胺细胞程序死亡促进剂

Also Published As

Publication number Publication date
WO2010138588A9 (en) 2011-05-05
DK2435432T3 (en) 2015-08-31
RU2573832C2 (ru) 2016-01-27
KR20120034671A (ko) 2012-04-12
IL215644A (en) 2017-08-31
IL215644A0 (en) 2012-01-31
UY32668A (es) 2010-12-31
HK1215576A1 (en) 2016-09-02
TW201607946A (zh) 2016-03-01
JP2025072583A (ja) 2025-05-09
CN104876927A (zh) 2015-09-02
EP4682148A2 (en) 2026-01-21
CN102448959A (zh) 2012-05-09
JP2017048219A (ja) 2017-03-09
EP3656771A1 (en) 2020-05-27
JP2012528178A (ja) 2012-11-12
RU2628885C2 (ru) 2017-08-22
PL2435432T6 (pl) 2024-02-12
BRPI1014359B1 (pt) 2019-11-05
ES2546294T7 (es) 2024-06-06
SG175253A1 (en) 2011-11-28
HUE027698T2 (en) 2016-10-28
EP2435432A2 (en) 2012-04-04
CR20170019A (es) 2017-05-12
CN104876927B (zh) 2017-06-23
RU2011152973A (ru) 2013-07-10
RS54234B2 (sr) 2024-02-29
KR102001418B1 (ko) 2019-07-19
PH12015500297A1 (en) 2015-12-07
CN109897038A (zh) 2019-06-18
KR101723378B1 (ko) 2017-04-06
MX339469B (es) 2016-05-27
RU2535347C3 (ru) 2019-05-14
JP2022033939A (ja) 2022-03-02
PL2435432T3 (pl) 2015-12-31
KR20230128571A (ko) 2023-09-05
US20110124628A1 (en) 2011-05-26
JP2018138577A (ja) 2018-09-06
PE20120345A1 (es) 2012-05-17
CR20110632A (es) 2012-02-15
BR122019016429B1 (pt) 2020-03-24
WO2010138588A3 (en) 2011-04-07
MX2011012257A (es) 2011-12-16
SI2435432T1 (sl) 2015-10-30
KR20180049164A (ko) 2018-05-10
PH12015500297B1 (en) 2023-10-20
CN109966294A (zh) 2019-07-05
AU2010254160B2 (en) 2015-02-12
CY2017019I1 (el) 2018-01-10
CA2759182A1 (en) 2010-12-02
AR076705A1 (es) 2011-06-29
CY2017019I2 (el) 2018-01-10
SI2435432T2 (sl) 2024-04-30
RU2535347C2 (ru) 2014-12-10
EP4474383A2 (en) 2024-12-11
SG10201704742YA (en) 2017-07-28
KR101659583B1 (ko) 2016-09-29
CN104906100A (zh) 2015-09-16
UY37825A (es) 2020-02-28
NO2017023I1 (no) 2017-05-29
ECSP11011554A (es) 2012-01-31
CL2011002949A1 (es) 2012-05-25
UA106079C2 (uk) 2014-07-25
HRP20151001T1 (hr) 2015-10-23
WO2010138588A2 (en) 2010-12-02
JP6353506B2 (ja) 2018-07-04
DK2435432T6 (da) 2023-12-18
LTPA2017015I1 (lt) 2017-06-12
TWI537269B (zh) 2016-06-11
JP2015110605A (ja) 2015-06-18
FI2435432T6 (fi) 2023-11-21
EP2435432B3 (en) 2023-10-25
BRPI1014359A2 (pt) 2016-04-05
PT2435432E (pt) 2015-10-13
EP4474383A3 (en) 2025-02-19
AR109974A2 (es) 2019-02-13
NZ595708A (en) 2014-03-28
EP2944638A1 (en) 2015-11-18
IL319747A (en) 2025-05-01
TW201107323A (en) 2011-03-01
CO6480950A2 (es) 2012-07-16
CA3052016A1 (en) 2010-12-02
TW201506025A (zh) 2015-02-16
AU2010254160A1 (en) 2011-11-24
HRP20151001T4 (hr) 2024-02-16
CN109897038B (zh) 2022-04-05
JP6038195B2 (ja) 2016-12-07
HK1163099A1 (en) 2012-09-07
KR101920202B1 (ko) 2018-11-21
KR20190130676A (ko) 2019-11-22
ZA201108616B (en) 2015-12-23
RU2015154494A (ru) 2017-06-22
RU2014132884A (ru) 2015-12-27
CA2929347A1 (en) 2010-12-02
KR20180124164A (ko) 2018-11-20
KR20190086591A (ko) 2019-07-22
IL299019A (en) 2023-02-01
ES2546294T3 (es) 2015-09-22
HUS1700021I1 (hu) 2017-06-28
JP2020023545A (ja) 2020-02-13
IL269092A (en) 2019-11-28
RS54234B1 (sr) 2015-12-31
ME02205B (me) 2016-02-20
IL253891A0 (en) 2017-10-31
IL286036A (en) 2021-10-31
TWI476195B (zh) 2015-03-11
CA3206963A1 (en) 2010-12-02
LTC2435432I2 (lt) 2018-06-11
SMT201500225B (it) 2015-10-30
KR20170037683A (ko) 2017-04-04
CA2759182C (en) 2016-06-07
TWI561523B (en) 2016-12-11
UY33047A (es) 2011-09-30
JP2023040165A (ja) 2023-03-22
DOP2011000367A (es) 2017-07-31
EP2435432B1 (en) 2015-06-24
KR20150065947A (ko) 2015-06-15
JP5747025B2 (ja) 2015-07-08
EP4682148A3 (en) 2026-03-18
NO2017023I2 (no) 2017-05-29
NL300873I2 (nl) 2017-10-24
MY155645A (en) 2015-11-13
AU2010254160C1 (en) 2023-07-06
JP2026001072A (ja) 2026-01-06
US8580794B2 (en) 2013-11-12
MX2019012154A (es) 2019-11-21
CY1117423T1 (el) 2017-04-26

Similar Documents

Publication Publication Date Title
RU2628885C2 (ru) Индуцирующие апоптоз средства для лечения злокачественной опухоли и иммунных и аутоиммунных заболеваний
CN103153993B (zh) 治疗癌症和免疫与自身免疫疾病的细胞程序死亡诱导药剂
US11897864B2 (en) Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
AU2015202183B2 (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
HK40009800A (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: ABBOTT HOSPITAL CO., LTD.

Free format text: FORMER OWNER: ABBOTT GMBH. + CO. KG

Effective date: 20131211

C41 Transfer of patent application or patent right or utility model
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Address after: Bahamas Nassau

Applicant after: AbbVie Inc.

Address before: Bahamas Nassau

Applicant before: Abbott Laboratories Ltd.

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: ABBOTT HOSPITAL CO., LTD. TO: ABBVIE BAHAMAS B.V.

TA01 Transfer of patent application right

Effective date of registration: 20131211

Address after: Bahamas Nassau

Applicant after: Abbott Laboratories Ltd.

Address before: Illinois State

Applicant before: ABBOTT LABORATORIES

C14 Grant of patent or utility model
GR01 Patent grant
C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20160927

Address after: Bermuda Hamilton

Patentee after: AbbVie Inc.

Address before: Bahamas Nassau

Patentee before: AbbVie Inc.