BR112023017371A2 - Compostos que têm ((3-nitrofenil)sulfonil)acetamida como inibidores de bcl-2 - Google Patents
Compostos que têm ((3-nitrofenil)sulfonil)acetamida como inibidores de bcl-2Info
- Publication number
- BR112023017371A2 BR112023017371A2 BR112023017371A BR112023017371A BR112023017371A2 BR 112023017371 A2 BR112023017371 A2 BR 112023017371A2 BR 112023017371 A BR112023017371 A BR 112023017371A BR 112023017371 A BR112023017371 A BR 112023017371A BR 112023017371 A2 BR112023017371 A2 BR 112023017371A2
- Authority
- BR
- Brazil
- Prior art keywords
- bcl
- inhibitors
- nitrophenyl
- acetamide
- sulfonyl
- Prior art date
Links
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 title abstract 4
- -1 (3-NITROPHENYL)SULFONYL Chemical class 0.000 title abstract 2
- 239000012664 BCL-2-inhibitor Substances 0.000 title abstract 2
- 229940123711 Bcl2 inhibitor Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 108010090931 Proto-Oncogene Proteins c-bcl-2 Proteins 0.000 abstract 1
- 102000013535 Proto-Oncogene Proteins c-bcl-2 Human genes 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 229940121649 protein inhibitor Drugs 0.000 abstract 1
- 239000012268 protein inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
compostos que têm ((3-nitrofenil)sulfonil)acetamida como inibidores de bcl-2. a presente invenção é genericamente direcionada a inibidores de proteínas bcl-2 úteis no tratamento de doenças e distúrbios modulados pela dita enzima e que têm a fórmula (i).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163163326P | 2021-03-19 | 2021-03-19 | |
PCT/US2022/020986 WO2022198069A1 (en) | 2021-03-19 | 2022-03-18 | Compounds having ((3-nitrophenyl)sulfonyl)acetamide as bcl-2 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023017371A2 true BR112023017371A2 (pt) | 2023-10-03 |
Family
ID=83321213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023017371A BR112023017371A2 (pt) | 2021-03-19 | 2022-03-18 | Compostos que têm ((3-nitrofenil)sulfonil)acetamida como inibidores de bcl-2 |
Country Status (11)
Country | Link |
---|---|
US (1) | US11834450B2 (pt) |
EP (1) | EP4308092A1 (pt) |
JP (1) | JP2024510434A (pt) |
KR (1) | KR20230159524A (pt) |
CN (1) | CN117642157A (pt) |
AR (1) | AR125046A1 (pt) |
AU (1) | AU2022240765A1 (pt) |
BR (1) | BR112023017371A2 (pt) |
CA (1) | CA3211639A1 (pt) |
MX (1) | MX2023011000A (pt) |
WO (1) | WO2022198069A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116270660A (zh) * | 2023-03-30 | 2023-06-23 | 广州麓鹏制药有限公司 | 一种含Bcl-2/Bcl-xl抑制剂的组合物及其制备方法与应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6720338B2 (en) | 2000-09-20 | 2004-04-13 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
US20020055631A1 (en) | 2000-09-20 | 2002-05-09 | Augeri David J. | N-acylsulfonamide apoptosis promoters |
US7767684B2 (en) | 2003-11-13 | 2010-08-03 | Abbott Laboratories | Apoptosis promoters |
WO2005049593A2 (en) | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
US8614318B2 (en) | 2003-11-13 | 2013-12-24 | Abbvie Inc. | Apoptosis promoters |
US7973161B2 (en) | 2003-11-13 | 2011-07-05 | Abbott Laboratories | Apoptosis promoters |
US7642260B2 (en) | 2003-11-13 | 2010-01-05 | Abbott Laboratories, Inc. | Apoptosis promoters |
US20080182845A1 (en) | 2006-11-16 | 2008-07-31 | Abbott Laboratories | Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection |
US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
US8586754B2 (en) | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
ME02205B (me) * | 2009-05-26 | 2016-02-20 | Abbvie Bahamas Ltd | INDUKUJUĆI AGENSI APOPTOZE ZA LEČENJE KANCERA I IMUNIH l AUTOIMUNIH OBOLJENJA |
US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
US9034875B2 (en) | 2009-05-26 | 2015-05-19 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
CN105218483A (zh) | 2010-03-25 | 2016-01-06 | Abbvie公司 | 用于治疗癌症和免疫以及自身免疫性疾病的细胞凋亡诱导剂 |
TWI535712B (zh) | 2010-08-06 | 2016-06-01 | 阿斯特捷利康公司 | 化合物 |
US10195213B2 (en) * | 2015-03-13 | 2019-02-05 | Unity Biotechnology, Inc. | Chemical entities that kill senescent cells for use in treating age-related disease |
CN117430601A (zh) * | 2018-04-29 | 2024-01-23 | 百济神州有限公司 | Bcl-2抑制剂 |
-
2022
- 2022-03-18 AR ARP220100652A patent/AR125046A1/es unknown
- 2022-03-18 KR KR1020237035757A patent/KR20230159524A/ko unknown
- 2022-03-18 CN CN202280022383.5A patent/CN117642157A/zh active Pending
- 2022-03-18 EP EP22772302.0A patent/EP4308092A1/en active Pending
- 2022-03-18 MX MX2023011000A patent/MX2023011000A/es unknown
- 2022-03-18 CA CA3211639A patent/CA3211639A1/en active Pending
- 2022-03-18 BR BR112023017371A patent/BR112023017371A2/pt unknown
- 2022-03-18 US US17/698,956 patent/US11834450B2/en active Active
- 2022-03-18 AU AU2022240765A patent/AU2022240765A1/en active Pending
- 2022-03-18 JP JP2023554303A patent/JP2024510434A/ja active Pending
- 2022-03-18 WO PCT/US2022/020986 patent/WO2022198069A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP4308092A1 (en) | 2024-01-24 |
JP2024510434A (ja) | 2024-03-07 |
CN117642157A (zh) | 2024-03-01 |
CA3211639A1 (en) | 2022-09-22 |
AR125046A1 (es) | 2023-05-31 |
MX2023011000A (es) | 2023-09-28 |
US11834450B2 (en) | 2023-12-05 |
AU2022240765A1 (en) | 2023-09-07 |
WO2022198069A1 (en) | 2022-09-22 |
US20220306625A1 (en) | 2022-09-29 |
KR20230159524A (ko) | 2023-11-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2023013356A2 (es) | Compuestos para la inhibición de nlrp3 y usos de estos | |
CL2022003510A1 (es) | Inhibidores de cisteína proteasas y sus métodos de uso | |
CO2018010504A2 (es) | Inhibidores del enlace proteína-proteína de wdr5 | |
CO2022018811A2 (es) | Inhibidores de la proteína kras g12c y usos de estos | |
BR112015021999A2 (pt) | inibidores de indoleamina 2,3-dioxigenase (ido) | |
MA38483A1 (fr) | Inhibiteurs de l'ido | |
BR112021020520A2 (pt) | Inibidores da di-hidro-orotato desidrogenase | |
BR112013031402A2 (pt) | derivados de hidantoína como inibidores de kv3 | |
BR122020016659B8 (pt) | moduladores de 2,3-dioxigenase de indolamina e métodos de modulação de atividade de inibição e de imunossupressão | |
BR112022015110A2 (pt) | Compostos e usos dos mesmos | |
BR112020016020A8 (pt) | Inibidor de atr e aplicação do mesmo | |
CO2022009438A2 (es) | Fluoroalquil-oxadiazoles y sus usos | |
BR112018013522A2 (pt) | compostos inibidores de metaloenzima | |
BR112023025358A2 (pt) | Inibidores de protease como antivirais | |
BR112014006763A2 (pt) | n-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexa-hidro-ciclopenta[e][1,3]oxazin-4-il)-fenil)-amidas como inibidores de bace1 | |
ATE538651T1 (de) | Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit | |
EA200401270A1 (ru) | Тиазолидинкарбоксамидные производные как модуляторы рецептора простагландина f | |
BR112023017371A2 (pt) | Compostos que têm ((3-nitrofenil)sulfonil)acetamida como inibidores de bcl-2 | |
EA201291055A1 (ru) | Ингибиторы протеинтирозинкиназной активности и их применение для лечения глазных заболеваний | |
BR112022014949A2 (pt) | Compostos e usos dos mesmos | |
BR112021006319A2 (pt) | compostos de indolinona para uso como inibidores de map4k1 | |
BR112023015210A2 (pt) | Inibidores de cdk2 e métodos de uso dos mesmos | |
BR112022015109A2 (pt) | Compostos e usos dos mesmos | |
BR112022013480A2 (pt) | Métodos de tratamento de coronavírus | |
BR112023017344A2 (pt) | Compostos que têm tetra-hidroindolizina-1-carboxamida como inibidores de bcl-2 |