KR101563752B1 - 옥사졸리디논 항생 유도체 - Google Patents

옥사졸리디논 항생 유도체 Download PDF

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Publication number
KR101563752B1
KR101563752B1 KR1020097023303A KR20097023303A KR101563752B1 KR 101563752 B1 KR101563752 B1 KR 101563752B1 KR 1020097023303 A KR1020097023303 A KR 1020097023303A KR 20097023303 A KR20097023303 A KR 20097023303A KR 101563752 B1 KR101563752 B1 KR 101563752B1
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South Korea
Prior art keywords
oxazolidin
benzo
methoxy
oxo
naphthyridin
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Expired - Fee Related
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KR1020097023303A
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English (en)
Korean (ko)
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KR20090130112A (ko
Inventor
마르쿠스 구드
크리스티안 후브쉬웨를렌
게으로그 루에디
쟌-필립페 수리베트
코르넬리아 줌비룬 액클린
Original Assignee
액테리온 파마슈티칼 리미티드
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Publication of KR101563752B1 publication Critical patent/KR101563752B1/ko
Assigned to 아이도시아 파마수티컬즈 리미티드 reassignment 아이도시아 파마수티컬즈 리미티드 권리의 전부이전등록 Assignors: 액테리온 파마슈티칼 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020097023303A 2007-04-11 2008-04-10 옥사졸리디논 항생 유도체 Expired - Fee Related KR101563752B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IBPCT/IB2007/051292 2007-04-11
IB2007051292 2007-04-11
IBPCT/IB2008/050746 2008-02-29
IB2008050746 2008-02-29

Publications (2)

Publication Number Publication Date
KR20090130112A KR20090130112A (ko) 2009-12-17
KR101563752B1 true KR101563752B1 (ko) 2015-10-27

Family

ID=39722506

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097023303A Expired - Fee Related KR101563752B1 (ko) 2007-04-11 2008-04-10 옥사졸리디논 항생 유도체

Country Status (16)

Country Link
US (1) US8114867B2 (https=)
EP (1) EP2146987B1 (https=)
JP (1) JP5363457B2 (https=)
KR (1) KR101563752B1 (https=)
CN (1) CN101657450B (https=)
AR (1) AR066012A1 (https=)
AU (1) AU2008238894B2 (https=)
BR (1) BRPI0809667A2 (https=)
CA (1) CA2679069C (https=)
CL (1) CL2008001003A1 (https=)
ES (1) ES2560870T3 (https=)
MX (1) MX2009010641A (https=)
PL (1) PL2146987T3 (https=)
RU (1) RU2506263C2 (https=)
TW (1) TWI415614B (https=)
WO (1) WO2008126024A2 (https=)

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ES2411930T3 (es) 2008-02-20 2013-07-09 Actelion Pharmaceuticals Ltd. Compuestos antibióticos azatricíclicos
RU2501799C2 (ru) 2008-02-22 2013-12-20 Актелион Фармасьютикалз Лтд Поизводные оксазолидинона
ES2399499T3 (es) * 2008-08-04 2013-04-01 Actelion Pharmaceuticals Ltd. Derivados de alquilaminometiloxazolidinona tricíclicos
BRPI0920895A8 (pt) 2008-10-07 2017-12-26 Actelion Pharmaceuticals Ltd Compostos antibióticos de oxazolidinona tricíclica
WO2010041219A1 (en) * 2008-10-10 2010-04-15 Actelion Pharmaceuticals Ltd 2-benzothiophenyl-and 2-naphthyl-0xaz0lidin0nes and their azaisostere analogues as antibacterial agents
CN102232078B (zh) 2008-12-12 2014-07-16 埃科特莱茵药品有限公司 5-氨基-2-(1-羟基-乙基)-四氢吡喃衍生物
EP2509997B1 (en) * 2009-12-07 2017-08-30 i2 Pharmaceuticals, Inc. Conjugates comprising an antibody surrogate scaffold with improved pharmacokinetic properties
EP2377850A1 (en) 2010-03-30 2011-10-19 Pharmeste S.r.l. TRPV1 vanilloid receptor antagonists with a bicyclic portion
TW201309689A (zh) 2011-02-07 2013-03-01 Daiichi Sankyo Co Ltd 含胺基之吡咯啶酮衍生物
CA2842885A1 (en) 2011-08-11 2013-02-14 Actelion Pharmaceuticals Ltd Quinazoline-2,4-dione derivatives
IN2014CN04126A (https=) * 2011-11-08 2015-07-10 Actelion Pharmaceuticals Ltd
CA2854266A1 (en) 2011-11-30 2013-06-06 Actelion Pharmaceuticals Ltd 3,7-disubstituted octahydro-2h-pyrido[4,3-e][1,3]oxazin-2-one antibiotics
WO2014024056A1 (en) 2012-08-06 2014-02-13 Daiichi Sankyo Company, Limited Pyrrolidine derivatives with antibacterial properties
CN104583205B (zh) * 2012-08-17 2017-03-08 巴斯夫欧洲公司 制造苯并噁嗪酮类的方法
PL2986607T3 (pl) 2013-04-16 2017-11-30 Idorsia Pharmaceuticals Ltd Przeciwbakteryjne pochodne biaromatyczne
AR102256A1 (es) * 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
WO2017137743A1 (en) * 2016-02-08 2017-08-17 Redx Pharma Plc Antibacterial compounds
EA201891654A1 (ru) * 2016-02-08 2019-01-31 РЭДКС ФАРМА ПиЭлСи Антибактериальные соединения
GB201602235D0 (en) * 2016-02-08 2016-03-23 Redx Pharma Plc Antibacterial compounds
GB2550437B (en) 2016-05-20 2021-06-23 Bugworks Res Inc Heterocyclic compounds useful as anti-bacterial agents and method for production
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
PL3634968T3 (pl) 2017-06-08 2023-07-31 Bugworks Research, Inc. Związki heterocykliczne użyteczne jako środki przeciwbakteryjne oraz sposób ich wytwarzania
WO2019106693A1 (en) * 2017-11-29 2019-06-06 Bugworks Research India Pvt Ltd Anti-bacterial heterocyclic compounds and their synthesis
EP3774790B1 (en) * 2018-03-28 2023-01-25 Bugworks Research, Inc. Oxazolidinone antibiotic compounds and process of preparation
CN117532894B (zh) * 2023-12-05 2024-06-14 东莞美泰电子有限公司 一种用于保护零件的pu皮革热压贴皮工艺

Citations (1)

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US20070060558A1 (en) 2004-07-30 2007-03-15 Palumed S.A. Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents

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Also Published As

Publication number Publication date
EP2146987A2 (en) 2010-01-27
KR20090130112A (ko) 2009-12-17
AU2008238894B2 (en) 2013-06-20
WO2008126024A3 (en) 2008-12-04
CA2679069C (en) 2016-06-07
EP2146987B1 (en) 2015-12-02
US20100137290A1 (en) 2010-06-03
ES2560870T3 (es) 2016-02-23
CL2008001003A1 (es) 2008-10-17
RU2009141310A (ru) 2011-05-20
BRPI0809667A2 (pt) 2014-10-07
TW200843780A (en) 2008-11-16
JP2010523645A (ja) 2010-07-15
RU2506263C2 (ru) 2014-02-10
AU2008238894A1 (en) 2008-10-23
CN101657450A (zh) 2010-02-24
PL2146987T3 (pl) 2016-05-31
JP5363457B2 (ja) 2013-12-11
CA2679069A1 (en) 2008-10-23
CN101657450B (zh) 2014-04-23
AR066012A1 (es) 2009-07-15
MX2009010641A (es) 2009-10-23
US8114867B2 (en) 2012-02-14
WO2008126024A2 (en) 2008-10-23
TWI415614B (zh) 2013-11-21

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