KR101563752B1 - 옥사졸리디논 항생 유도체 - Google Patents

옥사졸리디논 항생 유도체 Download PDF

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Publication number
KR101563752B1
KR101563752B1 KR1020097023303A KR20097023303A KR101563752B1 KR 101563752 B1 KR101563752 B1 KR 101563752B1 KR 1020097023303 A KR1020097023303 A KR 1020097023303A KR 20097023303 A KR20097023303 A KR 20097023303A KR 101563752 B1 KR101563752 B1 KR 101563752B1
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KR
South Korea
Prior art keywords
oxazolidin
benzo
methoxy
oxo
naphthyridin
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Expired - Fee Related
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KR1020097023303A
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English (en)
Korean (ko)
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KR20090130112A (ko
Inventor
마르쿠스 구드
크리스티안 후브쉬웨를렌
게으로그 루에디
쟌-필립페 수리베트
코르넬리아 줌비룬 액클린
Original Assignee
액테리온 파마슈티칼 리미티드
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Publication of KR20090130112A publication Critical patent/KR20090130112A/ko
Application granted granted Critical
Publication of KR101563752B1 publication Critical patent/KR101563752B1/ko
Assigned to 아이도시아 파마수티컬즈 리미티드 reassignment 아이도시아 파마수티컬즈 리미티드 권리의 전부이전등록 Assignors: 액테리온 파마슈티칼 리미티드
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020097023303A 2007-04-11 2008-04-10 옥사졸리디논 항생 유도체 Expired - Fee Related KR101563752B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IBPCT/IB2007/051292 2007-04-11
IB2007051292 2007-04-11
IBPCT/IB2008/050746 2008-02-29
IB2008050746 2008-02-29

Publications (2)

Publication Number Publication Date
KR20090130112A KR20090130112A (ko) 2009-12-17
KR101563752B1 true KR101563752B1 (ko) 2015-10-27

Family

ID=39722506

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097023303A Expired - Fee Related KR101563752B1 (ko) 2007-04-11 2008-04-10 옥사졸리디논 항생 유도체

Country Status (16)

Country Link
US (1) US8114867B2 (https=)
EP (1) EP2146987B1 (https=)
JP (1) JP5363457B2 (https=)
KR (1) KR101563752B1 (https=)
CN (1) CN101657450B (https=)
AR (1) AR066012A1 (https=)
AU (1) AU2008238894B2 (https=)
BR (1) BRPI0809667A2 (https=)
CA (1) CA2679069C (https=)
CL (1) CL2008001003A1 (https=)
ES (1) ES2560870T3 (https=)
MX (1) MX2009010641A (https=)
PL (1) PL2146987T3 (https=)
RU (1) RU2506263C2 (https=)
TW (1) TWI415614B (https=)
WO (1) WO2008126024A2 (https=)

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ES2411930T3 (es) 2008-02-20 2013-07-09 Actelion Pharmaceuticals Ltd. Compuestos antibióticos azatricíclicos
KR101592046B1 (ko) 2008-02-22 2016-02-05 액테리온 파마슈티칼 리미티드 옥사졸리디논 유도체
CN102105467A (zh) * 2008-08-04 2011-06-22 埃科特莱茵药品有限公司 三环烷氨基甲基噁唑烷酮衍生物
DK2344495T3 (en) 2008-10-07 2015-02-02 Actelion Pharmaceuticals Ltd TRICYCLIC OXAZOLIDINON ANTIBIOTIC COMPOUNDS
ES2395491T3 (es) * 2008-10-10 2013-02-13 Actelion Pharmaceuticals Ltd. 2-Benzotiofenil y 2-naftil-oxazolidinonas y sus análogos azaisósteros como agentes antibacterianos
AU2009325902B2 (en) 2008-12-12 2015-01-29 Idorsia Pharmaceuticals Ltd 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives
WO2011071957A1 (en) * 2009-12-07 2011-06-16 Sea Lane Biotechnologies, Llc Conjugates comprising an antibody surrogate scaffold with improved pharmacokinetic properties
EP2377850A1 (en) * 2010-03-30 2011-10-19 Pharmeste S.r.l. TRPV1 vanilloid receptor antagonists with a bicyclic portion
EP2674430A4 (en) 2011-02-07 2014-07-02 Daiichi Sankyo Co Ltd AMINO-GROUP-PYRROLIDINONE DERIVATIVES
RU2014108919A (ru) 2011-08-11 2015-09-20 Актелион Фармасьютиклз Лтд Хиназолин-2,4-дионовые производные
SG11201401710PA (en) * 2011-11-08 2014-09-26 Actelion Pharmaceuticals Ltd 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives
TW201326180A (zh) 2011-11-30 2013-07-01 Actelion Pharmaceuticals Ltd ３，７－二取代八氫－２Ｈ－吡啶并［４，３－ｅ］［１，３］□嗪－２－酮抗生素
WO2014024056A1 (en) 2012-08-06 2014-02-13 Daiichi Sankyo Company, Limited Pyrrolidine derivatives with antibacterial properties
CN104583205B (zh) * 2012-08-17 2017-03-08 巴斯夫欧洲公司 制造苯并噁嗪酮类的方法
KR20150143720A (ko) 2013-04-16 2015-12-23 액테리온 파마슈티칼 리미티드 항균성 이방향족 유도체
AR102256A1 (es) 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
WO2017137743A1 (en) * 2016-02-08 2017-08-17 Redx Pharma Plc Antibacterial compounds
SG11201806166WA (en) * 2016-02-08 2018-08-30 Redx Pharma Plc Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds
GB201602235D0 (en) * 2016-02-08 2016-03-23 Redx Pharma Plc Antibacterial compounds
GB2550437B (en) * 2016-05-20 2021-06-23 Bugworks Res Inc Heterocyclic compounds useful as anti-bacterial agents and method for production
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
PT3634968T (pt) 2017-06-08 2023-04-14 Bugworks Res Inc Compostos heterocíclicos úteis como agentes anti-bacterianos e método para a sua produção
CN111527093B (zh) * 2017-11-29 2023-06-09 巴格沃克斯研究有限公司 抗菌杂环化合物及其合成
RS64146B1 (sr) * 2018-03-28 2023-05-31 Bugworks Research Inc Oksazolidinonska antibiotska jedinjenja i postupak dobijanja
CN117532894B (zh) * 2023-12-05 2024-06-14 东莞美泰电子有限公司 一种用于保护零件的pu皮革热压贴皮工艺

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US20070060558A1 (en) 2004-07-30 2007-03-15 Palumed S.A. Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents

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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US20070060558A1 (en) 2004-07-30 2007-03-15 Palumed S.A. Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents

Also Published As

Publication number Publication date
JP5363457B2 (ja) 2013-12-11
AU2008238894A1 (en) 2008-10-23
CL2008001003A1 (es) 2008-10-17
RU2009141310A (ru) 2011-05-20
EP2146987B1 (en) 2015-12-02
TW200843780A (en) 2008-11-16
ES2560870T3 (es) 2016-02-23
CA2679069A1 (en) 2008-10-23
US8114867B2 (en) 2012-02-14
CA2679069C (en) 2016-06-07
CN101657450B (zh) 2014-04-23
CN101657450A (zh) 2010-02-24
TWI415614B (zh) 2013-11-21
PL2146987T3 (pl) 2016-05-31
RU2506263C2 (ru) 2014-02-10
EP2146987A2 (en) 2010-01-27
WO2008126024A3 (en) 2008-12-04
KR20090130112A (ko) 2009-12-17
AR066012A1 (es) 2009-07-15
AU2008238894B2 (en) 2013-06-20
JP2010523645A (ja) 2010-07-15
MX2009010641A (es) 2009-10-23
US20100137290A1 (en) 2010-06-03
BRPI0809667A2 (pt) 2014-10-07
WO2008126024A2 (en) 2008-10-23

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