SG11201806166WA - Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds - Google Patents

Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds

Info

Publication number
SG11201806166WA
SG11201806166WA SG11201806166WA SG11201806166WA SG11201806166WA SG 11201806166W A SG11201806166W A SG 11201806166WA SG 11201806166W A SG11201806166W A SG 11201806166WA SG 11201806166W A SG11201806166W A SG 11201806166WA SG 11201806166W A SG11201806166W A SG 11201806166WA
Authority
SG
Singapore
Prior art keywords
alderley
mereside
cheshire
block
international
Prior art date
Application number
SG11201806166WA
Inventor
Ian Cooper
Amanda Lyons
David Orr
James Kirkham
Kevin Blades
Original Assignee
Redx Pharma Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1602241.0A external-priority patent/GB201602241D0/en
Priority claimed from GBGB1616460.0A external-priority patent/GB201616460D0/en
Application filed by Redx Pharma Plc filed Critical Redx Pharma Plc
Publication of SG11201806166WA publication Critical patent/SG11201806166WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/137744 Al 17 August 2017 (17.08.2017) WIPO I PCT 1111111111111101110111111111110101111101110111011111101110111111111111111111110111111 (51) International Patent Classification: A61P 31/04 (2006.01) CO7D 263/58 (2006.01) A61P 31/06 (2006.01) A61K 31/423 (2006.01) (21) International Application Number: PCT/GB2017/050318 (22) International Filing Date: 8 February 2017 (08.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1602241.0 8 February 2016 (08.02.2016) GB 1616460.0 28 September 2016 (28.09.2016) GB (71) Applicant: REDX PHARMA PLC [GB/GB]; Block 33F, Mereside, Alderley Park, Alderley Edge Cheshire SK10 4TG (GB). (72) Inventors: COOPER, Ian; c/o Redx Pharma PLC, Block 33F, Mereside, Alderley Park, Alderley Edge, Cheshire SK10 4TG (GB). LYONS, Amanda; c/o Redx Pharma PLC, Block 33F, Mereside, Alderley Park, Alderley Edge, Cheshire SK10 4TG (GB). ORR, David; c/o Redx Pharma PLC, Block 33F, Mereside, Alderley Park, Alderley Edge, Cheshire SK10 4TG (GB). KIRKHAM, James; c/o Redx Pharma PLC, Block 33F, Mereside, Alderley Park, Alder- ley Edge, Cheshire SK10 4TG (GB). BLADES, Kevin; c/o Red Pharma PLC, Block 33 F, Mereside, Alderley Park, Alderley Edge, Cheshire SK10 4TG (GB). (74) Agents: HGF LIMITED (LEEDS) et al.; 1 City Walk, Leeds West Yorkshire LS11 9DX (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) W O 20 171377 / 44 Al (54) Title: HETEROCYCLIC COMPOUNDS, IN PARTICULAR 2-OXO-4,4,5,5,6,6,7,7-OCTAHYDROBENZOXAZOLE DE- RIVATIVES, AND THEIR USE AS ANTIBACTERIAL COMPOUNDS (57) : This invention relates to antibacterial drug compounds containing a bicyclic core, typically a bicycle in which one of the rings is an oxazolidinone. It also relates to pharmaceutical formulations of antibacterial drug compounds. It also relates to uses of the compounds in treating bacterial infections and in methods of treating bacterial infections.
SG11201806166WA 2016-02-08 2017-02-08 Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds SG11201806166WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1602241.0A GB201602241D0 (en) 2016-02-08 2016-02-08 Antibacterial compounds
GBGB1616460.0A GB201616460D0 (en) 2016-09-28 2016-09-28 Antibacterial compounds
PCT/GB2017/050318 WO2017137744A1 (en) 2016-02-08 2017-02-08 Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds

Publications (1)

Publication Number Publication Date
SG11201806166WA true SG11201806166WA (en) 2018-08-30

Family

ID=58046706

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201806166WA SG11201806166WA (en) 2016-02-08 2017-02-08 Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds

Country Status (11)

Country Link
US (1) US10487093B2 (en)
EP (1) EP3413976A1 (en)
JP (1) JP2019504850A (en)
KR (1) KR20180108781A (en)
CN (1) CN109121397A (en)
AU (1) AU2017218556A1 (en)
BR (1) BR112018016208A2 (en)
CA (1) CA3012583A1 (en)
EA (1) EA201891654A1 (en)
SG (1) SG11201806166WA (en)
WO (1) WO2017137744A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111171020A (en) * 2018-11-13 2020-05-19 上海轶诺药业有限公司 Hexa-membered and hexa-membered heterocyclic compounds and application thereof as protein receptor kinase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005030733A1 (en) * 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug combinations for the treatment of respiratory diseases containing long-acting beta-2 agonists and at least one other active ingredient
CL2008001002A1 (en) * 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION.
CL2008001003A1 (en) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION.
ES2398939T3 (en) 2008-02-22 2013-03-22 Actelion Pharmaceuticals Ltd. Oxazolidinone derivatives
CU24152B1 (en) * 2010-12-20 2016-02-29 Irm Llc 1,2 OXAZOL-8-AZABICICLO [3,2,1] OCTANO 8 IL AS FXR MODULATORS
KR20140054057A (en) * 2011-08-11 2014-05-08 액테리온 파마슈티칼 리미티드 Quinazoline-2,4-dione derivatives
SG11201401710PA (en) 2011-11-08 2014-09-26 Actelion Pharmaceuticals Ltd 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives
WO2013080156A1 (en) * 2011-11-30 2013-06-06 Actelion Pharmaceuticals Ltd 3,7-disubstituted octahydro-2h-pyrido[4,3-e][1,3]oxazin-2-one antibiotics

Also Published As

Publication number Publication date
EP3413976A1 (en) 2018-12-19
CA3012583A1 (en) 2017-08-17
CN109121397A (en) 2019-01-01
AU2017218556A1 (en) 2018-08-09
WO2017137744A1 (en) 2017-08-17
KR20180108781A (en) 2018-10-04
US20190055266A1 (en) 2019-02-21
US10487093B2 (en) 2019-11-26
BR112018016208A2 (en) 2018-12-18
EA201891654A1 (en) 2019-01-31
JP2019504850A (en) 2019-02-21

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