KR101532129B1 - L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법 - Google Patents

L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법 Download PDF

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KR101532129B1
KR101532129B1 KR1020130002913A KR20130002913A KR101532129B1 KR 101532129 B1 KR101532129 B1 KR 101532129B1 KR 1020130002913 A KR1020130002913 A KR 1020130002913A KR 20130002913 A KR20130002913 A KR 20130002913A KR 101532129 B1 KR101532129 B1 KR 101532129B1
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tryptophan
ala
leu
gly
seq
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KR20130082121A (ko
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이광호
박혜민
이효형
황영빈
이석명
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씨제이제일제당 (주)
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Priority to PH1/2014/501590A priority Critical patent/PH12014501590B1/en
Priority to PCT/KR2013/000214 priority patent/WO2013105800A2/ko
Priority to MYPI2014002060A priority patent/MY173848A/en
Priority to CN201380010032.3A priority patent/CN104204189B/zh
Priority to MX2014008470A priority patent/MX351721B/es
Priority to JP2014552128A priority patent/JP6449653B2/ja
Priority to US14/371,465 priority patent/US9587261B2/en
Priority to CA2860974A priority patent/CA2860974C/en
Priority to BR112014017074-6A priority patent/BR112014017074B1/pt
Priority to RU2014132889/10A priority patent/RU2593957C2/ru
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
    • H10K59/00—Integrated devices, or assemblies of multiple devices, comprising at least one organic light-emitting element covered by group H10K50/00
    • H10K59/10—OLED displays
    • H10K59/12—Active-matrix OLED [AMOLED] displays
    • H10K59/131—Interconnections, e.g. wiring lines or terminals
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
    • H10K50/00—Organic light-emitting devices
    • H10K50/80—Constructional details
    • H10K50/805—Electrodes
    • H10K50/82—Cathodes
    • H10K50/826—Multilayers, e.g. opaque multilayers

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  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020130002913A 2012-01-10 2013-01-10 L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법 Active KR101532129B1 (ko)

Priority Applications (11)

Application Number Priority Date Filing Date Title
MYPI2014002060A MY173848A (en) 2012-01-10 2013-01-10 A microorganism of the genus escherichia having enhanced l-tryptophan productivity and a method for producing l-tryptophan using the same
CN201380010032.3A CN104204189B (zh) 2012-01-10 2013-01-10 具有增强的l-色氨酸生产力的埃希氏菌属微生物以及使用其生产l-色氨酸的方法
MX2014008470A MX351721B (es) 2012-01-10 2013-01-10 Un microorganismo del género escherichia que tiene productividad aumentada de l-triptófano y un método para producir l-triptófano utilizando el mismo.
JP2014552128A JP6449653B2 (ja) 2012-01-10 2013-01-10 Ｌ−トリプトファン産生能が強化されたエシェリキア属微生物及びこれを用いてｌ−トリプトファンを産生する方法
US14/371,465 US9587261B2 (en) 2012-01-10 2013-01-10 Microorganism of the genus Escherichia having enhanced L-tryptophan productivity and a method for producing L-tryptophan using the same
CA2860974A CA2860974C (en) 2012-01-10 2013-01-10 A microorganism of the genus escherichia having enhanced l-tryptophan productivity and a method for producing l-tryptophan using the same
PH1/2014/501590A PH12014501590B1 (en) 2012-01-10 2013-01-10 A microorganism of the genus escherichia having enhanced l-tryptophan productivity and method for producing l-tryptophan using the same
PCT/KR2013/000214 WO2013105800A2 (ko) 2012-01-10 2013-01-10 L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법
RU2014132889/10A RU2593957C2 (ru) 2012-01-10 2013-01-10 МИКРООРГАНИЗМ ИЗ РОДА Escherichia, ОБЛАДАЮЩИЙ УСИЛЕННОЙ СПОСОБНОСТЬЮ К ПРОДУКЦИИ L-ТРИПТОФАНА, И СПОСОБ ПОЛУЧЕНИЯ L-ТРИПТОФАНА С ЕГО ИСПОЛЬЗОВАНИЕМ
BR112014017074-6A BR112014017074B1 (pt) 2012-01-10 2013-01-10 Escherichia coli recombinante tendo uma produtividade acentuada de l-triptofano e método para a produção de l-triptofano
JP2016132893A JP6475668B2 (ja) 2012-01-10 2016-07-04 Ｌ−トリプトファン産生能が強化されたエシェリキア属微生物及びこれを用いてｌ−トリプトファンを産生する方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020120002906 2012-01-10
KR20120002906 2012-01-10

Related Child Applications (1)

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KR1020150068980A Division KR101886480B1 (ko) 2012-01-10 2015-05-18 L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법

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KR20130082121A KR20130082121A (ko) 2013-07-18
KR101532129B1 true KR101532129B1 (ko) 2015-06-29

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KR1020130002913A Active KR101532129B1 (ko) 2012-01-10 2013-01-10 L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법
KR1020150068980A Active KR101886480B1 (ko) 2012-01-10 2015-05-18 L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법
KR1020160057013A Active KR101629159B1 (ko) 2012-01-10 2016-05-10 L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법

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KR1020150068980A Active KR101886480B1 (ko) 2012-01-10 2015-05-18 L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법
KR1020160057013A Active KR101629159B1 (ko) 2012-01-10 2016-05-10 L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법

Country Status (14)

Country Link
US (1) US9587261B2 (https=)
EP (1) EP2803720B1 (https=)
JP (2) JP6449653B2 (https=)
KR (3) KR101532129B1 (https=)
BR (1) BR112014017074B1 (https=)
CA (1) CA2860974C (https=)
DK (1) DK2803720T3 (https=)
ES (1) ES2910377T3 (https=)
HU (1) HUE057864T2 (https=)
MX (1) MX351721B (https=)
MY (1) MY173848A (https=)
PH (1) PH12014501590B1 (https=)
RU (1) RU2593957C2 (https=)
WO (1) WO2013105800A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
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KR101886480B1 (ko) * 2012-01-10 2018-08-07 씨제이제일제당 (주) L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법
WO2020111436A1 (ko) 2018-11-29 2020-06-04 씨제이제일제당 (주) Camp 수용 단백질 변이체 및 이를 이용한 l-아미노산 제조방법
WO2020111437A1 (ko) 2018-11-29 2020-06-04 씨제이제일제당 (주) Camp 수용 단백질 변이체 및 이를 이용한 l-아미노산 제조방법
WO2020111438A1 (ko) 2018-11-29 2020-06-04 씨제이제일제당 (주) Camp 수용 단백질 변이체 및 이를 이용한 l-아미노산 제조방법

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KR101835173B1 (ko) 2014-06-23 2018-03-07 씨제이제일제당 (주) L-트립토판 생산능을 갖는 에스케리키아속 미생물 및 이를 이용한 l-트립토판의 제조 방법
KR101835935B1 (ko) * 2014-10-13 2018-03-12 씨제이제일제당 (주) L-아르기닌을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아르기닌의 제조 방법
KR101704199B1 (ko) * 2015-05-14 2017-02-08 씨제이제일제당 (주) L-트립토판 생산능을 갖는 에스케리키아속 미생물 및 이를 이용한 l-트립토판의 제조 방법
KR101704198B1 (ko) * 2015-05-14 2017-02-08 씨제이제일제당 (주) L-트립토판 생산능을 갖는 에스케리키아속 미생물 및 이를 이용한 l-트립토판의 제조 방법
WO2017136795A1 (en) * 2016-02-04 2017-08-10 Synlogic, Inc. Bacteria engineered to treat diseases associated with tryptophan metabolism
US10947523B2 (en) 2017-11-15 2021-03-16 Technische Universitaet Hamburg Biotechnological production of L-tryptophan
KR102035844B1 (ko) * 2018-02-23 2019-10-23 씨제이제일제당 주식회사 L-트립토판을 생산하는 재조합 코리네형 미생물 및 이를 이용한 l-트립토판을 생산하는 방법
EP3756654A4 (en) 2018-03-23 2021-04-14 CJ Cheiljedang Corporation GRANULES CONTAINING L-AMINO ACID AND THEIR PREPARATION PROCESS
US11053526B2 (en) 2018-08-09 2021-07-06 Evonik Operations Gmbh Process for preparing L amino acids using improved strains of the enterobacteriaceae family
EP3677594A1 (en) * 2019-01-07 2020-07-08 Evonik Operations GmbH Method for producing l-tryptophan using improved strains of the enterobacteriaceae family
KR102205717B1 (ko) * 2019-04-05 2021-01-22 씨제이제일제당 주식회사 신규 l-트립토판 배출 단백질 변이체 및 이를 이용한 l-트립토판을 생산하는 방법
KR102134418B1 (ko) * 2019-06-17 2020-07-16 씨제이제일제당 주식회사 L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법
EP4048781A4 (en) 2019-10-23 2025-08-20 Genomatica Inc MICROORGANISMS AND METHODS FOR INCREASING COFACTORS
WO2021261952A1 (ko) 2020-06-26 2021-12-30 씨제이제일제당 (주) 발효액으로부터 아미노산 과립의 제조방법
KR102798719B1 (ko) * 2022-12-28 2025-04-24 씨제이제일제당 주식회사 외래 수용성 피리딘 뉴클레오타이드 트랜스 하이드로게나제가 도입된 미생물 및 이를 이용한 l-트립토판의 생산 방법
KR20240139382A (ko) 2023-03-14 2024-09-23 씨제이제일제당 (주) 여과 유속이 개선된 아미노산의 제조방법
CN117660448B (zh) * 2023-11-09 2024-10-18 江苏集萃未来食品技术研究所有限公司 一种产l-色氨酸菌株的高通量筛选方法
CN120519363B (zh) * 2025-07-24 2025-10-28 山东艾科森特生物科技有限公司 一种l-色氨酸基因工程菌及其构建方法与应用

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KR101886480B1 (ko) * 2012-01-10 2018-08-07 씨제이제일제당 (주) L-트립토판 생산능이 강화된 에스케리키아속 미생물 및 이를 이용하여 l-트립토판을 생산하는 방법
WO2020111436A1 (ko) 2018-11-29 2020-06-04 씨제이제일제당 (주) Camp 수용 단백질 변이체 및 이를 이용한 l-아미노산 제조방법
WO2020111437A1 (ko) 2018-11-29 2020-06-04 씨제이제일제당 (주) Camp 수용 단백질 변이체 및 이를 이용한 l-아미노산 제조방법
WO2020111438A1 (ko) 2018-11-29 2020-06-04 씨제이제일제당 (주) Camp 수용 단백질 변이체 및 이를 이용한 l-아미노산 제조방법
US11697673B2 (en) 2018-11-29 2023-07-11 Cj Cheiljedang Corporation Camp receptor protein variant and method of producing L-amino acid using the same

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