KR101217057B1 - 오렉신 수용체 길항제로서의 치환된 디아제판 화합물 - Google Patents

오렉신 수용체 길항제로서의 치환된 디아제판 화합물 Download PDF

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KR101217057B1
KR101217057B1 KR1020097013822A KR20097013822A KR101217057B1 KR 101217057 B1 KR101217057 B1 KR 101217057B1 KR 1020097013822 A KR1020097013822 A KR 1020097013822A KR 20097013822 A KR20097013822 A KR 20097013822A KR 101217057 B1 KR101217057 B1 KR 101217057B1
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mmol
methyl
compound
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etoac
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KR20090087110A (ko
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제프리 엠. 버그만
마이클 제이. 브레슬린
폴 제이. 콜먼
크리스토퍼 디. 콕스
스와티 피. 머서
앤서니 제이. 로이커
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머크 샤프 앤드 돔 코포레이션
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Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007272854B2 (en) * 2006-07-14 2013-08-01 Merck Sharp & Dohme Corp. Bridged diazepan orexin receptor antagonists
DK2049529T3 (da) * 2006-07-14 2010-11-29 Merck Sharp & Dohme Substituerede diazepan-orexin-receptor- antagonister
PE20081229A1 (es) 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
AU2008255005B2 (en) 2007-05-18 2013-05-02 Merck Sharp & Dohme Corp. OXO bridged diazepan orexin receptor antagonists
HRP20120240T1 (hr) 2007-05-23 2012-04-30 Merck Sharp & Dohme Corp. Piridil piperidin antagonisti receptora za oreksin
CA2703904A1 (en) 2007-10-29 2009-05-07 Merck Sharp & Dohme Corp. Substituted diazepan orexin receptor antagonists
WO2009097995A1 (de) * 2008-02-07 2009-08-13 Sanofi-Aventis Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2369926B1 (en) * 2008-06-19 2015-04-22 Takeda Pharmaceutical Company Limited Pharmaceutical compositions and methods for treating age-related macular degeneration with melatonin analogues
US8466281B2 (en) 2008-10-21 2013-06-18 Merck Sharp & Dohme Corp. 2,5-disubstituted morpholine orexin receptor antagonists
CA2739927A1 (en) * 2008-10-21 2010-04-29 Merck Sharp & Dohme Corp. Disubstituted azepan orexin receptor antagonists
JP5785089B2 (ja) * 2008-11-04 2015-09-24 ケモセントリックス，インコーポレイティド Ｃｘｃｒ７の調節因子
US8853202B2 (en) 2008-11-04 2014-10-07 Chemocentryx, Inc. Modulators of CXCR7
US20110046047A1 (en) * 2009-05-20 2011-02-24 Joslin Diabets Center, Inc. Bone Morphogenetic Proteins for Appetite Control
KR101350845B1 (ko) 2009-09-15 2014-01-14 주식회사 만도 전자 브레이크의 간극 조정 장치 및 그 방법
JP5848251B2 (ja) * 2009-10-23 2016-01-27 ヤンセン ファーマシューティカ エヌ．ベー． オレキシン受容体調節因子としての縮合複素環式化合物
WO2011050200A1 (en) * 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
ES2735411T3 (es) 2009-10-23 2019-12-18 Janssen Pharmaceutica Nv Octahidropirrolo[3,4-c]pirroles disustituidos como moduladores del receptor de orexina
AU2010310596B2 (en) * 2009-10-24 2014-11-13 Indiana University Research And Technology Corporation Methods and compositions for panic disorders
CA2803118C (en) 2010-07-09 2015-11-03 Pfizer Limited Sulfonamide derivatives as nav 1.7 inhibitors
RS54101B1 (sr) 2010-09-22 2015-10-30 Eisai R&D Management Co. Ltd. Ciklopropansko jedinjenje
WO2012085857A1 (en) 2010-12-22 2012-06-28 Actelion Pharmaceuticals Ltd 3,8-diaza-bicyclo[4.2.0]oct-3-yl amides
EP2680697B1 (en) * 2011-03-03 2018-01-10 Merck Sharp & Dohme Corp. Process for the preparation of an orexin receptor antagonist
US9586962B2 (en) 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
WO2012150707A1 (ja) * 2011-05-02 2012-11-08 国立大学法人熊本大学 幹細胞からインスリン産生細胞への分化誘導を促進する低分子化合物および該化合物を用いた幹細胞からインスリン産生細胞への分化誘導方法
CN102827073A (zh) * 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
WO2013050938A1 (en) 2011-10-04 2013-04-11 Actelion Pharmaceuticals Ltd 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
EP2776430B1 (en) 2011-11-08 2016-03-16 Actelion Pharmaceuticals Ltd. 2- (1,2,3-triazol-2-yl) benzamide and 3-(1,2,3-triazol-2-yl) picolinamide derivatives as orexin receptor antagonists
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
JP6346862B2 (ja) 2012-02-07 2018-06-20 エオラス セラピューティクス， インコーポレイテッド オレキシンレセプターアンタゴニストとしての置換プロリン／ピペリジン
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
WO2013169610A1 (en) 2012-05-09 2013-11-14 Merck Sharp & Dohme Corp. Process for the preparation of an intermediate for an orexin receptor antagonist
MX368859B (es) 2012-05-31 2019-10-18 Merck Sharp & Dohme Formulaciones de dosis solida de un antagonista del receptor de orexina.
KR101689093B1 (ko) 2012-06-04 2016-12-22 액테리온 파마슈티칼 리미티드 벤즈이미다졸-프롤린 유도체
WO2014057435A1 (en) 2012-10-10 2014-04-17 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives
US20160272627A1 (en) * 2012-11-12 2016-09-22 Dr. Reddy's Laboratories Limited Polymorphic forms of suvoroxant
KR102196374B1 (ko) 2012-11-29 2020-12-31 케모센트릭스, 인크. Cxcr7 길항제
US8999393B1 (en) * 2013-01-09 2015-04-07 Edgemont Pharmaceuticals Llc Sustained release formulations of lorazepam
WO2014141065A1 (en) 2013-03-12 2014-09-18 Actelion Pharmaceuticals Ltd Azetidine amide derivatives as orexin receptor antagonists
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
CA2917671A1 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. 2,4-or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer
WO2015003355A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
WO2015008218A2 (en) * 2013-07-15 2015-01-22 Dr. Reddy’S Laboratories Limited Process for the preparation of suvorexant and intermediates useful in the synthesis of suvorexant
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
ES2651475T3 (es) 2013-12-03 2018-01-26 Idorsia Pharmaceuticals Ltd Forma cristalina de (S)-(2-(6-cloro-7-metil-1H-benzo[d]imidazol-2-il)-2-metilpirrolidin-1-il)(5-metoxi-2-(2H-1,2,3-triazol-2-il)fenil)metanona y su uso como antagonistas del receptor de orexina
UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
MY179605A (en) 2013-12-04 2020-11-11 Idorsia Pharmaceuticals Ltd Use of benzimidazole-proline derivatives
WO2015095111A1 (en) * 2013-12-18 2015-06-25 Merck Sharp & Dohme Corp. Diazepane orexin receptor antagonists
WO2015095442A1 (en) * 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Piperidinyloxy lactone orexin receptor antagonists
KR20220070066A (ko) 2014-03-14 2022-05-27 아지오스 파마슈티컬스 아이엔씨. 치료적으로 활성인 화합물의 약제학적 조성물
JP6737708B2 (ja) 2014-04-17 2020-08-12 サンド・アクチエンゲゼルシヤフト オレキシン受容体拮抗薬を含む固体分散体
EP3134092B1 (en) 2014-04-21 2020-06-24 Merck Sharp & Dohme Corp. Pharmaceutical salts of an orexin receptor antagonist
WO2015180060A1 (zh) * 2014-05-28 2015-12-03 杭州普晒医药科技有限公司 一种二氮杂环庚烷化合物的盐及其晶型与无定型物
WO2016020404A1 (en) * 2014-08-04 2016-02-11 Sandoz Ag Process for the resolution of (r,s)-diazepane and diazepanone derivatives
US10030010B2 (en) 2014-08-04 2018-07-24 Sandoz Ag Route of synthesis for the preparation of suvorexant
WO2016020403A1 (en) * 2014-08-04 2016-02-11 Sandoz Ag Preparation of a benzoic acid derivative and its use for the preparation of suvorexant
JP6283748B2 (ja) 2014-08-06 2018-02-21 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピリミジン−１−オール化合物の製造方法及びその中間体
ES2901418T3 (es) 2014-08-13 2022-03-22 Eolas Therapeutics Inc Difluoropirrolidinas como moduladores del receptor de orexina
MX376164B (es) * 2014-10-23 2025-03-07 Eisai R&D Man Co Ltd Composiciones y metodos para tratar el insomnio.
WO2016065583A1 (en) 2014-10-30 2016-05-06 Merck Sharp & Dohme Corp. Oxazole orexin receptor antagonists
WO2016065587A1 (en) 2014-10-30 2016-05-06 Merck Sharp & Dohme Corp. Pyrazole orexin receptor antagonists
WO2016065586A1 (en) 2014-10-30 2016-05-06 Merck Sharp & Dohme Corp. Pyrazole, triazole and tetrazole orexin receptor antagonists
WO2016065585A1 (en) 2014-10-30 2016-05-06 Merck Sharp & Dohme Corp. Piperidine isoxazole and isothiazole orexin receptor antagonists
WO2016065584A1 (en) 2014-10-30 2016-05-06 Merck Sharp & Dohme Corp. Piperidine oxadiazole and thiadiazole orexin receptor antagonists
WO2016085783A1 (en) 2014-11-26 2016-06-02 Merck Sharp & Dohme Corp. Bridged diazepane orexin receptor antagonists
WO2016085784A1 (en) * 2014-11-26 2016-06-02 Merck Sharp & Dohme Corp. Methyl diazepane orexin receptor antagonists
WO2016086358A1 (en) 2014-12-02 2016-06-09 Merck Sharp & Dohme Corp. Hydroxymethyl piperidine orexin receptor antagonists
WO2016086357A1 (en) 2014-12-02 2016-06-09 Merck Sharp & Dohme Corp. Methyl oxazole orexin receptor antagonists
WO2016095204A1 (en) 2014-12-19 2016-06-23 Merck Sharp & Dohme Corp. Pyrrolidine orexin receptor antagonists
US9938276B2 (en) 2014-12-19 2018-04-10 Merck Sharp & Dohme Corp. 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists
WO2016100161A1 (en) 2014-12-19 2016-06-23 Merck Sharp & Dohme Corp. Ethyldiamine orexin receptor antagonists
WO2016095205A1 (en) 2014-12-19 2016-06-23 Merck Sharp & Dohme Corp. Heteroaryl orexin receptor antagonists
US9987255B2 (en) 2014-12-19 2018-06-05 Merck Sharp & Dohme Corp. 5,5-bicyclic oxazole orexin receptor antagonists
WO2016101119A1 (en) 2014-12-23 2016-06-30 Merck Sharp & Dohme Corp. Fused heteroaryl derivatives as orexin receptor antagonists
WO2016101118A1 (en) 2014-12-23 2016-06-30 Merck Sharp & Dohme Corp. Amidoethyl azole orexin receptor antagonists
CZ201587A3 (cs) 2015-02-10 2016-08-17 Zentiva, K.S. Amorfní pevná forma suvorexantu s kyselinou sírovou
WO2016149628A1 (en) * 2015-03-19 2016-09-22 Chembridge Corporation Tgr5 agonists
JP6698633B2 (ja) * 2015-04-24 2020-05-27 武田薬品工業株式会社 複素環化合物
AR105025A1 (es) * 2015-06-19 2017-08-30 Astellas Pharma Inc Compuesto de imidazodiazepina
WO2017001499A1 (en) 2015-06-30 2017-01-05 Hexal Ag Liquid composition comprising suvorexant
US10196383B2 (en) 2015-07-17 2019-02-05 Sunshine Lake Pharma Co., Ltd. Substituted quinazoline compounds and preparation and uses thereof
PT3362065T (pt) 2015-10-15 2024-06-21 Servier Lab Terapia de combinação compreendendo ivosidenib, citarabina e daunorubicina ou idarubicina para o tratamento de leucemia mielóide aguda
US10653710B2 (en) 2015-10-15 2020-05-19 Agios Pharmaceuticals, Inc. Combination therapy for treating malignancies
EA201891054A1 (ru) 2015-10-29 2018-10-31 Юниверсити Оф Цукуба Морфинановое производное и его медицинское применение
WO2017072264A1 (en) 2015-10-29 2017-05-04 Hexal Ag Solid composition comprising suvorexant
US10370380B2 (en) 2015-11-23 2019-08-06 Sunshine Lake Pharma Co., Ltd. Octahydropyrrolo[3,4-c]pyrrole derivatives and uses thereof
CN107021955B (zh) * 2016-02-01 2021-03-30 上海奥博生物医药股份有限公司 苏沃雷生中间体化合物及其制备方法
SI3414241T1 (sl) 2016-02-12 2022-10-28 Astrazeneca Ab Halo-substituitani piperidini kot modulatorji receptorja oreksina
CA2960253A1 (en) 2016-03-10 2017-09-10 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
CN107179356B (zh) * 2016-03-11 2021-07-16 广东东阳光药业有限公司 一种用hplc法测定苏沃雷生有关物质的方法
CN107304204B (zh) * 2016-04-18 2020-12-22 广东东阳光药业有限公司 一种制备n-杂环化合物的方法
US20190151304A1 (en) 2016-05-10 2019-05-23 Inserm (Institut National De La Santé Et De La Rechercjae Médicale Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory
JP2019517585A (ja) 2016-06-06 2019-06-24 エナンティア，エセ．エレ． スボレキサントの中間体及びその共結晶のキラル分割
CA3045313A1 (en) * 2016-12-19 2018-06-28 Druggability Technologies Ip Holdco Limited Pharmaceutical formulations of suvorexant
GB201702174D0 (en) 2017-02-09 2017-03-29 Benevolentai Bio Ltd Orexin receptor antagonists
CA3059394C (en) * 2017-05-03 2023-09-12 Idorsia Pharmaceuticals Ltd Preparation of 2-([1,2,3]triazol-2-yl)-benzoic acid derivatives
GB201707504D0 (en) 2017-05-10 2017-06-21 Benevolentai Bio Ltd Orexin receptor antagonists
GB201707499D0 (en) 2017-05-10 2017-06-21 Benevolentai Bio Ltd Orexin receptor antagonists
WO2019024845A1 (zh) * 2017-08-01 2019-02-07 苏州科睿思制药有限公司 一种食欲素受体拮抗剂的晶型及其制备方法和用途
HRP20220710T1 (hr) 2018-04-24 2022-07-22 Merck Patent Gmbh Antiproliferacijski spojevi i njihova uporaba
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
WO2020007977A1 (en) * 2018-07-06 2020-01-09 Idorsia Pharmaceuticals Ltd 7-trifluoromethyl-[1,4]diazepan derivatives
BR112021011222A2 (pt) 2018-12-12 2021-08-24 Chemocentryx, Inc. Inibidores de cxcr7 para o tratamento de câncer
CA3140170A1 (en) 2019-06-04 2020-12-10 Belew Mekonnen Imidazolo derivatives, compositions and methods as orexin antagonists
CZ310035B6 (cs) * 2019-12-09 2024-05-29 Univerzita PalackĂ©ho v Olomouci N-(furan-2-ylmethyl)-7H-purin-6-amin pro modulaci cirkadiánních rytmů
EP4175572A4 (en) 2020-08-12 2024-03-27 Spruce Biosciences, Inc. Methods and compositions for treating polycystic ovary syndrome
CN111943945B (zh) * 2020-09-03 2022-07-12 上海应用技术大学 一种苏沃雷生中间体及其制备方法
WO2022051583A1 (en) * 2020-09-03 2022-03-10 Orexia Therapeutics Limited Medium- or macro-cyclic benzyl-substituted heterocycle derivatives and their uses as orexin-2 receptor agonists

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060258672A1 (en) * 2005-05-13 2006-11-16 Joseph Barbosa Multicyclic compounds and methods of their use

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS536156B2 (enExample) * 1972-10-30 1978-03-04
US4426382A (en) * 1980-02-13 1984-01-17 Sankyo Company Limited 4-Amino-6,7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use
JPH0747574B2 (ja) * 1989-03-03 1995-05-24 大日本製薬株式会社 ピリジン誘導体及びそれを有効成分とする向精神剤
EP0794178A4 (en) * 1994-11-25 1998-02-25 Nippon Chemiphar Co CHINAZOLIN DERIVATIVES
GB9606805D0 (en) 1996-03-30 1996-06-05 Glaxo Wellcome Inc Medicaments
AR016817A1 (es) 1997-08-14 2001-08-01 Smithkline Beecham Plc Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento
WO1999058533A1 (en) 1998-05-08 1999-11-18 Smithkline Beecham Plc Phenylurea and phenylthio urea derivatives
WO2000047576A1 (en) 1999-02-12 2000-08-17 Smithkline Beecham Plc Cinnamide derivatives as orexin-1 receptors antagonists
US6596730B1 (en) 1999-02-12 2003-07-22 Smithkline Beecham P.L.C. Phenyl urea and phenyl thiourea derivatives
WO2000047577A1 (en) 1999-02-12 2000-08-17 Smithkline Beecham Plc Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
US6414002B1 (en) 1999-09-22 2002-07-02 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
PT1274687E (pt) 2000-03-14 2005-04-29 Actelion Pharmaceuticals Ltd Derivados de 1,2,3,4-tetra-hidroisoquinolina
CA2408343A1 (en) 2000-05-11 2002-11-07 Banyu Pharmaceutical Co., Ltd. N-acyltetrahydroisoquinoline derivatives
DE60110066T2 (de) 2000-06-16 2006-02-02 Smithkline Beecham P.L.C., Brentford Piperidine zur verwendung als orexinrezeptorantagonisten
DE10036818A1 (de) * 2000-07-28 2002-02-07 Solvay Pharm Gmbh Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten
US6943160B2 (en) 2000-11-28 2005-09-13 Smithkline Beecham Plc Morpholine derivatives as antagonists of orexin receptors
WO2002051232A2 (en) 2000-12-27 2002-07-04 Actelion Pharmaceuticals Ltd. Novel benzazepines and related heterocyclic derivatives
ES2299567T3 (es) 2001-05-05 2008-06-01 Smithkline Beecham Plc N-aroilaminas ciclicas.
EP1435955A2 (en) 2001-05-05 2004-07-14 SmithKline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
WO2003002561A1 (en) 2001-06-28 2003-01-09 Smithkline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
GB0115862D0 (en) 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
GB0124463D0 (en) 2001-10-11 2001-12-05 Smithkline Beecham Plc Compounds
GB0126292D0 (en) 2001-11-01 2002-01-02 Smithkline Beecham Plc Compounds
GB0127145D0 (en) 2001-11-10 2002-01-02 Smithkline Beecham Compounds
GB0130341D0 (en) 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
GB0130393D0 (en) 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
GB0130335D0 (en) 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
NZ538029A (en) 2002-07-09 2006-08-31 Actelion Pharmaceuticals Ltd 7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2H-pyrrolo[2,1-b]-quinazolinone derivatives
AU2003262516A1 (en) 2002-09-18 2004-04-08 Glaxo Group Limited N-aroyl cyclic amines as orexin receptor antagonists
JP4528125B2 (ja) 2002-10-11 2010-08-18 アクテリオン ファーマシューティカルズ リミテッド スルホニルアミノ−酢酸誘導体
GB0225938D0 (en) 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
GB0225884D0 (en) 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
US6951882B2 (en) 2002-12-12 2005-10-04 Janssen Pharmaceutica N.V. Substituted 4-phenyl-[1,3]-dioxanes
EP1633724B1 (en) * 2003-03-12 2011-05-04 Kudos Pharmaceuticals Limited Phthalazinone derivatives
CL2004000553A1 (es) 2003-03-20 2005-02-04 Actelion Pharmaceuticals Ltd Uso de compuestos derivados de guanidina como antagonistas del receptor de neuropeptido ff; compuestos derivados de guanidina; procedimientos de preparacion; y composicion farmaceutica que los comprende.
DE602004021786D1 (de) 2003-03-26 2009-08-13 Actelion Pharmaceuticals Ltd Tetrahydroisochinolylacetamidderivate zur verwendung als orexinrezeptorantagonisten
JP2007523846A (ja) 2003-04-28 2007-08-23 アクテリオン　ファマシューティカルズ　リミテッド キノキサリノン誘導体
KR100774621B1 (ko) * 2003-09-09 2007-11-14 에프. 호프만-라 로슈 아게 정신병 치료용의 글라이신 섭취 억제제로서의1-벤조일-피페라진 유도체
HUP0304101A3 (en) 2003-12-22 2008-10-28 Sanofi Aventis Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
HUP0400405A3 (en) 2004-02-10 2009-03-30 Sanofi Synthelabo Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
KR100848747B1 (ko) 2004-03-01 2008-07-25 액테리온 파마슈티칼 리미티드 치환된 1,2,3,4-테트라하이드로이소퀴놀린 유도체
WO2006067224A2 (en) 2004-12-23 2006-06-29 Biovitrum Ab (Publ) Spiro-benzodioxole and spiro-benzodioxane compounds as orexin receptor antagonists
EP1871752A4 (en) 2005-04-12 2009-09-30 Merck & Co Inc ANTAGONISTS OF THE AMIDOPROPOXYPHENYLOREXIN RECEPTOR
US20060258762A1 (en) * 2005-05-13 2006-11-16 Dobransky Michael A Hydrocarbon or hydrofluorocarbon blown ASTM E-84 class I rigid polyurethane foams
US20090118200A1 (en) 2005-05-23 2009-05-07 Bergman Jeffrey M Proline bis-amide orexin receptor antagonists
JP2009503106A (ja) 2005-08-04 2009-01-29 メルク エンド カムパニー インコーポレーテッド アミノエタンスルホンアミドオレキシン受容体アンタゴニスト
EP1922071A2 (en) 2005-08-26 2008-05-21 Merck & Co., Inc. Diazaspirodecane orexin receptor antagonists
CA2647678A1 (en) * 2006-03-29 2007-11-08 Merck & Co., Inc. Diazepan orexin receptor antagonists
DK2049529T3 (da) * 2006-07-14 2010-11-29 Merck Sharp & Dohme Substituerede diazepan-orexin-receptor- antagonister
AU2007272854B2 (en) 2006-07-14 2013-08-01 Merck Sharp & Dohme Corp. Bridged diazepan orexin receptor antagonists
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
CA2703904A1 (en) * 2007-10-29 2009-05-07 Merck Sharp & Dohme Corp. Substituted diazepan orexin receptor antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060258672A1 (en) * 2005-05-13 2006-11-16 Joseph Barbosa Multicyclic compounds and methods of their use

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