AR063979A1 - Antagonistas de receptor de orexina de diazepam sustituidos - Google Patents
Antagonistas de receptor de orexina de diazepam sustituidosInfo
- Publication number
- AR063979A1 AR063979A1 ARP070105246A ARP070105246A AR063979A1 AR 063979 A1 AR063979 A1 AR 063979A1 AR P070105246 A ARP070105246 A AR P070105246A AR P070105246 A ARP070105246 A AR P070105246A AR 063979 A1 AR063979 A1 AR 063979A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- substituents selected
- alkyl
- cycloalkyl
- Prior art date
Links
Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract
La presente está dirigida a compuestos de diazepam sustituidos que son antagonistas de receptores de orexina, y que son utiles en el tratamiento o la prevencion de trastornos o enfermedades neurologicas y psiquiátricas en los que están implicados los receptores de orexina. También está dirigida a composiciones farmacéuticas que comprenden estos compuestos y al uso de estos compuestos y composiciones en la prevencion o el tratamiento de dichas enfermedades en las que están implicados receptores de orexina. Reivindicacion 1: Un compuesto de formula 1, en la que R1 es fenilo que está sustituido con R1a, R1b y R1c; R2 es heteroarilo que está sustituido con R2a, R2b y R2c; R1a, R1b, R1c, R2a, R2b y R2c se seleccionan independientemente del grupo constituido por: (1) hidrogeno, (2) halogeno, (3) hidroxilo, (4) -(C=O)m-On-alquilo C1-6, en el que m es 0 o 1, n es 0 o 1 (en el que si rn es 0 o n es 0, está presente un enlace), en la que los R2a y R2b o R2b y R2c adyacentes pueden estar unidos conjuntamente formando un anillo cicloalquilo o cicloalcoxi, y en los que el alquilo está no sustituido o sustituido con uno o más sustituyentes seleccionados de R13, (5) -(C=O)rn-On-cicloalquilo C3-6, en el que el cicloalquilo está no sustituido o sustituido con uno o más sustituyentes seleccionados de R13, (6) -(C=O)rn-alquenilo C2-4, en el que el alquenilo está no sustituido o sustituido con uno o más sustituyentes seleccionados de R13, (7) -(C=O)m- alquinilo C2-4, en el que el alquinilo está no sustituido o sustituido con uno o más sustituyentes seleccionados de R13, (8) -(C=O)m-On-fenilo o -(C=O)m-On-naftilo, en los que el fenilo o naftilo está no sustituido o sustituido con uno o más sustituyentes seleccionados de R13, (9) -(C=O)m-On-heterociclo, en el que el heterociclo está no sustituido o sustituido con uno o más sustituyentes seleccionados de R13, (10) -(C=O)m-NR10R11, en el que R10 y R11 se seleccionan independientemente del grupo constituido por: (a) hidrogeno, (b) alquilo C1-6, que está no sustituido o sustituido con uno o más sustituyentes seleccionados de R13, (c) alquenilo C3-6, que está no sustituido o sustituido con uno o más sustituyentes seleccionados de R13, (d) cicloalquilo, que está no sustituido o sustituido con uno o más sustituyentes seleccionados de R13, (e) fenilo, que está no sustituido o sustituido con uno o más sustituyentes seleccionados de R13, y (f) heterociclo, que está no sustituido o sustituido con uno o más sustituyentes seleccionados de R13, (11) -S(O)2-NR10R11, (12) -S(O)q-R12, en el que q es 0, 1 o 2 y en el que R12 se selecciona de las definiciones de R10 y R11, (13) -CO2H, (14) -CN, (15) -NO2, (16) =O, y (17) -B(OH)2, con la condicion de que al menos uno de R2a, R2b o R2c sea halogeno o alquilo C1-6, o en la que los R2a y R2b o R2b y R2c adyacentes están unidos conjuntamente formando un anillo cicloalquilo o cicloalcoxi, en el que el alquilo, cicloalquilo o cicloalcoxi está no sustituido o sustituido con uno o más sustituyentes seleccionados de R13; R3 es -alquilo C1-6 o -cicloalquilo C3-6, que están no sustituidos o sustituidos con uno o más sustituyentes seleccionados de R13; R13 se selecciona del grupo constituido por: (1) halogeno, (2) hidroxilo, (3) -(C=O)m-On-alquilo C1-6, en el que el alquilo está no sustituido o sustituido con uno o más sustituyentes seleccionados de R14, (4) -On-perfluoroalquilo C1-3, (5) -(C=O)m-On-cicloalquilo C3-6, en el que el cicloalquilo está no sustituido o sustituido con uno o más sustituyentes seleccionados de R14, (6) -(C=O)m-alquenilo C2-4, en el que el alquenilo está no sustituido o sustituido con uno o más sustituyentes seleccionados de R14, (7) - (C=O)m-On-fenilo o -(C=O)m-On-naftilo, en los que el fenilo o naftilo está no sustituido o sustituido con uno o más sustituyentes seleccionados de R14, (8) -(C=O)m-On-heterociclo, en el que el heterociclo está no sustituido o sustituido con uno o más sustituyentes seleccionados de R14, (9) -(C=O)m-NR10R11, (10) -S(O)2-NR10R11, (11) -S(O)q-R12, (12) -CO2H, (13) -CN, (14) =O, y (15) -NO2; R14 se selecciona del grupo constituido por: (1) hidroxilo, (2) halogeno, (3) alquilo C1-6, (4) - cicloalquilo C3-6, (5) -O-alquilo C1-6, (6) -O(C=O)-alquilo C1-6, (7) -NH-alquilo C1-6, (8) fenilo, (9) heterociclo, (10) -CO2H, y (11) -CN; o una sal farmacéuticamente aceptable del mismo.
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US87239306P | 2006-12-01 | 2006-12-01 | |
US95974207P | 2007-07-16 | 2007-07-16 |
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Application Number | Title | Priority Date | Filing Date |
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ARP070105246A AR063979A1 (es) | 2006-12-01 | 2007-11-27 | Antagonistas de receptor de orexina de diazepam sustituidos |
ARP120104304A AR088881A2 (es) | 2006-12-01 | 2012-11-15 | Una composicion farmaceutica que comprende 5-cloro-2-{(5r)-5-metil-4-[5-metil-2-(2h-1,2,3-triazol-2-il)benzoil]-1,4-diazepan-1-il}-1,3-benzoxazol; o una sal farmaceuticamente aceptable del mismo y su uso en la preparacion de medicamentos |
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ARP120104304A AR088881A2 (es) | 2006-12-01 | 2012-11-15 | Una composicion farmaceutica que comprende 5-cloro-2-{(5r)-5-metil-4-[5-metil-2-(2h-1,2,3-triazol-2-il)benzoil]-1,4-diazepan-1-il}-1,3-benzoxazol; o una sal farmaceuticamente aceptable del mismo y su uso en la preparacion de medicamentos |
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Families Citing this family (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2049529T3 (pl) * | 2006-07-14 | 2011-01-31 | Merck Sharp & Dohme | Podstawione związki diazepanowe - antagoniści receptora oreksyny |
EP2049110B1 (en) * | 2006-07-14 | 2014-08-20 | Merck Sharp & Dohme Corp. | Bridged diazepan orexin receptor antagonists |
PE20081229A1 (es) * | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
AU2008255005B2 (en) | 2007-05-18 | 2013-05-02 | Merck Sharp & Dohme Corp. | OXO bridged diazepan orexin receptor antagonists |
PL2152690T3 (pl) * | 2007-05-23 | 2012-06-29 | Merck Sharp & Dohme | Pirydylo piperydynowi antagoniści receptora oreksyny |
EP2214676B1 (en) | 2007-10-29 | 2012-11-21 | Merck Sharp & Dohme Corp. | Substituted diazepan orexin receptor antagonists |
WO2009097995A1 (de) * | 2008-02-07 | 2009-08-13 | Sanofi-Aventis | Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8785491B2 (en) * | 2008-06-19 | 2014-07-22 | Takeda Pharmaceuticals U.S.A., Inc. | Pharmaceutical compositions and methods for treating age-related macular degeneration with melatonin analogues |
CA2739927A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | Disubstituted azepan orexin receptor antagonists |
CA2739917A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted morpholine orexin receptor antagonists |
US8853202B2 (en) | 2008-11-04 | 2014-10-07 | Chemocentryx, Inc. | Modulators of CXCR7 |
BRPI0921496A2 (pt) * | 2008-11-04 | 2016-01-19 | Chemocentryx Inc | composto, composição farmacêutica, e, métodos para tratar doença ou distúrbio, para inibir ligação de quimiocinas a um receptor, para formar imagem de um dito tumor, orgão ou tecido, e para detectar níveis elevados de cxcr7 em uma amostra |
US20110046047A1 (en) * | 2009-05-20 | 2011-02-24 | Joslin Diabets Center, Inc. | Bone Morphogenetic Proteins for Appetite Control |
KR101350845B1 (ko) | 2009-09-15 | 2014-01-14 | 주식회사 만도 | 전자 브레이크의 간극 조정 장치 및 그 방법 |
WO2011050202A1 (en) | 2009-10-23 | 2011-04-28 | Janssen Pharmaceutica Nv | Fused heterocyclic compounds as orexin receptor modulators |
JP5847087B2 (ja) * | 2009-10-23 | 2016-01-20 | ヤンセン ファーマシューティカ エヌ.ベー. | オレキシン受容体調節因子としての縮合複素環式化合物 |
DK2491038T3 (da) | 2009-10-23 | 2016-07-18 | Janssen Pharmaceutica Nv | Disubstituerede octahydropyrrolo [3,4-c]pyrroler som orexin receptormodulatorer |
CA2778613C (en) | 2009-10-24 | 2018-11-27 | Indiana University Research And Technology Corporation | Methods and compositions for panic disorders |
US9096558B2 (en) | 2010-07-09 | 2015-08-04 | Pfizer Limited | N-sulfonylbenzamide compounds |
SI2626350T1 (sl) | 2010-09-22 | 2015-09-30 | Eisai R&D Management Co., Ltd. | Spojina ciklopropana |
WO2012085852A1 (en) | 2010-12-22 | 2012-06-28 | Actelion Pharmaceuticals Ltd | 3,8-diaza-bicyclo[4.2.0]oct-8-yl amides |
EP2680697B1 (en) | 2011-03-03 | 2018-01-10 | Merck Sharp & Dohme Corp. | Process for the preparation of an orexin receptor antagonist |
WO2012145581A1 (en) | 2011-04-20 | 2012-10-26 | Janssen Pharmaceutica Nv | Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators |
US9617517B2 (en) | 2011-05-02 | 2017-04-11 | National University Corporation Kumamoto University | Small chemical compound which promotes induction of differentiation of stem cells into insulin-producing cells and method for inducing differentiation of stem cells into insulin-producing cells using said small chemical compound |
CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
WO2013050938A1 (en) | 2011-10-04 | 2013-04-11 | Actelion Pharmaceuticals Ltd | 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives |
AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
AR088692A1 (es) | 2011-11-08 | 2014-06-25 | Actelion Pharmaceuticals Ltd | Derivados de 2-(1,2,3-triazol-2-il)benzamina y 3-(1,2,3-triazol-2-il)picolinamida |
US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
SG11201404738QA (en) | 2012-02-07 | 2014-10-30 | Eolas Therapeutics Inc | Substituted prolines / piperidines as orexin receptor antagonists |
US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
EP2847343A4 (en) | 2012-05-09 | 2016-04-06 | Merck Sharp & Dohme | METHOD FOR PREPARING AN INTERMEDIATE FOR AN OREXIN RECEPTOR ANTAGONIST |
EP2854816B1 (en) * | 2012-05-31 | 2020-07-08 | Merck Sharp & Dohme Corp. | Solid dosage formulations of an orexin receptor antagonist |
NZ703448A (en) | 2012-06-04 | 2017-07-28 | Actelion Pharmaceuticals Ltd | Benzimidazole-proline derivatives |
CN104703980B (zh) | 2012-10-10 | 2017-09-22 | 埃科特莱茵药品有限公司 | 属于[邻双(杂)芳基]‑[2‑(间双(杂)芳基)吡咯烷‑1‑基]甲酮衍生物的食欲素受体拮抗剂 |
US20160272627A1 (en) * | 2012-11-12 | 2016-09-22 | Dr. Reddy's Laboratories Limited | Polymorphic forms of suvoroxant |
CN105189484B (zh) | 2012-11-29 | 2018-05-04 | 凯莫森特里克斯股份有限公司 | Cxcr7拮抗剂 |
US8999393B1 (en) * | 2013-01-09 | 2015-04-07 | Edgemont Pharmaceuticals Llc | Sustained release formulations of lorazepam |
EP2970241A1 (en) | 2013-03-12 | 2016-01-20 | Actelion Pharmaceuticals Ltd. | Azetidine amide derivatives as orexin receptor antagonists |
WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
CN105593215B (zh) | 2013-07-11 | 2019-01-15 | 安吉奥斯医药品有限公司 | 用于治疗癌症的作为idh2突变体抑制剂的2,4-或4,6-二氨基嘧啶化合物 |
CA2918451A1 (en) * | 2013-07-15 | 2015-01-22 | Dr. Reddy's Laboratories Limited | Process for the preparation of suvorexant and intermediates useful in the synthesis of suvorexant |
US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
UA119151C2 (uk) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
CA2929423C (en) | 2013-12-03 | 2021-12-07 | Actelion Pharmaceuticals Ltd | Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1 ,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists |
AU2014358766B2 (en) | 2013-12-04 | 2019-01-17 | Idorsia Pharmaceuticals Ltd | Use of benzimidazole-proline derivatives |
US9732077B2 (en) | 2013-12-18 | 2017-08-15 | Merck Sharp & Dohme Corp. | Diazepane orexin receptor antagonists |
WO2015095442A1 (en) * | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Piperidinyloxy lactone orexin receptor antagonists |
KR20220070066A (ko) | 2014-03-14 | 2022-05-27 | 아지오스 파마슈티컬스 아이엔씨. | 치료적으로 활성인 화합물의 약제학적 조성물 |
WO2015158910A2 (en) | 2014-04-17 | 2015-10-22 | Sandoz Ag | Solid dispersion comprising an orexin receptor antagonist |
WO2015164160A1 (en) | 2014-04-21 | 2015-10-29 | Merck Sharp & Dohme Corp. | Pharmaceutical salts of an orexin receptor antagonist |
WO2015180060A1 (zh) * | 2014-05-28 | 2015-12-03 | 杭州普晒医药科技有限公司 | 一种二氮杂环庚烷化合物的盐及其晶型与无定型物 |
WO2016020404A1 (en) * | 2014-08-04 | 2016-02-11 | Sandoz Ag | Process for the resolution of (r,s)-diazepane and diazepanone derivatives |
CN106573882B (zh) * | 2014-08-04 | 2020-09-01 | 桑多斯股份公司 | 制备苏沃雷生的合成途径 |
WO2016020403A1 (en) * | 2014-08-04 | 2016-02-11 | Sandoz Ag | Preparation of a benzoic acid derivative and its use for the preparation of suvorexant |
EP3178814B1 (en) | 2014-08-06 | 2019-04-10 | Eisai R&D Management Co., Ltd. | Method for producing pyrimidin-1-ol compound, and intermediate thereof |
EP3180332B1 (en) | 2014-08-13 | 2021-10-27 | Eolas Therapeutics Inc. | Difluoropyrrolidines as orexin receptor modulators |
AU2015336463B2 (en) | 2014-10-23 | 2020-06-18 | Eisai R&D Management Co., Ltd. | Compositions and methods for treating insomnia |
WO2016065586A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Pyrazole, triazole and tetrazole orexin receptor antagonists |
WO2016065585A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Piperidine isoxazole and isothiazole orexin receptor antagonists |
WO2016065587A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Pyrazole orexin receptor antagonists |
WO2016065584A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Piperidine oxadiazole and thiadiazole orexin receptor antagonists |
WO2016065583A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Oxazole orexin receptor antagonists |
WO2016085784A1 (en) * | 2014-11-26 | 2016-06-02 | Merck Sharp & Dohme Corp. | Methyl diazepane orexin receptor antagonists |
US9994570B2 (en) | 2014-11-26 | 2018-06-12 | Merck Sharp & Dohme Corp. | Bridged diazepane orexin receptor antagonists |
WO2016086357A1 (en) | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Methyl oxazole orexin receptor antagonists |
WO2016086358A1 (en) | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Hydroxymethyl piperidine orexin receptor antagonists |
US9987255B2 (en) | 2014-12-19 | 2018-06-05 | Merck Sharp & Dohme Corp. | 5,5-bicyclic oxazole orexin receptor antagonists |
WO2016095204A1 (en) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Pyrrolidine orexin receptor antagonists |
WO2016100157A2 (en) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists |
WO2016100161A1 (en) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Ethyldiamine orexin receptor antagonists |
WO2016095205A1 (en) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Heteroaryl orexin receptor antagonists |
WO2016101119A1 (en) | 2014-12-23 | 2016-06-30 | Merck Sharp & Dohme Corp. | Fused heteroaryl derivatives as orexin receptor antagonists |
WO2016101118A1 (en) | 2014-12-23 | 2016-06-30 | Merck Sharp & Dohme Corp. | Amidoethyl azole orexin receptor antagonists |
CZ201587A3 (cs) | 2015-02-10 | 2016-08-17 | Zentiva, K.S. | Amorfní pevná forma suvorexantu s kyselinou sírovou |
WO2016149628A1 (en) * | 2015-03-19 | 2016-09-22 | Chembridge Corporation | Tgr5 agonists |
US10131653B2 (en) | 2015-04-24 | 2018-11-20 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
AR105025A1 (es) * | 2015-06-19 | 2017-08-30 | Astellas Pharma Inc | Compuesto de imidazodiazepina |
WO2017001499A1 (en) | 2015-06-30 | 2017-01-05 | Hexal Ag | Liquid composition comprising suvorexant |
WO2017012502A1 (en) | 2015-07-17 | 2017-01-26 | Sunshine Lake Pharma Co., Ltd. | Substituted quinazoline compounds and preparation and uses thereof |
HRP20211790T1 (hr) | 2015-10-15 | 2022-03-04 | Les Laboratoires Servier | Kombinirana terapija za liječenje maligniteta |
PL3362065T3 (pl) | 2015-10-15 | 2024-09-16 | Les Laboratoires Servier | Terapia skojarzona zawierająca iwosidenib, cytarabinę i daunorubicynę lub idarubicynę do leczenia ostrej białaczki szpikowej |
SG11201803191VA (en) | 2015-10-29 | 2018-05-30 | Univ Tsukuba | Morphinan derivative and medical usage thereof |
WO2017072264A1 (en) | 2015-10-29 | 2017-05-04 | Hexal Ag | Solid composition comprising suvorexant |
US10370380B2 (en) | 2015-11-23 | 2019-08-06 | Sunshine Lake Pharma Co., Ltd. | Octahydropyrrolo[3,4-c]pyrrole derivatives and uses thereof |
CN107021955B (zh) * | 2016-02-01 | 2021-03-30 | 上海奥博生物医药股份有限公司 | 苏沃雷生中间体化合物及其制备方法 |
CN109219606B (zh) | 2016-02-12 | 2021-10-01 | 阿斯利康(瑞典)有限公司 | 食欲素受体调节剂的卤素取代的哌啶 |
CA3016706A1 (en) | 2016-03-10 | 2017-09-14 | Janssen Pharmaceutica Nv | Methods of treating depression using orexin-2 receptor antagonists |
CN107179356B (zh) * | 2016-03-11 | 2021-07-16 | 广东东阳光药业有限公司 | 一种用hplc法测定苏沃雷生有关物质的方法 |
CN107304204B (zh) * | 2016-04-18 | 2020-12-22 | 广东东阳光药业有限公司 | 一种制备n-杂环化合物的方法 |
WO2017194548A1 (en) | 2016-05-10 | 2017-11-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases |
CN109195954A (zh) | 2016-06-06 | 2019-01-11 | 南迪亚公司 | 沃雷生的中间体的手性拆分及其共晶 |
EP3554508A4 (en) * | 2016-12-19 | 2020-08-05 | Druggability Technologies IP Holdco Limited | SUVOREXANT PHARMACEUTICAL FORMULATIONS |
GB201702174D0 (en) | 2017-02-09 | 2017-03-29 | Benevolentai Bio Ltd | Orexin receptor antagonists |
MX2019012902A (es) * | 2017-05-03 | 2019-12-16 | Idorsia Pharmaceuticals Ltd | Preparacion de derivados de acido 2-([1,2,3]triazol-2-il)-benzoico . |
GB201707499D0 (en) | 2017-05-10 | 2017-06-21 | Benevolentai Bio Ltd | Orexin receptor antagonists |
GB201707504D0 (en) | 2017-05-10 | 2017-06-21 | Benevolentai Bio Ltd | Orexin receptor antagonists |
CN115710250A (zh) * | 2017-08-01 | 2023-02-24 | 博健制药有限责任公司 | 一种食欲素受体拮抗剂的晶型及其制备方法和用途 |
US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
WO2020007977A1 (en) * | 2018-07-06 | 2020-01-09 | Idorsia Pharmaceuticals Ltd | 7-trifluoromethyl-[1,4]diazepan derivatives |
MX2021006915A (es) | 2018-12-12 | 2021-08-24 | Chemocentryx Inc | Inhibidores de cxcr7 para el tratamiento de cancer. |
CZ310035B6 (cs) * | 2019-12-09 | 2024-05-29 | Univerzita PalackĂ©ho v Olomouci | N-(furan-2-ylmethyl)-7H-purin-6-amin pro modulaci cirkadiánních rytmů |
MX2023001688A (es) | 2020-08-12 | 2023-02-22 | Spruce Biosciences Inc | Metodos y composiciones para tratar el sindrome de ovario poliquistico. |
CN111943945B (zh) * | 2020-09-03 | 2022-07-12 | 上海应用技术大学 | 一种苏沃雷生中间体及其制备方法 |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS536156B2 (es) * | 1972-10-30 | 1978-03-04 | ||
GB2068961B (en) * | 1980-02-13 | 1983-11-30 | Sankyo Co | Quinazoline derivatives |
JPH0747574B2 (ja) * | 1989-03-03 | 1995-05-24 | 大日本製薬株式会社 | ピリジン誘導体及びそれを有効成分とする向精神剤 |
EP0794178A4 (en) * | 1994-11-25 | 1998-02-25 | Nippon Chemiphar Co | CHINAZOLIN DERIVATIVES |
GB9606805D0 (en) | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
AR016817A1 (es) | 1997-08-14 | 2001-08-01 | Smithkline Beecham Plc | Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento |
ES2196806T3 (es) | 1998-05-08 | 2003-12-16 | Smithkline Beecham Plc | Derivados de fenilurea y de feniltiourea. |
WO2000047576A1 (en) | 1999-02-12 | 2000-08-17 | Smithkline Beecham Plc | Cinnamide derivatives as orexin-1 receptors antagonists |
JP2002536447A (ja) | 1999-02-12 | 2002-10-29 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | フェニル尿素およびフェニルチオ尿素誘導体 |
JP2002536445A (ja) | 1999-02-12 | 2002-10-29 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | オレキシン受容体アンタゴニストとしてのフェニル尿素およびフェニルチオ尿素誘導体 |
US6414002B1 (en) | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
MXPA02008797A (es) | 2000-03-14 | 2005-09-08 | Actelion Pharmaceuticals Ltd | Derivados de 1,2,3,4-tetrahidroisoquinolina. |
CA2408343A1 (en) * | 2000-05-11 | 2002-11-07 | Banyu Pharmaceutical Co., Ltd. | N-acyltetrahydroisoquinoline derivatives |
PT1289955E (pt) | 2000-06-16 | 2005-08-31 | Smithkline Beecham Plc | Piperidinas para utilizacao como antagonistas dos receptores da orexina |
DE10036818A1 (de) * | 2000-07-28 | 2002-02-07 | Solvay Pharm Gmbh | Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten |
EP1353918B1 (en) | 2000-11-28 | 2005-01-12 | Smithkline Beecham Plc | Morpholine derivatives as antagonists of orexin receptors |
WO2002051232A2 (en) | 2000-12-27 | 2002-07-04 | Actelion Pharmaceuticals Ltd. | Novel benzazepines and related heterocyclic derivatives |
US7432270B2 (en) | 2001-05-05 | 2008-10-07 | Smithkline Beecham P.L.C. | N-aroyl cyclic amines |
US20040192673A1 (en) | 2001-05-05 | 2004-09-30 | Pascale Gaillard | N-aroyl cyclic amine derivatives as orexin receptor antagonists |
GB0115862D0 (en) | 2001-06-28 | 2001-08-22 | Smithkline Beecham Plc | Compounds |
EP1399441B1 (en) | 2001-06-28 | 2006-07-05 | Smithkline Beecham Plc | N-aroyl cyclic amine derivatives as orexin receptor antagonists |
GB0124463D0 (en) | 2001-10-11 | 2001-12-05 | Smithkline Beecham Plc | Compounds |
GB0126292D0 (en) | 2001-11-01 | 2002-01-02 | Smithkline Beecham Plc | Compounds |
GB0127145D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Compounds |
GB0130335D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
GB0130393D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
GB0130341D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
WO2004004733A1 (en) | 2002-07-09 | 2004-01-15 | Actelion Pharmaceuticals Ltd. | 7,8,9,10-tetrahydro-6h-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2h-pyrrolo[2,1-b]-quinazolinone derivatives |
EP1539747B1 (en) | 2002-09-18 | 2006-11-02 | Glaxo Group Limited | N-aroyl cyclic amines as orexin receptor antagonists |
CN1332942C (zh) | 2002-10-11 | 2007-08-22 | 埃科特莱茵药品有限公司 | 磺酰基氨基-乙酸衍生物及其作为阿立新受体拮抗剂的应用 |
GB0225938D0 (en) | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
GB0225884D0 (en) | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
AU2003299648A1 (en) | 2002-12-12 | 2004-06-30 | Janssen Pharmaceutica, N.V. | Substituted 4-phenyl-(1,3)-dioxanes |
PL1633724T3 (pl) * | 2003-03-12 | 2011-10-31 | Kudos Pharm Ltd | Pochodne ftalazynonu |
CL2004000553A1 (es) | 2003-03-20 | 2005-02-04 | Actelion Pharmaceuticals Ltd | Uso de compuestos derivados de guanidina como antagonistas del receptor de neuropeptido ff; compuestos derivados de guanidina; procedimientos de preparacion; y composicion farmaceutica que los comprende. |
EP1611104B1 (en) | 2003-03-26 | 2009-07-01 | Actelion Pharmaceuticals Ltd. | Tetrahydroisoquinolyl acetamide derivatives for use as orexin receptor antagonists |
CN1780820A (zh) | 2003-04-28 | 2006-05-31 | 埃科特莱茵药品有限公司 | 作为阿立新受体拮抗剂的喹喔啉-3-酮衍生物 |
ES2322651T3 (es) * | 2003-09-09 | 2009-06-24 | F. Hoffmann-La Roche Ag | Derivados de 1-benzoil-piperazina como inhibidores de absorcion de glicina para el tratamiento de psicosis. |
HUP0304101A3 (en) | 2003-12-22 | 2008-10-28 | Sanofi Aventis | Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates |
HUP0400405A3 (en) | 2004-02-10 | 2009-03-30 | Sanofi Synthelabo | Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates |
AU2005250077B2 (en) | 2004-03-01 | 2011-06-09 | Idorsia Pharmaceuticals Ltd | Substituted 1,2,3,4-tetrahydroisoquinoline derivatives |
WO2006067224A2 (en) | 2004-12-23 | 2006-06-29 | Biovitrum Ab (Publ) | Spiro-benzodioxole and spiro-benzodioxane compounds as orexin receptor antagonists |
AU2006235302A1 (en) | 2005-04-12 | 2006-10-19 | Merck & Co., Inc. | Amidopropoxyphenyl orexin receptor antagonists |
WO2006124748A2 (en) * | 2005-05-13 | 2006-11-23 | Lexicon Genetics Incorporated | Multicyclic compounds and methods of their use |
US20060258762A1 (en) * | 2005-05-13 | 2006-11-16 | Dobransky Michael A | Hydrocarbon or hydrofluorocarbon blown ASTM E-84 class I rigid polyurethane foams |
CA2609203A1 (en) | 2005-05-23 | 2006-11-30 | Merck & Co., Inc | Proline bis-amide orexin receptor antagonists |
JP2009503106A (ja) | 2005-08-04 | 2009-01-29 | メルク エンド カムパニー インコーポレーテッド | アミノエタンスルホンアミドオレキシン受容体アンタゴニスト |
WO2007025069A2 (en) | 2005-08-26 | 2007-03-01 | Merck & Co., Inc. | Diazaspirodecane orexin receptor antagonists |
US8685961B2 (en) | 2006-03-29 | 2014-04-01 | Merck Sharp & Dohme Corp. | Diazepan orexin receptor antagonists |
EP2049110B1 (en) | 2006-07-14 | 2014-08-20 | Merck Sharp & Dohme Corp. | Bridged diazepan orexin receptor antagonists |
PL2049529T3 (pl) | 2006-07-14 | 2011-01-31 | Merck Sharp & Dohme | Podstawione związki diazepanowe - antagoniści receptora oreksyny |
PE20081229A1 (es) * | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
EP2214676B1 (en) * | 2007-10-29 | 2012-11-21 | Merck Sharp & Dohme Corp. | Substituted diazepan orexin receptor antagonists |
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