KR101113163B1 - 스타틴, 특히 아토르바스타틴의 제조에 유용한 중간체화합물 및 그 제조방법 - Google Patents
스타틴, 특히 아토르바스타틴의 제조에 유용한 중간체화합물 및 그 제조방법 Download PDFInfo
- Publication number
- KR101113163B1 KR101113163B1 KR1020067000774A KR20067000774A KR101113163B1 KR 101113163 B1 KR101113163 B1 KR 101113163B1 KR 1020067000774 A KR1020067000774 A KR 1020067000774A KR 20067000774 A KR20067000774 A KR 20067000774A KR 101113163 B1 KR101113163 B1 KR 101113163B1
- Authority
- KR
- South Korea
- Prior art keywords
- group
- compound
- formula
- general formula
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *C1CC(C=C)OC(CC[n]2c(*)c(*)c(*)c2*)C1 Chemical compound *C1CC(C=C)OC(CC[n]2c(*)c(*)c(*)c2*)C1 0.000 description 7
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0317393.7 | 2003-07-25 | ||
| GB0317393A GB0317393D0 (en) | 2003-07-25 | 2003-07-25 | Process and compounds |
| GB0406760A GB0406760D0 (en) | 2004-03-26 | 2004-03-26 | Process and compounds |
| GB0406760.9 | 2004-03-26 | ||
| PCT/GB2004/003206 WO2005012246A1 (en) | 2003-07-25 | 2004-07-23 | Process and intermediate compounds useful in the preparation of statins, particularly atorvastatin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20060040679A KR20060040679A (ko) | 2006-05-10 |
| KR101113163B1 true KR101113163B1 (ko) | 2012-02-17 |
Family
ID=34117641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067000774A Expired - Fee Related KR101113163B1 (ko) | 2003-07-25 | 2004-07-23 | 스타틴, 특히 아토르바스타틴의 제조에 유용한 중간체화합물 및 그 제조방법 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7414141B2 (https=) |
| EP (2) | EP1648866A1 (https=) |
| JP (1) | JP4820965B2 (https=) |
| KR (1) | KR101113163B1 (https=) |
| AU (1) | AU2004261468B2 (https=) |
| BR (1) | BRPI0412786A (https=) |
| CA (1) | CA2530163C (https=) |
| HR (1) | HRP20051020A2 (https=) |
| IL (1) | IL173012A (https=) |
| NO (1) | NO335650B1 (https=) |
| WO (1) | WO2005012246A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1671947A1 (en) * | 2004-12-20 | 2006-06-21 | Ratiopharm GmbH | Process for preparing pyrrole derivatives and intermediates |
| DE102005022284A1 (de) * | 2005-05-13 | 2006-11-23 | Ratiopharm Gmbh | Verfahren zur Herstellung von Statinen |
| WO2009019561A2 (en) * | 2007-08-03 | 2009-02-12 | Pfizer Products Inc. | Process for preparing chiral compounds |
| AU2013202895B2 (en) * | 2009-03-10 | 2014-09-18 | Redx Pharma Plc | Rosuvastatin and atorvastatin derivatives |
| GB0904102D0 (en) * | 2009-03-10 | 2009-04-22 | Bradford Pharma Ltd | Use of atorvastatin lactols as medicaments |
| GB0904104D0 (en) * | 2009-03-10 | 2009-04-22 | Bradford Pharma Ltd | Atorvastatin and rosuvastatin derivatives |
| GB0904100D0 (en) * | 2009-03-10 | 2009-04-22 | Bradford Pharma Ltd | Use of rosuvastatin lactols as medicaments |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992006968A1 (en) * | 1990-10-17 | 1992-04-30 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
| WO2004096788A1 (en) | 2003-05-02 | 2004-11-11 | Dsm Ip Assets B.V. | Process fot the preparation of (4-hydroxy-6-oxo-tetrahydropyran-2-yl) acetonitrile and derivatives thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5298627A (en) * | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5385929A (en) * | 1994-05-04 | 1995-01-31 | Warner-Lambert Company | [(Hydroxyphenylamino) carbonyl] pyrroles |
| US5795749A (en) | 1995-04-05 | 1998-08-18 | The Scripps Research Institution | Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives |
| DE10131522A1 (de) * | 2001-07-02 | 2003-01-16 | Creavis Tech & Innovation Gmbh | Verfahren zur Herstellung gesättigter Alkohole, Ketone, Aldehyde und Carbonsäuren |
| HRPK20040255B3 (en) * | 2001-08-16 | 2006-02-28 | Teva Pharmaceutical Industries Ltd. | Processes for preparing calcium salt forms of statins |
| US7078430B2 (en) | 2002-07-08 | 2006-07-18 | Ranbaxy Laboratories Limited | HMG CoA-reductase inhibitors |
| AU2003263031A1 (en) * | 2002-09-20 | 2004-04-08 | Diversa Corporation | Chemoenzymatic methods for the synthesis of statins and stain intermediates |
| JP2006523670A (ja) | 2003-04-14 | 2006-10-19 | ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー | ５−（４−フルオロフェニル）−１−［２−（（２ｒ，４ｒ）−４−ヒドロキシ−６−オキソ−テトラヒドロ−ピラン−２−イル）エチル］−２−イソプロピル−４−フェニル−１ｈ−ピロール−３−カルボン酸フェニルアミドの調製方法 |
-
2004
- 2004-07-23 BR BRPI0412786-2A patent/BRPI0412786A/pt not_active IP Right Cessation
- 2004-07-23 KR KR1020067000774A patent/KR101113163B1/ko not_active Expired - Fee Related
- 2004-07-23 WO PCT/GB2004/003206 patent/WO2005012246A1/en not_active Ceased
- 2004-07-23 JP JP2006521652A patent/JP4820965B2/ja not_active Expired - Fee Related
- 2004-07-23 US US10/563,459 patent/US7414141B2/en not_active Expired - Fee Related
- 2004-07-23 EP EP04767938A patent/EP1648866A1/en not_active Withdrawn
- 2004-07-23 EP EP12160668A patent/EP2522656A3/en not_active Withdrawn
- 2004-07-23 CA CA2530163A patent/CA2530163C/en not_active Expired - Fee Related
- 2004-07-23 HR HR20051020A patent/HRP20051020A2/hr not_active Application Discontinuation
- 2004-07-23 AU AU2004261468A patent/AU2004261468B2/en not_active Ceased
-
2006
- 2006-01-08 IL IL173012A patent/IL173012A/en not_active IP Right Cessation
- 2006-02-24 NO NO20060903A patent/NO335650B1/no not_active IP Right Cessation
-
2008
- 2008-08-14 US US12/191,518 patent/US8614335B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992006968A1 (en) * | 1990-10-17 | 1992-04-30 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
| WO2004096788A1 (en) | 2003-05-02 | 2004-11-11 | Dsm Ip Assets B.V. | Process fot the preparation of (4-hydroxy-6-oxo-tetrahydropyran-2-yl) acetonitrile and derivatives thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| US7414141B2 (en) | 2008-08-19 |
| CA2530163C (en) | 2012-10-02 |
| KR20060040679A (ko) | 2006-05-10 |
| EP2522656A3 (en) | 2013-03-20 |
| US8614335B2 (en) | 2013-12-24 |
| WO2005012246A1 (en) | 2005-02-10 |
| JP4820965B2 (ja) | 2011-11-24 |
| CA2530163A1 (en) | 2005-02-10 |
| JP2006528655A (ja) | 2006-12-21 |
| EP2522656A2 (en) | 2012-11-14 |
| US20070043221A1 (en) | 2007-02-22 |
| AU2004261468A1 (en) | 2005-02-10 |
| HRP20051020A2 (hr) | 2006-04-30 |
| NO335650B1 (no) | 2015-01-19 |
| IL173012A (en) | 2015-05-31 |
| US20090062553A1 (en) | 2009-03-05 |
| NO20060903L (no) | 2005-01-26 |
| AU2004261468B2 (en) | 2011-04-14 |
| IL173012A0 (en) | 2006-06-11 |
| BRPI0412786A (pt) | 2006-09-26 |
| EP1648866A1 (en) | 2006-04-26 |
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