BRPI0412786A - processo para a preparação de um composto, e, composto - Google Patents
processo para a preparação de um composto, e, compostoInfo
- Publication number
- BRPI0412786A BRPI0412786A BRPI0412786-2A BRPI0412786A BRPI0412786A BR PI0412786 A BRPI0412786 A BR PI0412786A BR PI0412786 A BRPI0412786 A BR PI0412786A BR PI0412786 A BRPI0412786 A BR PI0412786A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- formula
- hydrogen
- give
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 17
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- -1 and Chemical class 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- 125000006239 protecting group Chemical group 0.000 abstract 3
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007142 ring opening reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0317393A GB0317393D0 (en) | 2003-07-25 | 2003-07-25 | Process and compounds |
| GB0406760A GB0406760D0 (en) | 2004-03-26 | 2004-03-26 | Process and compounds |
| PCT/GB2004/003206 WO2005012246A1 (en) | 2003-07-25 | 2004-07-23 | Process and intermediate compounds useful in the preparation of statins, particularly atorvastatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0412786A true BRPI0412786A (pt) | 2006-09-26 |
Family
ID=34117641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0412786-2A BRPI0412786A (pt) | 2003-07-25 | 2004-07-23 | processo para a preparação de um composto, e, composto |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7414141B2 (https=) |
| EP (2) | EP1648866A1 (https=) |
| JP (1) | JP4820965B2 (https=) |
| KR (1) | KR101113163B1 (https=) |
| AU (1) | AU2004261468B2 (https=) |
| BR (1) | BRPI0412786A (https=) |
| CA (1) | CA2530163C (https=) |
| HR (1) | HRP20051020A2 (https=) |
| IL (1) | IL173012A (https=) |
| NO (1) | NO335650B1 (https=) |
| WO (1) | WO2005012246A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1671947A1 (en) * | 2004-12-20 | 2006-06-21 | Ratiopharm GmbH | Process for preparing pyrrole derivatives and intermediates |
| DE102005022284A1 (de) * | 2005-05-13 | 2006-11-23 | Ratiopharm Gmbh | Verfahren zur Herstellung von Statinen |
| WO2009019561A2 (en) * | 2007-08-03 | 2009-02-12 | Pfizer Products Inc. | Process for preparing chiral compounds |
| AU2013202895B2 (en) * | 2009-03-10 | 2014-09-18 | Redx Pharma Plc | Rosuvastatin and atorvastatin derivatives |
| GB0904102D0 (en) * | 2009-03-10 | 2009-04-22 | Bradford Pharma Ltd | Use of atorvastatin lactols as medicaments |
| GB0904104D0 (en) * | 2009-03-10 | 2009-04-22 | Bradford Pharma Ltd | Atorvastatin and rosuvastatin derivatives |
| GB0904100D0 (en) * | 2009-03-10 | 2009-04-22 | Bradford Pharma Ltd | Use of rosuvastatin lactols as medicaments |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5103024A (en) | 1990-10-17 | 1992-04-07 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
| US5298627A (en) * | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5385929A (en) * | 1994-05-04 | 1995-01-31 | Warner-Lambert Company | [(Hydroxyphenylamino) carbonyl] pyrroles |
| US5795749A (en) | 1995-04-05 | 1998-08-18 | The Scripps Research Institution | Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives |
| DE10131522A1 (de) * | 2001-07-02 | 2003-01-16 | Creavis Tech & Innovation Gmbh | Verfahren zur Herstellung gesättigter Alkohole, Ketone, Aldehyde und Carbonsäuren |
| HRPK20040255B3 (en) * | 2001-08-16 | 2006-02-28 | Teva Pharmaceutical Industries Ltd. | Processes for preparing calcium salt forms of statins |
| US7078430B2 (en) | 2002-07-08 | 2006-07-18 | Ranbaxy Laboratories Limited | HMG CoA-reductase inhibitors |
| AU2003263031A1 (en) * | 2002-09-20 | 2004-04-08 | Diversa Corporation | Chemoenzymatic methods for the synthesis of statins and stain intermediates |
| JP2006523670A (ja) | 2003-04-14 | 2006-10-19 | ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー | ５−（４−フルオロフェニル）−１−［２−（（２ｒ，４ｒ）−４−ヒドロキシ−６−オキソ−テトラヒドロ−ピラン−２−イル）エチル］−２−イソプロピル−４−フェニル−１ｈ−ピロール−３−カルボン酸フェニルアミドの調製方法 |
| PL1620423T3 (pl) * | 2003-05-02 | 2008-07-31 | Dsm Sinochem Pharm Nl Bv | Sposób wytwarzania (4-hydroksy-6-okso-tetrahydropiran-2-ylo) acetonitrylu i jego pochodnych |
-
2004
- 2004-07-23 BR BRPI0412786-2A patent/BRPI0412786A/pt not_active IP Right Cessation
- 2004-07-23 KR KR1020067000774A patent/KR101113163B1/ko not_active Expired - Fee Related
- 2004-07-23 WO PCT/GB2004/003206 patent/WO2005012246A1/en not_active Ceased
- 2004-07-23 JP JP2006521652A patent/JP4820965B2/ja not_active Expired - Fee Related
- 2004-07-23 US US10/563,459 patent/US7414141B2/en not_active Expired - Fee Related
- 2004-07-23 EP EP04767938A patent/EP1648866A1/en not_active Withdrawn
- 2004-07-23 EP EP12160668A patent/EP2522656A3/en not_active Withdrawn
- 2004-07-23 CA CA2530163A patent/CA2530163C/en not_active Expired - Fee Related
- 2004-07-23 HR HR20051020A patent/HRP20051020A2/hr not_active Application Discontinuation
- 2004-07-23 AU AU2004261468A patent/AU2004261468B2/en not_active Ceased
-
2006
- 2006-01-08 IL IL173012A patent/IL173012A/en not_active IP Right Cessation
- 2006-02-24 NO NO20060903A patent/NO335650B1/no not_active IP Right Cessation
-
2008
- 2008-08-14 US US12/191,518 patent/US8614335B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7414141B2 (en) | 2008-08-19 |
| CA2530163C (en) | 2012-10-02 |
| KR20060040679A (ko) | 2006-05-10 |
| EP2522656A3 (en) | 2013-03-20 |
| US8614335B2 (en) | 2013-12-24 |
| WO2005012246A1 (en) | 2005-02-10 |
| JP4820965B2 (ja) | 2011-11-24 |
| CA2530163A1 (en) | 2005-02-10 |
| JP2006528655A (ja) | 2006-12-21 |
| EP2522656A2 (en) | 2012-11-14 |
| US20070043221A1 (en) | 2007-02-22 |
| AU2004261468A1 (en) | 2005-02-10 |
| HRP20051020A2 (hr) | 2006-04-30 |
| NO335650B1 (no) | 2015-01-19 |
| IL173012A (en) | 2015-05-31 |
| US20090062553A1 (en) | 2009-03-05 |
| NO20060903L (no) | 2005-01-26 |
| AU2004261468B2 (en) | 2011-04-14 |
| IL173012A0 (en) | 2006-06-11 |
| KR101113163B1 (ko) | 2012-02-17 |
| EP1648866A1 (en) | 2006-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B25D | Requested change of name of applicant approved |
Owner name: NPIL PHARMACEUTICALS (UK) LIMITED (GB) |
|
| B25D | Requested change of name of applicant approved |
Owner name: PIRAMAL HEALTHCARE UK LIMITED (GB) |
|
| B25G | Requested change of headquarter approved |
Owner name: PIRAMAL HEALTHCARE UK LIMITED (GB) |
|
| B25A | Requested transfer of rights approved |
Owner name: BRADFORD PHARMA LIMITED (GB) |
|
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |