IL173012A - Process and intermediate compounds useful in the preparation of statins, especially atorvastatin - Google Patents
Process and intermediate compounds useful in the preparation of statins, especially atorvastatinInfo
- Publication number
- IL173012A IL173012A IL173012A IL17301206A IL173012A IL 173012 A IL173012 A IL 173012A IL 173012 A IL173012 A IL 173012A IL 17301206 A IL17301206 A IL 17301206A IL 173012 A IL173012 A IL 173012A
- Authority
- IL
- Israel
- Prior art keywords
- statins
- preparation
- compounds useful
- intermediate compounds
- particularly atorvastatin
- Prior art date
Links
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title 1
- 229960005370 atorvastatin Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0317393A GB0317393D0 (en) | 2003-07-25 | 2003-07-25 | Process and compounds |
| GB0406760A GB0406760D0 (en) | 2004-03-26 | 2004-03-26 | Process and compounds |
| PCT/GB2004/003206 WO2005012246A1 (en) | 2003-07-25 | 2004-07-23 | Process and intermediate compounds useful in the preparation of statins, particularly atorvastatin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL173012A0 IL173012A0 (en) | 2006-06-11 |
| IL173012A true IL173012A (en) | 2015-05-31 |
Family
ID=34117641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL173012A IL173012A (en) | 2003-07-25 | 2006-01-08 | Process and intermediate compounds useful in the preparation of statins, especially atorvastatin |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7414141B2 (https=) |
| EP (2) | EP1648866A1 (https=) |
| JP (1) | JP4820965B2 (https=) |
| KR (1) | KR101113163B1 (https=) |
| AU (1) | AU2004261468B2 (https=) |
| BR (1) | BRPI0412786A (https=) |
| CA (1) | CA2530163C (https=) |
| HR (1) | HRP20051020A2 (https=) |
| IL (1) | IL173012A (https=) |
| NO (1) | NO335650B1 (https=) |
| WO (1) | WO2005012246A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1671947A1 (en) * | 2004-12-20 | 2006-06-21 | Ratiopharm GmbH | Process for preparing pyrrole derivatives and intermediates |
| DE102005022284A1 (de) * | 2005-05-13 | 2006-11-23 | Ratiopharm Gmbh | Verfahren zur Herstellung von Statinen |
| WO2009019561A2 (en) * | 2007-08-03 | 2009-02-12 | Pfizer Products Inc. | Process for preparing chiral compounds |
| AU2013202895B2 (en) * | 2009-03-10 | 2014-09-18 | Redx Pharma Plc | Rosuvastatin and atorvastatin derivatives |
| GB0904102D0 (en) * | 2009-03-10 | 2009-04-22 | Bradford Pharma Ltd | Use of atorvastatin lactols as medicaments |
| GB0904104D0 (en) * | 2009-03-10 | 2009-04-22 | Bradford Pharma Ltd | Atorvastatin and rosuvastatin derivatives |
| GB0904100D0 (en) * | 2009-03-10 | 2009-04-22 | Bradford Pharma Ltd | Use of rosuvastatin lactols as medicaments |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5103024A (en) | 1990-10-17 | 1992-04-07 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
| US5298627A (en) * | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5385929A (en) * | 1994-05-04 | 1995-01-31 | Warner-Lambert Company | [(Hydroxyphenylamino) carbonyl] pyrroles |
| US5795749A (en) | 1995-04-05 | 1998-08-18 | The Scripps Research Institution | Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives |
| DE10131522A1 (de) * | 2001-07-02 | 2003-01-16 | Creavis Tech & Innovation Gmbh | Verfahren zur Herstellung gesättigter Alkohole, Ketone, Aldehyde und Carbonsäuren |
| HRPK20040255B3 (en) * | 2001-08-16 | 2006-02-28 | Teva Pharmaceutical Industries Ltd. | Processes for preparing calcium salt forms of statins |
| US7078430B2 (en) | 2002-07-08 | 2006-07-18 | Ranbaxy Laboratories Limited | HMG CoA-reductase inhibitors |
| AU2003263031A1 (en) * | 2002-09-20 | 2004-04-08 | Diversa Corporation | Chemoenzymatic methods for the synthesis of statins and stain intermediates |
| JP2006523670A (ja) | 2003-04-14 | 2006-10-19 | ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー | ５−（４−フルオロフェニル）−１−［２−（（２ｒ，４ｒ）−４−ヒドロキシ−６−オキソ−テトラヒドロ−ピラン−２−イル）エチル］−２−イソプロピル−４−フェニル−１ｈ−ピロール−３−カルボン酸フェニルアミドの調製方法 |
| PL1620423T3 (pl) * | 2003-05-02 | 2008-07-31 | Dsm Sinochem Pharm Nl Bv | Sposób wytwarzania (4-hydroksy-6-okso-tetrahydropiran-2-ylo) acetonitrylu i jego pochodnych |
-
2004
- 2004-07-23 BR BRPI0412786-2A patent/BRPI0412786A/pt not_active IP Right Cessation
- 2004-07-23 KR KR1020067000774A patent/KR101113163B1/ko not_active Expired - Fee Related
- 2004-07-23 WO PCT/GB2004/003206 patent/WO2005012246A1/en not_active Ceased
- 2004-07-23 JP JP2006521652A patent/JP4820965B2/ja not_active Expired - Fee Related
- 2004-07-23 US US10/563,459 patent/US7414141B2/en not_active Expired - Fee Related
- 2004-07-23 EP EP04767938A patent/EP1648866A1/en not_active Withdrawn
- 2004-07-23 EP EP12160668A patent/EP2522656A3/en not_active Withdrawn
- 2004-07-23 CA CA2530163A patent/CA2530163C/en not_active Expired - Fee Related
- 2004-07-23 HR HR20051020A patent/HRP20051020A2/hr not_active Application Discontinuation
- 2004-07-23 AU AU2004261468A patent/AU2004261468B2/en not_active Ceased
-
2006
- 2006-01-08 IL IL173012A patent/IL173012A/en not_active IP Right Cessation
- 2006-02-24 NO NO20060903A patent/NO335650B1/no not_active IP Right Cessation
-
2008
- 2008-08-14 US US12/191,518 patent/US8614335B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7414141B2 (en) | 2008-08-19 |
| CA2530163C (en) | 2012-10-02 |
| KR20060040679A (ko) | 2006-05-10 |
| EP2522656A3 (en) | 2013-03-20 |
| US8614335B2 (en) | 2013-12-24 |
| WO2005012246A1 (en) | 2005-02-10 |
| JP4820965B2 (ja) | 2011-11-24 |
| CA2530163A1 (en) | 2005-02-10 |
| JP2006528655A (ja) | 2006-12-21 |
| EP2522656A2 (en) | 2012-11-14 |
| US20070043221A1 (en) | 2007-02-22 |
| AU2004261468A1 (en) | 2005-02-10 |
| HRP20051020A2 (hr) | 2006-04-30 |
| NO335650B1 (no) | 2015-01-19 |
| US20090062553A1 (en) | 2009-03-05 |
| NO20060903L (no) | 2005-01-26 |
| AU2004261468B2 (en) | 2011-04-14 |
| IL173012A0 (en) | 2006-06-11 |
| BRPI0412786A (pt) | 2006-09-26 |
| KR101113163B1 (ko) | 2012-02-17 |
| EP1648866A1 (en) | 2006-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |