JP4820965B2 - スタチン、特にアトルバスタチンの調製において有用な方法および中間体化合物 - Google Patents

スタチン、特にアトルバスタチンの調製において有用な方法および中間体化合物 Download PDF

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Publication number
JP4820965B2
JP4820965B2 JP2006521652A JP2006521652A JP4820965B2 JP 4820965 B2 JP4820965 B2 JP 4820965B2 JP 2006521652 A JP2006521652 A JP 2006521652A JP 2006521652 A JP2006521652 A JP 2006521652A JP 4820965 B2 JP4820965 B2 JP 4820965B2
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group
formula
compound
protecting
preparation
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JP2006521652A
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Japanese (ja)
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JP2006528655A (ja
JP2006528655A5 (https=
Inventor
ムーディ、デイヴィド・ジョン
ウィッフェン、ジョナサン・ウィリアム
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Bradford Pharma Ltd
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Bradford Pharma Ltd
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Priority claimed from GB0317393A external-priority patent/GB0317393D0/en
Priority claimed from GB0406760A external-priority patent/GB0406760D0/en
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Publication of JP2006528655A5 publication Critical patent/JP2006528655A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyrane Compounds (AREA)
JP2006521652A 2003-07-25 2004-07-23 スタチン、特にアトルバスタチンの調製において有用な方法および中間体化合物 Expired - Fee Related JP4820965B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0317393.7 2003-07-25
GB0317393A GB0317393D0 (en) 2003-07-25 2003-07-25 Process and compounds
GB0406760A GB0406760D0 (en) 2004-03-26 2004-03-26 Process and compounds
GB0406760.9 2004-03-26
PCT/GB2004/003206 WO2005012246A1 (en) 2003-07-25 2004-07-23 Process and intermediate compounds useful in the preparation of statins, particularly atorvastatin

Publications (3)

Publication Number Publication Date
JP2006528655A JP2006528655A (ja) 2006-12-21
JP2006528655A5 JP2006528655A5 (https=) 2011-04-14
JP4820965B2 true JP4820965B2 (ja) 2011-11-24

Family

ID=34117641

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006521652A Expired - Fee Related JP4820965B2 (ja) 2003-07-25 2004-07-23 スタチン、特にアトルバスタチンの調製において有用な方法および中間体化合物

Country Status (11)

Country Link
US (2) US7414141B2 (https=)
EP (2) EP1648866A1 (https=)
JP (1) JP4820965B2 (https=)
KR (1) KR101113163B1 (https=)
AU (1) AU2004261468B2 (https=)
BR (1) BRPI0412786A (https=)
CA (1) CA2530163C (https=)
HR (1) HRP20051020A2 (https=)
IL (1) IL173012A (https=)
NO (1) NO335650B1 (https=)
WO (1) WO2005012246A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1671947A1 (en) * 2004-12-20 2006-06-21 Ratiopharm GmbH Process for preparing pyrrole derivatives and intermediates
DE102005022284A1 (de) * 2005-05-13 2006-11-23 Ratiopharm Gmbh Verfahren zur Herstellung von Statinen
WO2009019561A2 (en) * 2007-08-03 2009-02-12 Pfizer Products Inc. Process for preparing chiral compounds
AU2013202895B2 (en) * 2009-03-10 2014-09-18 Redx Pharma Plc Rosuvastatin and atorvastatin derivatives
GB0904102D0 (en) * 2009-03-10 2009-04-22 Bradford Pharma Ltd Use of atorvastatin lactols as medicaments
GB0904104D0 (en) * 2009-03-10 2009-04-22 Bradford Pharma Ltd Atorvastatin and rosuvastatin derivatives
GB0904100D0 (en) * 2009-03-10 2009-04-22 Bradford Pharma Ltd Use of rosuvastatin lactols as medicaments

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03502798A (ja) * 1988-02-22 1991-06-27 ワーナー−ランバート・コンパニー コレステロール合成の阻害剤トランス‐６‐〔２‐（置換ピロール‐１‐イル）アルキル〕ピラン‐２‐オンの改良法
JPH07304735A (ja) * 1994-05-04 1995-11-21 Warner Lambert Co 〔（ヒドロキシフェニルアミノ）カルボニル〕ピロール
JPH08507521A (ja) * 1993-03-03 1996-08-13 ワーナー−ランバート・コンパニー コレステロール合成のトランス−６−〔２−（置換−ピロール−１−イル）アルキル〕ピラン−２−オン阻害剤の新規な製法
WO2003016317A1 (en) * 2001-08-16 2003-02-27 Teva Pharmaceutical Industries Ltd. Processes for preparing calcium salt forms of statins
JP2005533831A (ja) * 2002-07-08 2005-11-10 ランバクシー ラボラトリーズ リミテッド ＨＭＧＣｏＡ−リダクターゼインヒビター
JP2006512086A (ja) * 2002-09-20 2006-04-13 ダイヴァーサ コーポレイション スタチンおよびスタチン中間体の合成のための酵素化学的方法
JP2006523670A (ja) * 2003-04-14 2006-10-19 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー ５−（４−フルオロフェニル）−１−［２−（（２ｒ，４ｒ）−４−ヒドロキシ−６−オキソ−テトラヒドロ−ピラン−２−イル）エチル］−２−イソプロピル−４−フェニル−１ｈ−ピロール−３−カルボン酸フェニルアミドの調製方法
JP2006525323A (ja) * 2003-05-02 2006-11-09 ディーエスエム アイピー アセッツ ビー．ブイ． （４−ヒドロキシ−６−オキソ−テトラヒドロピラン−２−イル）アセトニトリルの調製方法およびその誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5103024A (en) 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5795749A (en) 1995-04-05 1998-08-18 The Scripps Research Institution Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives
DE10131522A1 (de) * 2001-07-02 2003-01-16 Creavis Tech & Innovation Gmbh Verfahren zur Herstellung gesättigter Alkohole, Ketone, Aldehyde und Carbonsäuren

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03502798A (ja) * 1988-02-22 1991-06-27 ワーナー−ランバート・コンパニー コレステロール合成の阻害剤トランス‐６‐〔２‐（置換ピロール‐１‐イル）アルキル〕ピラン‐２‐オンの改良法
JPH08507521A (ja) * 1993-03-03 1996-08-13 ワーナー−ランバート・コンパニー コレステロール合成のトランス−６−〔２−（置換−ピロール−１−イル）アルキル〕ピラン−２−オン阻害剤の新規な製法
JPH07304735A (ja) * 1994-05-04 1995-11-21 Warner Lambert Co 〔（ヒドロキシフェニルアミノ）カルボニル〕ピロール
WO2003016317A1 (en) * 2001-08-16 2003-02-27 Teva Pharmaceutical Industries Ltd. Processes for preparing calcium salt forms of statins
JP2005533831A (ja) * 2002-07-08 2005-11-10 ランバクシー ラボラトリーズ リミテッド ＨＭＧＣｏＡ−リダクターゼインヒビター
JP2006512086A (ja) * 2002-09-20 2006-04-13 ダイヴァーサ コーポレイション スタチンおよびスタチン中間体の合成のための酵素化学的方法
JP2006523670A (ja) * 2003-04-14 2006-10-19 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー ５−（４−フルオロフェニル）−１−［２−（（２ｒ，４ｒ）−４−ヒドロキシ−６−オキソ−テトラヒドロ−ピラン−２−イル）エチル］−２−イソプロピル−４−フェニル−１ｈ−ピロール−３−カルボン酸フェニルアミドの調製方法
JP2006525323A (ja) * 2003-05-02 2006-11-09 ディーエスエム アイピー アセッツ ビー．ブイ． （４−ヒドロキシ−６−オキソ−テトラヒドロピラン−２−イル）アセトニトリルの調製方法およびその誘導体

Also Published As

Publication number Publication date
US7414141B2 (en) 2008-08-19
CA2530163C (en) 2012-10-02
KR20060040679A (ko) 2006-05-10
EP2522656A3 (en) 2013-03-20
US8614335B2 (en) 2013-12-24
WO2005012246A1 (en) 2005-02-10
CA2530163A1 (en) 2005-02-10
JP2006528655A (ja) 2006-12-21
EP2522656A2 (en) 2012-11-14
US20070043221A1 (en) 2007-02-22
AU2004261468A1 (en) 2005-02-10
HRP20051020A2 (hr) 2006-04-30
NO335650B1 (no) 2015-01-19
IL173012A (en) 2015-05-31
US20090062553A1 (en) 2009-03-05
NO20060903L (no) 2005-01-26
AU2004261468B2 (en) 2011-04-14
IL173012A0 (en) 2006-06-11
BRPI0412786A (pt) 2006-09-26
KR101113163B1 (ko) 2012-02-17
EP1648866A1 (en) 2006-04-26

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