HRP20051020A2 - Postupak i međuspojevi korisni u dobivanju statina, posebice atorvastatin - Google Patents

Postupak i međuspojevi korisni u dobivanju statina, posebice atorvastatin Download PDF

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Publication number
HRP20051020A2
HRP20051020A2 HR20051020A HRP20051020A HRP20051020A2 HR P20051020 A2 HRP20051020 A2 HR P20051020A2 HR 20051020 A HR20051020 A HR 20051020A HR P20051020 A HRP20051020 A HR P20051020A HR P20051020 A2 HRP20051020 A2 HR P20051020A2
Authority
HR
Croatia
Prior art keywords
formula
group
compound
image
hydrogen
Prior art date
Application number
HR20051020A
Other languages
English (en)
Croatian (hr)
Inventor
John Moody David
William Wiffen Jonathan
Original Assignee
Avecia Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0317393A external-priority patent/GB0317393D0/en
Priority claimed from GB0406760A external-priority patent/GB0406760D0/en
Application filed by Avecia Pharmaceuticals Limited filed Critical Avecia Pharmaceuticals Limited
Publication of HRP20051020A2 publication Critical patent/HRP20051020A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyrane Compounds (AREA)
HR20051020A 2003-07-25 2004-07-23 Postupak i međuspojevi korisni u dobivanju statina, posebice atorvastatin HRP20051020A2 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0317393A GB0317393D0 (en) 2003-07-25 2003-07-25 Process and compounds
GB0406760A GB0406760D0 (en) 2004-03-26 2004-03-26 Process and compounds
PCT/GB2004/003206 WO2005012246A1 (en) 2003-07-25 2004-07-23 Process and intermediate compounds useful in the preparation of statins, particularly atorvastatin

Publications (1)

Publication Number Publication Date
HRP20051020A2 true HRP20051020A2 (hr) 2006-04-30

Family

ID=34117641

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20051020A HRP20051020A2 (hr) 2003-07-25 2004-07-23 Postupak i međuspojevi korisni u dobivanju statina, posebice atorvastatin

Country Status (11)

Country Link
US (2) US7414141B2 (https=)
EP (2) EP1648866A1 (https=)
JP (1) JP4820965B2 (https=)
KR (1) KR101113163B1 (https=)
AU (1) AU2004261468B2 (https=)
BR (1) BRPI0412786A (https=)
CA (1) CA2530163C (https=)
HR (1) HRP20051020A2 (https=)
IL (1) IL173012A (https=)
NO (1) NO335650B1 (https=)
WO (1) WO2005012246A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1671947A1 (en) * 2004-12-20 2006-06-21 Ratiopharm GmbH Process for preparing pyrrole derivatives and intermediates
DE102005022284A1 (de) * 2005-05-13 2006-11-23 Ratiopharm Gmbh Verfahren zur Herstellung von Statinen
WO2009019561A2 (en) * 2007-08-03 2009-02-12 Pfizer Products Inc. Process for preparing chiral compounds
AU2013202895B2 (en) * 2009-03-10 2014-09-18 Redx Pharma Plc Rosuvastatin and atorvastatin derivatives
GB0904102D0 (en) * 2009-03-10 2009-04-22 Bradford Pharma Ltd Use of atorvastatin lactols as medicaments
GB0904104D0 (en) * 2009-03-10 2009-04-22 Bradford Pharma Ltd Atorvastatin and rosuvastatin derivatives
GB0904100D0 (en) * 2009-03-10 2009-04-22 Bradford Pharma Ltd Use of rosuvastatin lactols as medicaments

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US5003080A (en) 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5103024A (en) 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5385929A (en) * 1994-05-04 1995-01-31 Warner-Lambert Company [(Hydroxyphenylamino) carbonyl] pyrroles
US5795749A (en) 1995-04-05 1998-08-18 The Scripps Research Institution Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives
DE10131522A1 (de) * 2001-07-02 2003-01-16 Creavis Tech & Innovation Gmbh Verfahren zur Herstellung gesättigter Alkohole, Ketone, Aldehyde und Carbonsäuren
HRPK20040255B3 (en) * 2001-08-16 2006-02-28 Teva Pharmaceutical Industries Ltd. Processes for preparing calcium salt forms of statins
US7078430B2 (en) 2002-07-08 2006-07-18 Ranbaxy Laboratories Limited HMG CoA-reductase inhibitors
AU2003263031A1 (en) * 2002-09-20 2004-04-08 Diversa Corporation Chemoenzymatic methods for the synthesis of statins and stain intermediates
JP2006523670A (ja) 2003-04-14 2006-10-19 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー ５−（４−フルオロフェニル）−１−［２−（（２ｒ，４ｒ）−４−ヒドロキシ−６−オキソ−テトラヒドロ−ピラン−２−イル）エチル］−２−イソプロピル−４−フェニル−１ｈ−ピロール−３−カルボン酸フェニルアミドの調製方法
PL1620423T3 (pl) * 2003-05-02 2008-07-31 Dsm Sinochem Pharm Nl Bv Sposób wytwarzania (4-hydroksy-6-okso-tetrahydropiran-2-ylo) acetonitrylu i jego pochodnych

Also Published As

Publication number Publication date
US7414141B2 (en) 2008-08-19
CA2530163C (en) 2012-10-02
KR20060040679A (ko) 2006-05-10
EP2522656A3 (en) 2013-03-20
US8614335B2 (en) 2013-12-24
WO2005012246A1 (en) 2005-02-10
JP4820965B2 (ja) 2011-11-24
CA2530163A1 (en) 2005-02-10
JP2006528655A (ja) 2006-12-21
EP2522656A2 (en) 2012-11-14
US20070043221A1 (en) 2007-02-22
AU2004261468A1 (en) 2005-02-10
NO335650B1 (no) 2015-01-19
IL173012A (en) 2015-05-31
US20090062553A1 (en) 2009-03-05
NO20060903L (no) 2005-01-26
AU2004261468B2 (en) 2011-04-14
IL173012A0 (en) 2006-06-11
BRPI0412786A (pt) 2006-09-26
KR101113163B1 (ko) 2012-02-17
EP1648866A1 (en) 2006-04-26

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Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: NPIL PHARMACEUTICALS (UK) LIMITED, GB

Owner name: PIRAMAL HEALTCARE UK LIMITED, GB

PPPP Transfer of rights

Owner name: BRADFORD PHARMA LIMITED, GB

PNAN Change of the applicant name, address/residence

Owner name: BRADFORD PHARMA LIMITED, GB

PPPP Transfer of rights

Owner name: REDX PHARMA LIMITED, GB

ODRP Renewal fee for the maintenance of a patent

Payment date: 20150629

Year of fee payment: 12

PNAN Change of the applicant name, address/residence

Owner name: REDX PHARMA PLC, GB

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