KR101052387B1 - 라세믹 일라프라졸의 고체상 형태 - Google Patents

라세믹 일라프라졸의 고체상 형태 Download PDF

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Publication number
KR101052387B1
KR101052387B1 KR1020097013519A KR20097013519A KR101052387B1 KR 101052387 B1 KR101052387 B1 KR 101052387B1 KR 1020097013519 A KR1020097013519 A KR 1020097013519A KR 20097013519 A KR20097013519 A KR 20097013519A KR 101052387 B1 KR101052387 B1 KR 101052387B1
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burglar
location
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racemic ilaprazole
ilaprazole
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Korean (ko)
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KR20090086615A (ko
Inventor
존 엠. 브랙켓
데이비드 티. 조나이티스
웨이 라이
지 후아 리우
스테판 디. 파렌트
진유 쉔
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일양약품주식회사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020097013519A 2006-12-29 2007-12-28 라세믹 일라프라졸의 고체상 형태 Active KR101052387B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87760806P 2006-12-29 2006-12-29
US60/877,608 2006-12-29
US88749907P 2007-01-31 2007-01-31
US60/887,499 2007-01-31
PCT/US2007/089127 WO2008083333A1 (en) 2006-12-29 2007-12-28 Solid state forms of racemic ilaprazole

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020117016139A Division KR20110091594A (ko) 2006-12-29 2007-12-28 라세믹 일라프라졸의 고체상 형태

Publications (2)

Publication Number Publication Date
KR20090086615A KR20090086615A (ko) 2009-08-13
KR101052387B1 true KR101052387B1 (ko) 2011-07-28

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ID=39313094

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020097013519A Active KR101052387B1 (ko) 2006-12-29 2007-12-28 라세믹 일라프라졸의 고체상 형태
KR1020117016139A Withdrawn KR20110091594A (ko) 2006-12-29 2007-12-28 라세믹 일라프라졸의 고체상 형태
KR1020097013491A Ceased KR20090086121A (ko) 2006-12-29 2007-12-28 용매화 일라프라졸의 결정형

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020117016139A Withdrawn KR20110091594A (ko) 2006-12-29 2007-12-28 라세믹 일라프라졸의 고체상 형태
KR1020097013491A Ceased KR20090086121A (ko) 2006-12-29 2007-12-28 용매화 일라프라졸의 결정형

Country Status (18)

Country Link
US (4) US7999110B2 (enExample)
EP (2) EP2102191B1 (enExample)
JP (2) JP5315254B2 (enExample)
KR (3) KR101052387B1 (enExample)
CN (2) CN101687849B (enExample)
AU (2) AU2007341984B2 (enExample)
CA (2) CA2674347C (enExample)
DK (1) DK2102192T3 (enExample)
ES (1) ES2398846T3 (enExample)
IL (2) IL199234A (enExample)
MX (2) MX2009006530A (enExample)
MY (2) MY146462A (enExample)
NO (2) NO20092398L (enExample)
NZ (2) NZ577509A (enExample)
PL (1) PL2102192T3 (enExample)
PT (1) PT2102192E (enExample)
RU (2) RU2464270C2 (enExample)
WO (2) WO2008083333A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210019469A (ko) 2021-02-02 2021-02-22 주식회사 파마코스텍 일라프라졸 나트륨 결정형 및 신규한 제조방법
KR102250509B1 (ko) 2020-12-09 2021-05-11 유니셀랩 주식회사 새로운 일라프라졸/자일리톨 공결정
KR20220065235A (ko) 2020-11-13 2022-05-20 주식회사 파마코스텍 일라프라졸 혼형 결정의 신규한 제조방법
KR20250156870A (ko) 2024-04-25 2025-11-04 엠에프씨 주식회사 일라프라졸 마그네슘염 수화물의 제조방법

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101144600B1 (ko) * 2009-12-08 2012-05-16 일양약품주식회사 일라프라졸의 결정형 ａ, ｂ의 제조방법 및 이들 결정형의 변환방법
CN103204843B (zh) * 2012-01-13 2014-12-31 丽珠医药集团股份有限公司 结晶型艾普拉唑钠乙醇化物及其制备方法
CN103204842B (zh) * 2012-01-13 2014-10-15 丽珠医药集团股份有限公司 结晶型艾普拉唑钠水合物及其制备方法
WO2013114232A1 (en) * 2012-02-02 2013-08-08 Lupin Limited Process for preparation of crystalline form l of ilaprazole
CN102746275B (zh) * 2012-06-21 2014-07-16 丽珠医药集团股份有限公司 结晶型艾普拉唑钠及其制备方法
CN102746277B (zh) * 2012-06-21 2014-05-14 丽珠医药集团股份有限公司 一种结晶形式的艾普拉唑钠及其制备方法
CN103172618B (zh) * 2013-02-27 2014-09-03 丽珠医药集团股份有限公司 艾普拉唑晶型及其制备方法
CN104370886B (zh) * 2014-11-18 2016-05-18 宁夏康亚药业有限公司 艾普拉唑晶型及其制备方法和应用
CN105055342A (zh) * 2015-08-13 2015-11-18 青岛蓝盛洋医药生物科技有限责任公司 一种治疗消化性溃疡的药物艾普拉唑钠组合物冻干粉针剂
CN105055343A (zh) * 2015-08-31 2015-11-18 青岛蓝盛洋医药生物科技有限责任公司 一种治疗胃病的药物艾普拉唑钠组合物冻干粉针剂
CN106749191A (zh) * 2016-12-10 2017-05-31 珠海保税区丽珠合成制药有限公司 艾普拉唑晶型ⅱ及其制备方法
KR101961028B1 (ko) * 2017-10-12 2019-03-21 중앙대학교 산학협력단 일라프라졸을 유효성분으로 함유하는 급성 위염의 예방 또는 치료용 약학 조성물
KR102332996B1 (ko) * 2020-04-13 2021-12-01 중앙대학교 산학협력단 일라프라졸을 유효성분으로 함유하는 장폐색증 예방 또는 치료용 약학조성물
CN117050060A (zh) * 2023-07-20 2023-11-14 浙江美诺华药物化学有限公司 一种艾普拉唑晶型f的制备方法
CN119462610A (zh) * 2024-11-06 2025-02-18 甘肃皓天科技股份有限公司 一种艾普拉唑新晶型及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0179401B1 (ko) * 1994-02-28 1999-03-20 송택선 신규한 5-피롤릴-2-피리딜메틸설피닐벤즈이미다졸 유도체
WO2000076519A1 (en) 1999-06-10 2000-12-21 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2232159C2 (ru) * 1999-07-29 2004-07-10 Регентский Совет Университета Калифорнии Производные бензимидазола и фармацевтические композиции, содержащие пролекарство ингибитора протонного насоса
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
CA2480352A1 (en) 2002-03-27 2003-10-09 Teva Pharmaceutical Industries Ltd. Lansoprazole polymorphs and processes for preparation thereof
ATE528301T1 (de) 2005-03-25 2011-10-15 Livzon Pharmaceutical Group Verfahren zur herstellung von substituierten sulfoxidzusammensetzungen
EP1879577A1 (en) * 2005-05-04 2008-01-23 AstraZeneca AB Proton pump inhibitors in the treatment of sleep disturbance due to silent gastro-esophageal reflux

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0179401B1 (ko) * 1994-02-28 1999-03-20 송택선 신규한 5-피롤릴-2-피리딜메틸설피닐벤즈이미다졸 유도체
WO2000076519A1 (en) 1999-06-10 2000-12-21 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220065235A (ko) 2020-11-13 2022-05-20 주식회사 파마코스텍 일라프라졸 혼형 결정의 신규한 제조방법
KR102250509B1 (ko) 2020-12-09 2021-05-11 유니셀랩 주식회사 새로운 일라프라졸/자일리톨 공결정
KR20210019469A (ko) 2021-02-02 2021-02-22 주식회사 파마코스텍 일라프라졸 나트륨 결정형 및 신규한 제조방법
KR20250156870A (ko) 2024-04-25 2025-11-04 엠에프씨 주식회사 일라프라졸 마그네슘염 수화물의 제조방법

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Publication number Publication date
CA2674358A1 (en) 2008-07-10
RU2466129C2 (ru) 2012-11-10
CA2674347A1 (en) 2008-07-10
AU2007341992A1 (en) 2008-07-10
JP2010514807A (ja) 2010-05-06
HK1140483A1 (en) 2010-10-15
RU2009122242A (ru) 2011-02-10
JP5315253B2 (ja) 2013-10-16
KR20090086121A (ko) 2009-08-10
AU2007341992B2 (en) 2012-07-05
EP2102191A1 (en) 2009-09-23
KR20110091594A (ko) 2011-08-11
RU2009122241A (ru) 2011-02-10
CN101687849A (zh) 2010-03-31
CN101687848A (zh) 2010-03-31
ES2398846T3 (es) 2013-03-22
US20110046184A1 (en) 2011-02-24
US8592600B2 (en) 2013-11-26
HK1140484A1 (en) 2010-10-15
KR20090086615A (ko) 2009-08-13
PL2102192T3 (pl) 2013-04-30
DK2102192T3 (da) 2013-03-04
CA2674347C (en) 2013-08-06
NO342530B1 (no) 2018-06-11
JP5315254B2 (ja) 2013-10-16
IL199242A (en) 2013-10-31
US20080200516A1 (en) 2008-08-21
PT2102192E (pt) 2013-01-23
RU2464270C2 (ru) 2012-10-20
CN101687849B (zh) 2013-05-29
WO2008083341A1 (en) 2008-07-10
NO20092464L (no) 2009-09-28
CA2674358C (en) 2013-10-08
CN101687848B (zh) 2013-05-15
MY145936A (en) 2012-05-31
EP2102192B1 (en) 2012-11-14
WO2008083333A1 (en) 2008-07-10
US7999110B2 (en) 2011-08-16
MY146462A (en) 2012-08-15
AU2007341984A1 (en) 2008-07-10
JP2010514806A (ja) 2010-05-06
IL199234A (en) 2013-07-31
US20110082174A1 (en) 2011-04-07
EP2102191B1 (en) 2012-11-21
MX2009006530A (es) 2009-08-18
US7989632B2 (en) 2011-08-02
EP2102192A1 (en) 2009-09-23
NZ577129A (en) 2012-02-24
US20080200517A1 (en) 2008-08-21
MX2009006529A (es) 2009-08-18
NO20092398L (no) 2009-09-28
NZ577509A (en) 2012-01-12
US8592599B2 (en) 2013-11-26
AU2007341984B2 (en) 2012-07-05

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