MX2009006529A - Formas cristalinas de ilaprazol solvatado. - Google Patents

Formas cristalinas de ilaprazol solvatado.

Info

Publication number
MX2009006529A
MX2009006529A MX2009006529A MX2009006529A MX2009006529A MX 2009006529 A MX2009006529 A MX 2009006529A MX 2009006529 A MX2009006529 A MX 2009006529A MX 2009006529 A MX2009006529 A MX 2009006529A MX 2009006529 A MX2009006529 A MX 2009006529A
Authority
MX
Mexico
Prior art keywords
ilaprazole
crystalline forms
methyl
relates
gastric acid
Prior art date
Application number
MX2009006529A
Other languages
English (en)
Inventor
John M Brackett
David T Jonaitis
Wei Lai
Stephan D Parent
Original Assignee
Il Yang Pharmaceutical Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Il Yang Pharmaceutical Company filed Critical Il Yang Pharmaceutical Company
Publication of MX2009006529A publication Critical patent/MX2009006529A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención se refiere a formas cristalinas de varios solvatos de ilaprazol, 2[[(4-metoxi-3-metil-2-piridinil)-metil]sulfinil]-5- (1H-pirrol-1-il)-1H-bencimidazol. La invención se refiere también a una composición farmacéutica para inhibir la secreción de ácido gástrico, que comprende hidrato de ilaprazol cristalino de acuerdo con la invención, en una cantidad efectiva para inhibir la secreción de ácido gástrico, y un portador aceptable para uso farmacéutico. La invención provee también métodos de tratamiento para diversos trastornos gastrointestinales (GI) relacionados con el ácido.
MX2009006529A 2006-12-29 2007-12-28 Formas cristalinas de ilaprazol solvatado. MX2009006529A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87760806P 2006-12-29 2006-12-29
US88749907P 2007-01-31 2007-01-31
PCT/US2007/089137 WO2008083341A1 (en) 2006-12-29 2007-12-28 Crystalline forms of solvated ilaprazole

Publications (1)

Publication Number Publication Date
MX2009006529A true MX2009006529A (es) 2009-08-18

Family

ID=39313094

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2009006530A MX2009006530A (es) 2006-12-29 2007-12-28 Formas de estado solido de ilaprazol racemico.
MX2009006529A MX2009006529A (es) 2006-12-29 2007-12-28 Formas cristalinas de ilaprazol solvatado.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2009006530A MX2009006530A (es) 2006-12-29 2007-12-28 Formas de estado solido de ilaprazol racemico.

Country Status (19)

Country Link
US (4) US7989632B2 (es)
EP (2) EP2102192B1 (es)
JP (2) JP5315254B2 (es)
KR (3) KR101052387B1 (es)
CN (2) CN101687849B (es)
AU (2) AU2007341992B2 (es)
CA (2) CA2674347C (es)
DK (1) DK2102192T3 (es)
ES (1) ES2398846T3 (es)
HK (2) HK1140483A1 (es)
IL (2) IL199234A (es)
MX (2) MX2009006530A (es)
MY (2) MY146462A (es)
NO (2) NO20092398L (es)
NZ (2) NZ577129A (es)
PL (1) PL2102192T3 (es)
PT (1) PT2102192E (es)
RU (2) RU2466129C2 (es)
WO (2) WO2008083333A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101144600B1 (ko) * 2009-12-08 2012-05-16 일양약품주식회사 일라프라졸의 결정형 ａ, ｂ의 제조방법 및 이들 결정형의 변환방법
CN103204843B (zh) * 2012-01-13 2014-12-31 丽珠医药集团股份有限公司 结晶型艾普拉唑钠乙醇化物及其制备方法
CN103204842B (zh) * 2012-01-13 2014-10-15 丽珠医药集团股份有限公司 结晶型艾普拉唑钠水合物及其制备方法
WO2013114232A1 (en) * 2012-02-02 2013-08-08 Lupin Limited Process for preparation of crystalline form l of ilaprazole
CN102746277B (zh) * 2012-06-21 2014-05-14 丽珠医药集团股份有限公司 一种结晶形式的艾普拉唑钠及其制备方法
CN102746275B (zh) * 2012-06-21 2014-07-16 丽珠医药集团股份有限公司 结晶型艾普拉唑钠及其制备方法
CN103172618B (zh) * 2013-02-27 2014-09-03 丽珠医药集团股份有限公司 艾普拉唑晶型及其制备方法
CN104370886B (zh) * 2014-11-18 2016-05-18 宁夏康亚药业有限公司 艾普拉唑晶型及其制备方法和应用
CN105055342A (zh) * 2015-08-13 2015-11-18 青岛蓝盛洋医药生物科技有限责任公司 一种治疗消化性溃疡的药物艾普拉唑钠组合物冻干粉针剂
CN105055343A (zh) * 2015-08-31 2015-11-18 青岛蓝盛洋医药生物科技有限责任公司 一种治疗胃病的药物艾普拉唑钠组合物冻干粉针剂
CN106749191A (zh) * 2016-12-10 2017-05-31 珠海保税区丽珠合成制药有限公司 艾普拉唑晶型ⅱ及其制备方法
KR101961028B1 (ko) * 2017-10-12 2019-03-21 중앙대학교 산학협력단 일라프라졸을 유효성분으로 함유하는 급성 위염의 예방 또는 치료용 약학 조성물
KR102332996B1 (ko) * 2020-04-13 2021-12-01 중앙대학교 산학협력단 일라프라졸을 유효성분으로 함유하는 장폐색증 예방 또는 치료용 약학조성물
KR20220065235A (ko) 2020-11-13 2022-05-20 주식회사 파마코스텍 일라프라졸 혼형 결정의 신규한 제조방법
KR102250509B1 (ko) 2020-12-09 2021-05-11 유니셀랩 주식회사 새로운 일라프라졸/자일리톨 공결정
KR20210019469A (ko) 2021-02-02 2021-02-22 주식회사 파마코스텍 일라프라졸 나트륨 결정형 및 신규한 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0179401B1 (ko) * 1994-02-28 1999-03-20 송택선 신규한 5-피롤릴-2-피리딜메틸설피닐벤즈이미다졸 유도체
US6331539B1 (en) 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
RU2232159C2 (ru) * 1999-07-29 2004-07-10 Регентский Совет Университета Калифорнии Производные бензимидазола и фармацевтические композиции, содержащие пролекарство ингибитора протонного насоса
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
KR20040093187A (ko) 2002-03-27 2004-11-04 테바 파마슈티컬 인더스트리즈 리미티드 란소프라졸 다형 및 그것의 제조 방법
CA2597632C (en) 2005-03-25 2012-05-15 Livzon Pharmaceutical Group Inc. Substituted sulfoxide compounds, methods for preparing the same and use thereof
WO2006118534A1 (en) * 2005-05-04 2006-11-09 Astrazeneca Ab Proton pump inhibitors in the treatment of sleep disturbance due to silent gastro-esophageal reflux

Also Published As

Publication number Publication date
CN101687848B (zh) 2013-05-15
MY146462A (en) 2012-08-15
NZ577509A (en) 2012-01-12
MY145936A (en) 2012-05-31
RU2466129C2 (ru) 2012-11-10
JP5315253B2 (ja) 2013-10-16
RU2464270C2 (ru) 2012-10-20
RU2009122241A (ru) 2011-02-10
PL2102192T3 (pl) 2013-04-30
CA2674347C (en) 2013-08-06
ES2398846T3 (es) 2013-03-22
WO2008083333A1 (en) 2008-07-10
HK1140483A1 (en) 2010-10-15
MX2009006530A (es) 2009-08-18
AU2007341984A1 (en) 2008-07-10
AU2007341992A1 (en) 2008-07-10
US8592600B2 (en) 2013-11-26
IL199242A (en) 2013-10-31
JP2010514806A (ja) 2010-05-06
CN101687849B (zh) 2013-05-29
US20110082174A1 (en) 2011-04-07
KR20110091594A (ko) 2011-08-11
DK2102192T3 (da) 2013-03-04
EP2102192A1 (en) 2009-09-23
US7999110B2 (en) 2011-08-16
PT2102192E (pt) 2013-01-23
NO342530B1 (no) 2018-06-11
NO20092398L (no) 2009-09-28
US20080200516A1 (en) 2008-08-21
KR20090086121A (ko) 2009-08-10
AU2007341984B2 (en) 2012-07-05
JP5315254B2 (ja) 2013-10-16
CA2674347A1 (en) 2008-07-10
CN101687849A (zh) 2010-03-31
NO20092464L (no) 2009-09-28
KR101052387B1 (ko) 2011-07-28
EP2102191A1 (en) 2009-09-23
CA2674358A1 (en) 2008-07-10
US7989632B2 (en) 2011-08-02
EP2102192B1 (en) 2012-11-14
AU2007341992B2 (en) 2012-07-05
RU2009122242A (ru) 2011-02-10
CN101687848A (zh) 2010-03-31
WO2008083341A1 (en) 2008-07-10
EP2102191B1 (en) 2012-11-21
HK1140484A1 (en) 2010-10-15
CA2674358C (en) 2013-10-08
NZ577129A (en) 2012-02-24
US20080200517A1 (en) 2008-08-21
KR20090086615A (ko) 2009-08-13
IL199234A (en) 2013-07-31
US20110046184A1 (en) 2011-02-24
US8592599B2 (en) 2013-11-26
JP2010514807A (ja) 2010-05-06

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