KR101025675B1 - 키나제 억제제로서 유용한 피롤로-트리아진 아닐린 화합물 - Google Patents

키나제 억제제로서 유용한 피롤로-트리아진 아닐린 화합물 Download PDF

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KR101025675B1
KR101025675B1 KR1020047017020A KR20047017020A KR101025675B1 KR 101025675 B1 KR101025675 B1 KR 101025675B1 KR 1020047017020 A KR1020047017020 A KR 1020047017020A KR 20047017020 A KR20047017020 A KR 20047017020A KR 101025675 B1 KR101025675 B1 KR 101025675B1
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alkyl
compound
mmol
optionally substituted
phenyl
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KR20040102157A (ko
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알라릭 디크만
존 하인즈
카테리나 레프트헤리스
춘쟌 류
스티븐 티. 로블스키
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브리스톨-마이어스 스큅 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines

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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
KR1020047017020A 2002-04-23 2003-04-15 키나제 억제제로서 유용한 피롤로-트리아진 아닐린 화합물 Expired - Fee Related KR101025675B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37493802P 2002-04-23 2002-04-23
US60/374,938 2002-04-23
PCT/US2003/012426 WO2003090912A1 (en) 2002-04-23 2003-04-15 Pyrrolo-triazine aniline compounds useful as kinase inhibitors

Publications (2)

Publication Number Publication Date
KR20040102157A KR20040102157A (ko) 2004-12-03
KR101025675B1 true KR101025675B1 (ko) 2011-03-30

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KR1020047017020A Expired - Fee Related KR101025675B1 (ko) 2002-04-23 2003-04-15 키나제 억제제로서 유용한 피롤로-트리아진 아닐린 화합물

Country Status (30)

Country Link
US (5) US7160883B2 (enExample)
EP (2) EP2289894A3 (enExample)
JP (2) JP4669225B2 (enExample)
KR (1) KR101025675B1 (enExample)
CN (2) CN102093363B (enExample)
AR (1) AR039649A1 (enExample)
AU (1) AU2003231034B2 (enExample)
BR (1) BR0309669A (enExample)
CA (1) CA2483164C (enExample)
DK (1) DK1497019T3 (enExample)
ES (1) ES2543711T3 (enExample)
GE (1) GEP20074148B (enExample)
HR (1) HRP20040988A2 (enExample)
HU (1) HUE025353T2 (enExample)
IL (2) IL164573A (enExample)
IS (1) IS7505A (enExample)
MX (1) MXPA04010379A (enExample)
MY (1) MY132094A (enExample)
NO (1) NO329503B1 (enExample)
NZ (1) NZ536014A (enExample)
PE (1) PE20040590A1 (enExample)
PL (1) PL219736B1 (enExample)
PT (1) PT1497019E (enExample)
RS (1) RS92004A (enExample)
RU (1) RU2375363C2 (enExample)
SI (1) SI1497019T1 (enExample)
TW (1) TWI312782B (enExample)
UA (1) UA78562C2 (enExample)
WO (1) WO2003090912A1 (enExample)
ZA (1) ZA200408541B (enExample)

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US6670357B2 (en) * 2000-11-17 2003-12-30 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
US6867300B2 (en) 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
BR0309669A (pt) * 2002-04-23 2005-03-01 Bristol Myers Squibb Co Compostos de anilina de pirrolo-triazina úteis como inibidores de cinase
TW200400034A (en) 2002-05-20 2004-01-01 Bristol Myers Squibb Co Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
TW200401638A (en) * 2002-06-20 2004-02-01 Bristol Myers Squibb Co Heterocyclic inhibitors of kinases
TWI329112B (en) * 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
AU2003265349A1 (en) * 2002-08-02 2004-02-23 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
TW200420565A (en) * 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
US7034151B2 (en) 2003-02-05 2006-04-25 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine kinase inhibitors
EP1667983A4 (en) * 2003-09-23 2010-07-21 Merck Sharp & Dohme PYRAZOL MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
US7419978B2 (en) * 2003-10-22 2008-09-02 Bristol-Myers Squibb Company Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
US7309708B2 (en) * 2003-11-20 2007-12-18 Birstol-Myers Squibb Company Hepatitis C virus inhibitors
CA2548571A1 (en) * 2003-12-10 2005-06-30 Merck Patent Gmbh Diacylhydrazine derivatives
US7102001B2 (en) 2003-12-12 2006-09-05 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine
DE602004025504D1 (de) * 2003-12-23 2010-03-25 Novartis Ag Bicyclische heterocyclische p-38-kinase-inhibitoren
US7064203B2 (en) 2003-12-29 2006-06-20 Bristol Myers Squibb Company Di-substituted pyrrolotriazine compounds
MY145634A (en) 2003-12-29 2012-03-15 Bristol Myers Squibb Co Pyrrolotriazine compounds as kinase inhibitors
US7459562B2 (en) * 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) * 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7102002B2 (en) 2004-06-16 2006-09-05 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7439246B2 (en) * 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US7432373B2 (en) * 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US7173031B2 (en) * 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
TW200600513A (en) 2004-06-30 2006-01-01 Bristol Myers Squibb Co A method for preparing pyrrolotriazine compounds
US7253167B2 (en) * 2004-06-30 2007-08-07 Bristol-Myers Squibb Company Tricyclic-heteroaryl compounds useful as kinase inhibitors
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