KR100991641B1 - 저콜레스테린혈증 화제용 소이(ｓｏｙ）7Ｓ글로불린알파’서브유닛의 효소적 수식과 추출, 정제 공정 - Google Patents

저콜레스테린혈증 화제용 소이(ｓｏｙ）7Ｓ글로불린알파’서브유닛의 효소적 수식과 추출, 정제 공정 Download PDF

Info

Publication number
KR100991641B1
KR100991641B1 KR1020047011441A KR20047011441A KR100991641B1 KR 100991641 B1 KR100991641 B1 KR 100991641B1 KR 1020047011441 A KR1020047011441 A KR 1020047011441A KR 20047011441 A KR20047011441 A KR 20047011441A KR 100991641 B1 KR100991641 B1 KR 100991641B1
Authority
KR
South Korea
Prior art keywords
subunit
conglycinin
soy
polypeptide fragment
matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020047011441A
Other languages
English (en)
Korean (ko)
Other versions
KR20040077786A (ko
Inventor
마셀로 두란티
파올로 모라쪼니
Original Assignee
인데나 에스피아
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 인데나 에스피아 filed Critical 인데나 에스피아
Publication of KR20040077786A publication Critical patent/KR20040077786A/ko
Application granted granted Critical
Publication of KR100991641B1 publication Critical patent/KR100991641B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/14—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from leguminous or other vegetable seeds; from press-cake or oil-bearing seeds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/14—Vegetable proteins
    • A23J3/16—Vegetable proteins from soybean
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/185—Vegetable proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C13—SUGAR INDUSTRY
    • C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
    • C13K1/00—Glucose; Glucose-containing syrups
    • C13K1/06—Glucose; Glucose-containing syrups obtained by saccharification of starch or raw materials containing starch
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
KR1020047011441A 2002-01-29 2003-01-27 저콜레스테린혈증 화제용 소이(ｓｏｙ）7Ｓ글로불린알파’서브유닛의 효소적 수식과 추출, 정제 공정 Expired - Fee Related KR100991641B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2002A000147 2002-01-29
IT2002MI000147A ITMI20020147A1 (it) 2002-01-29 2002-01-29 Estrazione purificazione e modificazione di polipeptidi da seme di soia
PCT/EP2003/000798 WO2003063608A1 (en) 2002-01-29 2003-01-27 A process for the extraction, purification and enzymatic modification of soy 7s globulin alpha' subunit for use as hypocholesterolemizing agent

Publications (2)

Publication Number Publication Date
KR20040077786A KR20040077786A (ko) 2004-09-06
KR100991641B1 true KR100991641B1 (ko) 2010-11-04

Family

ID=11449014

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047011441A Expired - Fee Related KR100991641B1 (ko) 2002-01-29 2003-01-27 저콜레스테린혈증 화제용 소이(ｓｏｙ）7Ｓ글로불린알파’서브유닛의 효소적 수식과 추출, 정제 공정

Country Status (20)

Country Link
US (3) US7465467B2 (enExample)
EP (1) EP1469741B1 (enExample)
JP (1) JP4522706B2 (enExample)
KR (1) KR100991641B1 (enExample)
CN (1) CN100558243C (enExample)
AT (1) ATE341943T1 (enExample)
AU (1) AU2003208346B8 (enExample)
CA (1) CA2474106C (enExample)
CY (1) CY1107514T1 (enExample)
DE (1) DE60308994T2 (enExample)
DK (1) DK1469741T3 (enExample)
ES (1) ES2274208T3 (enExample)
IL (1) IL163225A (enExample)
IT (1) ITMI20020147A1 (enExample)
NO (1) NO327156B1 (enExample)
PL (1) PL209342B1 (enExample)
PT (1) PT1469741E (enExample)
RU (1) RU2300898C2 (enExample)
SG (1) SG152048A1 (enExample)
WO (1) WO2003063608A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6171640B1 (en) * 1997-04-04 2001-01-09 Monsanto Company High beta-conglycinin products and their use
EP1561384B1 (en) * 2002-11-12 2007-10-10 Fuji Oil Company, Ltd. Fractionated soybean protein and process for producing the same
JP4687463B2 (ja) * 2003-12-11 2011-05-25 不二製油株式会社 改良大豆７ｓたん白及びその製造法
JP5382840B2 (ja) * 2005-08-23 2014-01-08 特定非営利活動法人プライメイト・アゴラ サルモデルで薬効が確認された骨粗鬆症の予防又は治療剤
EP2384124B1 (en) * 2008-12-31 2015-09-16 Solae, Llc Protein hydrolysate compositions
EP2264054A1 (en) * 2009-06-17 2010-12-22 Indena S.p.A. Cloning, yeast expression, purification and biological activity of a truncated form of the soybean 7S globulin alfa ' subunit involved in Hep G2 cell cholesterol homeostasis
SI2264055T1 (sl) * 2009-06-17 2014-05-30 Indena S.P.A. Kloniranje, izraĺ˝anje v kvasovki, äśiĺ äśenje in bioloĺ ka aktivnost ekstenzijske regije alfa'podenote sojinega 7s globulina udeleĺ˝ene pri homeostazi holesterola hepg2 celice
CN101904406B (zh) * 2010-07-02 2012-07-25 山西大学 一种葵花籽多肽的制备方法和用途
CN104163767B (zh) * 2014-07-25 2017-01-18 湖北泓肽生物科技有限公司 一种氨基酸和多肽水溶性物质的纯化方法
CN114874301A (zh) * 2022-05-10 2022-08-09 吉林农业大学 不同亚基组成β-伴大豆球蛋白的制备方法及应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409248A (en) 1981-08-10 1983-10-11 A. E. Staley Manufacturing Company Heat-gelling and foam-stabilizing enzymatically modified vegetable isolates
JPH06197788A (ja) 1993-01-06 1994-07-19 Fuji Oil Co Ltd 蛋白質の製造法
DE69700759T2 (de) * 1996-03-28 2000-05-31 Fuji Oil Co., Ltd. Verfahren zur Herstellung eines Sojaproteinhydrolysats
ATE347604T1 (de) * 1996-06-14 2006-12-15 Du Pont Suppressi0n spezifischer klassen von soja- sojasamenproteingenen
US6171640B1 (en) * 1997-04-04 2001-01-09 Monsanto Company High beta-conglycinin products and their use
US6365802B2 (en) * 1998-08-14 2002-04-02 Calgene Llc Methods for increasing stearate content in soybean oil
FR2784029B1 (fr) * 1998-10-05 2001-01-05 Pharmascience Lab Methode de prevention et/ou de traitement cosmetique des vergetures de la peau et utilisation en dermatologie
MXPA01010486A (es) * 1999-04-15 2002-03-27 Calgene Llc Secuencias de acido nucleico para proteinas implicadas en la sintesis de tocoferol.
CA2274414A1 (en) 1999-06-11 2000-12-11 Universite Laval Dietary fish protein for use in restoring normal insulin function insulin-resistant individuals
AUPQ877300A0 (en) 2000-07-13 2000-08-03 Johnson & Johnson Pacific Pty Limited Topical treatment of skin
KR101238752B1 (ko) * 2002-04-18 2013-03-06 몬산토 테크놀로지 엘엘씨 심혈관 질환의 위험성을 감소시키기 위한 오일 바디 결합 단백질 조성물 및 이의 사용 방법
EP1508573B1 (en) * 2003-08-20 2009-10-28 Seikagaku Corporation Stabilizing agent for enzymes
EP1841333A1 (en) * 2005-01-14 2007-10-10 Solae, Llc Soy protein for infant formula

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LOVATI M R ET AL: "SOYBEAN PROTEIN PRODUCTS AS REGULATORS OF LIVER LOW-DENSITY LIPOPROTEIN RECEPTORS I. INDENTIFICATION OF ACTIVE BETTA-CONGLYCININ SUBUNITS" JOURNAL OF AGRICULTURAL AND FOOD CHEMISTR
MANZONI C ET AL: "Soybean protein products as regulators of liver low-density lipoprotein receptors. II. alpha alpha su rich commercial soy concentrate and alpha su deficient mutant differently affect

Also Published As

Publication number Publication date
CN1622760A (zh) 2005-06-01
US20080261885A1 (en) 2008-10-23
NO20043186L (no) 2004-07-26
DK1469741T3 (da) 2007-02-19
CA2474106A1 (en) 2003-08-07
US20110118182A1 (en) 2011-05-19
AU2003208346B8 (en) 2008-07-10
PT1469741E (pt) 2007-01-31
IL163225A (en) 2007-06-17
US20050164337A1 (en) 2005-07-28
NO327156B1 (no) 2009-05-04
AU2003208346A2 (en) 2003-09-02
CN100558243C (zh) 2009-11-11
DE60308994T2 (de) 2007-06-14
PL209342B1 (pl) 2011-08-31
DE60308994D1 (de) 2006-11-23
PL370294A1 (en) 2005-05-16
US7901718B2 (en) 2011-03-08
RU2004123201A (ru) 2005-10-27
KR20040077786A (ko) 2004-09-06
ATE341943T1 (de) 2006-11-15
EP1469741A1 (en) 2004-10-27
EP1469741B1 (en) 2006-10-11
RU2300898C2 (ru) 2007-06-20
CA2474106C (en) 2011-11-22
HK1073590A1 (zh) 2005-10-14
WO2003063608A1 (en) 2003-08-07
SG152048A1 (en) 2009-05-29
ITMI20020147A1 (it) 2003-07-29
AU2003208346B2 (en) 2008-03-06
JP4522706B2 (ja) 2010-08-11
ES2274208T3 (es) 2007-05-16
JP2005516043A (ja) 2005-06-02
CY1107514T1 (el) 2013-03-13
US8257758B2 (en) 2012-09-04
ITMI20020147A0 (it) 2002-01-29
US7465467B2 (en) 2008-12-16

Similar Documents

Publication Publication Date Title
US8257758B2 (en) Process for the extraction, purification and enzymatic modification of soy 7S globulin alpha' subunit for use as hypocholesterolemizing agent
US11241470B2 (en) Phaseolus vulgaris extracts, their use and formulations containing them
JP5504301B2 (ja) Ｉｉ型糖尿病の治療のためのルーピンコングルチンの使用
AU2003208346A1 (en) A process for the extraction, purification and enzymatic modification of soy 7S globulin alpha' subunit for use as hypocholesterolemizing agent
JPH05236909A (ja) グルタミン含量の高いペプチド組成物、その製造方法及び経腸栄養剤
JP4461680B2 (ja) 血中中性脂肪低減用組成物
JPH1129594A (ja) アンジオテンシン変換酵素阻害物質、その製造方法およびそれを用いた血圧降下剤
HK1073590B (en) A process for the extraction, purification and enzymatic modification of soy 7s globulin alpha' subunit for use as hypocholesterolemizing agent
CN120795074A (zh) 缓解卵巢衰退的海参卵肽及其制备方法和应用
JP4837896B2 (ja) 精力増強剤
CN120289562A (zh) 一种龙头鱼降尿酸肽及其制备方法与应用
CN120554449A (zh) 具有降尿酸作用的骆驼乳降尿酸肽及其应用
CN103014105A (zh) 利用猪股骨制备降血压肽的方法

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20131023

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

FPAY Annual fee payment

Payment date: 20140926

Year of fee payment: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

FPAY Annual fee payment

Payment date: 20151001

Year of fee payment: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

FPAY Annual fee payment

Payment date: 20160928

Year of fee payment: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

FPAY Annual fee payment

Payment date: 20170922

Year of fee payment: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20181028

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20181028