JP4522706B2 - 血中コレステロール低下剤として使用するための大豆β−コングリシニンα’サブユニットの選択的抽出、精製及び酵素的改変方法 - Google Patents
血中コレステロール低下剤として使用するための大豆β−コングリシニンα’サブユニットの選択的抽出、精製及び酵素的改変方法 Download PDFInfo
- Publication number
- JP4522706B2 JP4522706B2 JP2003563319A JP2003563319A JP4522706B2 JP 4522706 B2 JP4522706 B2 JP 4522706B2 JP 2003563319 A JP2003563319 A JP 2003563319A JP 2003563319 A JP2003563319 A JP 2003563319A JP 4522706 B2 JP4522706 B2 JP 4522706B2
- Authority
- JP
- Japan
- Prior art keywords
- subunit
- conglycinin
- soybean
- mac
- polypeptide fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000605 extraction Methods 0.000 title claims abstract description 11
- 108700037728 Glycine max beta-conglycinin Proteins 0.000 title claims description 25
- 238000000746 purification Methods 0.000 title claims description 9
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- 239000012634 fragment Substances 0.000 claims abstract description 16
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- 102000000853 LDL receptors Human genes 0.000 description 2
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Images
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/14—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from leguminous or other vegetable seeds; from press-cake or oil-bearing seeds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/14—Vegetable proteins
- A23J3/16—Vegetable proteins from soybean
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
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- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K1/00—Glucose; Glucose-containing syrups
- C13K1/06—Glucose; Glucose-containing syrups obtained by saccharification of starch or raw materials containing starch
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
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- General Health & Medical Sciences (AREA)
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- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2002A000147 | 2002-01-29 | ||
| IT2002MI000147A ITMI20020147A1 (it) | 2002-01-29 | 2002-01-29 | Estrazione purificazione e modificazione di polipeptidi da seme di soia |
| PCT/EP2003/000798 WO2003063608A1 (en) | 2002-01-29 | 2003-01-27 | A process for the extraction, purification and enzymatic modification of soy 7s globulin alpha' subunit for use as hypocholesterolemizing agent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005516043A JP2005516043A (ja) | 2005-06-02 |
| JP2005516043A5 JP2005516043A5 (enExample) | 2006-03-09 |
| JP4522706B2 true JP4522706B2 (ja) | 2010-08-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003563319A Expired - Fee Related JP4522706B2 (ja) | 2002-01-29 | 2003-01-27 | 血中コレステロール低下剤として使用するための大豆β−コングリシニンα’サブユニットの選択的抽出、精製及び酵素的改変方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7465467B2 (enExample) |
| EP (1) | EP1469741B1 (enExample) |
| JP (1) | JP4522706B2 (enExample) |
| KR (1) | KR100991641B1 (enExample) |
| CN (1) | CN100558243C (enExample) |
| AT (1) | ATE341943T1 (enExample) |
| AU (1) | AU2003208346B8 (enExample) |
| CA (1) | CA2474106C (enExample) |
| CY (1) | CY1107514T1 (enExample) |
| DE (1) | DE60308994T2 (enExample) |
| DK (1) | DK1469741T3 (enExample) |
| ES (1) | ES2274208T3 (enExample) |
| IL (1) | IL163225A (enExample) |
| IT (1) | ITMI20020147A1 (enExample) |
| NO (1) | NO327156B1 (enExample) |
| PL (1) | PL209342B1 (enExample) |
| PT (1) | PT1469741E (enExample) |
| RU (1) | RU2300898C2 (enExample) |
| SG (1) | SG152048A1 (enExample) |
| WO (1) | WO2003063608A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104163767A (zh) * | 2014-07-25 | 2014-11-26 | 湖北泓肽生物科技有限公司 | 一种氨基酸和多肽等水溶性物质的纯化方法 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6171640B1 (en) * | 1997-04-04 | 2001-01-09 | Monsanto Company | High beta-conglycinin products and their use |
| EP1561384B1 (en) * | 2002-11-12 | 2007-10-10 | Fuji Oil Company, Ltd. | Fractionated soybean protein and process for producing the same |
| JP4687463B2 (ja) * | 2003-12-11 | 2011-05-25 | 不二製油株式会社 | 改良大豆７ｓたん白及びその製造法 |
| JP5382840B2 (ja) * | 2005-08-23 | 2014-01-08 | 特定非営利活動法人プライメイト・アゴラ | サルモデルで薬効が確認された骨粗鬆症の予防又は治療剤 |
| EP2384124B1 (en) * | 2008-12-31 | 2015-09-16 | Solae, Llc | Protein hydrolysate compositions |
| EP2264054A1 (en) * | 2009-06-17 | 2010-12-22 | Indena S.p.A. | Cloning, yeast expression, purification and biological activity of a truncated form of the soybean 7S globulin alfa ' subunit involved in Hep G2 cell cholesterol homeostasis |
| SI2264055T1 (sl) * | 2009-06-17 | 2014-05-30 | Indena S.P.A. | Kloniranje, izraĺ˝anje v kvasovki, äśiĺ äśenje in bioloĺ ka aktivnost ekstenzijske regije alfa'podenote sojinega 7s globulina udeleĺ˝ene pri homeostazi holesterola hepg2 celice |
| CN101904406B (zh) * | 2010-07-02 | 2012-07-25 | 山西大学 | 一种葵花籽多肽的制备方法和用途 |
| CN114874301A (zh) * | 2022-05-10 | 2022-08-09 | 吉林农业大学 | 不同亚基组成β-伴大豆球蛋白的制备方法及应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4409248A (en) | 1981-08-10 | 1983-10-11 | A. E. Staley Manufacturing Company | Heat-gelling and foam-stabilizing enzymatically modified vegetable isolates |
| JPH06197788A (ja) | 1993-01-06 | 1994-07-19 | Fuji Oil Co Ltd | 蛋白質の製造法 |
| DE69700759T2 (de) * | 1996-03-28 | 2000-05-31 | Fuji Oil Co., Ltd. | Verfahren zur Herstellung eines Sojaproteinhydrolysats |
| ATE347604T1 (de) * | 1996-06-14 | 2006-12-15 | Du Pont | Suppressi0n spezifischer klassen von soja- sojasamenproteingenen |
| US6171640B1 (en) * | 1997-04-04 | 2001-01-09 | Monsanto Company | High beta-conglycinin products and their use |
| US6365802B2 (en) * | 1998-08-14 | 2002-04-02 | Calgene Llc | Methods for increasing stearate content in soybean oil |
| FR2784029B1 (fr) * | 1998-10-05 | 2001-01-05 | Pharmascience Lab | Methode de prevention et/ou de traitement cosmetique des vergetures de la peau et utilisation en dermatologie |
| MXPA01010486A (es) * | 1999-04-15 | 2002-03-27 | Calgene Llc | Secuencias de acido nucleico para proteinas implicadas en la sintesis de tocoferol. |
| CA2274414A1 (en) | 1999-06-11 | 2000-12-11 | Universite Laval | Dietary fish protein for use in restoring normal insulin function insulin-resistant individuals |
| AUPQ877300A0 (en) | 2000-07-13 | 2000-08-03 | Johnson & Johnson Pacific Pty Limited | Topical treatment of skin |
| KR101238752B1 (ko) * | 2002-04-18 | 2013-03-06 | 몬산토 테크놀로지 엘엘씨 | 심혈관 질환의 위험성을 감소시키기 위한 오일 바디 결합 단백질 조성물 및 이의 사용 방법 |
| EP1508573B1 (en) * | 2003-08-20 | 2009-10-28 | Seikagaku Corporation | Stabilizing agent for enzymes |
| EP1841333A1 (en) * | 2005-01-14 | 2007-10-10 | Solae, Llc | Soy protein for infant formula |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104163767A (zh) * | 2014-07-25 | 2014-11-26 | 湖北泓肽生物科技有限公司 | 一种氨基酸和多肽等水溶性物质的纯化方法 |
| CN104163767B (zh) * | 2014-07-25 | 2017-01-18 | 湖北泓肽生物科技有限公司 | 一种氨基酸和多肽水溶性物质的纯化方法 |
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