PL209342B1 - Sposób selektywnej ekstrakcji, oczyszczania i enzymatycznej modyfikacji podjednostki α' sojowej β-konglicyniny, jej fragmenty polipeptydowe i ich zastosowanie oraz kompozycje farmaceutyczne, dodatki lub produkty spożywcze zawierające te fragmenty polipeptydowe - Google Patents
Sposób selektywnej ekstrakcji, oczyszczania i enzymatycznej modyfikacji podjednostki α' sojowej β-konglicyniny, jej fragmenty polipeptydowe i ich zastosowanie oraz kompozycje farmaceutyczne, dodatki lub produkty spożywcze zawierające te fragmenty polipeptydoweInfo
- Publication number
- PL209342B1 PL209342B1 PL370294A PL37029403A PL209342B1 PL 209342 B1 PL209342 B1 PL 209342B1 PL 370294 A PL370294 A PL 370294A PL 37029403 A PL37029403 A PL 37029403A PL 209342 B1 PL209342 B1 PL 209342B1
- Authority
- PL
- Poland
- Prior art keywords
- subunit
- conglycinin
- polypeptide fragments
- treatment
- mac
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 34
- 238000000605 extraction Methods 0.000 title claims abstract description 14
- 238000000746 purification Methods 0.000 title claims abstract description 12
- 230000008569 process Effects 0.000 title claims abstract description 8
- 230000009144 enzymatic modification Effects 0.000 title claims abstract description 5
- 108010044091 Globulins Proteins 0.000 title description 2
- 102000006395 Globulins Human genes 0.000 title description 2
- 108700037728 Glycine max beta-conglycinin Proteins 0.000 claims abstract description 26
- 229920001184 polypeptide Polymers 0.000 claims abstract description 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 108090000317 Chymotrypsin Proteins 0.000 claims abstract description 10
- 229960002376 chymotrypsin Drugs 0.000 claims abstract description 10
- 238000001042 affinity chromatography Methods 0.000 claims abstract description 4
- 229910052751 metal Inorganic materials 0.000 claims abstract description 3
- 239000002184 metal Substances 0.000 claims abstract description 3
- 239000012634 fragment Substances 0.000 claims description 28
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 26
- 235000010469 Glycine max Nutrition 0.000 claims description 14
- 244000068988 Glycine max Species 0.000 claims description 13
- 102000004169 proteins and genes Human genes 0.000 claims description 13
- 108090000623 proteins and genes Proteins 0.000 claims description 13
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- 239000011159 matrix material Substances 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 10
- 239000011701 zinc Substances 0.000 claims description 8
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 7
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 7
- 235000013305 food Nutrition 0.000 claims description 7
- 238000001556 precipitation Methods 0.000 claims description 7
- 229910052725 zinc Inorganic materials 0.000 claims description 7
- 108091005804 Peptidases Proteins 0.000 claims description 6
- 102000035195 Peptidases Human genes 0.000 claims description 6
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 6
- 239000004202 carbamide Substances 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 230000002255 enzymatic effect Effects 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 230000009467 reduction Effects 0.000 claims description 6
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims description 6
- 150000003626 triacylglycerols Chemical class 0.000 claims description 6
- 230000007170 pathology Effects 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 208000031226 Hyperlipidaemia Diseases 0.000 claims description 4
- 239000000969 carrier Substances 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 235000013373 food additive Nutrition 0.000 claims description 3
- 239000002778 food additive Substances 0.000 claims description 3
- 229910052759 nickel Inorganic materials 0.000 claims description 3
- 229920000936 Agarose Polymers 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000004587 chromatography analysis Methods 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 101710094135 Beta-conglycinin alpha' subunit Proteins 0.000 abstract 1
- 239000003398 denaturant Substances 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 description 12
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 12
- 235000018102 proteins Nutrition 0.000 description 12
- 235000005911 diet Nutrition 0.000 description 7
- 230000037213 diet Effects 0.000 description 7
- 230000000260 hypercholesteremic effect Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 239000007858 starting material Substances 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 235000012000 cholesterol Nutrition 0.000 description 5
- 239000000872 buffer Substances 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 108010073771 Soybean Proteins Proteins 0.000 description 3
- 235000013312 flour Nutrition 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 102000000853 LDL receptors Human genes 0.000 description 2
- 108010001831 LDL receptors Proteins 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 description 2
- 229960001214 clofibrate Drugs 0.000 description 2
- 239000013578 denaturing buffer Substances 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 235000021590 normal diet Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229940001941 soy protein Drugs 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 229920004011 Macrolon® Polymers 0.000 description 1
- 235000019764 Soybean Meal Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- -1 bisulfite ions Chemical class 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000011026 diafiltration Methods 0.000 description 1
- 235000021004 dietary regimen Nutrition 0.000 description 1
- 238000001641 gel filtration chromatography Methods 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001631 vena cava inferior Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/14—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from leguminous or other vegetable seeds; from press-cake or oil-bearing seeds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/14—Vegetable proteins
- A23J3/16—Vegetable proteins from soybean
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K1/00—Glucose; Glucose-containing syrups
- C13K1/06—Glucose; Glucose-containing syrups obtained by saccharification of starch or raw materials containing starch
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI000147A ITMI20020147A1 (it) | 2002-01-29 | 2002-01-29 | Estrazione purificazione e modificazione di polipeptidi da seme di soia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL370294A1 PL370294A1 (en) | 2005-05-16 |
| PL209342B1 true PL209342B1 (pl) | 2011-08-31 |
Family
ID=11449014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL370294A PL209342B1 (pl) | 2002-01-29 | 2003-01-27 | Sposób selektywnej ekstrakcji, oczyszczania i enzymatycznej modyfikacji podjednostki α' sojowej β-konglicyniny, jej fragmenty polipeptydowe i ich zastosowanie oraz kompozycje farmaceutyczne, dodatki lub produkty spożywcze zawierające te fragmenty polipeptydowe |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7465467B2 (enExample) |
| EP (1) | EP1469741B1 (enExample) |
| JP (1) | JP4522706B2 (enExample) |
| KR (1) | KR100991641B1 (enExample) |
| CN (1) | CN100558243C (enExample) |
| AT (1) | ATE341943T1 (enExample) |
| AU (1) | AU2003208346B8 (enExample) |
| CA (1) | CA2474106C (enExample) |
| CY (1) | CY1107514T1 (enExample) |
| DE (1) | DE60308994T2 (enExample) |
| DK (1) | DK1469741T3 (enExample) |
| ES (1) | ES2274208T3 (enExample) |
| IL (1) | IL163225A (enExample) |
| IT (1) | ITMI20020147A1 (enExample) |
| NO (1) | NO327156B1 (enExample) |
| PL (1) | PL209342B1 (enExample) |
| PT (1) | PT1469741E (enExample) |
| RU (1) | RU2300898C2 (enExample) |
| SG (1) | SG152048A1 (enExample) |
| WO (1) | WO2003063608A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6171640B1 (en) * | 1997-04-04 | 2001-01-09 | Monsanto Company | High beta-conglycinin products and their use |
| EP1561384B1 (en) * | 2002-11-12 | 2007-10-10 | Fuji Oil Company, Ltd. | Fractionated soybean protein and process for producing the same |
| JP4687463B2 (ja) * | 2003-12-11 | 2011-05-25 | 不二製油株式会社 | 改良大豆７ｓたん白及びその製造法 |
| JP5382840B2 (ja) * | 2005-08-23 | 2014-01-08 | 特定非営利活動法人プライメイト・アゴラ | サルモデルで薬効が確認された骨粗鬆症の予防又は治療剤 |
| EP2384124B1 (en) * | 2008-12-31 | 2015-09-16 | Solae, Llc | Protein hydrolysate compositions |
| EP2264054A1 (en) * | 2009-06-17 | 2010-12-22 | Indena S.p.A. | Cloning, yeast expression, purification and biological activity of a truncated form of the soybean 7S globulin alfa ' subunit involved in Hep G2 cell cholesterol homeostasis |
| SI2264055T1 (sl) * | 2009-06-17 | 2014-05-30 | Indena S.P.A. | Kloniranje, izraĺ˝anje v kvasovki, äśiĺ äśenje in bioloĺ ka aktivnost ekstenzijske regije alfa'podenote sojinega 7s globulina udeleĺ˝ene pri homeostazi holesterola hepg2 celice |
| CN101904406B (zh) * | 2010-07-02 | 2012-07-25 | 山西大学 | 一种葵花籽多肽的制备方法和用途 |
| CN104163767B (zh) * | 2014-07-25 | 2017-01-18 | 湖北泓肽生物科技有限公司 | 一种氨基酸和多肽水溶性物质的纯化方法 |
| CN114874301A (zh) * | 2022-05-10 | 2022-08-09 | 吉林农业大学 | 不同亚基组成β-伴大豆球蛋白的制备方法及应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4409248A (en) | 1981-08-10 | 1983-10-11 | A. E. Staley Manufacturing Company | Heat-gelling and foam-stabilizing enzymatically modified vegetable isolates |
| JPH06197788A (ja) | 1993-01-06 | 1994-07-19 | Fuji Oil Co Ltd | 蛋白質の製造法 |
| DE69700759T2 (de) * | 1996-03-28 | 2000-05-31 | Fuji Oil Co., Ltd. | Verfahren zur Herstellung eines Sojaproteinhydrolysats |
| ATE347604T1 (de) * | 1996-06-14 | 2006-12-15 | Du Pont | Suppressi0n spezifischer klassen von soja- sojasamenproteingenen |
| US6171640B1 (en) * | 1997-04-04 | 2001-01-09 | Monsanto Company | High beta-conglycinin products and their use |
| US6365802B2 (en) * | 1998-08-14 | 2002-04-02 | Calgene Llc | Methods for increasing stearate content in soybean oil |
| FR2784029B1 (fr) * | 1998-10-05 | 2001-01-05 | Pharmascience Lab | Methode de prevention et/ou de traitement cosmetique des vergetures de la peau et utilisation en dermatologie |
| MXPA01010486A (es) * | 1999-04-15 | 2002-03-27 | Calgene Llc | Secuencias de acido nucleico para proteinas implicadas en la sintesis de tocoferol. |
| CA2274414A1 (en) | 1999-06-11 | 2000-12-11 | Universite Laval | Dietary fish protein for use in restoring normal insulin function insulin-resistant individuals |
| AUPQ877300A0 (en) | 2000-07-13 | 2000-08-03 | Johnson & Johnson Pacific Pty Limited | Topical treatment of skin |
| KR101238752B1 (ko) * | 2002-04-18 | 2013-03-06 | 몬산토 테크놀로지 엘엘씨 | 심혈관 질환의 위험성을 감소시키기 위한 오일 바디 결합 단백질 조성물 및 이의 사용 방법 |
| EP1508573B1 (en) * | 2003-08-20 | 2009-10-28 | Seikagaku Corporation | Stabilizing agent for enzymes |
| EP1841333A1 (en) * | 2005-01-14 | 2007-10-10 | Solae, Llc | Soy protein for infant formula |
-
2002
- 2002-01-29 IT IT2002MI000147A patent/ITMI20020147A1/it unknown
-
2003
- 2003-01-27 SG SG200506973-7A patent/SG152048A1/en unknown
- 2003-01-27 RU RU2004123201/13A patent/RU2300898C2/ru not_active IP Right Cessation
- 2003-01-27 US US10/502,582 patent/US7465467B2/en not_active Expired - Fee Related
- 2003-01-27 WO PCT/EP2003/000798 patent/WO2003063608A1/en not_active Ceased
- 2003-01-27 DK DK03706387T patent/DK1469741T3/da active
- 2003-01-27 AU AU2003208346A patent/AU2003208346B8/en not_active Ceased
- 2003-01-27 CA CA2474106A patent/CA2474106C/en not_active Expired - Fee Related
- 2003-01-27 PT PT03706387T patent/PT1469741E/pt unknown
- 2003-01-27 AT AT03706387T patent/ATE341943T1/de active
- 2003-01-27 JP JP2003563319A patent/JP4522706B2/ja not_active Expired - Fee Related
- 2003-01-27 ES ES03706387T patent/ES2274208T3/es not_active Expired - Lifetime
- 2003-01-27 KR KR1020047011441A patent/KR100991641B1/ko not_active Expired - Fee Related
- 2003-01-27 EP EP03706387A patent/EP1469741B1/en not_active Expired - Lifetime
- 2003-01-27 CN CNB038028050A patent/CN100558243C/zh not_active Expired - Fee Related
- 2003-01-27 DE DE60308994T patent/DE60308994T2/de not_active Expired - Lifetime
- 2003-01-27 PL PL370294A patent/PL209342B1/pl unknown
-
2004
- 2004-07-27 NO NO20043186A patent/NO327156B1/no not_active IP Right Cessation
- 2004-07-27 IL IL163225A patent/IL163225A/en not_active IP Right Cessation
-
2006
- 2006-11-28 CY CY20061101709T patent/CY1107514T1/el unknown
-
2008
- 2008-04-17 US US12/104,473 patent/US7901718B2/en not_active Expired - Fee Related
-
2011
- 2011-01-26 US US13/013,966 patent/US8257758B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8257758B2 (en) | Process for the extraction, purification and enzymatic modification of soy 7S globulin alpha' subunit for use as hypocholesterolemizing agent | |
| Chen et al. | Evaluating nutritional quality of single stage-and two stage-fermented soybean meal | |
| JP5504301B2 (ja) | Ｉｉ型糖尿病の治療のためのルーピンコングルチンの使用 | |
| EP1494536B1 (en) | Oil body associated protein compositions and methods of use thereof for reducing the risk of cardiovascular disease | |
| Higuchi et al. | Participation of lectin in biological effects of raw winged bean seeds on rats | |
| AU2003208346A1 (en) | A process for the extraction, purification and enzymatic modification of soy 7S globulin alpha' subunit for use as hypocholesterolemizing agent | |
| CN116987147A (zh) | 一种具有体内抗氧化活性的枸杞蛋白肽及其制备方法 | |
| JPWO2002026243A1 (ja) | 血中中性脂肪低減用組成物 | |
| EP3666269A1 (en) | Blood flow improver | |
| HK1073590B (en) | A process for the extraction, purification and enzymatic modification of soy 7s globulin alpha' subunit for use as hypocholesterolemizing agent | |
| Czerwiński et al. | Response of rats to a moderate intake of soyabean lectin | |
| WO2007075448A2 (en) | Method for producing plant extracts enriched with protease inhibitors for regulation of appetite and food intake in mammals | |
| CN117551174B (zh) | 一种源自翅果油树种仁油粕的多肽及辅助抗炎抗氧化的降血脂组合物 | |
| KR20040022392A (ko) | 김 단백질을 함유한 조성물 및 식품 | |
| CN120795074A (zh) | 缓解卵巢衰退的海参卵肽及其制备方法和应用 | |
| De Groot et al. | Presented in part at the 35th Annual Meeting of the Institute of Food Technologists, Chicago, June 1975. | |
| CN1681524A (zh) | 降低身体脂肪百分比的药剂或身体脂肪百分比增加抑制剂 |