KR100882066B1 - 비결정 아토르바스타틴 칼슘의 제조방법 - Google Patents

비결정 아토르바스타틴 칼슘의 제조방법 Download PDF

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Publication number
KR100882066B1
KR100882066B1 KR1020037009509A KR20037009509A KR100882066B1 KR 100882066 B1 KR100882066 B1 KR 100882066B1 KR 1020037009509 A KR1020037009509 A KR 1020037009509A KR 20037009509 A KR20037009509 A KR 20037009509A KR 100882066 B1 KR100882066 B1 KR 100882066B1
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South Korea
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solution
atorvastatin
process according
calcium
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Korean (ko)
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KR20030077003A (ko
Inventor
고라즈드솔사크
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레크 파마슈티칼 앤드 케미칼 컴퍼니 디.디.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020037009509A 2001-01-23 2002-01-22 비결정 아토르바스타틴 칼슘의 제조방법 Expired - Fee Related KR100882066B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SI200100010A SI20814A (sl) 2001-01-23 2001-01-23 Priprava amorfnega atorvastatina
SIP-01100010 2001-01-23
SIP-200100010 2001-01-23
PCT/IB2002/000161 WO2002059087A1 (en) 2001-01-23 2002-01-22 Preparation of non-crystalline atorvastatin calcium

Publications (2)

Publication Number Publication Date
KR20030077003A KR20030077003A (ko) 2003-09-29
KR100882066B1 true KR100882066B1 (ko) 2009-02-10

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KR1020037009509A Expired - Fee Related KR100882066B1 (ko) 2001-01-23 2002-01-22 비결정 아토르바스타틴 칼슘의 제조방법

Country Status (27)

Country Link
US (2) US6750353B2 (enExample)
EP (1) EP1373202B1 (enExample)
JP (1) JP4336106B2 (enExample)
KR (1) KR100882066B1 (enExample)
CN (1) CN1260213C (enExample)
AT (1) ATE294159T1 (enExample)
AU (1) AU2002219455B2 (enExample)
BG (1) BG108017A (enExample)
BR (1) BR0206637A (enExample)
CA (1) CA2435954C (enExample)
CZ (1) CZ20031988A3 (enExample)
DE (1) DE60203894T2 (enExample)
DK (1) DK1373202T3 (enExample)
EE (1) EE05270B1 (enExample)
ES (1) ES2240748T3 (enExample)
HR (1) HRP20030575B1 (enExample)
HU (1) HU227535B1 (enExample)
IL (2) IL157068A0 (enExample)
MX (1) MXPA03006548A (enExample)
PL (1) PL209428B1 (enExample)
RS (1) RS51010B (enExample)
RU (1) RU2324679C2 (enExample)
SI (2) SI20814A (enExample)
SK (1) SK286593B6 (enExample)
UA (1) UA73829C2 (enExample)
WO (1) WO2002059087A1 (enExample)
ZA (1) ZA200305307B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101050722B1 (ko) 2008-12-02 2011-07-21 대웅바이오 주식회사 무정형 아토르바스타틴 칼슘염의 제조방법

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US7411075B1 (en) 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
US7501450B2 (en) 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
ES2319870T3 (es) 2000-12-27 2009-05-14 Teva Pharmaceutical Industries Limited Formas cristalinas de atorvastatina.
EP1365995A2 (en) * 2001-02-27 2003-12-03 Council of Scientific and Industrial Research Essential oil composiiton for potable water disinfection
HUP0400381A2 (hu) 2001-06-29 2004-09-28 Warner-Lambert Company Llc [R-(R*,R*)]-2-(4fluorfenil)-béta, delta-dihidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)karbonil]-1H-pirrol-1-heptánsav 2:1 arányú kalciumsójának (atorvasztatin) kristályos formái
HU227124B1 (en) * 2001-09-14 2010-07-28 Egis Gyogyszergyar Nyilvanosan Polymorphs of 1-pyrrole derivative, intermediate for the preparation of atorvastatin
KR20090045420A (ko) 2002-02-19 2009-05-07 테바 파마슈티컬 인더스트리즈 리미티드 아토르바스타틴 헤미-칼슘 용매화합물의 탈용매화
ITMI20020907A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
CA2385529A1 (en) * 2002-05-21 2003-11-21 Bernard Charles Sherman Stable dosage forms comprising atorvastatin calcium
EA013500B1 (ru) * 2003-04-11 2010-06-30 Лек Фармасьютиклз Д.Д. Способ получения аморфной кальциевой соли аторвастатина
US7790197B2 (en) 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US7655692B2 (en) 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
JP2007516166A (ja) 2003-07-02 2007-06-21 エギシュ　ヂョヂセルヂャール　エルテー 血小板凝集阻害剤の無晶形の製法
AU2003247327A1 (en) * 2003-07-15 2005-01-28 Eos Eczacibasi Ozgun Kimyasal Urunler Sanyi Ve Ticaret A.S. Process for the preparation of amortphous atorvastatin calcium without interconversion of any crystalline form
AU2003272082A1 (en) * 2003-10-07 2005-04-21 Biocon Limited Process for the production of atorvastatin calcium
US7943786B2 (en) * 2003-12-29 2011-05-17 Ljubomir Antoncic Process for preparing amorphous (4R-cis)-6-[2-[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]-dioxane-4-yl-acetic acid
CA2666359A1 (en) 2004-03-17 2005-10-06 Yatendra Kumar Process for the production of atorvastatin calcium in amorphous form
US7875731B2 (en) 2004-05-05 2011-01-25 Pfizer Inc. Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)Carbonyl]-1H-pyrrole-1-heptanoic acid
AU2005263550C1 (en) * 2004-07-16 2013-01-17 Lek Pharmaceuticals D.D. Oxidative degradation products of atorvastatin calcium
CA2672554C (en) 2004-07-20 2012-01-03 Warner-Lambert Company Llc Novel forms of [r-(r*,r*)]-2-(4-fluorophenyl).beta.,.delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1)
WO2006011155A1 (en) * 2004-07-26 2006-02-02 Apollo International Limited One pot process for amorphous atorvastain calcium
WO2006021969A1 (en) * 2004-08-27 2006-03-02 Biocon Limited Process for atorvastatin calcium amorphous
EP1807055A1 (en) 2004-10-28 2007-07-18 Warner-Lambert Company LLC Process for forming amorphous atorvastatin
ES2270722B1 (es) * 2005-09-15 2008-03-01 Ercros Industrial, S.A. Procedimiento para la obtencion de atorvastatina calcica amorfa.
US20090216029A1 (en) * 2005-09-16 2009-08-27 Yatendra Kumar Process for the production of atorvastatin calcium in amorphous form
CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
DK1957452T3 (da) 2005-11-21 2010-07-26 Warner Lambert Co Nye former af [R-(R*,R*)]-2-(4-fluorphenyl)-B,B-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptansyre- magnesium
EP1810667A1 (en) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
EP1979313A1 (en) * 2006-01-31 2008-10-15 Jubilant Organosys Limited Process for the preparation of amorphous atorvastatin calcium salt
CN100406438C (zh) * 2006-06-30 2008-07-30 浙江新东港药业股份有限公司 一种无定型阿伐他汀钙的制备方法
US20100113802A1 (en) * 2006-11-02 2010-05-06 Cadila Pharmaceuticals Limited Process for preparing amorphous atorvastatin hemi calcium salt and its itermediate
KR100833439B1 (ko) * 2007-01-02 2008-05-29 씨제이제일제당 (주) 비결정형 아토르바스타틴 칼슘의 개선된 제조방법
CN101969766B (zh) * 2007-10-17 2015-05-06 托德·F·奥沃凯泰斯 固态化合物的改良方法及使用其制备的共-无定形组合物
WO2009139730A1 (en) * 2008-05-13 2009-11-19 Ulkar Kimya San. Ve Tic. A.S. Preparation of novel non-crystalline forms of atorvastatin calcium
US8115015B2 (en) * 2009-01-26 2012-02-14 Cadila Healthcare Limited Process for the preparation of amorphous atorvastatin calcium
EP2560951B1 (en) * 2010-04-19 2016-05-25 DSM Sinochem Pharmaceuticals Netherlands B.V. Production of atorvastatin low in ether impurities
HUP1000299A2 (hu) 2010-06-08 2012-02-28 Nanoform Cardiovascular Therapeutics Ltd Nanostrukturált Atorvastatint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás elõállításukra
CN102796036B (zh) * 2012-09-12 2014-06-04 江苏阿尔法药业有限公司 一种阿托伐他汀钙的制备方法
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
WO2015187974A1 (en) 2014-06-06 2015-12-10 Ovokaitys Todd Frank Methods and compositions for increasing the bioactivity of nutrients
CN113321607A (zh) * 2020-02-28 2021-08-31 北京福元医药股份有限公司沧州分公司 一种阿托伐他汀钙中间体的纯化方法
MX2023006721A (es) 2020-12-08 2023-07-04 Todd Frank Ovokaitys Metodos y sistemas para producción incrementada de celulas madre.

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WO2000071116A1 (en) * 1999-05-25 2000-11-30 Ranbaxy Laboratories Limited Process for the production of amorphous atorvastatin calcium

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101050722B1 (ko) 2008-12-02 2011-07-21 대웅바이오 주식회사 무정형 아토르바스타틴 칼슘염의 제조방법

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HRP20030575B1 (hr) 2011-10-31
IL157068A0 (en) 2004-02-08
HUP0302797A3 (en) 2009-09-28
CN1260213C (zh) 2006-06-21
PL361763A1 (en) 2004-10-04
ES2240748T3 (es) 2005-10-16
SK286593B6 (sk) 2009-01-07
IL157068A (en) 2009-09-01
PL209428B1 (pl) 2011-08-31
EP1373202A1 (en) 2004-01-02
AU2002219455B2 (en) 2007-04-26
RU2003124962A (ru) 2005-01-10
DE60203894D1 (de) 2005-06-02
JP2005503997A (ja) 2005-02-10
HUP0302797A2 (hu) 2003-11-28
US6750353B2 (en) 2004-06-15
SK9082003A3 (en) 2003-12-02
CA2435954A1 (en) 2002-08-01
DE60203894T2 (de) 2006-01-19
SI1373202T1 (sl) 2005-12-31
CN1487921A (zh) 2004-04-07
HU227535B1 (en) 2011-08-29
EE200300333A (et) 2003-10-15
ZA200305307B (en) 2004-07-09
EE05270B1 (et) 2010-02-15
US20040072895A1 (en) 2004-04-15
KR20030077003A (ko) 2003-09-29
CA2435954C (en) 2008-06-03
RS51010B (sr) 2010-10-31
DK1373202T3 (da) 2005-05-17
ATE294159T1 (de) 2005-05-15
RU2324679C2 (ru) 2008-05-20
SI20814A (sl) 2002-08-31
US20030109569A1 (en) 2003-06-12
YU56803A (sh) 2006-05-25
BR0206637A (pt) 2004-08-03
HRP20030575A2 (en) 2005-06-30
UA73829C2 (en) 2005-09-15
EP1373202B1 (en) 2005-04-27
BG108017A (bg) 2004-08-31
WO2002059087A1 (en) 2002-08-01
CZ20031988A3 (cs) 2003-11-12
US7074940B2 (en) 2006-07-11
JP4336106B2 (ja) 2009-09-30
MXPA03006548A (es) 2004-10-15

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