KR100810930B1 - 나테글리니드 ｂ형 결정의 제조방법 - Google Patents

나테글리니드 ｂ형 결정의 제조방법 Download PDF

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Publication number
KR100810930B1
KR100810930B1 KR1020037005671A KR20037005671A KR100810930B1 KR 100810930 B1 KR100810930 B1 KR 100810930B1 KR 1020037005671 A KR1020037005671 A KR 1020037005671A KR 20037005671 A KR20037005671 A KR 20037005671A KR 100810930 B1 KR100810930 B1 KR 100810930B1
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KR
South Korea
Prior art keywords
nateglinide
crystal
crystals
producing
type
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Expired - Fee Related
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KR1020037005671A
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English (en)
Korean (ko)
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KR20030059212A (ko
Inventor
스미카와미치토
마루오마코토
미야자키가즈오
니시나시게히로
마쓰자와유키코
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아지노모토 가부시키가이샤
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Publication of KR100810930B1 publication Critical patent/KR100810930B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020037005671A 2000-10-24 2001-10-23 나테글리니드 ｂ형 결정의 제조방법 Expired - Fee Related KR100810930B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000324375 2000-10-24
JPJP-P-2000-00324375 2000-10-24
PCT/JP2001/009293 WO2002034713A1 (en) 2000-10-24 2001-10-23 Process for producing b-form nateglinide crystal

Publications (2)

Publication Number Publication Date
KR20030059212A KR20030059212A (ko) 2003-07-07
KR100810930B1 true KR100810930B1 (ko) 2008-03-10

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KR1020037005671A Expired - Fee Related KR100810930B1 (ko) 2000-10-24 2001-10-23 나테글리니드 ｂ형 결정의 제조방법

Country Status (18)

Country Link
US (2) US20030229249A1 (cg-RX-API-DMAC7.html)
EP (1) EP1334964B1 (cg-RX-API-DMAC7.html)
JP (1) JP4225057B2 (cg-RX-API-DMAC7.html)
KR (1) KR100810930B1 (cg-RX-API-DMAC7.html)
CN (1) CN100422143C (cg-RX-API-DMAC7.html)
AT (1) ATE370115T1 (cg-RX-API-DMAC7.html)
AU (1) AU2001296001A1 (cg-RX-API-DMAC7.html)
BR (1) BR0114846A (cg-RX-API-DMAC7.html)
CA (1) CA2426745C (cg-RX-API-DMAC7.html)
CY (1) CY1106839T1 (cg-RX-API-DMAC7.html)
DE (1) DE60130014T2 (cg-RX-API-DMAC7.html)
DK (1) DK1334964T3 (cg-RX-API-DMAC7.html)
ES (1) ES2288997T3 (cg-RX-API-DMAC7.html)
MX (1) MXPA03003575A (cg-RX-API-DMAC7.html)
PT (1) PT1334964E (cg-RX-API-DMAC7.html)
RU (1) RU2275354C2 (cg-RX-API-DMAC7.html)
TW (1) TWI293290B (cg-RX-API-DMAC7.html)
WO (1) WO2002034713A1 (cg-RX-API-DMAC7.html)

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KR20070104953A (ko) * 2000-03-17 2007-10-29 아지노모토 가부시키가이샤 신경 장애용 약제
ATE368641T1 (de) * 2000-10-18 2007-08-15 Ajinomoto Kk Verfahren zur herstellung von nateglinidin- kristallen
CN1273442C (zh) * 2000-10-18 2006-09-06 味之素株式会社 酰基苯丙氨酸的制备方法
MXPA03003685A (es) * 2000-10-24 2004-01-26 Ajinomoto Kk Preparaciones que contienen nateglinida.
AU2001296000A1 (en) * 2000-10-24 2002-05-27 Ajinomoto Co., Inc. Nateglinide-containing hydrophilic drug preparations
US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals
JP4538842B2 (ja) * 2002-04-15 2010-09-08 味の素株式会社 新規ナテグリニド結晶
US6861553B2 (en) 2002-07-03 2005-03-01 Teva Pharmaceuticals Industries Ltd. Process for preparing nateglinide and intermediates thereof
US7358390B2 (en) 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7420084B2 (en) * 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7534913B2 (en) 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
US7148376B2 (en) 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
IL166308A0 (en) * 2002-07-18 2006-01-15 Polymorphic forms of nateglinide
EP1535900B1 (en) * 2003-11-26 2006-12-27 A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A. Process for the preparation of nateglinide, preferably in b-form
US20060004102A1 (en) * 2004-05-07 2006-01-05 Shlomit Wizel Polymorphic forms of nateglinide
WO2005110395A1 (en) * 2004-05-19 2005-11-24 University Of South Carolina System and device for magnetic drug targeting with magnetic drug carrier particles
US20080096970A1 (en) * 2004-05-20 2008-04-24 Sundaram Venkataraman Stable Nateglinide Form B Compositions
US7425648B2 (en) 2005-01-03 2008-09-16 A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. Process for the preparation of nateglinide, preferably in B-form
WO2006080524A1 (ja) * 2005-01-31 2006-08-03 Ajinomoto Co., Inc. 血糖降下剤を含有する、耐糖能異常、境界型糖尿病、インスリン抵抗性及び高インスリン血症の改善ないし治療用医薬組成物
WO2007135533A1 (en) * 2006-05-23 2007-11-29 Aurobindo Pharma Limited Process for preparing nateglinide b-type crystals
KR100837843B1 (ko) * 2006-12-26 2008-06-13 씨제이제일제당 (주) 나테글리나이드 결정형, 그 제조방법, 및 그를 포함하는약제학적 조성물
AU2011266820A1 (en) 2010-06-14 2013-01-24 Cipla Limited A process for the preparation of nateglinide
WO2014037832A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment of epilepsy and neurological diseases
WO2013167985A1 (en) 2012-05-07 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of neurological disorders
US9399634B2 (en) 2012-05-07 2016-07-26 Cellix Bio Private Limited Compositions and methods for the treatment of depression
WO2013168021A1 (en) 2012-05-07 2013-11-14 Mahesh Kandula Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders
WO2013167992A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of inflammatory disorders
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WO2013168023A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for treatment of parkinson's disease
US9434704B2 (en) 2012-05-08 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of neurological degenerative disorders
EP2847161A4 (en) * 2012-05-08 2015-12-23 Cellix Bio Private Ltd COMPOSITIONS AND METHOD FOR TREATING DIABETES
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WO2013168002A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of neurological conditions
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US9499527B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of familial amyloid polyneuropathy
WO2013168015A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of asthma and allergy
US9273061B2 (en) 2012-05-10 2016-03-01 Cellix Bio Private Limited Compositions and methods for the treatment of chronic pain
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WO2013175344A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
JP2015518854A (ja) 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 多発性硬化症の治療のための組成物および方法
US9492409B2 (en) 2012-05-23 2016-11-15 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
WO2014020480A2 (en) 2012-08-03 2014-02-06 Mahesh Kandula Compositions and methods for the treatment migraine and neurologic diseases
WO2014037833A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment inflammation and lipid disorders
SG11201407325YA (en) 2012-09-08 2014-12-30 Cellix Bio Private Ltd Compositions and methods for treatment of inflammation and lipid disorders
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
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JP6564868B2 (ja) 2014-10-27 2019-08-21 セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ 多発性硬化症の治療のための、フマル酸モノメチルエステルとピペラジン又はエチレンジアミンとの３つの成分の塩
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CN104402756B (zh) * 2014-11-27 2016-08-31 天方药业有限公司 一种高纯度那格列奈的制备方法
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US5463116A (en) 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them

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ATE503472T1 (de) * 1996-11-15 2011-04-15 Ajinomoto Kk Nateglinide-tablettenzubereitungen
US6844006B1 (en) * 1999-07-09 2005-01-18 Pennfield Oil Company Process and apparatus for the preparation of chlortetracycline-containing animal feed compositions
CA2395993A1 (en) * 1999-12-28 2001-07-05 Ajinomoto Co., Inc. Antidiabetic preparation for oral administration
KR20070104953A (ko) * 2000-03-17 2007-10-29 아지노모토 가부시키가이샤 신경 장애용 약제
CN1273442C (zh) * 2000-10-18 2006-09-06 味之素株式会社 酰基苯丙氨酸的制备方法
ATE368641T1 (de) * 2000-10-18 2007-08-15 Ajinomoto Kk Verfahren zur herstellung von nateglinidin- kristallen
MXPA03003685A (es) * 2000-10-24 2004-01-26 Ajinomoto Kk Preparaciones que contienen nateglinida.
US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals

Patent Citations (1)

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US5463116A (en) 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them

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US20070232829A1 (en) 2007-10-04
CA2426745C (en) 2009-09-15
EP1334964B1 (en) 2007-08-15
ES2288997T3 (es) 2008-02-01
DK1334964T3 (da) 2007-09-24
TWI293290B (cg-RX-API-DMAC7.html) 2008-02-11
EP1334964A4 (en) 2005-09-28
ATE370115T1 (de) 2007-09-15
JP4225057B2 (ja) 2009-02-18
BR0114846A (pt) 2004-02-25
MXPA03003575A (es) 2003-07-14
CA2426745A1 (en) 2003-04-23
WO2002034713A1 (en) 2002-05-02
KR20030059212A (ko) 2003-07-07
CN1483018A (zh) 2004-03-17
JPWO2002034713A1 (ja) 2004-03-04
DE60130014T2 (de) 2008-05-08
US20030229249A1 (en) 2003-12-11
EP1334964A1 (en) 2003-08-13
AU2001296001A1 (en) 2002-05-06
PT1334964E (pt) 2007-09-20
RU2275354C2 (ru) 2006-04-27
CN100422143C (zh) 2008-10-01
US7544834B2 (en) 2009-06-09
CY1106839T1 (el) 2012-05-23
DE60130014D1 (de) 2007-09-27

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