AU2001296001A1 - Process for producing b-form nateglinide crystal - Google Patents

Process for producing b-form nateglinide crystal

Info

Publication number
AU2001296001A1
AU2001296001A1 AU2001296001A AU9600101A AU2001296001A1 AU 2001296001 A1 AU2001296001 A1 AU 2001296001A1 AU 2001296001 A AU2001296001 A AU 2001296001A AU 9600101 A AU9600101 A AU 9600101A AU 2001296001 A1 AU2001296001 A1 AU 2001296001A1
Authority
AU
Australia
Prior art keywords
producing
nateglinide
type crystals
crystals
nateglinide crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001296001A
Inventor
Makoto Maruo
Yukiko Matsuzawa
Kazuo Miyazaki
Shigehiro Nishina
Michito Sumikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of AU2001296001A1 publication Critical patent/AU2001296001A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method for producing B-type crystals of nateglinide substantially free of H-type crystals is provided, which comprises drying solvated wet crystals of nateglinide at a low temperature until no solvent remains and making a crystal conversion thereof. According to this method, B-type crystals of nateglinide can be produced at an industrial scale without allowing other forms of the crystalline polymorphism to coexist.
AU2001296001A 2000-10-24 2001-10-23 Process for producing b-form nateglinide crystal Abandoned AU2001296001A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000324375 2000-10-24
JP2000-324375 2000-10-24
PCT/JP2001/009293 WO2002034713A1 (en) 2000-10-24 2001-10-23 Process for producing b-form nateglinide crystal

Publications (1)

Publication Number Publication Date
AU2001296001A1 true AU2001296001A1 (en) 2002-05-06

Family

ID=18801920

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001296001A Abandoned AU2001296001A1 (en) 2000-10-24 2001-10-23 Process for producing b-form nateglinide crystal

Country Status (18)

Country Link
US (2) US20030229249A1 (en)
EP (1) EP1334964B1 (en)
JP (1) JP4225057B2 (en)
KR (1) KR100810930B1 (en)
CN (1) CN100422143C (en)
AT (1) ATE370115T1 (en)
AU (1) AU2001296001A1 (en)
BR (1) BR0114846A (en)
CA (1) CA2426745C (en)
CY (1) CY1106839T1 (en)
DE (1) DE60130014T2 (en)
DK (1) DK1334964T3 (en)
ES (1) ES2288997T3 (en)
MX (1) MXPA03003575A (en)
PT (1) PT1334964E (en)
RU (1) RU2275354C2 (en)
TW (1) TWI293290B (en)
WO (1) WO2002034713A1 (en)

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US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals
WO2003087039A1 (en) * 2002-04-15 2003-10-23 Ajinomoto Co., Inc. Novel nateglinide crystal
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US7148376B2 (en) 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7534913B2 (en) * 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
EP1467964A1 (en) * 2002-07-18 2004-10-20 Teva Pharmaceutical Industries Limited Polymorphic forms of nateglinide
US7358390B2 (en) 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7420084B2 (en) * 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
ES2279921T3 (en) * 2003-11-26 2007-09-01 A.M.S.A. Anonima Materie Sintetiche E Affini S.P.A. PROCEDURE FOR THE PREPARATION OF NATEGLINIDE PREFERRED IN FORM B.
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WO2005113485A2 (en) * 2004-05-20 2005-12-01 Dr. Reddy's Laboratories Ltd. Stable nateglinide form b compositions
US7425648B2 (en) 2005-01-03 2008-09-16 A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. Process for the preparation of nateglinide, preferably in B-form
JP4974057B2 (en) * 2005-01-31 2012-07-11 味の素株式会社 A pharmaceutical composition for improving or treating impaired glucose tolerance, borderline diabetes, insulin resistance and hyperinsulinemia, comprising a hypoglycemic agent
WO2007135533A1 (en) * 2006-05-23 2007-11-29 Aurobindo Pharma Limited Process for preparing nateglinide b-type crystals
KR100837843B1 (en) * 2006-12-26 2008-06-13 씨제이제일제당 (주) Crystalline form of nateglinide, process for the preparation thereof, and pharmaceutical composition comprising the same
US9150499B2 (en) 2010-06-14 2015-10-06 Cipla Limited Process for the preparation of nateglinide
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US9346742B2 (en) 2012-05-10 2016-05-24 Cellix Bio Private Limited Compositions and methods for the treatment of fibromyalgia pain
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US9765020B2 (en) 2012-05-23 2017-09-19 Cellix Bio Private Limited Dichlorophenyl-imino compounds and compositions, and methods for the treatment of mucositis
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US9227974B2 (en) 2012-05-23 2016-01-05 Cellex Bio Private Limited Compositions and methods for the treatment of respiratory disorders
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CN104402756B (en) * 2014-11-27 2016-08-31 天方药业有限公司 A kind of preparation method of high-purity Nateglinide
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
JP6679616B2 (en) 2015-01-06 2020-04-22 セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ Compositions and methods for the treatment of inflammation and pain
CN109369443A (en) * 2018-11-05 2019-02-22 扬子江药业集团江苏海慈生物药业有限公司 A kind of preparation method of new Nateglinide H crystal form

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BR0114728B1 (en) * 2000-10-18 2014-01-14 Method for producing an acylphenylalanine
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US7411089B2 (en) * 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals

Also Published As

Publication number Publication date
DE60130014D1 (en) 2007-09-27
DK1334964T3 (en) 2007-09-24
ATE370115T1 (en) 2007-09-15
US20030229249A1 (en) 2003-12-11
PT1334964E (en) 2007-09-20
KR20030059212A (en) 2003-07-07
US7544834B2 (en) 2009-06-09
EP1334964A1 (en) 2003-08-13
RU2275354C2 (en) 2006-04-27
ES2288997T3 (en) 2008-02-01
KR100810930B1 (en) 2008-03-10
US20070232829A1 (en) 2007-10-04
CN1483018A (en) 2004-03-17
JP4225057B2 (en) 2009-02-18
CN100422143C (en) 2008-10-01
EP1334964B1 (en) 2007-08-15
BR0114846A (en) 2004-02-25
DE60130014T2 (en) 2008-05-08
EP1334964A4 (en) 2005-09-28
CA2426745C (en) 2009-09-15
CY1106839T1 (en) 2012-05-23
MXPA03003575A (en) 2003-07-14
CA2426745A1 (en) 2003-04-23
TWI293290B (en) 2008-02-11
JPWO2002034713A1 (en) 2004-03-04
WO2002034713A1 (en) 2002-05-02

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