KR100760446B1 - 항정신병약 시클릭 ｎ-아르알킬 아민 - Google Patents

항정신병약 시클릭 ｎ-아르알킬 아민 Download PDF

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Publication number
KR100760446B1
KR100760446B1 KR1020017016966A KR20017016966A KR100760446B1 KR 100760446 B1 KR100760446 B1 KR 100760446B1 KR 1020017016966 A KR1020017016966 A KR 1020017016966A KR 20017016966 A KR20017016966 A KR 20017016966A KR 100760446 B1 KR100760446 B1 KR 100760446B1
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formula
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group
hydrogen
atom
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Korean (ko)
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KR20020016877A (ko
Inventor
로버트 브와제그렝
마르텡 부리
피에르 레
레이몽 폴
마르텡 퐁셀레
장-클라우드 베르리에르
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사노피-아벤티스
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020017016966A 1999-07-02 2000-06-27 항정신병약 시클릭 ｎ-아르알킬 아민 Expired - Fee Related KR100760446B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9908532A FR2795724B1 (fr) 1999-07-02 1999-07-02 Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant
FR99/08532 1999-07-02

Publications (2)

Publication Number Publication Date
KR20020016877A KR20020016877A (ko) 2002-03-06
KR100760446B1 true KR100760446B1 (ko) 2007-10-04

Family

ID=9547628

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017016966A Expired - Fee Related KR100760446B1 (ko) 1999-07-02 2000-06-27 항정신병약 시클릭 ｎ-아르알킬 아민

Country Status (31)

Country Link
US (1) US6908914B1 (enExample)
EP (1) EP1196403B1 (enExample)
JP (1) JP4931309B2 (enExample)
KR (1) KR100760446B1 (enExample)
CN (1) CN1156462C (enExample)
AR (1) AR029374A1 (enExample)
AT (1) ATE309231T1 (enExample)
AU (1) AU778299B2 (enExample)
BG (1) BG65209B1 (enExample)
BR (1) BR0012463B1 (enExample)
CA (1) CA2376691C (enExample)
CO (1) CO5021196A1 (enExample)
CZ (1) CZ300936B6 (enExample)
DE (1) DE60023898T2 (enExample)
DK (1) DK1196403T3 (enExample)
EA (1) EA004048B1 (enExample)
ES (1) ES2250160T3 (enExample)
FR (1) FR2795724B1 (enExample)
HK (1) HK1043122A1 (enExample)
HR (1) HRP20010949B1 (enExample)
HU (1) HU228983B1 (enExample)
IL (2) IL147069A0 (enExample)
ME (1) MEP25508A (enExample)
MX (1) MXPA01013207A (enExample)
NO (1) NO322230B1 (enExample)
NZ (1) NZ516342A (enExample)
RS (1) RS50266B (enExample)
TW (1) TWI285640B (enExample)
UA (1) UA71009C2 (enExample)
WO (1) WO2001002380A1 (enExample)
ZA (1) ZA200200018B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE50207026D1 (de) * 2001-08-23 2006-07-06 Bayer Cropscience Sa Substituierte propargylamine
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989012443A1 (en) * 1988-06-17 1989-12-28 Fisons Corporation Novel dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties
EP0529659A2 (en) * 1991-08-30 1993-03-03 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Agent for forming spheroids of hepatocytes and process for culturing hepatocytes for formation of spheroids
US5296596A (en) * 1990-06-14 1994-03-22 Elf Sanofi Hexahydroazepine derivatives, a process for their preparation
WO1998004251A1 (fr) * 1996-07-29 1998-02-05 Sanofi Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales
WO1998041508A1 (en) * 1997-03-18 1998-09-24 Smithkline Beecham Plc Substituted isoquinoline derivatives and their use as anticonvulsants

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790971A (fr) * 1971-11-09 1973-05-07 Janssen Pharmaceutica Nv Metode ter voorkoming van patologische reakties die de funktie van het komplement vereisen
JPS504086A (enExample) * 1973-01-18 1975-01-16
GB1475314A (en) * 1973-11-02 1977-06-01 Cm Ind Phenyl-propylamine derivatives
US4104383A (en) * 1973-11-02 1978-08-01 C M Industries Derivatives of phenylpropenylamine
US4912222A (en) * 1988-06-17 1990-03-27 Fisons Corporation Antihistamines related to cyproheptadine
US4855462A (en) * 1988-06-17 1989-08-08 Pennwalt Corporation Antihistamines
JPH06509069A (ja) * 1991-06-27 1994-10-13 バージニア・コモンウェルス・ユニバーシティ シグマレセプターリガンドおよびその用途
US5486517A (en) * 1994-05-10 1996-01-23 Warner-Lambert Company Benzimidazoles and imidazopyridines as central nervous system agents

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989012443A1 (en) * 1988-06-17 1989-12-28 Fisons Corporation Novel dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties
US5296596A (en) * 1990-06-14 1994-03-22 Elf Sanofi Hexahydroazepine derivatives, a process for their preparation
EP0529659A2 (en) * 1991-08-30 1993-03-03 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Agent for forming spheroids of hepatocytes and process for culturing hepatocytes for formation of spheroids
WO1998004251A1 (fr) * 1996-07-29 1998-02-05 Sanofi Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales
WO1998041508A1 (en) * 1997-03-18 1998-09-24 Smithkline Beecham Plc Substituted isoquinoline derivatives and their use as anticonvulsants

Also Published As

Publication number Publication date
CN1156462C (zh) 2004-07-07
ATE309231T1 (de) 2005-11-15
JP4931309B2 (ja) 2012-05-16
UA71009C2 (uk) 2004-11-15
DE60023898T2 (de) 2006-08-10
ZA200200018B (en) 2003-01-02
CZ20014697A3 (cs) 2002-04-17
NO322230B1 (no) 2006-08-28
FR2795724B1 (fr) 2002-12-13
BG106255A (en) 2002-10-31
HRP20010949B1 (en) 2006-06-30
CN1367783A (zh) 2002-09-04
WO2001002380A1 (fr) 2001-01-11
IL147069A0 (en) 2002-08-14
HUP0202200A3 (en) 2002-12-28
AU5992400A (en) 2001-01-22
DE60023898D1 (de) 2005-12-15
HUP0202200A2 (en) 2002-10-28
WO2001002380A8 (fr) 2001-06-28
PL356186A1 (en) 2004-06-14
NO20016392L (no) 2002-03-04
RS50266B (sr) 2009-07-15
EA200101209A1 (ru) 2002-06-27
BR0012463B1 (pt) 2014-11-04
DK1196403T3 (da) 2006-03-20
KR20020016877A (ko) 2002-03-06
NZ516342A (en) 2003-08-29
MEP25508A (en) 2010-06-10
EP1196403A1 (fr) 2002-04-17
NO20016392D0 (no) 2001-12-27
YU91101A (sh) 2004-09-03
ES2250160T3 (es) 2006-04-16
AR029374A1 (es) 2003-06-25
CA2376691A1 (en) 2001-01-11
HU228983B1 (en) 2013-07-29
BG65209B1 (bg) 2007-07-31
US6908914B1 (en) 2005-06-21
JP2003503487A (ja) 2003-01-28
HK1043122A1 (zh) 2002-09-06
FR2795724A1 (fr) 2001-01-05
CZ300936B6 (cs) 2009-09-16
EA004048B1 (ru) 2003-12-25
HRP20010949A2 (en) 2003-04-30
IL147069A (en) 2006-09-05
CO5021196A1 (es) 2001-03-27
BR0012463A (pt) 2002-04-02
EP1196403B1 (fr) 2005-11-09
MXPA01013207A (es) 2002-06-21
AU778299B2 (en) 2004-11-25
CA2376691C (en) 2009-09-01
TWI285640B (en) 2007-08-21

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