KR100669053B1 - 리포좀에 사용하기 위한 절단가능 결합을 갖는 콘쥬게이트 - Google Patents

리포좀에 사용하기 위한 절단가능 결합을 갖는 콘쥬게이트 Download PDF

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KR100669053B1
KR100669053B1 KR1020017013571A KR20017013571A KR100669053B1 KR 100669053 B1 KR100669053 B1 KR 100669053B1 KR 1020017013571 A KR1020017013571 A KR 1020017013571A KR 20017013571 A KR20017013571 A KR 20017013571A KR 100669053 B1 KR100669053 B1 KR 100669053B1
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conjugate
mitomycin
drug
therapeutic drug
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KR1020017013571A
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KR20010114247A (ko
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자리프스키사무엘
가비존앨버토에이
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알자 코포레이션
하다시트 메디칼 리서치 서비시즈 앤드 디벨롭먼트 캄파니 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K9/127—Liposomes
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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KR1020017013571A 1999-04-23 2000-04-21 리포좀에 사용하기 위한 절단가능 결합을 갖는 콘쥬게이트 KR100669053B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13089799P 1999-04-23 1999-04-23
US60/130,897 1999-04-23
PCT/US2000/010922 WO2000064484A2 (en) 1999-04-23 2000-04-21 Conjugate having a cleavable linkage for use in a liposome

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KR20010114247A KR20010114247A (ko) 2001-12-31
KR100669053B1 true KR100669053B1 (ko) 2007-01-15

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KR1020017013571A KR100669053B1 (ko) 1999-04-23 2000-04-21 리포좀에 사용하기 위한 절단가능 결합을 갖는 콘쥬게이트
KR1020017013588A KR100642955B1 (ko) 1999-04-23 2000-04-21 방출성 결합 및 그를 함유하는 조성물

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US (8) US6342244B1 (US06605299-20030812-C00002.png)
EP (3) EP1880736A1 (US06605299-20030812-C00002.png)
JP (1) JP4558952B2 (US06605299-20030812-C00002.png)
KR (2) KR100669053B1 (US06605299-20030812-C00002.png)
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