KR100640113B1 - 구충제 아르테미시닌 유도체(엔도퍼옥시드) - Google Patents

구충제 아르테미시닌 유도체(엔도퍼옥시드) Download PDF

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KR100640113B1
KR100640113B1 KR1020017000572A KR20017000572A KR100640113B1 KR 100640113 B1 KR100640113 B1 KR 100640113B1 KR 1020017000572 A KR1020017000572 A KR 1020017000572A KR 20017000572 A KR20017000572 A KR 20017000572A KR 100640113 B1 KR100640113 B1 KR 100640113B1
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formula
group
compound
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dihydroartemisinin
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Expired - Fee Related
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KR1020017000572A
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Korean (ko)
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KR20010071899A (ko
Inventor
리차드 킹스톤 하이네스
호-와이 찬
와이-룬 람
힝-우 창
만-키 청
아른트 보에르스테
가브리엘 쉬무크
기젤라 그레이프
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바이엘 악티엔게젤샤프트
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020017000572A 1998-07-14 1999-07-14 구충제 아르테미시닌 유도체(엔도퍼옥시드) Expired - Fee Related KR100640113B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98305596.3 1998-07-14
EP98305596 1998-07-14

Publications (2)

Publication Number Publication Date
KR20010071899A KR20010071899A (ko) 2001-07-31
KR100640113B1 true KR100640113B1 (ko) 2006-10-31

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KR1020017000572A Expired - Fee Related KR100640113B1 (ko) 1998-07-14 1999-07-14 구충제 아르테미시닌 유도체(엔도퍼옥시드)

Country Status (27)

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US (4) US6984640B1 (enExample)
EP (2) EP1655302A3 (enExample)
JP (1) JP2002520416A (enExample)
KR (1) KR100640113B1 (enExample)
CN (1) CN1122035C (enExample)
AT (1) ATE314373T1 (enExample)
AU (1) AU765860B2 (enExample)
BG (1) BG105137A (enExample)
BR (1) BR9912810A (enExample)
CA (1) CA2337119A1 (enExample)
DE (1) DE69929203T2 (enExample)
DK (1) DK1095042T5 (enExample)
ES (1) ES2257062T4 (enExample)
HK (1) HK1040709B (enExample)
HU (1) HUP0102851A3 (enExample)
IL (1) IL140402A0 (enExample)
NO (1) NO20010223L (enExample)
NZ (1) NZ509324A (enExample)
PL (1) PL345503A1 (enExample)
PT (1) PT1095042E (enExample)
RU (1) RU2236413C2 (enExample)
SI (1) SI1095042T1 (enExample)
SK (1) SK542001A3 (enExample)
TR (1) TR200100073T2 (enExample)
UA (1) UA75325C2 (enExample)
WO (1) WO2000004024A1 (enExample)
YU (1) YU2101A (enExample)

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EP1714967A1 (en) * 2005-04-22 2006-10-25 Bayer HealthCare AG Antiparasitic artemisinin derivatives
US8431611B2 (en) 2006-10-20 2013-04-30 Johns Hopkins University Artemisinin derivatives
US8193376B2 (en) 2007-01-01 2012-06-05 Bioderm Research Artemisinin derivatives with natural amino acids, peptides, and amino sugars for the treatment of infection and topical condition in mammals
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JP5438098B2 (ja) * 2008-04-29 2014-03-12 ノバルティス アーゲー 寄生虫性疾患の処置のためのスピロ−インドール誘導体
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US8815942B2 (en) 2010-10-20 2014-08-26 The Royal Institution For The Advancement Of Learning/Mcgill University Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease
RU2466133C1 (ru) * 2011-06-24 2012-11-10 ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ НАУКИ ИНСТИТУТ ОРГАНИЧЕСКОЙ ХИМИИ им. Н.Д. ЗЕЛИНСКОГО РОССИЙСКОЙ АКАДЕМИИ НАУК (ИОХ РАН) Трициклические органические монопероксиды и способ их получения
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BR112014026158A2 (pt) * 2012-04-18 2017-06-27 Hadasit Med Res Service métodos e composições para o tratamento de infecções virais
JP5994059B2 (ja) * 2012-09-05 2016-09-21 国立大学法人東京農工大学 抗マラリア活性を有するアザアルテミシニン誘導体及びその製造方法
EP3450549B1 (en) * 2012-10-29 2020-09-30 University Of Rochester Artemisinin derivatives, methods for their preparation and their use as antimalarial agents
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CN103664982A (zh) * 2013-12-06 2014-03-26 湖南科源生物制品有限公司 青蒿素类似物及其制备方法
CN103896960A (zh) * 2014-01-14 2014-07-02 李学强 一种高效、绿色的青蒿砜制备方法
USD740677S1 (en) 2014-03-26 2015-10-13 Gk Packaging, Inc. Bottle
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USD784820S1 (en) 2015-02-05 2017-04-25 Gk Packaging, Inc. Bottle
CN105198898A (zh) * 2015-09-23 2015-12-30 山东大学（威海） 一种用于预防和/或治疗癌症的化合物
USD774914S1 (en) 2015-10-13 2016-12-27 Gk Packaging, Inc. Bottle
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CN110448552B (zh) * 2019-08-23 2023-05-12 西南大学 二氢青蒿素衍生物在制备抗疟药物中的应用
CN110483547B (zh) * 2019-08-28 2022-08-16 西南大学 二氢青蒿素的简单酚类偶联物、合成方法及应用
CN110642869B (zh) * 2019-09-26 2022-03-15 西南大学 二氢青蒿素的硫醚、亚砜与砜衍生物及其应用
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CN114276365B (zh) * 2021-12-30 2023-06-13 威胜生物医药(苏州)股份有限公司 一种蒿甲醚杂质脱水双氢青蒿素的制备方法

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IL140402A0 (en) 2002-02-10
DK1095042T3 (da) 2006-04-18
AU4921899A (en) 2000-02-07
BG105137A (en) 2001-08-31
HUP0102851A2 (hu) 2001-11-28
YU2101A (sh) 2005-06-10
KR20010071899A (ko) 2001-07-31
US20070021409A1 (en) 2007-01-25
BR9912810A (pt) 2001-05-02
US20060287305A1 (en) 2006-12-21
SI1095042T1 (sl) 2006-04-30
NZ509324A (en) 2003-07-25
CA2337119A1 (en) 2000-01-27
EP1095042A1 (en) 2001-05-02
NO20010223D0 (no) 2001-01-12
PL345503A1 (en) 2001-12-17
HK1040709B (zh) 2004-06-25
DK1095042T5 (da) 2006-11-06
HK1040709A1 (en) 2002-06-21
US20070191354A1 (en) 2007-08-16
CN1317006A (zh) 2001-10-10
EP1095042B1 (en) 2005-12-28
US7439238B2 (en) 2008-10-21
NO20010223L (no) 2001-03-12
DE69929203T2 (de) 2006-08-31
RU2236413C2 (ru) 2004-09-20
TR200100073T2 (tr) 2001-05-21
US6984640B1 (en) 2006-01-10
ES2257062T3 (es) 2006-07-16
AU765860B2 (en) 2003-10-02
US7452915B2 (en) 2008-11-18
PT1095042E (pt) 2006-05-31
CN1122035C (zh) 2003-09-24
SK542001A3 (en) 2001-08-06
UA75325C2 (en) 2006-04-17
HUP0102851A3 (en) 2003-03-28
DE69929203D1 (de) 2006-02-02
JP2002520416A (ja) 2002-07-09
ES2257062T4 (es) 2007-03-16
WO2000004024A1 (en) 2000-01-27
EP1655302A2 (en) 2006-05-10
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ATE314373T1 (de) 2006-01-15
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