HK1040709B - 抗寄生蟲青蒿素衍生物，製備方法及組合物和用途 - Google Patents

抗寄生蟲青蒿素衍生物，製備方法及組合物和用途

Info

Publication number
HK1040709B
HK1040709B HK02102362.4A HK02102362A HK1040709B HK 1040709 B HK1040709 B HK 1040709B HK 02102362 A HK02102362 A HK 02102362A HK 1040709 B HK1040709 B HK 1040709B
Authority
HK
Hong Kong
Prior art keywords
preparing
composition
artemisinin derivatives
substituted derivatives
antiparasitic
Prior art date
Application number
HK02102362.4A
Other languages
English (en)
Other versions
HK1040709A1 (en
Inventor
Kingston Haynes Richard
Chan Ho-Wai
Lam Wai-Lun
Tsang Hing-Wo
Cheung Man-Ki
Voerste Arnd
Schmuck Gabriele
Greif Gisela
Original Assignee
香港科技大學
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 香港科技大學 filed Critical 香港科技大學
Publication of HK1040709A1 publication Critical patent/HK1040709A1/xx
Publication of HK1040709B publication Critical patent/HK1040709B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK02102362.4A 1998-07-14 2002-03-27 抗寄生蟲青蒿素衍生物，製備方法及組合物和用途 HK1040709B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98305596 1998-07-14
PCT/GB1999/002267 WO2000004024A1 (en) 1998-07-14 1999-07-14 Antiparasitic artemisinin derivatives (endoperoxides)

Publications (2)

Publication Number Publication Date
HK1040709A1 HK1040709A1 (en) 2002-06-21
HK1040709B true HK1040709B (zh) 2004-06-25

Family

ID=8234942

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02102362.4A HK1040709B (zh) 1998-07-14 2002-03-27 抗寄生蟲青蒿素衍生物，製備方法及組合物和用途

Country Status (27)

Country Link
US (4) US6984640B1 (zh)
EP (2) EP1655302A3 (zh)
JP (1) JP2002520416A (zh)
KR (1) KR100640113B1 (zh)
CN (1) CN1122035C (zh)
AT (1) ATE314373T1 (zh)
AU (1) AU765860B2 (zh)
BG (1) BG105137A (zh)
BR (1) BR9912810A (zh)
CA (1) CA2337119A1 (zh)
DE (1) DE69929203T2 (zh)
DK (1) DK1095042T5 (zh)
ES (1) ES2257062T4 (zh)
HK (1) HK1040709B (zh)
HU (1) HUP0102851A3 (zh)
IL (1) IL140402A0 (zh)
NO (1) NO20010223L (zh)
NZ (1) NZ509324A (zh)
PL (1) PL345503A1 (zh)
PT (1) PT1095042E (zh)
RU (1) RU2236413C2 (zh)
SI (1) SI1095042T1 (zh)
SK (1) SK542001A3 (zh)
TR (1) TR200100073T2 (zh)
UA (1) UA75325C2 (zh)
WO (1) WO2000004024A1 (zh)
YU (1) YU2101A (zh)

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EP1714967A1 (en) * 2005-04-22 2006-10-25 Bayer HealthCare AG Antiparasitic artemisinin derivatives
US8431611B2 (en) 2006-10-20 2013-04-30 Johns Hopkins University Artemisinin derivatives
US8193376B2 (en) 2007-01-01 2012-06-05 Bioderm Research Artemisinin derivatives with natural amino acids, peptides, and amino sugars for the treatment of infection and topical condition in mammals
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US8815942B2 (en) 2010-10-20 2014-08-26 The Royal Institution For The Advancement Of Learning/Mcgill University Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease
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WO2014070673A1 (en) * 2012-10-29 2014-05-08 University Of Rochester Artemisinin derivatives, methods for their preparation and their use as antimalarial agents
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CN103896960A (zh) * 2014-01-14 2014-07-02 李学强 一种高效、绿色的青蒿砜制备方法
USD740125S1 (en) 2014-03-26 2015-10-06 Gk Packaging, Inc. Bottle
USD740677S1 (en) 2014-03-26 2015-10-13 Gk Packaging, Inc. Bottle
USD742748S1 (en) 2014-06-13 2015-11-10 Gk Packaging, Inc. Bottle
USD753503S1 (en) 2014-09-25 2016-04-12 Gk Packaging, Inc. Bottle
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CN105198898A (zh) * 2015-09-23 2015-12-30 山东大学（威海） 一种用于预防和/或治疗癌症的化合物
USD807190S1 (en) 2015-10-13 2018-01-09 Gk Packaging, Inc. Bottle
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CN110448552B (zh) * 2019-08-23 2023-05-12 西南大学 二氢青蒿素衍生物在制备抗疟药物中的应用
CN110483547B (zh) * 2019-08-28 2022-08-16 西南大学 二氢青蒿素的简单酚类偶联物、合成方法及应用
CN110642869B (zh) * 2019-09-26 2022-03-15 西南大学 二氢青蒿素的硫醚、亚砜与砜衍生物及其应用
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Also Published As

Publication number Publication date
US6984640B1 (en) 2006-01-10
EP1095042B9 (en) 2006-07-05
EP1655302A2 (en) 2006-05-10
KR100640113B1 (ko) 2006-10-31
KR20010071899A (ko) 2001-07-31
SI1095042T1 (sl) 2006-04-30
HK1040709A1 (en) 2002-06-21
HUP0102851A3 (en) 2003-03-28
WO2000004024A1 (en) 2000-01-27
AU765860B2 (en) 2003-10-02
CN1122035C (zh) 2003-09-24
NO20010223L (no) 2001-03-12
EP1095042A1 (en) 2001-05-02
US20070021409A1 (en) 2007-01-25
ES2257062T3 (es) 2006-07-16
US7452915B2 (en) 2008-11-18
EP1095042B1 (en) 2005-12-28
HUP0102851A2 (hu) 2001-11-28
YU2101A (sh) 2005-06-10
US20070191354A1 (en) 2007-08-16
DK1095042T3 (da) 2006-04-18
RU2236413C2 (ru) 2004-09-20
DK1095042T5 (da) 2006-11-06
NZ509324A (en) 2003-07-25
US7439238B2 (en) 2008-10-21
ES2257062T4 (es) 2007-03-16
DE69929203T2 (de) 2006-08-31
AU4921899A (en) 2000-02-07
TR200100073T2 (tr) 2001-05-21
EP1655302A3 (en) 2006-08-23
IL140402A0 (en) 2002-02-10
BR9912810A (pt) 2001-05-02
JP2002520416A (ja) 2002-07-09
PL345503A1 (en) 2001-12-17
PT1095042E (pt) 2006-05-31
US20060287305A1 (en) 2006-12-21
DE69929203D1 (de) 2006-02-02
CN1317006A (zh) 2001-10-10
CA2337119A1 (en) 2000-01-27
SK542001A3 (en) 2001-08-06
NO20010223D0 (no) 2001-01-12
ATE314373T1 (de) 2006-01-15
UA75325C2 (en) 2006-04-17
BG105137A (en) 2001-08-31

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