KR100587556B1 - 신경 및 신장 증식을 자극하기 위한 ＲＥＴ리간드（ＲｅｔＬ) - Google Patents

신경 및 신장 증식을 자극하기 위한 ＲＥＴ리간드（ＲｅｔＬ) Download PDF

Info

Publication number
KR100587556B1
KR100587556B1 KR1020057007519A KR20057007519A KR100587556B1 KR 100587556 B1 KR100587556 B1 KR 100587556B1 KR 1020057007519 A KR1020057007519 A KR 1020057007519A KR 20057007519 A KR20057007519 A KR 20057007519A KR 100587556 B1 KR100587556 B1 KR 100587556B1
Authority
KR
South Korea
Prior art keywords
seq
ret
human
cdna
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020057007519A
Other languages
English (en)
Korean (ko)
Other versions
KR20050056275A (ko
Inventor
미첼 사니콜라-나델
캐더린 헤션
리챠드 엘 케이트
Original Assignee
바이오겐 아이덱 엠에이 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 바이오겐 아이덱 엠에이 인코포레이티드 filed Critical 바이오겐 아이덱 엠에이 인코포레이티드
Publication of KR20050056275A publication Critical patent/KR20050056275A/ko
Application granted granted Critical
Publication of KR100587556B1 publication Critical patent/KR100587556B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
KR1020057007519A 1996-05-08 1997-05-07 신경 및 신장 증식을 자극하기 위한 ＲＥＴ리간드（ＲｅｔＬ) Expired - Fee Related KR100587556B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US1742796P 1996-05-08 1996-05-08
US60/017,427 1996-05-08
US1930096P 1996-06-07 1996-06-07
US60/019,300 1996-06-07
US2185996P 1996-07-16 1996-07-16
US60/021,859 1996-07-16
US4353397P 1997-04-11 1997-04-11
US60/043,533 1997-04-11

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1019980709223A Division KR100554901B1 (ko) 1996-05-08 1997-05-07 신경및신장증식을자극하기위한RET리간드(RetL)

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020067002921A Division KR20060024843A (ko) 1996-05-08 1997-05-07 신경 및 신장 증식을 자극하기 위한 ＲＥＴ리간드（ＲｅｔＬ)

Publications (2)

Publication Number Publication Date
KR20050056275A KR20050056275A (ko) 2005-06-14
KR100587556B1 true KR100587556B1 (ko) 2006-06-08

Family

ID=27360789

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020057007519A Expired - Fee Related KR100587556B1 (ko) 1996-05-08 1997-05-07 신경 및 신장 증식을 자극하기 위한 ＲＥＴ리간드（ＲｅｔＬ)
KR1020067002921A Ceased KR20060024843A (ko) 1996-05-08 1997-05-07 신경 및 신장 증식을 자극하기 위한 ＲＥＴ리간드（ＲｅｔＬ)

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020067002921A Ceased KR20060024843A (ko) 1996-05-08 1997-05-07 신경 및 신장 증식을 자극하기 위한 ＲＥＴ리간드（ＲｅｔＬ)

Country Status (24)

Country Link
EP (2) EP1757617A1 (https=)
JP (1) JP2002515743A (https=)
KR (2) KR100587556B1 (https=)
CN (2) CN1163509C (https=)
AT (1) ATE335003T1 (https=)
AU (1) AU732392B2 (https=)
BG (2) BG109433A (https=)
BR (1) BR9710665A (https=)
CA (1) CA2253871C (https=)
CZ (1) CZ296516B6 (https=)
DE (1) DE69736428T2 (https=)
DK (1) DK0914339T3 (https=)
EA (1) EA002544B1 (https=)
EE (1) EE9800377A (https=)
ES (1) ES2270465T3 (https=)
IL (1) IL126918A (https=)
IS (1) IS2361B (https=)
NO (2) NO323612B1 (https=)
NZ (1) NZ332706A (https=)
PT (1) PT914339E (https=)
RO (1) RO120343B1 (https=)
SK (1) SK286115B6 (https=)
TR (2) TR199802252T2 (https=)
WO (1) WO1997044356A2 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696259B1 (en) 1995-11-13 2004-02-24 Licentia Ltd. Assays using glial cell line-derived neurotrophic factor receptors
EP0846764A3 (en) * 1996-11-27 1998-09-30 Smithkline Beecham Plc Glial cell line-derived neurotrophic factor alpha receptor family
EP0948620A2 (en) * 1996-12-06 1999-10-13 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
US6372453B1 (en) 1997-02-18 2002-04-16 Genetech, Inc. Neurturin receptor
AU730430B2 (en) * 1997-02-18 2001-03-08 Genentech Inc. Neurturin receptor
US6777196B2 (en) 1997-02-18 2004-08-17 Genentech, Inc. Neurturin receptor
US6025157A (en) * 1997-02-18 2000-02-15 Genentech, Inc. Neurturin receptor
EP0983296A4 (en) * 1997-04-17 2002-11-06 Univ Washington RECEPTORS FOR TGF BETA RELATED NEUROTROPHIC FACTORS
WO1998053069A2 (en) * 1997-05-20 1998-11-26 Human Genome Sciences, Inc. Gdnf receptors
KR20010012826A (ko) * 1997-05-22 2001-02-26 세파론, 인코포레이티드 신경교 세포주-유래 향신경성 인자 수용체
WO1998054213A2 (en) * 1997-05-30 1998-12-03 Amgen Inc. Neurotrophic factor receptors
WO1999049039A2 (en) * 1998-03-23 1999-09-30 Genentech, Inc. GFRα3 AND ITS USES
US7026138B1 (en) 1998-03-23 2006-04-11 Genentech, Inc. Polynucleotides encoding GFRα3
US20020055467A1 (en) 1998-07-06 2002-05-09 Johansen Teit E. Novel neurotrophic factors
US6593133B1 (en) 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
WO2001016169A2 (en) * 1999-09-01 2001-03-08 Biogen, Inc. RET LIGAND 5 (Retl5) FROM HUMAN AND MOUSE
EA008743B1 (ru) 2003-01-31 2007-08-31 Байоджен Айдек Ма Инк. Полимерные конъюгаты мутантного неубластина
ME03376B (me) 2010-05-20 2020-01-20 Array Biopharma Inc Makrociklička jedinjenja kао inhibiтori trk kinaze
US10023855B2 (en) 2011-10-31 2018-07-17 Macrogen, Inc. Fusion protein comprising C-terminal domain of RET protein and use thereof as a diagnosing marker
EP2878672A4 (en) * 2012-07-26 2016-02-17 Nat Cancer Ct FUSIONSGEN OF CEP55-GEN AND RET-GEN
WO2014176696A1 (en) 2013-04-30 2014-11-06 Université de Montréal Novel biomarkers for acute myeloid leukemia
BR112018000808A2 (pt) 2015-07-16 2018-09-04 Array Biopharma Inc compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase
TWI752098B (zh) 2016-10-10 2022-01-11 美商亞雷生物製藥股份有限公司 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
WO2018136661A1 (en) 2017-01-18 2018-07-26 Andrews Steven W SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
TWI876442B (zh) 2017-10-10 2025-03-11 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
EP3740490A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors
JP7060694B2 (ja) 2018-01-18 2022-04-26 アレイ バイオファーマ インコーポレイテッド Ｒｅｔキナーゼ阻害剤としての置換ピロロ［２，３－ｄ］ピリミジン化合物
US11472802B2 (en) 2018-01-18 2022-10-18 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
CN112996794A (zh) 2018-09-10 2021-06-18 阿雷生物药品公司 作为ret激酶抑制剂的稠合杂环化合物
EP4347645A1 (en) * 2021-06-03 2024-04-10 Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud Foundation Neuro-mesenchyme units control ilc2 and obesity via a brain-adipose circuit

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169637A (en) 1983-03-24 1992-12-08 The Liposome Company, Inc. Stable plurilamellar vesicles
CA1237671A (en) 1983-08-01 1988-06-07 Michael W. Fountain Enhancement of pharmaceutical activity
US4762915A (en) 1985-01-18 1988-08-09 Liposome Technology, Inc. Protein-liposome conjugates
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US4956288A (en) 1988-04-22 1990-09-11 Biogen, Inc. Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
US5185154A (en) 1989-02-02 1993-02-09 Liposome Technology, Inc. Method for instant preparation of a drug containing large unilamellar vesicles
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
JP3021800B2 (ja) 1990-07-24 2000-03-15 セイコーエプソン株式会社 半導体装置及びその製造方法
US5219990A (en) 1991-01-28 1993-06-15 Biogen, Inc. Papillomavirus e2 trans-activation repressors
FR2693107B1 (fr) 1992-07-01 1994-09-23 Chauvin Laboratoire Moyens pour la prévention de la cataracte secondaire.
WO1995016709A2 (en) * 1993-12-13 1995-06-22 Biogen, Inc. Anti-mullerian hormone receptor polypeptides and antibodies thereto
KR19990067508A (ko) * 1995-11-13 1999-08-25 한누 사리올라 신경교 세포주 유래 신경영양성 인자 수용체
DE69724241T2 (de) * 1996-03-14 2004-06-09 Genentech, Inc., South San Francisco Gdnf-rezeptor und dessen verwendung
US6455277B1 (en) * 1996-04-22 2002-09-24 Amgen Inc. Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides

Also Published As

Publication number Publication date
CN1232469A (zh) 1999-10-20
WO1997044356A2 (en) 1997-11-27
JP2002515743A (ja) 2002-05-28
KR20050056275A (ko) 2005-06-14
TR200103297T2 (tr) 2002-06-21
AU732392B2 (en) 2001-04-26
NZ332706A (en) 1999-10-28
CN1624126A (zh) 2005-06-08
CZ361598A3 (cs) 1999-03-17
ATE335003T1 (de) 2006-08-15
SK286115B6 (sk) 2008-03-05
SK152498A3 (en) 1999-08-06
BG64907B1 (bg) 2006-08-31
AU3472997A (en) 1997-12-09
NO985231D0 (no) 1998-11-09
DE69736428D1 (de) 2006-09-14
BG102973A (en) 1999-08-31
NO324957B1 (no) 2008-01-14
DE69736428T2 (de) 2007-08-30
CA2253871A1 (en) 1997-11-27
BR9710665A (pt) 1999-08-17
TR199802252T2 (xx) 1999-02-22
NO323612B1 (no) 2007-06-18
BG109433A (en) 2007-08-31
IL126918A0 (en) 1999-09-22
CN1163509C (zh) 2004-08-25
RO120343B1 (ro) 2005-12-30
PT914339E (pt) 2006-12-29
IL126918A (en) 2007-06-03
IS4884A (is) 1998-11-06
IS2361B (is) 2008-05-15
DK0914339T3 (da) 2006-12-04
NO20065528L (no) 1999-01-08
EA002544B1 (ru) 2002-06-27
EP0914339A2 (en) 1999-05-12
EP0914339B1 (en) 2006-08-02
NO985231L (no) 1999-01-08
EP1757617A1 (en) 2007-02-28
EE9800377A (et) 1999-04-15
CA2253871C (en) 2005-04-26
KR20060024843A (ko) 2006-03-17
EA199800990A1 (ru) 1999-06-24
CZ296516B6 (cs) 2006-04-12
WO1997044356A3 (en) 1998-02-19
ES2270465T3 (es) 2007-04-01

Similar Documents

Publication Publication Date Title
KR100587556B1 (ko) 신경 및 신장 증식을 자극하기 위한 ＲＥＴ리간드（ＲｅｔＬ)
US6861509B1 (en) Antibodies to Ret and RetL3
EP0907735B1 (en) Modulators of tissue regeneration
JPH11513883A (ja) ヒト血管内皮増殖因子２
WO2001016169A2 (en) RET LIGAND 5 (Retl5) FROM HUMAN AND MOUSE
KR100554901B1 (ko) 신경및신장증식을자극하기위한RET리간드(RetL)
HK1021821A1 (en) Ret ligand 3 (retl3) for stimulating neural and renal growth
HK1021821B (en) Ret ligand 3 (retl3) for stimulating neural and renal growth
HK1101184A (en) Ret ligand (retl) for stimulating neural and renal growth
KR100498530B1 (ko) 조직재생조절물질
CA2496906A1 (en) Ret ligand (retl) for stimulating neural and renal growth
MXPA98009309A (en) Compounds that promote tej growth

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A16-div-PA0104

St.27 status event code: A-0-1-A10-A18-div-PA0104

A201 Request for examination
AMND Amendment
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

AMND Amendment
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E601 Decision to refuse application
PE0601 Decision on rejection of patent

St.27 status event code: N-2-6-B10-B15-exm-PE0601

A107 Divisional application of patent
AMND Amendment
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

J201 Request for trial against refusal decision
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A16-div-PA0104

St.27 status event code: A-0-1-A10-A18-div-PA0104

PJ0201 Trial against decision of rejection

St.27 status event code: A-3-3-V10-V11-apl-PJ0201

PB0901 Examination by re-examination before a trial

St.27 status event code: A-6-3-E10-E12-rex-PB0901

B701 Decision to grant
PB0701 Decision of registration after re-examination before a trial

St.27 status event code: A-3-4-F10-F13-rex-PB0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

Fee payment year number: 1

St.27 status event code: A-2-2-U10-U12-oth-PR1002

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

Not in force date: 20090531

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

St.27 status event code: A-4-4-U10-U13-oth-PC1903

PC1903 Unpaid annual fee

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20090531

St.27 status event code: N-4-6-H10-H13-oth-PC1903

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000