KR100563867B1 - 혈관 수축제로써의 인다졸 아마이드 화합물 - Google Patents

혈관 수축제로써의 인다졸 아마이드 화합물 Download PDF

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Publication number
KR100563867B1
KR100563867B1 KR1019997009198A KR19997009198A KR100563867B1 KR 100563867 B1 KR100563867 B1 KR 100563867B1 KR 1019997009198 A KR1019997009198 A KR 1019997009198A KR 19997009198 A KR19997009198 A KR 19997009198A KR 100563867 B1 KR100563867 B1 KR 100563867B1
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South Korea
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formula
compound
delete delete
pharmaceutically acceptable
acid
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Expired - Fee Related
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KR1019997009198A
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English (en)
Korean (ko)
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KR20010006120A (ko
Inventor
알리시알레싼드라
브루파니마리오
카쫄라니콜라
기안난겔리마릴레나
핀자마리오
Original Assignee
아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이
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Publication of KR20010006120A publication Critical patent/KR20010006120A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Paints Or Removers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
KR1019997009198A 1997-04-15 1998-04-02 혈관 수축제로써의 인다졸 아마이드 화합물 Expired - Fee Related KR100563867B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT97MI000867A IT1291569B1 (it) 1997-04-15 1997-04-15 Indazolammidi come agenti serotoninergici
ITMI97A000867 1997-04-15
PCT/EP1998/002129 WO1998046589A2 (en) 1997-04-15 1998-04-02 Indazole amide compounds as serotoninergic agents

Publications (2)

Publication Number Publication Date
KR20010006120A KR20010006120A (ko) 2001-01-26
KR100563867B1 true KR100563867B1 (ko) 2006-03-24

Family

ID=11376888

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019997009198A Expired - Fee Related KR100563867B1 (ko) 1997-04-15 1998-04-02 혈관 수축제로써의 인다졸 아마이드 화합물

Country Status (26)

Country Link
US (1) US6197769B1 (enExample)
EP (1) EP0975623B1 (enExample)
JP (2) JP4578581B2 (enExample)
KR (1) KR100563867B1 (enExample)
CN (1) CN1318416C (enExample)
AR (1) AR012426A1 (enExample)
AT (1) ATE219490T1 (enExample)
AU (1) AU740360B2 (enExample)
BG (1) BG64006B1 (enExample)
CA (1) CA2286870C (enExample)
CZ (1) CZ295190B6 (enExample)
DE (1) DE69806141T2 (enExample)
DK (1) DK0975623T3 (enExample)
EA (1) EA002352B1 (enExample)
ES (1) ES2178205T3 (enExample)
GE (1) GEP20022654B (enExample)
HU (1) HU227973B1 (enExample)
IL (1) IL132127A (enExample)
IT (1) IT1291569B1 (enExample)
PL (1) PL193308B1 (enExample)
PT (1) PT975623E (enExample)
SK (1) SK284731B6 (enExample)
TR (1) TR199902546T2 (enExample)
UA (1) UA58550C2 (enExample)
WO (1) WO1998046589A2 (enExample)
ZA (1) ZA982926B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
PT1379520E (pt) 2001-02-23 2006-08-31 Merck & Co Inc Antagonistas (nao-aril)-heterociclicos n-substituidos de nmda/nr2b
CA2443108A1 (en) * 2001-04-03 2002-10-17 Merck & Co. Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
ITMI20030287A1 (it) 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20030972A1 (it) * 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
ES2332808T3 (es) * 2004-11-05 2010-02-12 Theravance, Inc. Compuestos agonistas del receptor 5-ht4.
US7396933B2 (en) * 2004-11-05 2008-07-08 Theravance, Inc. Quinolinone-carboxamide compounds
MX2007007818A (es) * 2004-12-22 2007-09-11 Theravance Inc Compuestos de indazol-carboxamida.
JP2008530225A (ja) * 2005-02-17 2008-08-07 セラヴァンス， インコーポレーテッド インダゾール−カルボキサミド化合物の結晶型
CN101163701A (zh) * 2005-03-02 2008-04-16 施万制药 作为5-ht4受体激动剂的喹啉酮化合物
ITMI20062230A1 (it) * 2006-11-22 2008-05-23 Acraf Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
UA99927C2 (uk) * 2007-11-12 2012-10-25 Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. Медикамент, який є активним при невропатичному болі
US8377968B2 (en) * 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
KR20140041519A (ko) * 2011-06-07 2014-04-04 다이닛본 스미토모 세이야꾸 가부시끼가이샤 인다졸-유도체 및 피롤로피리딘-유도체 및 그의 약제학적 용도
SI2817302T1 (sl) * 2012-02-21 2016-03-31 Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A 1H-indazol-3-karboksamidne spojine kot inhibitorji glikogen sintaza-kinaze-3beta
CN104080781B (zh) * 2012-02-21 2016-05-11 方济各安吉利克化学联合股份有限公司 1H-吲唑-3-甲酰胺化合物作为糖原合酶激酶3β抑制剂的用途
US10208023B2 (en) 2013-03-01 2019-02-19 Mark G. DeGiacomo Heterocyclic inhibitors of the sodium channel
TW202116314A (zh) 2019-07-11 2021-05-01 美商普雷西斯精密藥品公司 T型鈣離子通道調節劑之調配物及其使用方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003725A1 (en) * 1991-08-20 1993-03-04 Smithkline Beecham Plc 5-ht4 receptor antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
KR19990022096A (ko) * 1995-05-31 1999-03-25 쇼다 오사무 모노시클릭 아미노기를 갖는 인다졸 유도체
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003725A1 (en) * 1991-08-20 1993-03-04 Smithkline Beecham Plc 5-ht4 receptor antagonists

Also Published As

Publication number Publication date
EA002352B1 (ru) 2002-04-25
ITMI970867A1 (it) 1998-10-15
AR012426A1 (es) 2000-10-18
JP5237324B2 (ja) 2013-07-17
SK142399A3 (en) 2000-08-14
JP2001518906A (ja) 2001-10-16
CZ362599A3 (cs) 2000-04-12
UA58550C2 (uk) 2003-08-15
IL132127A0 (en) 2001-03-19
IT1291569B1 (it) 1999-01-11
EP0975623B1 (en) 2002-06-19
IL132127A (en) 2005-06-19
HUP0002057A3 (en) 2002-01-28
CN1252798A (zh) 2000-05-10
ZA982926B (en) 1998-10-09
BG103863A (en) 2000-07-31
CA2286870A1 (en) 1998-10-22
SK284731B6 (sk) 2005-10-06
DK0975623T3 (da) 2002-10-14
CZ295190B6 (cs) 2005-06-15
DE69806141D1 (de) 2002-07-25
PL193308B1 (pl) 2007-01-31
EA199900935A1 (ru) 2000-04-24
CA2286870C (en) 2007-05-22
HK1027811A1 (en) 2001-01-23
EP0975623A2 (en) 2000-02-02
TR199902546T2 (xx) 2000-05-22
KR20010006120A (ko) 2001-01-26
DE69806141T2 (de) 2003-01-30
WO1998046589A2 (en) 1998-10-22
HU227973B1 (hu) 2012-07-30
ATE219490T1 (de) 2002-07-15
GEP20022654B (en) 2002-03-25
ES2178205T3 (es) 2002-12-16
HUP0002057A2 (hu) 2001-04-28
AU7215998A (en) 1998-11-11
AU740360B2 (en) 2001-11-01
PT975623E (pt) 2002-10-31
JP4578581B2 (ja) 2010-11-10
WO1998046589A3 (en) 1999-01-28
PL336348A1 (en) 2000-06-19
JP2010195813A (ja) 2010-09-09
US6197769B1 (en) 2001-03-06
CN1318416C (zh) 2007-05-30
BG64006B1 (bg) 2003-09-30

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