CN1318416C - 5－羟色胺能试剂吲唑酰胺化合物 - Google Patents

5－羟色胺能试剂吲唑酰胺化合物 Download PDF

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Publication number
CN1318416C
CN1318416C CNB988041987A CN98804198A CN1318416C CN 1318416 C CN1318416 C CN 1318416C CN B988041987 A CNB988041987 A CN B988041987A CN 98804198 A CN98804198 A CN 98804198A CN 1318416 C CN1318416 C CN 1318416C
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China
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compound
formula
acid
medicinal
following
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Expired - Fee Related
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CNB988041987A
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English (en)
Chinese (zh)
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CN1252798A (zh
Inventor
A·阿利西
M·布鲁法尼
N·卡佐拉
M·吉安南格里
M·宾扎
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Angelini Acraf SpA
Original Assignee
Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
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Publication of CN1252798A publication Critical patent/CN1252798A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Paints Or Removers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
CNB988041987A 1997-04-15 1998-04-02 5－羟色胺能试剂吲唑酰胺化合物 Expired - Fee Related CN1318416C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000867A IT1291569B1 (it) 1997-04-15 1997-04-15 Indazolammidi come agenti serotoninergici
ITMI97A000867 1997-04-15

Publications (2)

Publication Number Publication Date
CN1252798A CN1252798A (zh) 2000-05-10
CN1318416C true CN1318416C (zh) 2007-05-30

Family

ID=11376888

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988041987A Expired - Fee Related CN1318416C (zh) 1997-04-15 1998-04-02 5－羟色胺能试剂吲唑酰胺化合物

Country Status (26)

Country Link
US (1) US6197769B1 (enExample)
EP (1) EP0975623B1 (enExample)
JP (2) JP4578581B2 (enExample)
KR (1) KR100563867B1 (enExample)
CN (1) CN1318416C (enExample)
AR (1) AR012426A1 (enExample)
AT (1) ATE219490T1 (enExample)
AU (1) AU740360B2 (enExample)
BG (1) BG64006B1 (enExample)
CA (1) CA2286870C (enExample)
CZ (1) CZ295190B6 (enExample)
DE (1) DE69806141T2 (enExample)
DK (1) DK0975623T3 (enExample)
EA (1) EA002352B1 (enExample)
ES (1) ES2178205T3 (enExample)
GE (1) GEP20022654B (enExample)
HU (1) HU227973B1 (enExample)
IL (1) IL132127A (enExample)
IT (1) IT1291569B1 (enExample)
PL (1) PL193308B1 (enExample)
PT (1) PT975623E (enExample)
SK (1) SK284731B6 (enExample)
TR (1) TR199902546T2 (enExample)
UA (1) UA58550C2 (enExample)
WO (1) WO1998046589A2 (enExample)
ZA (1) ZA982926B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
PT1379520E (pt) 2001-02-23 2006-08-31 Merck & Co Inc Antagonistas (nao-aril)-heterociclicos n-substituidos de nmda/nr2b
CA2443108A1 (en) * 2001-04-03 2002-10-17 Merck & Co. Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
ITMI20030287A1 (it) 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20030972A1 (it) * 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
ES2332808T3 (es) * 2004-11-05 2010-02-12 Theravance, Inc. Compuestos agonistas del receptor 5-ht4.
US7396933B2 (en) * 2004-11-05 2008-07-08 Theravance, Inc. Quinolinone-carboxamide compounds
MX2007007818A (es) * 2004-12-22 2007-09-11 Theravance Inc Compuestos de indazol-carboxamida.
JP2008530225A (ja) * 2005-02-17 2008-08-07 セラヴァンス， インコーポレーテッド インダゾール−カルボキサミド化合物の結晶型
CN101163701A (zh) * 2005-03-02 2008-04-16 施万制药 作为5-ht4受体激动剂的喹啉酮化合物
ITMI20062230A1 (it) * 2006-11-22 2008-05-23 Acraf Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
UA99927C2 (uk) * 2007-11-12 2012-10-25 Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. Медикамент, який є активним при невропатичному болі
US8377968B2 (en) * 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
KR20140041519A (ko) * 2011-06-07 2014-04-04 다이닛본 스미토모 세이야꾸 가부시끼가이샤 인다졸-유도체 및 피롤로피리딘-유도체 및 그의 약제학적 용도
SI2817302T1 (sl) * 2012-02-21 2016-03-31 Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A 1H-indazol-3-karboksamidne spojine kot inhibitorji glikogen sintaza-kinaze-3beta
CN104080781B (zh) * 2012-02-21 2016-05-11 方济各安吉利克化学联合股份有限公司 1H-吲唑-3-甲酰胺化合物作为糖原合酶激酶3β抑制剂的用途
US10208023B2 (en) 2013-03-01 2019-02-19 Mark G. DeGiacomo Heterocyclic inhibitors of the sodium channel
TW202116314A (zh) 2019-07-11 2021-05-01 美商普雷西斯精密藥品公司 T型鈣離子通道調節劑之調配物及其使用方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0501322A1 (en) * 1991-02-25 1992-09-02 Glaxo Group Limited 3-Piperidinylmethylcarboxylate substituted indoles
WO1993003725A1 (en) * 1991-08-20 1993-03-04 Smithkline Beecham Plc 5-ht4 receptor antagonists
EP0732333A1 (en) * 1995-03-16 1996-09-18 Eli Lilly And Company Indazolecarboxamides
WO1996038420A1 (en) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amino group

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0501322A1 (en) * 1991-02-25 1992-09-02 Glaxo Group Limited 3-Piperidinylmethylcarboxylate substituted indoles
WO1993003725A1 (en) * 1991-08-20 1993-03-04 Smithkline Beecham Plc 5-ht4 receptor antagonists
EP0732333A1 (en) * 1995-03-16 1996-09-18 Eli Lilly And Company Indazolecarboxamides
WO1996038420A1 (en) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amino group

Also Published As

Publication number Publication date
EA002352B1 (ru) 2002-04-25
ITMI970867A1 (it) 1998-10-15
AR012426A1 (es) 2000-10-18
JP5237324B2 (ja) 2013-07-17
SK142399A3 (en) 2000-08-14
JP2001518906A (ja) 2001-10-16
CZ362599A3 (cs) 2000-04-12
UA58550C2 (uk) 2003-08-15
IL132127A0 (en) 2001-03-19
IT1291569B1 (it) 1999-01-11
EP0975623B1 (en) 2002-06-19
IL132127A (en) 2005-06-19
HUP0002057A3 (en) 2002-01-28
CN1252798A (zh) 2000-05-10
ZA982926B (en) 1998-10-09
BG103863A (en) 2000-07-31
CA2286870A1 (en) 1998-10-22
SK284731B6 (sk) 2005-10-06
DK0975623T3 (da) 2002-10-14
CZ295190B6 (cs) 2005-06-15
DE69806141D1 (de) 2002-07-25
PL193308B1 (pl) 2007-01-31
EA199900935A1 (ru) 2000-04-24
CA2286870C (en) 2007-05-22
HK1027811A1 (en) 2001-01-23
EP0975623A2 (en) 2000-02-02
TR199902546T2 (xx) 2000-05-22
KR20010006120A (ko) 2001-01-26
DE69806141T2 (de) 2003-01-30
WO1998046589A2 (en) 1998-10-22
HU227973B1 (hu) 2012-07-30
ATE219490T1 (de) 2002-07-15
GEP20022654B (en) 2002-03-25
ES2178205T3 (es) 2002-12-16
HUP0002057A2 (hu) 2001-04-28
AU7215998A (en) 1998-11-11
AU740360B2 (en) 2001-11-01
PT975623E (pt) 2002-10-31
JP4578581B2 (ja) 2010-11-10
WO1998046589A3 (en) 1999-01-28
KR100563867B1 (ko) 2006-03-24
PL336348A1 (en) 2000-06-19
JP2010195813A (ja) 2010-09-09
US6197769B1 (en) 2001-03-06
BG64006B1 (bg) 2003-09-30

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