KR100546038B1 - 항염증및항혈전성활성을지닌새로운화합물및그조성물 - Google Patents

항염증및항혈전성활성을지닌새로운화합물및그조성물 Download PDF

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Publication number
KR100546038B1
KR100546038B1 KR1019980703206A KR19980703206A KR100546038B1 KR 100546038 B1 KR100546038 B1 KR 100546038B1 KR 1019980703206 A KR1019980703206 A KR 1019980703206A KR 19980703206 A KR19980703206 A KR 19980703206A KR 100546038 B1 KR100546038 B1 KR 100546038B1
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KR
South Korea
Prior art keywords
ono
inflammatory
linear
formula
compound according
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Expired - Fee Related
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KR1019980703206A
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English (en)
Korean (ko)
Other versions
KR19990067247A (ko
Inventor
피에로 델 솔다토
프란체스코 사니콜로
Original Assignee
니콕스 에스. 에이.
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Publication of KR19990067247A publication Critical patent/KR19990067247A/ko
Application granted granted Critical
Publication of KR100546038B1 publication Critical patent/KR100546038B1/ko
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019980703206A 1995-10-31 1996-10-29 항염증및항혈전성활성을지닌새로운화합물및그조성물 Expired - Fee Related KR100546038B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI95A002263 1995-10-31
IT95MI002263A IT1276071B1 (it) 1995-10-31 1995-10-31 Compositi ad attivita' anti-infiammatoria
PCT/EP1996/004696 WO1997016405A1 (en) 1995-10-31 1996-10-29 New compounds and their compositions having anti-inflammatory and anti-thrombotic activities

Publications (2)

Publication Number Publication Date
KR19990067247A KR19990067247A (ko) 1999-08-16
KR100546038B1 true KR100546038B1 (ko) 2006-10-04

Family

ID=11372460

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980703206A Expired - Fee Related KR100546038B1 (ko) 1995-10-31 1996-10-29 항염증및항혈전성활성을지닌새로운화합물및그조성물

Country Status (18)

Country Link
US (1) US6040341A (https=)
EP (1) EP0871606B1 (https=)
JP (1) JP3880067B2 (https=)
KR (1) KR100546038B1 (https=)
AT (1) ATE193883T1 (https=)
AU (1) AU709338B2 (https=)
BR (1) BR9611175B1 (https=)
CA (1) CA2235996C (https=)
DE (1) DE69608916T2 (https=)
DK (1) DK0871606T3 (https=)
ES (1) ES2148808T3 (https=)
GR (1) GR3033827T3 (https=)
HU (1) HUP9802986A3 (https=)
IT (1) IT1276071B1 (https=)
PT (1) PT871606E (https=)
RU (1) RU2165921C2 (https=)
SI (1) SI0871606T1 (https=)
WO (1) WO1997016405A1 (https=)

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US6136804A (en) 1998-03-13 2000-10-24 Merck & Co., Inc. Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
ES2136581B1 (es) 1998-05-27 2000-09-16 Uriach & Cia Sa J Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb.
EP1085845A2 (en) 1998-06-08 2001-03-28 Advanced Medicine, Inc. Multibinding inhibitors of cyclooxygenase-2
WO2000018352A2 (en) * 1998-09-28 2000-04-06 Merck & Co., Inc. A method for treating inflammatory diseases by administering a thrombin inhibitor
EP1126838A4 (en) 1998-10-30 2005-02-16 Nitromed Inc NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
IT1307928B1 (it) * 1999-01-26 2001-11-29 Nicox Sa Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.
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US6509377B1 (en) * 1999-05-26 2003-01-21 J. Uriach & Cia, S.A. Use of a 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-κB
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ITMI991517A1 (it) * 1999-07-09 2001-01-09 Nicox Sa Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico
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CA2393724A1 (en) 1999-12-23 2001-06-28 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
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JP4092203B2 (ja) * 2000-12-21 2008-05-28 ニトロメッド，インク． 新規のシクロオキシゲナーゼ２選択的阻害剤としての置換アリール化合物、組成物、および使用方法
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
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ITMI20011240A1 (it) * 2001-06-13 2002-12-13 Nicox Sa Farmaci per le vasculopatie
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
US7011854B2 (en) 2002-02-04 2006-03-14 Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
AU2003229005A1 (en) * 2002-05-10 2003-11-11 Merck And Co., Inc. Combination therapy for treating cyclooxygenase-2 mediated diseases in patients at risk of thrombotic cardiovascular events
US20050215611A1 (en) * 2002-05-10 2005-09-29 Hunt Richard H Combination therapy for treating cyclooxygenase-2 mediated diseases in patients at risk of thrombotic cardiovascular events
WO2003103602A2 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
EP1534683A4 (en) 2002-06-27 2005-08-24 Nitromed Inc CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHOD OF USE
AU2003279622A1 (en) * 2002-06-28 2004-01-19 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
CA2491127A1 (en) * 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
AU2003252515A1 (en) 2002-07-26 2004-02-16 Merck Frosst Canada And Co. Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
AU2003261281A1 (en) * 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
KR20050057496A (ko) * 2002-09-20 2005-06-16 니콕스 에스. 에이. Ｎｏ-공여 디클로페낙과 같은 ｎｏ-공여 화합물의제조방법
US20060247216A1 (en) * 2002-10-25 2006-11-02 Haj-Yehia Abdullah I Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
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ITMI20022658A1 (it) 2002-12-17 2004-06-18 Nicox Sa Farmaci per il dolore cronico.
US20070207217A1 (en) * 2003-02-03 2007-09-06 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO
US7166638B2 (en) * 2003-05-27 2007-01-23 Nicox S.A. Statin derivatives
US7169805B2 (en) 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
ATE424199T1 (de) 2003-06-19 2009-03-15 Nicox Sa Enalapril-nitroxy-derivate und verwandte verbindungen als ace-hemmer zur behandlung von kardiovaskulären erkrankungen
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US7521435B2 (en) * 2005-02-18 2009-04-21 Pharma Diagnostics, N.V. Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same
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US8236820B2 (en) * 2007-08-10 2012-08-07 Basil Rigas Anti-inflammatory compounds and uses thereof
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Also Published As

Publication number Publication date
PT871606E (pt) 2000-11-30
DE69608916D1 (de) 2000-07-20
JP3880067B2 (ja) 2007-02-14
AU7495096A (en) 1997-05-22
GR3033827T3 (en) 2000-10-31
DK0871606T3 (da) 2000-07-31
CA2235996A1 (en) 1997-05-09
US6040341A (en) 2000-03-21
CA2235996C (en) 2007-01-02
BR9611175A (pt) 1999-03-30
HUP9802986A2 (hu) 1999-04-28
RU2165921C2 (ru) 2001-04-27
BR9611175B1 (pt) 2009-01-13
SI0871606T1 (en) 2000-08-31
IT1276071B1 (it) 1997-10-24
EP0871606A1 (en) 1998-10-21
WO1997016405A1 (en) 1997-05-09
ITMI952263A1 (it) 1997-05-01
AU709338B2 (en) 1999-08-26
EP0871606B1 (en) 2000-06-14
ATE193883T1 (de) 2000-06-15
HUP9802986A3 (en) 1999-12-28
JPH11514636A (ja) 1999-12-14
KR19990067247A (ko) 1999-08-16
DE69608916T2 (de) 2001-01-11
ES2148808T3 (es) 2000-10-16
ITMI952263A0 (https=) 1995-10-31

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