ATE424199T1 - Enalapril-nitroxy-derivate und verwandte verbindungen als ace-hemmer zur behandlung von kardiovaskulären erkrankungen - Google Patents
Enalapril-nitroxy-derivate und verwandte verbindungen als ace-hemmer zur behandlung von kardiovaskulären erkrankungenInfo
- Publication number
- ATE424199T1 ATE424199T1 AT04741779T AT04741779T ATE424199T1 AT E424199 T1 ATE424199 T1 AT E424199T1 AT 04741779 T AT04741779 T AT 04741779T AT 04741779 T AT04741779 T AT 04741779T AT E424199 T1 ATE424199 T1 AT E424199T1
- Authority
- AT
- Austria
- Prior art keywords
- enalapril
- treatment
- cardiovascular diseases
- related compounds
- ace inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03101796 | 2003-06-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE424199T1 true ATE424199T1 (de) | 2009-03-15 |
Family
ID=33547744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04741779T ATE424199T1 (de) | 2003-06-19 | 2004-06-11 | Enalapril-nitroxy-derivate und verwandte verbindungen als ace-hemmer zur behandlung von kardiovaskulären erkrankungen |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7217733B2 (de) |
| EP (1) | EP1635816B1 (de) |
| KR (1) | KR20060021900A (de) |
| CN (1) | CN1809345A (de) |
| AR (1) | AR044839A1 (de) |
| AT (1) | ATE424199T1 (de) |
| AU (1) | AU2004246821A1 (de) |
| BR (1) | BRPI0411430A (de) |
| CA (1) | CA2529478A1 (de) |
| DE (1) | DE602004019779D1 (de) |
| ES (1) | ES2322263T3 (de) |
| IL (1) | IL172018A0 (de) |
| MX (1) | MXPA05013771A (de) |
| NO (1) | NO20060268L (de) |
| PL (1) | PL379197A1 (de) |
| RU (1) | RU2006100827A (de) |
| WO (1) | WO2004110432A1 (de) |
| ZA (1) | ZA200600526B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005018561A2 (en) * | 2003-08-20 | 2005-03-03 | Nitromed, Inc. | Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use |
| AU2005281359A1 (en) | 2004-08-26 | 2006-03-16 | Apparao Satyam | Prodrugs and codrugs containing novel bio-cleavable disulfide linkers |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| JP2009514809A (ja) * | 2005-10-18 | 2009-04-09 | ニコックス エス エイ | レニン阻害剤のニトロ誘導体 |
| ES2604562T3 (es) * | 2007-02-05 | 2017-03-07 | Nicox Science Ireland | Compuestos donantes de óxido nítrico |
| EP2534958A1 (de) | 2007-12-14 | 2012-12-19 | AeroDesigns, Inc | Abgabe von Aerosol-sprühbaren Nahrungsmittelprodukten |
| AR073259A1 (es) | 2008-07-29 | 2010-10-28 | Merck & Co Inc | Derivados de furosemida utiles como diureticos |
| WO2011160974A2 (en) | 2010-06-21 | 2011-12-29 | Nicox S.A. | Statin derivatives |
| JO3350B1 (ar) | 2011-03-07 | 2019-03-13 | Merck Sharp & Dohme | مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4574079A (en) * | 1983-05-27 | 1986-03-04 | Gavras Haralambos P | Radiolabeled angiotensin converting enzyme inhibitors for radiolabeling mammalian organ sites |
| IT1276071B1 (it) | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
| IT1295694B1 (it) * | 1996-11-14 | 1999-05-27 | Nicox Sa | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
| IT1311924B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1311923B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
-
2004
- 2004-06-11 WO PCT/EP2004/051089 patent/WO2004110432A1/en active Application Filing
- 2004-06-11 AU AU2004246821A patent/AU2004246821A1/en not_active Abandoned
- 2004-06-11 PL PL379197A patent/PL379197A1/pl not_active Application Discontinuation
- 2004-06-11 AT AT04741779T patent/ATE424199T1/de not_active IP Right Cessation
- 2004-06-11 EP EP04741779A patent/EP1635816B1/de not_active Expired - Lifetime
- 2004-06-11 BR BRPI0411430-2A patent/BRPI0411430A/pt not_active IP Right Cessation
- 2004-06-11 CN CNA2004800171279A patent/CN1809345A/zh active Pending
- 2004-06-11 ES ES04741779T patent/ES2322263T3/es not_active Expired - Lifetime
- 2004-06-11 DE DE602004019779T patent/DE602004019779D1/de not_active Expired - Lifetime
- 2004-06-11 RU RU2006100827/04A patent/RU2006100827A/ru unknown
- 2004-06-11 KR KR1020057024266A patent/KR20060021900A/ko not_active Application Discontinuation
- 2004-06-11 MX MXPA05013771A patent/MXPA05013771A/es active IP Right Grant
- 2004-06-11 CA CA002529478A patent/CA2529478A1/en not_active Abandoned
- 2004-06-17 US US10/869,038 patent/US7217733B2/en not_active Expired - Fee Related
- 2004-06-18 AR ARP040102150A patent/AR044839A1/es unknown
-
2005
- 2005-11-17 IL IL172018A patent/IL172018A0/en unknown
-
2006
- 2006-01-18 ZA ZA200600526A patent/ZA200600526B/en unknown
- 2006-01-18 NO NO20060268A patent/NO20060268L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05013771A (es) | 2006-03-08 |
| RU2006100827A (ru) | 2007-07-27 |
| WO2004110432A1 (en) | 2004-12-23 |
| NO20060268L (no) | 2006-03-15 |
| EP1635816B1 (de) | 2009-03-04 |
| CA2529478A1 (en) | 2004-12-23 |
| US7217733B2 (en) | 2007-05-15 |
| PL379197A1 (pl) | 2006-07-24 |
| ES2322263T3 (es) | 2009-06-18 |
| KR20060021900A (ko) | 2006-03-08 |
| AU2004246821A1 (en) | 2004-12-23 |
| AR044839A1 (es) | 2005-10-05 |
| EP1635816A1 (de) | 2006-03-22 |
| ZA200600526B (en) | 2007-01-31 |
| DE602004019779D1 (de) | 2009-04-16 |
| BRPI0411430A (pt) | 2006-07-25 |
| IL172018A0 (en) | 2009-02-11 |
| US20050004100A1 (en) | 2005-01-06 |
| CN1809345A (zh) | 2006-07-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE428424T1 (de) | 1-benzoyl-piperazin-derivate als glycin- aufnahmehemmer zur behandlung von psychosen | |
| DE602005022113D1 (de) | Phenyl)methanon-derivate als glycin-transporter 1 (glyt-1) hemmer zur behandlung von neurologischen und neuropsychiatrischen erkrankungen | |
| ATE430139T1 (de) | Pyrrolidin-1,2-dicarbonsäure-1-(phenylamid)-2-( - (3-oxo-morpholin-4-yl)-phenylamid) derivate und verwandte verbindungen als inhibitoren des koagulationsfaktors xa zur behandlung von thromboembolischen erkrankungen | |
| DE602006018583D1 (de) | Verfahren und zusammensetzung zur behandlung von peripheren gefässkrankheiten | |
| DE60335293D1 (de) | Pyrrolopyridazin-verbindungen und verwendungsverfahren dafür zur behandlung von proliferativen erkrankungen | |
| DE602005007717D1 (de) | Imidazolverbindungen zur behandlung von neurodegenerativen erkrankungen | |
| DE602004026891D1 (de) | Tlr7-liganden zur behandlung von hepatitis c | |
| DE602005026984D1 (de) | Chinolin-derivate zur behandlung von latenter tuberkulose | |
| ATE504580T1 (de) | Malonsäureamidderivate als inhibitoren von g- sekretase zur behandlung von alzheimer-krankheit | |
| ATE551100T1 (de) | Pharmazeutische zusammensetzung zur behandlung von kardiovaskulären und cerebrovasakulären erkrankungen | |
| ATE550338T1 (de) | Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit | |
| DE602004028763D1 (de) | Te zur behandlung von virenerkrankungen | |
| ATE410161T1 (de) | 4-bromo-5-(2-chloro-benzoylamino)-1h-pyrazol-3- carbonsäureamid-derivate und verwandte verbindungen als bradykinin b1 rezeptor antagonisten zur behandlung von entzündlichen erkrankungen | |
| ATE354563T1 (de) | Sulfonderivate zur hemmung von gamma-secretase | |
| DE602005012481D1 (de) | 2,7-substituierte 5-amino-4-hydroxy-8-(1h-indol-5-yl)-octanamid derivate als renin inhibitoren zur behandlung von bluthochdruck | |
| ATE446754T1 (de) | Verbindungen zur behandlung von schizophrenie und/oder glucoregulatorische auffälligkeiten | |
| DE60217532T8 (de) | Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas | |
| IL172018A0 (en) | Enalapril-nitroxyderivatives derivatives and related compounds as ace inhibitors for the treatment of cardiovascular diseases | |
| DE602004022153D1 (de) | Verbindungen zur behandlung von obesitas | |
| DE602005016141D1 (de) | S-mirtazapin zur behandlung von hitzewallungen | |
| DE602004001134D1 (de) | Tetrazolderivate und verfahren zur behandlung von stoffwechselbedingten erkrankungen damit | |
| DE602004022035D1 (de) | Verwendung von pthalide derivativen zur behandlung | |
| DE602004006118D1 (de) | 2,3,4,5-TETRAHYDROBENZOiFöi1,4öOXAZEPIN-5-CARBONSÄUREAMID DERIVATE ALS GAMMA-SECRETASE INHIBITOREN ZUR BEHANDLUNG VON ALZHEIMER | |
| ATE482707T1 (de) | 1-ä2h-1-benzopyran-2-on-8-ylü- piperazin- derivate zur behandlung von schmerzen | |
| ATE457725T1 (de) | Kynurenine 3-hydroxylase inhibitoren zur behandlung von diabetes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |