AR044839A1 - Enalapril- nitroxiderivados y compuestos relacionados como inhibidores de ace para el tratamiento de enfermedades cardiovasculares - Google Patents
Enalapril- nitroxiderivados y compuestos relacionados como inhibidores de ace para el tratamiento de enfermedades cardiovascularesInfo
- Publication number
- AR044839A1 AR044839A1 ARP040102150A ARP040102150A AR044839A1 AR 044839 A1 AR044839 A1 AR 044839A1 AR P040102150 A ARP040102150 A AR P040102150A AR P040102150 A ARP040102150 A AR P040102150A AR 044839 A1 AR044839 A1 AR 044839A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- coo
- equal
- branched
- free valence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente se refiere a enalapril- nitroxi derivados. Dichos compuestos se pueden emplear para tratar enfermedades cardiovasculares y renales y procesos inflamatorios. Reivindicación 1: Un compuesto caracterizado porque responde a la fórmula general (1) o una sal aceptable para uso farmacéutico o un estereoisómero del mismo: A-(X1-ONO2)s donde s es un entero igual a 1 o 2; A se selecciona entre los siguientes grupos de fórmula (1a) donde n es un entero entre 1 y 6, preferiblemente igual a 1 o 2; N0 es -COO- o -COOR0 donde R0 es H o un alquilo (C1-10) lineal o ramificado; R1 se selecciona entre el grupo que consiste en las fórmulas (2 a 14) donde N2 tiene el mismo significado que se definió para N0 y pueden ser iguales o diferentes, N2a es H, -C(O)-, -COO-, -COOR0, -C(O)R0- donde R0 es un alquilo(C1-10) lineal o ramificado; con la condición de que por lo menos uno de los grupos N0, N2 o N2a sea -COO- o -C(O)- es decir que tenga una valencia libre capaz de unirse a un X1; (1b) donde n se definió antes, y es preferiblemente igual a 4; N3 es H o como se muestra en la fórmula (15); R2 puede ser como se muestra en las fórmulas (16-17) donde N2 es igual a -COO-, que tiene una valencia libre capaz de unirse a un X1; (1c) fórmula (18) donde R1c se selecciona entre H, -COCH3, o como se muestra en la fórmula (19) donde N2 es igual a -COO-, que tiene una valencia libre capaz de unirse a un X1; (1d) como se muestra en la fórmula (20) donde N2 tiene los valores que se han definido, con la condición de que por lo menos uno de los grupos N2 sea igual a -COO-, es decir que tenga una valencia libre capaz de unirse a un X1; X1 es un alquileno (C1-6) lineal o de ser posible ramificado, sustituido opcionalmente con por lo menos un átomo de halógeno, o un radical bivalente igual a -(CH2-CH2-O)2- o -(CH2-CH2-S)2-; con la condición que cuando A sea (1a) y R1 sea el grupo de fórmula (3) o A sea (1c) y R1c sea -COCH3, X1 será diferente de un alquileno (C1-6) lineal o de ser posible ramificado.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03101796 | 2003-06-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044839A1 true AR044839A1 (es) | 2005-10-05 |
Family
ID=33547744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102150A AR044839A1 (es) | 2003-06-19 | 2004-06-18 | Enalapril- nitroxiderivados y compuestos relacionados como inhibidores de ace para el tratamiento de enfermedades cardiovasculares |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7217733B2 (es) |
| EP (1) | EP1635816B1 (es) |
| KR (1) | KR20060021900A (es) |
| CN (1) | CN1809345A (es) |
| AR (1) | AR044839A1 (es) |
| AT (1) | ATE424199T1 (es) |
| AU (1) | AU2004246821A1 (es) |
| BR (1) | BRPI0411430A (es) |
| CA (1) | CA2529478A1 (es) |
| DE (1) | DE602004019779D1 (es) |
| ES (1) | ES2322263T3 (es) |
| IL (1) | IL172018A0 (es) |
| MX (1) | MXPA05013771A (es) |
| NO (1) | NO20060268L (es) |
| PL (1) | PL379197A1 (es) |
| RU (1) | RU2006100827A (es) |
| WO (1) | WO2004110432A1 (es) |
| ZA (1) | ZA200600526B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004266705A1 (en) * | 2003-08-20 | 2005-03-03 | Nitromed, Inc. | Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| MX2007002210A (es) | 2004-08-26 | 2007-05-07 | Nicholas Piramal India Ltd | Profarmacos que contienen enlazantes bioescindibles novedosos. |
| WO2007045551A2 (en) * | 2005-10-18 | 2007-04-26 | Nicox S.A. | Renin inhibitors nitroderivatives |
| WO2008095841A2 (en) | 2007-02-05 | 2008-08-14 | Nicox S.A. | Nitric oxide donor compounds |
| CA2709071C (en) | 2007-12-14 | 2016-11-15 | Labogroup S.A.S. | Delivering aerosolizable food products |
| AR073259A1 (es) * | 2008-07-29 | 2010-10-28 | Merck & Co Inc | Derivados de furosemida utiles como diureticos |
| WO2011160974A2 (en) | 2010-06-21 | 2011-12-29 | Nicox S.A. | Statin derivatives |
| JO3350B1 (ar) | 2011-03-07 | 2019-03-13 | Merck Sharp & Dohme | مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4574079A (en) * | 1983-05-27 | 1986-03-04 | Gavras Haralambos P | Radiolabeled angiotensin converting enzyme inhibitors for radiolabeling mammalian organ sites |
| IT1276071B1 (it) | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
| IT1295694B1 (it) * | 1996-11-14 | 1999-05-27 | Nicox Sa | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
| IT1311924B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1311923B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
-
2004
- 2004-06-11 BR BRPI0411430-2A patent/BRPI0411430A/pt not_active IP Right Cessation
- 2004-06-11 CA CA002529478A patent/CA2529478A1/en not_active Abandoned
- 2004-06-11 MX MXPA05013771A patent/MXPA05013771A/es active IP Right Grant
- 2004-06-11 RU RU2006100827/04A patent/RU2006100827A/ru unknown
- 2004-06-11 DE DE602004019779T patent/DE602004019779D1/de not_active Expired - Lifetime
- 2004-06-11 PL PL379197A patent/PL379197A1/pl not_active Application Discontinuation
- 2004-06-11 KR KR1020057024266A patent/KR20060021900A/ko not_active Application Discontinuation
- 2004-06-11 EP EP04741779A patent/EP1635816B1/en not_active Expired - Lifetime
- 2004-06-11 CN CNA2004800171279A patent/CN1809345A/zh active Pending
- 2004-06-11 AT AT04741779T patent/ATE424199T1/de not_active IP Right Cessation
- 2004-06-11 ES ES04741779T patent/ES2322263T3/es not_active Expired - Lifetime
- 2004-06-11 AU AU2004246821A patent/AU2004246821A1/en not_active Abandoned
- 2004-06-11 WO PCT/EP2004/051089 patent/WO2004110432A1/en active Application Filing
- 2004-06-17 US US10/869,038 patent/US7217733B2/en not_active Expired - Fee Related
- 2004-06-18 AR ARP040102150A patent/AR044839A1/es unknown
-
2005
- 2005-11-17 IL IL172018A patent/IL172018A0/en unknown
-
2006
- 2006-01-18 ZA ZA200600526A patent/ZA200600526B/en unknown
- 2006-01-18 NO NO20060268A patent/NO20060268L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1635816B1 (en) | 2009-03-04 |
| NO20060268L (no) | 2006-03-15 |
| KR20060021900A (ko) | 2006-03-08 |
| IL172018A0 (en) | 2009-02-11 |
| EP1635816A1 (en) | 2006-03-22 |
| US7217733B2 (en) | 2007-05-15 |
| PL379197A1 (pl) | 2006-07-24 |
| ZA200600526B (en) | 2007-01-31 |
| MXPA05013771A (es) | 2006-03-08 |
| BRPI0411430A (pt) | 2006-07-25 |
| ES2322263T3 (es) | 2009-06-18 |
| RU2006100827A (ru) | 2007-07-27 |
| AU2004246821A1 (en) | 2004-12-23 |
| DE602004019779D1 (de) | 2009-04-16 |
| US20050004100A1 (en) | 2005-01-06 |
| CA2529478A1 (en) | 2004-12-23 |
| WO2004110432A1 (en) | 2004-12-23 |
| ATE424199T1 (de) | 2009-03-15 |
| CN1809345A (zh) | 2006-07-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1109369T1 (el) | Υποκατεστημενες πυρρολοπυριδινες, οι ενωσεις που τις περιεχουν, η διαδικασια παρασκευης τους και η χρηση τους | |
| BR0115312A (pt) | Derivados heterociclilalquil piperidina, sua preparação e as composições que os contêm | |
| SV2009003281A (es) | Inhibidores espiro cetona de acetil-coa carboxilasa.0 | |
| AR056456A1 (es) | Procedimiento para la preparacion de betamiméticos | |
| EA200701176A1 (ru) | Новые соединения нафталина, способ их получения и фармацевтические композиции, содержащие их | |
| HN2012001162A (es) | Triazolopiridinas | |
| ECSP077290A (es) | Derivados de isoxazolina y su uso como herbicidas | |
| UY29469A1 (es) | Compuestos sulfoximino-macrocíclicos y sus sales, composiciones farmacéuticas que comprenden dichos compuestos, métodos de preparación y usos de los mismos. | |
| NO20044822L (no) | Fortykkede syreblanding og anvendelser derav | |
| RU2013103076A (ru) | МАЛОРАЗДРАЖАЮЩИЕ ПРОЗРАЧНЫЕ ОЧИЩАЮЩИЕ КОМПОЗИЦИИ С ОТНОСИТЕЛЬНО НИЗКИМ pН | |
| AR048039A1 (es) | Profarmacos de piperazina y agentes antivirales de piperidina sustituidos | |
| BRPI0913457A2 (pt) | "composto, composição farmacêutica, e, uso do composto" | |
| DK1789527T3 (da) | Rensningssammensætninger til mikroelektroniksubstrater | |
| CL2008000959A1 (es) | Compuestos derivados de 1,2,4-tiadiazina o 1,4-tiazina; composiciones farmaceuticas que los contienen; y su uso para la prevencion y/o tratamiento de infecciones producidas por el virus de la hepatitis c. | |
| AR044839A1 (es) | Enalapril- nitroxiderivados y compuestos relacionados como inhibidores de ace para el tratamiento de enfermedades cardiovasculares | |
| PA8660601A1 (es) | Pirazolopiridinas y sales de las mismas, una composicion farmaceutica que comprende dichos compuestos, un metodo para prepararlos y su uso | |
| AR044561A1 (es) | Derivados de estatina | |
| AR056574A1 (es) | Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso | |
| DE602006017724D1 (de) | Salicylsäurederivate | |
| UY29510A1 (es) | Derivados de urea, metodos para su fabricación, y usos de los mismos | |
| DK1940818T3 (da) | Aminosyrederivater indeholdende en disulfanylgruppe i form af blandede disulfanyl- og aminopeptidaseinhibitorer | |
| PH12017501427A1 (en) | Benzoxaborole compounds and uses thereof | |
| GEP20125548B (en) | New dihidroindolone compounds, a process for its preparation and pharmaceutical compositions containing them | |
| ATE461185T1 (de) | Sulfoniumsalze als photoinitiatoren | |
| ATE554774T1 (de) | 2-methylen-19-nor-(20s-24epi)-1alpha,25- dihydrovitamin-d2 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |