KR100499214B1 - 아베르멕틴의 b2:b1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자 - Google Patents
아베르멕틴의 b2:b1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자 Download PDFInfo
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- KR100499214B1 KR100499214B1 KR10-2000-7008870A KR20007008870A KR100499214B1 KR 100499214 B1 KR100499214 B1 KR 100499214B1 KR 20007008870 A KR20007008870 A KR 20007008870A KR 100499214 B1 KR100499214 B1 KR 100499214B1
- Authority
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- South Korea
- Prior art keywords
- avec
- delete delete
- streptomyces avermitilis
- avermectin
- streptomyces
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7463698P | 1998-02-13 | 1998-02-13 | |
| US60/074,636 | 1998-02-13 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR10-2004-7008310A Division KR20040053390A (ko) | 1998-02-13 | 1999-01-25 | 아베르멕틴의 비2:비1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20010052166A KR20010052166A (ko) | 2001-06-25 |
| KR100499214B1 true KR100499214B1 (ko) | 2005-07-07 |
Family
ID=22120706
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR10-2000-7008870A KR100499214B1 (ko) | 1998-02-13 | 1999-01-25 | 아베르멕틴의 b2:b1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자 |
| KR10-2004-7015691A KR20040099389A (ko) | 1998-02-13 | 1999-01-25 | 스트렙토마이세스 하이그로스코피쿠스 유전자 |
| KR10-2004-7008310A KR20040053390A (ko) | 1998-02-13 | 1999-01-25 | 아베르멕틴의 비2:비1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR10-2004-7015691A KR20040099389A (ko) | 1998-02-13 | 1999-01-25 | 스트렙토마이세스 하이그로스코피쿠스 유전자 |
| KR10-2004-7008310A KR20040053390A (ko) | 1998-02-13 | 1999-01-25 | 아베르멕틴의 비2:비1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자 |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP1053335A1 (no) |
| JP (2) | JP2002503473A (no) |
| KR (3) | KR100499214B1 (no) |
| CN (2) | CN1521180A (no) |
| AP (1) | AP9901463A0 (no) |
| AR (1) | AR018085A1 (no) |
| AU (1) | AU752343C (no) |
| BG (1) | BG64911B1 (no) |
| BR (1) | BR9907893A (no) |
| CA (2) | CA2521289A1 (no) |
| CO (1) | CO5070698A1 (no) |
| DZ (1) | DZ2720A1 (no) |
| EA (1) | EA003905B1 (no) |
| GT (1) | GT199900014A (no) |
| HN (1) | HN1999000008A (no) |
| HR (1) | HRP20000539A2 (no) |
| HU (1) | HUP0100784A3 (no) |
| IL (2) | IL137610A0 (no) |
| IS (1) | IS5567A (no) |
| MA (1) | MA24760A1 (no) |
| NO (1) | NO20004044L (no) |
| NZ (2) | NZ505676A (no) |
| OA (1) | OA11449A (no) |
| PA (1) | PA8467601A1 (no) |
| PE (1) | PE20000352A1 (no) |
| PL (1) | PL194270B1 (no) |
| SK (1) | SK11722000A3 (no) |
| TN (1) | TNSN99017A1 (no) |
| TW (1) | TW585910B (no) |
| WO (1) | WO1999041389A1 (no) |
| YU (1) | YU50900A (no) |
| ZA (1) | ZA991138B (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1521180A (zh) * | 1998-02-13 | 2004-08-18 | �Ʒ� | 介导除虫菌素b2：b1比例的除虫链霉菌基因 |
| US6248579B1 (en) * | 1998-02-13 | 2001-06-19 | Pfizer Inc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
| WO2001012821A1 (en) * | 1999-08-12 | 2001-02-22 | Pfizer Products Inc. | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
| US7630836B2 (en) * | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| JP2005517406A (ja) * | 2002-02-12 | 2005-06-16 | ファイザー・プロダクツ・インク | Ｂ２：Ｂ１アベルメクチン比を支配するＳｔｒｅｐｔｏｍｙｃｅｓａｖｅｒｍｉｔｉｌｉｓ遺伝子 |
| CN107338210B (zh) * | 2017-09-05 | 2021-08-17 | 天津科技大学 | 一种阿维链霉菌合成培养基及其发酵液的制备方法 |
| CN111269296B (zh) * | 2020-03-06 | 2021-11-05 | 山东大学 | 一种nLsA蛋白及其结构基因和应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR900004419A (ko) * | 1988-09-20 | 1990-04-12 | 아오이 죠이찌 | 압연기의 롤갭설정방법 및 장치 |
| EP0445460A1 (en) * | 1990-03-05 | 1991-09-11 | The Kitasato Institute | A microorganism for selective production of a specific component of avermectin and a method for selective production thereof |
| US5252474A (en) * | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| WO1999041389A1 (en) * | 1998-02-13 | 1999-08-19 | Pfizer Products Inc. | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4429042A (en) * | 1978-09-08 | 1984-01-31 | Merck & Co., Inc. | Strain of Streptomyces for producing antiparasitic compounds |
| IN167980B (no) * | 1987-01-23 | 1991-01-19 | Pfizer | |
| EP0313297B1 (en) * | 1987-10-23 | 1993-05-19 | Pfizer Inc. | Process for production of avermectin aglycones and cultures therefor |
| NZ233116A (en) * | 1989-03-31 | 1994-09-27 | Merck & Co Inc | Cloning genes from steptomyces avermitilis for avermectin biosynthesis |
| FI942725A (fi) * | 1993-12-16 | 1995-06-17 | Pfizer | Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta |
-
1999
- 1999-01-25 CN CNA2004100054154A patent/CN1521180A/zh active Pending
- 1999-01-25 CN CN99805027A patent/CN1297485A/zh active Pending
- 1999-01-25 SK SK1172-2000A patent/SK11722000A3/sk unknown
- 1999-01-25 NZ NZ505676A patent/NZ505676A/xx unknown
- 1999-01-25 CA CA002521289A patent/CA2521289A1/en not_active Abandoned
- 1999-01-25 JP JP2000531570A patent/JP2002503473A/ja active Pending
- 1999-01-25 KR KR10-2000-7008870A patent/KR100499214B1/ko not_active IP Right Cessation
- 1999-01-25 PL PL99342468A patent/PL194270B1/pl not_active IP Right Cessation
- 1999-01-25 AU AU18878/99A patent/AU752343C/en not_active Ceased
- 1999-01-25 EA EA200000758A patent/EA003905B1/ru not_active IP Right Cessation
- 1999-01-25 HU HU0100784A patent/HUP0100784A3/hu not_active Application Discontinuation
- 1999-01-25 KR KR10-2004-7015691A patent/KR20040099389A/ko active Search and Examination
- 1999-01-25 BR BR9907893-7A patent/BR9907893A/pt not_active Application Discontinuation
- 1999-01-25 NZ NZ518657A patent/NZ518657A/en unknown
- 1999-01-25 IL IL13761099A patent/IL137610A0/xx unknown
- 1999-01-25 CA CA002320031A patent/CA2320031A1/en not_active Abandoned
- 1999-01-25 WO PCT/IB1999/000130 patent/WO1999041389A1/en not_active Application Discontinuation
- 1999-01-25 KR KR10-2004-7008310A patent/KR20040053390A/ko active Search and Examination
- 1999-01-25 YU YU50900A patent/YU50900A/sh unknown
- 1999-01-25 EP EP99900270A patent/EP1053335A1/en not_active Withdrawn
- 1999-01-26 PA PA19998467601A patent/PA8467601A1/es unknown
- 1999-02-01 GT GT199900014A patent/GT199900014A/es unknown
- 1999-02-05 HN HN1991000008A patent/HN1999000008A/es unknown
- 1999-02-08 PE PE1999000099A patent/PE20000352A1/es not_active Application Discontinuation
- 1999-02-09 TW TW088102005A patent/TW585910B/zh active
- 1999-02-10 MA MA25460A patent/MA24760A1/fr unknown
- 1999-02-10 DZ DZ990021A patent/DZ2720A1/xx active
- 1999-02-10 TN TNTNSN99017A patent/TNSN99017A1/fr unknown
- 1999-02-11 AR ARP990100571A patent/AR018085A1/es unknown
- 1999-02-11 AP APAP/P/1999/001463A patent/AP9901463A0/en unknown
- 1999-02-12 CO CO99008652A patent/CO5070698A1/es unknown
- 1999-02-12 ZA ZA9901138A patent/ZA991138B/xx unknown
-
2000
- 2000-07-20 IS IS5567A patent/IS5567A/is unknown
- 2000-08-04 OA OA1200000217A patent/OA11449A/en unknown
- 2000-08-11 HR HR20000539A patent/HRP20000539A2/hr not_active Application Discontinuation
- 2000-08-11 NO NO20004044A patent/NO20004044L/no not_active Application Discontinuation
- 2000-09-12 BG BG104759A patent/BG64911B1/bg unknown
-
2004
- 2004-04-27 JP JP2004130624A patent/JP4011036B2/ja not_active Expired - Fee Related
-
2007
- 2007-05-31 IL IL183596A patent/IL183596A0/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR900004419A (ko) * | 1988-09-20 | 1990-04-12 | 아오이 죠이찌 | 압연기의 롤갭설정방법 및 장치 |
| US5252474A (en) * | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| EP0445460A1 (en) * | 1990-03-05 | 1991-09-11 | The Kitasato Institute | A microorganism for selective production of a specific component of avermectin and a method for selective production thereof |
| WO1999041389A1 (en) * | 1998-02-13 | 1999-08-19 | Pfizer Products Inc. | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
Non-Patent Citations (6)
| Title |
|---|
| (13쪽, 요약문) (과기처 Avermectin 생산균주의 분자유전학적 육종 연구보고서 1996.10 * |
| J Antibiot (Tokyo) 1995 Jan;48(1):95-7 * |
| J Antibiot (Tokyo) 1995 Jul;48(7):549-62 * |
| J Bacteriol 1993 May;175(9):2552-63 * |
| J Bacteriol 1995 Jun;177(12):3504-11 * |
| The journal of Antibiotics vol.48 no 6, 1995년 P532-34 * |
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