CO5070698A1 - Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1 - Google Patents

Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1

Info

Publication number
CO5070698A1
CO5070698A1 CO99008652A CO99008652A CO5070698A1 CO 5070698 A1 CO5070698 A1 CO 5070698A1 CO 99008652 A CO99008652 A CO 99008652A CO 99008652 A CO99008652 A CO 99008652A CO 5070698 A1 CO5070698 A1 CO 5070698A1
Authority
CO
Colombia
Prior art keywords
avermitilis
avermectines
directs
relationship
streptomyces gene
Prior art date
Application number
CO99008652A
Other languages
English (en)
Spanish (es)
Inventor
Jonelle Stutzman Engwall Kim
Katoh Yoshihiro
Alastair Irvine Mcarthur Hamish
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CO5070698A1 publication Critical patent/CO5070698A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CO99008652A 1998-02-13 1999-02-12 Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1 CO5070698A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7463698P 1998-02-13 1998-02-13

Publications (1)

Publication Number Publication Date
CO5070698A1 true CO5070698A1 (es) 2001-08-28

Family

ID=22120706

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99008652A CO5070698A1 (es) 1998-02-13 1999-02-12 Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1

Country Status (32)

Country Link
EP (1) EP1053335A1 (no)
JP (2) JP2002503473A (no)
KR (3) KR100499214B1 (no)
CN (2) CN1521180A (no)
AP (1) AP9901463A0 (no)
AR (1) AR018085A1 (no)
AU (1) AU752343C (no)
BG (1) BG64911B1 (no)
BR (1) BR9907893A (no)
CA (2) CA2521289A1 (no)
CO (1) CO5070698A1 (no)
DZ (1) DZ2720A1 (no)
EA (1) EA003905B1 (no)
GT (1) GT199900014A (no)
HN (1) HN1999000008A (no)
HR (1) HRP20000539A2 (no)
HU (1) HUP0100784A3 (no)
IL (2) IL137610A0 (no)
IS (1) IS5567A (no)
MA (1) MA24760A1 (no)
NO (1) NO20004044L (no)
NZ (2) NZ505676A (no)
OA (1) OA11449A (no)
PA (1) PA8467601A1 (no)
PE (1) PE20000352A1 (no)
PL (1) PL194270B1 (no)
SK (1) SK11722000A3 (no)
TN (1) TNSN99017A1 (no)
TW (1) TW585910B (no)
WO (1) WO1999041389A1 (no)
YU (1) YU50900A (no)
ZA (1) ZA991138B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1521180A (zh) * 1998-02-13 2004-08-18 �Ʒ� 介导除虫菌素b2:b1比例的除虫链霉菌基因
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
WO2001012821A1 (en) * 1999-08-12 2001-02-22 Pfizer Products Inc. Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
US7630836B2 (en) * 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
JP2005517406A (ja) * 2002-02-12 2005-06-16 ファイザー・プロダクツ・インク B2:B1アベルメクチン比を支配するStreptomycesavermitilis遺伝子
CN107338210B (zh) * 2017-09-05 2021-08-17 天津科技大学 一种阿维链霉菌合成培养基及其发酵液的制备方法
CN111269296B (zh) * 2020-03-06 2021-11-05 山东大学 一种nLsA蛋白及其结构基因和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (no) * 1987-01-23 1991-01-19 Pfizer
EP0313297B1 (en) * 1987-10-23 1993-05-19 Pfizer Inc. Process for production of avermectin aglycones and cultures therefor
JPH0747171B2 (ja) * 1988-09-20 1995-05-24 株式会社東芝 圧延機の設定方法および装置
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
NZ233116A (en) * 1989-03-31 1994-09-27 Merck & Co Inc Cloning genes from steptomyces avermitilis for avermectin biosynthesis
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法
FI942725A (fi) * 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
CN1521180A (zh) * 1998-02-13 2004-08-18 �Ʒ� 介导除虫菌素b2:b1比例的除虫链霉菌基因

Also Published As

Publication number Publication date
BG64911B1 (bg) 2006-08-31
EA200000758A1 (ru) 2001-04-23
PA8467601A1 (es) 2000-09-29
JP4011036B2 (ja) 2007-11-21
PE20000352A1 (es) 2000-05-16
HN1999000008A (es) 1999-10-29
AU752343B2 (en) 2002-09-19
CA2320031A1 (en) 1999-08-19
CN1297485A (zh) 2001-05-30
IL137610A0 (en) 2001-07-24
BR9907893A (pt) 2000-11-14
HRP20000539A2 (en) 2001-04-30
SK11722000A3 (sk) 2001-04-09
KR20040053390A (ko) 2004-06-23
AP9901463A0 (en) 1999-03-31
AR018085A1 (es) 2001-10-31
BG104759A (en) 2001-04-30
TNSN99017A1 (fr) 2005-11-10
KR20010052166A (ko) 2001-06-25
TW585910B (en) 2004-05-01
CN1521180A (zh) 2004-08-18
JP2002503473A (ja) 2002-02-05
NZ505676A (en) 2003-02-28
AU752343C (en) 2005-11-03
IS5567A (is) 2000-07-20
KR100499214B1 (ko) 2005-07-07
EP1053335A1 (en) 2000-11-22
YU50900A (sh) 2004-03-12
PL194270B1 (pl) 2007-05-31
IL183596A0 (no) 2007-09-20
AU1887899A (en) 1999-08-30
HUP0100784A3 (en) 2004-10-28
EA003905B1 (ru) 2003-10-30
WO1999041389A1 (en) 1999-08-19
GT199900014A (es) 2000-07-25
OA11449A (en) 2003-12-03
PL342468A1 (en) 2001-06-04
MA24760A1 (fr) 1999-10-01
KR20040099389A (ko) 2004-11-26
CA2521289A1 (en) 1999-08-19
HUP0100784A2 (hu) 2001-06-28
ZA991138B (en) 2000-08-14
JP2004283174A (ja) 2004-10-14
DZ2720A1 (fr) 2003-09-01
NZ518657A (en) 2003-10-31
NO20004044L (no) 2000-10-11
NO20004044D0 (no) 2000-08-11

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