KR100219970B1 - 재조합 비만 단백질 - Google Patents

재조합 비만 단백질 Download PDF

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Publication number
KR100219970B1
KR100219970B1 KR1019960014570A KR19960014570A KR100219970B1 KR 100219970 B1 KR100219970 B1 KR 100219970B1 KR 1019960014570 A KR1019960014570 A KR 1019960014570A KR 19960014570 A KR19960014570 A KR 19960014570A KR 100219970 B1 KR100219970 B1 KR 100219970B1
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KR
South Korea
Prior art keywords
protein
human
composition
kda
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019960014570A
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English (en)
Korean (ko)
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KR960041194A (ko
Inventor
캠필드 아서
데보스 르네
기세즈 이브스
Original Assignee
프리돌린 클라우스너
에프. 호프만-라 로슈 아게
롤란드 비. 보레르
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Application filed by 프리돌린 클라우스너, 에프. 호프만-라 로슈 아게, 롤란드 비. 보레르 filed Critical 프리돌린 클라우스너
Publication of KR960041194A publication Critical patent/KR960041194A/ko
Application granted granted Critical
Publication of KR100219970B1 publication Critical patent/KR100219970B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1019960014570A 1995-05-05 1996-05-04 재조합 비만 단백질 Expired - Fee Related KR100219970B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US435,777 1982-10-21
US43577795A 1995-05-05 1995-05-05
US8/435,777 1995-05-05
US48462995A 1995-06-07 1995-06-07
US484,629 1995-06-07
US8/484,629 1995-06-07

Publications (2)

Publication Number Publication Date
KR960041194A KR960041194A (ko) 1996-12-19
KR100219970B1 true KR100219970B1 (ko) 1999-10-01

Family

ID=27030682

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960014570A Expired - Fee Related KR100219970B1 (ko) 1995-05-05 1996-05-04 재조합 비만 단백질

Country Status (35)

Country Link
US (1) US6025325A (OSRAM)
EP (1) EP0741187A2 (OSRAM)
JP (1) JP3244627B2 (OSRAM)
KR (1) KR100219970B1 (OSRAM)
CN (1) CN1157290A (OSRAM)
AR (1) AR003087A1 (OSRAM)
AU (1) AU688210B2 (OSRAM)
BG (1) BG62975B1 (OSRAM)
BR (1) BR9602166A (OSRAM)
CA (1) CA2175298A1 (OSRAM)
CZ (1) CZ129796A3 (OSRAM)
DE (1) DE741187T1 (OSRAM)
ES (1) ES2093593T1 (OSRAM)
GR (1) GR960300075T1 (OSRAM)
HR (1) HRP960213A2 (OSRAM)
HU (1) HU220093B (OSRAM)
IL (1) IL118059A0 (OSRAM)
IS (1) IS4343A (OSRAM)
MA (1) MA23856A1 (OSRAM)
MY (1) MY132189A (OSRAM)
NO (1) NO961796L (OSRAM)
NZ (1) NZ286466A (OSRAM)
OA (1) OA10362A (OSRAM)
PE (1) PE50897A1 (OSRAM)
PL (1) PL186568B1 (OSRAM)
RO (1) RO117177B1 (OSRAM)
RU (1) RU96109211A (OSRAM)
SG (1) SG49337A1 (OSRAM)
SK (1) SK56996A3 (OSRAM)
SV (1) SV1996000030A (OSRAM)
TN (1) TNSN96066A1 (OSRAM)
TR (1) TR199600357A2 (OSRAM)
TW (1) TW464655B (OSRAM)
UY (1) UY24219A1 (OSRAM)
YU (1) YU26596A (OSRAM)

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Also Published As

Publication number Publication date
IL118059A0 (en) 1996-08-04
MX9601655A (es) 1997-07-31
RU96109211A (ru) 1998-10-27
GR960300075T1 (en) 1996-12-31
CZ129796A3 (en) 1997-01-15
PE50897A1 (es) 1997-12-19
JP3244627B2 (ja) 2002-01-07
EP0741187A3 (OSRAM) 1996-12-11
NZ286466A (en) 1998-03-25
AR003087A1 (es) 1998-07-08
SG49337A1 (en) 1998-05-18
HRP960213A2 (en) 1997-10-31
CN1157290A (zh) 1997-08-20
BR9602166A (pt) 1998-01-13
BG100558A (bg) 1997-03-31
AU688210B2 (en) 1998-03-05
ES2093593T1 (es) 1997-01-01
US6025325A (en) 2000-02-15
PL186568B1 (pl) 2004-01-30
NO961796D0 (no) 1996-05-03
NO961796L (no) 1996-11-06
RO117177B1 (ro) 2001-11-30
MA23856A1 (fr) 1996-12-31
CA2175298A1 (en) 1996-11-06
KR960041194A (ko) 1996-12-19
AU5197896A (en) 1996-11-14
HUP9601120A2 (en) 1996-11-28
HU220093B (hu) 2001-10-28
HUP9601120A3 (en) 1999-07-28
SK56996A3 (en) 1997-04-09
BG62975B1 (bg) 2000-12-29
YU26596A (sh) 1999-03-04
MY132189A (en) 2007-09-28
TR199600357A2 (tr) 1996-11-21
SV1996000030A (es) 1999-01-14
HU9601120D0 (en) 1996-06-28
DE741187T1 (de) 1997-04-30
EP0741187A2 (en) 1996-11-06
TW464655B (en) 2001-11-21
UY24219A1 (es) 2001-03-16
JPH093098A (ja) 1997-01-07
IS4343A (is) 1996-12-09
PL314051A1 (en) 1996-11-12
OA10362A (fr) 2001-11-15
TNSN96066A1 (fr) 2005-03-15

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