JPWO2022138987A5 - - Google Patents
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- JPWO2022138987A5 JPWO2022138987A5 JP2022571730A JP2022571730A JPWO2022138987A5 JP WO2022138987 A5 JPWO2022138987 A5 JP WO2022138987A5 JP 2022571730 A JP2022571730 A JP 2022571730A JP 2022571730 A JP2022571730 A JP 2022571730A JP WO2022138987 A5 JPWO2022138987 A5 JP WO2022138987A5
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- JP
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- Prior art keywords
- substituted
- unsubstituted
- compound
- group
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 23
- 150000003839 salts Chemical class 0.000 claims 18
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 17
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 16
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 12
- 125000002837 carbocyclic group Chemical group 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 239000001530 fumaric acid Substances 0.000 claims 8
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 8
- 239000013078 crystal Substances 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- 238000001228 spectrum Methods 0.000 claims 2
- 125000006618 5- to 10-membered aromatic heterocyclic group Chemical group 0.000 claims 1
- 238000001069 Raman spectroscopy Methods 0.000 claims 1
- 238000001237 Raman spectrum Methods 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003302 alkenyloxy group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000005133 alkynyloxy group Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000003595 spectral effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024113814A JP7738869B2 (ja) | 2021-04-14 | 2024-07-17 | ウイルス増殖阻害作用を有するトリアジン誘導体およびそれらを含有する医薬組成物 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021068672 | 2021-04-14 | ||
| JP2021068672 | 2021-04-14 | ||
| JP2021105802 | 2021-06-25 | ||
| JP2021105802 | 2021-06-25 | ||
| JP2021153819 | 2021-09-22 | ||
| JP2021153819 | 2021-09-22 | ||
| PCT/JP2022/006495 WO2022138987A1 (ja) | 2021-04-14 | 2022-02-17 | ウイルス増殖阻害作用を有するトリアジン誘導体およびそれらを含有する医薬組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024113814A Division JP7738869B2 (ja) | 2021-04-14 | 2024-07-17 | ウイルス増殖阻害作用を有するトリアジン誘導体およびそれらを含有する医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2022138987A1 JPWO2022138987A1 (https=) | 2022-06-30 |
| JPWO2022138987A5 true JPWO2022138987A5 (https=) | 2023-01-24 |
| JP7530596B2 JP7530596B2 (ja) | 2024-08-08 |
Family
ID=82159864
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022525557A Active JP7105430B1 (ja) | 2021-04-14 | 2022-02-17 | ウイルス増殖阻害作用を有するトリアジン誘導体およびそれらを含有する医薬組成物 |
| JP2022571730A Active JP7530596B2 (ja) | 2021-04-14 | 2022-02-17 | ウイルス増殖阻害作用を有するトリアジン誘導体およびそれらを含有する医薬組成物 |
| JP2024113814A Active JP7738869B2 (ja) | 2021-04-14 | 2024-07-17 | ウイルス増殖阻害作用を有するトリアジン誘導体およびそれらを含有する医薬組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022525557A Active JP7105430B1 (ja) | 2021-04-14 | 2022-02-17 | ウイルス増殖阻害作用を有するトリアジン誘導体およびそれらを含有する医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024113814A Active JP7738869B2 (ja) | 2021-04-14 | 2024-07-17 | ウイルス増殖阻害作用を有するトリアジン誘導体およびそれらを含有する医薬組成物 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US12559474B2 (https=) |
| EP (2) | EP4122926B1 (https=) |
| JP (3) | JP7105430B1 (https=) |
| KR (2) | KR20230159812A (https=) |
| CN (6) | CN117820248A (https=) |
| AU (1) | AU2022204775B2 (https=) |
| CA (1) | CA3195272C (https=) |
| CL (1) | CL2023003041A1 (https=) |
| CO (1) | CO2022016323A2 (https=) |
| DK (1) | DK4122926T3 (https=) |
| ES (1) | ES3038833T3 (https=) |
| FI (1) | FI4122926T3 (https=) |
| HR (1) | HRP20250770T1 (https=) |
| HU (1) | HUE072435T2 (https=) |
| IL (1) | IL298794B2 (https=) |
| LT (1) | LT4122926T (https=) |
| MX (1) | MX2022014458A (https=) |
| PH (1) | PH12022553603A1 (https=) |
| PL (1) | PL4122926T3 (https=) |
| PT (1) | PT4122926T (https=) |
| RS (1) | RS66997B1 (https=) |
| SI (1) | SI4122926T1 (https=) |
| SM (1) | SMT202500268T1 (https=) |
| TW (1) | TWI815396B (https=) |
| WO (2) | WO2022138988A1 (https=) |
| ZA (1) | ZA202212526B (https=) |
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| CN117820248A (zh) * | 2021-04-14 | 2024-04-05 | 盐野义制药株式会社 | 具有病毒增殖抑制作用的三嗪衍生物及含有其的药物组合物 |
| JP2024178473A (ja) * | 2021-09-03 | 2024-12-25 | 塩野義製薬株式会社 | ウイルス増殖阻害活性を有する二環性含窒素複素環誘導体およびそれらを含有する医薬組成物 |
| CN116782904A (zh) * | 2021-09-28 | 2023-09-19 | 盐野义制药株式会社 | 含有三嗪衍生物的医药组合物 |
| TW202320793A (zh) * | 2021-09-28 | 2023-06-01 | 日商塩野義製藥股份有限公司 | 含有三嗪衍生物之醫藥組合物 |
| CA3233206A1 (en) * | 2021-09-28 | 2023-04-06 | Yuki Tachibana | Pharmaceutical composition containing triazine derivative |
| JP7253866B1 (ja) * | 2021-11-24 | 2023-04-07 | 塩野義製薬株式会社 | トリアジン誘導体を含有する経口投与する製剤 |
| CN116514734A (zh) * | 2021-11-24 | 2023-08-01 | 盐野义制药株式会社 | 三嗪衍生物的制造方法和含有三嗪衍生物的口服给与的制剂 |
| JP7261529B1 (ja) | 2021-11-24 | 2023-04-20 | 塩野義製薬株式会社 | ウイルス増殖阻害作用を有するトリアジン誘導体の製造方法 |
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| CN119255987A (zh) * | 2022-05-27 | 2025-01-03 | 广州国家实验室 | 3c样蛋白酶抑制剂 |
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| CN113801097B (zh) | 2021-09-27 | 2022-11-22 | 成都施贝康生物医药科技有限公司 | 二氢嘧啶类化合物、其制备方法及用途 |
| CN113735838B (zh) | 2021-09-27 | 2022-07-08 | 成都施贝康生物医药科技有限公司 | 二氢嘧啶类化合物、其制备方法及用途 |
| CA3233206A1 (en) * | 2021-09-28 | 2023-04-06 | Yuki Tachibana | Pharmaceutical composition containing triazine derivative |
| TW202320793A (zh) | 2021-09-28 | 2023-06-01 | 日商塩野義製藥股份有限公司 | 含有三嗪衍生物之醫藥組合物 |
| CN116782904A (zh) * | 2021-09-28 | 2023-09-19 | 盐野义制药株式会社 | 含有三嗪衍生物的医药组合物 |
| JP7253866B1 (ja) | 2021-11-24 | 2023-04-07 | 塩野義製薬株式会社 | トリアジン誘導体を含有する経口投与する製剤 |
| WO2023054732A2 (ja) * | 2022-01-19 | 2023-04-06 | 塩野義製薬株式会社 | 新型コロナウイルス感染症治療用医薬 |
| CN117069706A (zh) * | 2022-05-10 | 2023-11-17 | 北京远大九和药业有限公司 | 一种化合物的结晶形式及其制备方法和用途 |
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