JPWO2019013311A5 - - Google Patents
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- Publication number
- JPWO2019013311A5 JPWO2019013311A5 JP2019529794A JP2019529794A JPWO2019013311A5 JP WO2019013311 A5 JPWO2019013311 A5 JP WO2019013311A5 JP 2019529794 A JP2019529794 A JP 2019529794A JP 2019529794 A JP2019529794 A JP 2019529794A JP WO2019013311 A5 JPWO2019013311 A5 JP WO2019013311A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- aromatic
- aromatic heterocyclic
- aromatic carbocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003118 aryl group Chemical group 0.000 claims 71
- 125000002837 carbocyclic group Chemical group 0.000 claims 46
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 41
- 125000000217 alkyl group Chemical group 0.000 claims 32
- 229910052736 halogen Inorganic materials 0.000 claims 28
- 150000002367 halogens Chemical class 0.000 claims 28
- -1 cyano, carboxy Chemical group 0.000 claims 27
- 229910052739 hydrogen Inorganic materials 0.000 claims 26
- 239000001257 hydrogen Substances 0.000 claims 26
- 150000002431 hydrogen Chemical class 0.000 claims 20
- 125000003545 alkoxy group Chemical group 0.000 claims 17
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000001424 substituent group Chemical group 0.000 claims 17
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 14
- 125000003342 alkenyl group Chemical group 0.000 claims 12
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 12
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 11
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 11
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 10
- 125000004414 alkyl thio group Chemical group 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 10
- 125000005090 alkenylcarbonyl group Chemical group 0.000 claims 9
- 125000003302 alkenyloxy group Chemical group 0.000 claims 9
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 claims 9
- 125000005136 alkenylsulfinyl group Chemical group 0.000 claims 9
- 125000005137 alkenylsulfonyl group Chemical group 0.000 claims 9
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 9
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- 125000005193 alkenylcarbonyloxy group Chemical group 0.000 claims 7
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 125000004438 haloalkoxy group Chemical group 0.000 claims 5
- 239000003205 fragrance Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 claims 3
- 101710186725 2-acylglycerol O-acyltransferase 2 Proteins 0.000 claims 2
- 102100024296 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Human genes 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- 208000013824 Acidemia Diseases 0.000 claims 1
- 208000010444 Acidosis Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022027456A JP7060298B1 (ja) | 2017-07-14 | 2022-02-25 | Ｍｇａｔ２阻害活性を有する縮合環誘導体 |
| JP2023014333A JP7493635B2 (ja) | 2017-07-14 | 2023-02-02 | Ｍｇａｔ２阻害活性を有する縮合環誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017137678 | 2017-07-14 | ||
| JP2017137678 | 2017-07-14 | ||
| PCT/JP2018/026417 WO2019013311A1 (ja) | 2017-07-14 | 2018-07-13 | Ｍｇａｔ２阻害活性を有する縮合環誘導体 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022027456A Division JP7060298B1 (ja) | 2017-07-14 | 2022-02-25 | Ｍｇａｔ２阻害活性を有する縮合環誘導体 |
| JP2023014333A Division JP7493635B2 (ja) | 2017-07-14 | 2023-02-02 | Ｍｇａｔ２阻害活性を有する縮合環誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2019013311A1 JPWO2019013311A1 (ja) | 2020-05-07 |
| JPWO2019013311A5 true JPWO2019013311A5 (https=) | 2022-03-07 |
| JP7224086B2 JP7224086B2 (ja) | 2023-02-17 |
Family
ID=65001726
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529794A Active JP7224086B2 (ja) | 2017-07-14 | 2018-07-13 | Ｍｇａｔ２阻害活性を有する縮合環誘導体 |
| JP2022027456A Active JP7060298B1 (ja) | 2017-07-14 | 2022-02-25 | Ｍｇａｔ２阻害活性を有する縮合環誘導体 |
| JP2023014333A Active JP7493635B2 (ja) | 2017-07-14 | 2023-02-02 | Ｍｇａｔ２阻害活性を有する縮合環誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022027456A Active JP7060298B1 (ja) | 2017-07-14 | 2022-02-25 | Ｍｇａｔ２阻害活性を有する縮合環誘導体 |
| JP2023014333A Active JP7493635B2 (ja) | 2017-07-14 | 2023-02-02 | Ｍｇａｔ２阻害活性を有する縮合環誘導体 |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US11198695B2 (https=) |
| EP (2) | EP4043463B1 (https=) |
| JP (3) | JP7224086B2 (https=) |
| KR (1) | KR102612176B1 (https=) |
| CN (2) | CN113501821B (https=) |
| AU (1) | AU2018298733B2 (https=) |
| BR (1) | BR112020000401A2 (https=) |
| CA (1) | CA3069799A1 (https=) |
| CL (1) | CL2020000086A1 (https=) |
| DK (1) | DK3653625T3 (https=) |
| ES (1) | ES2974287T3 (https=) |
| FI (1) | FI3653625T3 (https=) |
| HR (1) | HRP20240295T1 (https=) |
| HU (1) | HUE065838T2 (https=) |
| LT (1) | LT3653625T (https=) |
| MX (1) | MX394836B (https=) |
| PL (1) | PL3653625T3 (https=) |
| PT (1) | PT3653625T (https=) |
| RU (1) | RU2770437C2 (https=) |
| SA (1) | SA520411017B1 (https=) |
| SI (1) | SI3653625T1 (https=) |
| TW (1) | TWI782056B (https=) |
| WO (2) | WO2019013312A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI782056B (zh) * | 2017-07-14 | 2022-11-01 | 日商鹽野義製藥股份有限公司 | 具有ｍｇａｔ２抑制活性的縮合環衍生物 |
| MX2021008050A (es) * | 2019-01-11 | 2021-08-05 | Shionogi & Co | Derivado de dihidropirazolopirazinona que tiene actividad inhibidora de monoacilglicerol aciltransferasa 2 (mgat2). |
| JP7068743B2 (ja) * | 2019-01-11 | 2022-05-17 | 塩野義製薬株式会社 | Ｍｇａｔ２阻害活性を有する縮合環誘導体を含有する医薬組成物 |
| HRP20241159T1 (hr) | 2020-02-07 | 2024-12-06 | Gasherbrum Bio, Inc. | Heterociklički agonisti za glp-1 |
| JP2022016394A (ja) * | 2020-07-10 | 2022-01-21 | 塩野義製薬株式会社 | Ｍｇａｔ２阻害活性を有するジヒドロピラゾロピラジノン誘導体を含有する医薬組成物 |
| CN116368140A (zh) | 2020-09-10 | 2023-06-30 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| CN114685502A (zh) * | 2020-12-25 | 2022-07-01 | 由理生物医药（上海）有限公司 | 作为kras-g12c抑制剂的螺环类化合物 |
| US20240374587A1 (en) | 2021-09-08 | 2024-11-14 | Shionogi & Co., Ltd. | Medicine for prevention and treatment of diseases linked to anti-obesity activity |
| CA3243798A1 (en) * | 2022-02-09 | 2023-08-17 | Quanta Therapeutics, Inc. | Kras Modulators and Their Uses |
| WO2023230190A1 (en) | 2022-05-25 | 2023-11-30 | Quanta Therapeutics, Inc. | Pyrimidine based modulators and uses thereof |
| KR20250022711A (ko) | 2022-06-13 | 2025-02-17 | 시오노기 앤드 컴파니, 리미티드 | 다이하이드로피리딘온 유도체 또는 그 용매화물의 결정 |
| CN120957993A (zh) | 2023-02-16 | 2025-11-14 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| KR20260041941A (ko) | 2023-03-15 | 2026-03-27 | 콴타 테라퓨틱스, 인크. | Kras 조절 인자 및 이의 용도 |
| WO2025127097A1 (ja) * | 2023-12-13 | 2025-06-19 | 塩野義製薬株式会社 | 脂肪性肝疾患の治療用医薬 |
| JP2024100975A (ja) * | 2024-01-31 | 2024-07-26 | 塩野義製薬株式会社 | ジヒドロピリジノン誘導体を含有する医薬組成物 |
| WO2026008045A1 (zh) * | 2024-07-04 | 2026-01-08 | 苏州信诺维医药科技股份有限公司 | 一种含有炔基的螺环化合物及其用途 |
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| TWI782056B (zh) * | 2017-07-14 | 2022-11-01 | 日商鹽野義製藥股份有限公司 | 具有ｍｇａｔ２抑制活性的縮合環衍生物 |
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2018
- 2018-07-12 TW TW107124096A patent/TWI782056B/zh active
- 2018-07-13 CN CN202110774911.XA patent/CN113501821B/zh active Active
- 2018-07-13 KR KR1020207004424A patent/KR102612176B1/ko active Active
- 2018-07-13 FI FIEP18831430.6T patent/FI3653625T3/fi active
- 2018-07-13 DK DK18831430.6T patent/DK3653625T3/da active
- 2018-07-13 CA CA3069799A patent/CA3069799A1/en active Pending
- 2018-07-13 BR BR112020000401-4A patent/BR112020000401A2/pt not_active Application Discontinuation
- 2018-07-13 EP EP22165122.7A patent/EP4043463B1/en active Active
- 2018-07-13 US US16/628,753 patent/US11198695B2/en active Active
- 2018-07-13 PT PT188314306T patent/PT3653625T/pt unknown
- 2018-07-13 MX MX2020000286A patent/MX394836B/es unknown
- 2018-07-13 JP JP2019529794A patent/JP7224086B2/ja active Active
- 2018-07-13 PL PL18831430.6T patent/PL3653625T3/pl unknown
- 2018-07-13 HU HUE18831430A patent/HUE065838T2/hu unknown
- 2018-07-13 HR HRP20240295TT patent/HRP20240295T1/hr unknown
- 2018-07-13 WO PCT/JP2018/026418 patent/WO2019013312A1/ja not_active Ceased
- 2018-07-13 EP EP18831430.6A patent/EP3653625B1/en active Active
- 2018-07-13 SI SI201831073T patent/SI3653625T1/sl unknown
- 2018-07-13 AU AU2018298733A patent/AU2018298733B2/en active Active
- 2018-07-13 LT LTEPPCT/JP2018/026417T patent/LT3653625T/lt unknown
- 2018-07-13 RU RU2020106727A patent/RU2770437C2/ru active
- 2018-07-13 WO PCT/JP2018/026417 patent/WO2019013311A1/ja not_active Ceased
- 2018-07-13 CN CN201880059379.XA patent/CN111094288B/zh active Active
- 2018-07-13 ES ES18831430T patent/ES2974287T3/es active Active
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2020
- 2020-01-09 SA SA520411017A patent/SA520411017B1/ar unknown
- 2020-01-10 CL CL2020000086A patent/CL2020000086A1/es unknown
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2021
- 2021-11-12 US US17/525,010 patent/US12024519B2/en active Active
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2022
- 2022-02-25 JP JP2022027456A patent/JP7060298B1/ja active Active
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2023
- 2023-02-02 JP JP2023014333A patent/JP7493635B2/ja active Active
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2024
- 2024-05-16 US US18/665,923 patent/US12454533B2/en active Active
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