MA39335B1 - Inhibiteurs mgat2 de dihydropyridinone à substitution tétrazolone - Google Patents

Inhibiteurs mgat2 de dihydropyridinone à substitution tétrazolone

Info

Publication number
MA39335B1
MA39335B1 MA39335A MA39335A MA39335B1 MA 39335 B1 MA39335 B1 MA 39335B1 MA 39335 A MA39335 A MA 39335A MA 39335 A MA39335 A MA 39335A MA 39335 B1 MA39335 B1 MA 39335B1
Authority
MA
Morocco
Prior art keywords
tetrazolone
mgat2 inhibitors
inhibitors
substituted
substituted dihydropyridinone
Prior art date
Application number
MA39335A
Other languages
English (en)
Other versions
MA39335A1 (fr
Inventor
Saleem Ahmad
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52686513&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA39335(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MA39335A1 publication Critical patent/MA39335A1/fr
Publication of MA39335B1 publication Critical patent/MA39335B1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des composés de formule (i) : un stéréo-isomère, un tautomère, un sel pharmaceutiquement acceptable, un polymorphe, un solvate de ces derniers, toutes les variables de la formule étant telles que définies dans ce document. Ces composés sont des inhibiteurs de monoacylglycérol acyltransférase de type 2 (mgat2) qui peuvent être utilisés en tant que médicaments.
MA39335A 2014-03-07 2015-03-05 Inhibiteurs mgat2 de dihydropyridinone à substitution tétrazolone MA39335B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461949490P 2014-03-07 2014-03-07
PCT/US2015/018870 WO2015134699A1 (fr) 2014-03-07 2015-03-05 Inhibiteurs mgat2 de dihydropyridinone à substitution tétrazolone

Publications (2)

Publication Number Publication Date
MA39335A1 MA39335A1 (fr) 2017-09-29
MA39335B1 true MA39335B1 (fr) 2019-12-31

Family

ID=52686513

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39335A MA39335B1 (fr) 2014-03-07 2015-03-05 Inhibiteurs mgat2 de dihydropyridinone à substitution tétrazolone

Country Status (31)

Country Link
US (6) US9688656B2 (fr)
EP (1) EP3114120B1 (fr)
JP (1) JP6449919B2 (fr)
KR (1) KR102336371B1 (fr)
CN (1) CN106061968B (fr)
AU (1) AU2015227140B2 (fr)
BR (1) BR112016019487B1 (fr)
CA (1) CA2941951C (fr)
CL (1) CL2016002238A1 (fr)
CY (1) CY1121746T1 (fr)
DK (1) DK3114120T3 (fr)
EA (1) EA030561B1 (fr)
ES (1) ES2719713T3 (fr)
HR (1) HRP20190668T1 (fr)
HU (1) HUE044272T2 (fr)
IL (1) IL247592B (fr)
LT (1) LT3114120T (fr)
MA (1) MA39335B1 (fr)
MX (1) MX2016011223A (fr)
MY (1) MY176921A (fr)
NZ (1) NZ724890A (fr)
PE (1) PE20161369A1 (fr)
PH (1) PH12016501517B1 (fr)
PL (1) PL3114120T3 (fr)
PT (1) PT3114120T (fr)
RS (1) RS58740B1 (fr)
SG (1) SG11201607393XA (fr)
SI (1) SI3114120T1 (fr)
TR (1) TR201906325T4 (fr)
WO (1) WO2015134699A1 (fr)
ZA (1) ZA201606174B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8791091B2 (en) 2011-12-02 2014-07-29 Bristol-Myers Squibb Company Aryl dihydropyridinone and piperidinone MGAT2 inhibitors
SI3114120T1 (sl) * 2014-03-07 2019-04-30 Bristol-Myers Squibb Company Tetrazolon-substituirani dihidropiridinon mgat2 inhibitorji
WO2015191681A2 (fr) 2014-06-11 2015-12-17 Bristol-Myers Squibb Company Pyridinones substituées utilisées comme inhibiteurs de mgat2
CN105218518B (zh) * 2015-09-15 2018-01-12 青岛科标检测研究院有限公司 一种可用于制备供热采暖系统清洗剂的化合物及其制备方法
WO2017069224A1 (fr) * 2015-10-22 2017-04-27 塩野義製薬株式会社 Dérivé spiro hétérocyclique présentant une activité inhibitrice de mgat2
JPWO2017110841A1 (ja) * 2015-12-21 2018-10-11 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有する非芳香族複素環誘導体
JP2020158390A (ja) * 2017-06-20 2020-10-01 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有する非芳香族複素環誘導体およびそれらを含有する医薬組成物
TWI782056B (zh) 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物
AU2020207716A1 (en) 2019-01-11 2021-07-15 Shionogi & Co., Ltd. Dihydropyrazolopyrazinone derivative having MGAT2 inhibitory activity
WO2023038039A1 (fr) * 2021-09-08 2023-03-16 塩野義製薬株式会社 Médicament destiné à la prévention et au traitement de maladies liées à l'activité anti-obésité
EP4201923A1 (fr) 2021-12-23 2023-06-28 Karl-Franzens-Universität Graz 2,3-dihydropyridine-4-ones 5-substitués et leur procédé de préparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
US20100016365A1 (en) 2008-07-17 2010-01-21 Auspex Pharmaceuticals, Inc. Substituted 4-amino-piperidines
US8791091B2 (en) 2011-12-02 2014-07-29 Bristol-Myers Squibb Company Aryl dihydropyridinone and piperidinone MGAT2 inhibitors
EP3004059B1 (fr) 2013-05-29 2017-09-20 Bristol-Myers Squibb Company Dihydropyridinone utilisée en tant qu'inhibiteur de mgat2
SI3114120T1 (sl) 2014-03-07 2019-04-30 Bristol-Myers Squibb Company Tetrazolon-substituirani dihidropiridinon mgat2 inhibitorji
WO2015134701A1 (fr) 2014-03-07 2015-09-11 Bristol-Myers Squibb Company Composés de dihydropyridinone inhibiteurs de la mgat2 destinés à être utilisés dans le traitement de troubles métaboliques

Also Published As

Publication number Publication date
EA201691670A1 (ru) 2016-12-30
SI3114120T1 (sl) 2019-04-30
HRP20190668T1 (hr) 2019-06-14
TR201906325T4 (tr) 2019-05-21
EA030561B1 (ru) 2018-08-31
PH12016501517A1 (en) 2017-02-06
US20180370945A1 (en) 2018-12-27
KR102336371B1 (ko) 2021-12-06
IL247592B (en) 2018-12-31
US11479538B2 (en) 2022-10-25
US20170260159A1 (en) 2017-09-14
CA2941951C (fr) 2021-11-16
BR112016019487A2 (fr) 2017-08-15
PL3114120T3 (pl) 2019-08-30
CA2941951A1 (fr) 2015-09-11
EP3114120B1 (fr) 2019-02-13
US9896431B2 (en) 2018-02-20
ZA201606174B (en) 2018-05-30
AU2015227140B2 (en) 2019-01-24
US10093650B2 (en) 2018-10-09
CN106061968A (zh) 2016-10-26
JP6449919B2 (ja) 2019-01-09
US9688656B2 (en) 2017-06-27
KR20160120789A (ko) 2016-10-18
CY1121746T1 (el) 2020-07-31
WO2015134699A1 (fr) 2015-09-11
DK3114120T3 (da) 2019-05-20
US20170015648A1 (en) 2017-01-19
ES2719713T3 (es) 2019-07-12
EP3114120A1 (fr) 2017-01-11
RS58740B1 (sr) 2019-06-28
SG11201607393XA (en) 2016-10-28
US20200095221A1 (en) 2020-03-26
US10329273B2 (en) 2019-06-25
JP2017508794A (ja) 2017-03-30
AU2015227140A1 (en) 2016-10-20
US10538505B2 (en) 2020-01-21
HUE044272T2 (hu) 2019-10-28
MY176921A (en) 2020-08-26
PT3114120T (pt) 2019-05-08
MX2016011223A (es) 2016-11-30
US20190263776A1 (en) 2019-08-29
CN106061968B (zh) 2020-03-27
LT3114120T (lt) 2019-05-10
MA39335A1 (fr) 2017-09-29
CL2016002238A1 (es) 2017-03-03
US20180127394A1 (en) 2018-05-10
PH12016501517B1 (en) 2017-02-06
NZ724890A (en) 2019-11-29
BR112016019487B1 (pt) 2023-01-17
PE20161369A1 (es) 2016-12-17

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