EA201891578A1 - Композиции 2-(4-хлорфенил)-n-((2-(2,6-диоксопиперидин-3-ил)-1-оксоизоиндолин-5-ил)метил-2,2-дифторацетамида - Google Patents

Композиции 2-(4-хлорфенил)-n-((2-(2,6-диоксопиперидин-3-ил)-1-оксоизоиндолин-5-ил)метил-2,2-дифторацетамида

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Publication number
EA201891578A1
EA201891578A1 EA201891578A EA201891578A EA201891578A1 EA 201891578 A1 EA201891578 A1 EA 201891578A1 EA 201891578 A EA201891578 A EA 201891578A EA 201891578 A EA201891578 A EA 201891578A EA 201891578 A1 EA201891578 A1 EA 201891578A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dioxopiperidin
compositions
methyl
oxyoisoindolin
diphtoracetamide
Prior art date
Application number
EA201891578A
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English (en)
Other versions
EA037508B1 (ru
Inventor
Хо-Вах Хьюи
Ю Пью
Original Assignee
Селджин Корпорейшн
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Publication date
Application filed by Селджин Корпорейшн filed Critical Селджин Корпорейшн
Publication of EA201891578A1 publication Critical patent/EA201891578A1/ru
Publication of EA037508B1 publication Critical patent/EA037508B1/ru

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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids

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Abstract

В настоящем документе предложены лиофилизированные композиции 2-(4-хлорфенил)-N-((2-(2,6-диоксопиперидин-3-ил)-1-оксоизоиндолин-5-ил)метил)-2,2-дифторацетамида или его стереоизомера, или смеси стереоизомеров, фармацевтически приемлемой соли, таутомера, пролекарства, сольвата, гидрата, сокристалла, клатрата или полиморфа. В настоящем документе также предложены способы применения указанных композиций и лекарственных форм для лечения, сдерживания развития и/или предупреждения рака.
EA201891578A 2016-01-08 2017-01-06 Композиции 2-(4-хлорфенил)-n-((2-(2,6-диоксопиперидин-3-ил)-1-оксоизоиндолин-5-ил)метил)-2,2-дифторацетамида EA037508B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662276756P 2016-01-08 2016-01-08
PCT/US2017/012483 WO2017120437A1 (en) 2016-01-08 2017-01-06 Formulations of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

Publications (2)

Publication Number Publication Date
EA201891578A1 true EA201891578A1 (ru) 2018-11-30
EA037508B1 EA037508B1 (ru) 2021-04-06

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EA201891578A EA037508B1 (ru) 2016-01-08 2017-01-06 Композиции 2-(4-хлорфенил)-n-((2-(2,6-диоксопиперидин-3-ил)-1-оксоизоиндолин-5-ил)метил)-2,2-дифторацетамида

Country Status (18)

Country Link
US (4) US10052315B2 (ru)
EP (2) EP4275707A3 (ru)
JP (2) JP6871256B2 (ru)
KR (1) KR20180100565A (ru)
CN (2) CN108601777B (ru)
AU (2) AU2017205167B2 (ru)
BR (1) BR112018013884A2 (ru)
CA (1) CA3010797C (ru)
CL (1) CL2018001830A1 (ru)
CO (1) CO2018008305A2 (ru)
EA (1) EA037508B1 (ru)
EC (1) ECSP18051143A (ru)
ES (1) ES2956767T3 (ru)
IL (1) IL260403B (ru)
SA (1) SA518391983B1 (ru)
SG (2) SG10202007913WA (ru)
WO (1) WO2017120437A1 (ru)
ZA (1) ZA201804482B (ru)

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ZA201804482B (en) 2019-10-30
SG10202007913WA (en) 2020-10-29
EA037508B1 (ru) 2021-04-06
EP3399979B1 (en) 2023-06-28
SA518391983B1 (ar) 2021-07-26
CA3010797A1 (en) 2017-07-13
AU2017205167B2 (en) 2021-07-01
CO2018008305A2 (es) 2018-08-21
EP3399979A1 (en) 2018-11-14
AU2021240184A1 (en) 2021-10-28
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IL260403B (en) 2021-10-31
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