MX2022006133A - Procesos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin- 3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida. - Google Patents

Procesos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin- 3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida.

Info

Publication number
MX2022006133A
MX2022006133A MX2022006133A MX2022006133A MX2022006133A MX 2022006133 A MX2022006133 A MX 2022006133A MX 2022006133 A MX2022006133 A MX 2022006133A MX 2022006133 A MX2022006133 A MX 2022006133A MX 2022006133 A MX2022006133 A MX 2022006133A
Authority
MX
Mexico
Prior art keywords
oxoisoindolin
chlorophenyl
methyl
preparing
processes
Prior art date
Application number
MX2022006133A
Other languages
English (en)
Inventor
Michael James Williams
Joshua Hansen
Marie G Beauchamps
Weihong Zhang
Jianxin Han
Michael J Zacuto
Gregg Feigelson
Mohit A Kothare
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2022006133A publication Critical patent/MX2022006133A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/04—Preparation of carboxylic acid nitriles by reaction of cyanogen halides, e.g. ClCN, with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/16—Preparation of carboxylic acid nitriles by reaction of cyanides with lactones or compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/55—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and esterified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a procesos para preparar 2-(4-clorofenil)-N-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin- 5-il)metil)-2,2-difluoroacetamida.
MX2022006133A 2019-12-06 2020-12-04 Procesos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin- 3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida. MX2022006133A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962945013P 2019-12-06 2019-12-06
PCT/US2020/063195 WO2021113566A1 (en) 2019-12-06 2020-12-04 Processes for preparing 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

Publications (1)

Publication Number Publication Date
MX2022006133A true MX2022006133A (es) 2022-06-17

Family

ID=76209533

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022006133A MX2022006133A (es) 2019-12-06 2020-12-04 Procesos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin- 3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida.

Country Status (11)

Country Link
US (2) US11312699B2 (es)
EP (1) EP4069228A4 (es)
JP (1) JP2023505254A (es)
KR (1) KR20220110795A (es)
CN (1) CN114761004A (es)
AU (1) AU2020396543A1 (es)
BR (1) BR112022010019A2 (es)
CA (1) CA3158942A1 (es)
IL (1) IL293481A (es)
MX (1) MX2022006133A (es)
WO (1) WO2021113566A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023104155A1 (zh) * 2021-12-08 2023-06-15 标新生物医药科技(上海)有限公司 E3泛素连接酶配体化合物、基于该配体化合物开发的蛋白降解剂及它们的应用

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WO2017214014A1 (en) 2016-06-06 2017-12-14 Celgene Corporation Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
EP3548483A4 (en) * 2016-12-01 2020-06-10 Arvinas Operations, Inc. TETRAHYDRONAPHTHALINE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS AN ESTROGEN RECEPTOR-DEGRADING AGENT
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JP2019011495A (ja) 2017-06-30 2019-01-24 株式会社Ｕａｃｊ押出加工 熱交換器に配管部材を接続するためのアルミニウム合金製コネクタ及び該コネクタを備える熱交換器接続用配管部材、並びにこれらの製造方法
EP3735243A4 (en) 2018-01-02 2021-08-25 Celgene Corporation ISOTOPOLOGISTS OF 2- (4-CHLOROPHENYL) -N - ((2- (2,6-DIOXOPIPERIDIN-3-YL) -1-OXOISOINDOLIN-5-YL) METHYL) -2,2-DIFLUOROACETAMIDE
US10905684B2 (en) * 2018-06-13 2021-02-02 Biotheryx, Inc. Aminoamide compounds
EA202191833A1 (ru) 2018-12-31 2021-10-11 Селджин Корпорейшн Композиции и способы применения 2-(4-хлорфенил)-n-((2-(2,6-диоксопиперидин-3-ил)-1-оксоизоиндолин-5-ил)метил)-2,2-дифторацетамида
TW202110818A (zh) * 2019-05-24 2021-03-16 美商拜歐斯瑞克斯公司 靶向蛋白質之化合物及其醫藥組合物以及其治療應用
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MX2022011523A (es) 2020-03-16 2022-12-13 Celgene Corp Terapia combinada para leucemia mielógena aguda.

Also Published As

Publication number Publication date
CA3158942A1 (en) 2021-06-10
IL293481A (en) 2022-08-01
EP4069228A1 (en) 2022-10-12
EP4069228A4 (en) 2024-04-17
WO2021113566A1 (en) 2021-06-10
KR20220110795A (ko) 2022-08-09
BR112022010019A2 (pt) 2022-08-16
AU2020396543A1 (en) 2022-06-16
CN114761004A (zh) 2022-07-15
US11312699B2 (en) 2022-04-26
JP2023505254A (ja) 2023-02-08
US20220213056A1 (en) 2022-07-07
US20210171493A1 (en) 2021-06-10

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