BR112022010019A2 - Processos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida - Google Patents

Processos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida

Info

Publication number
BR112022010019A2
BR112022010019A2 BR112022010019A BR112022010019A BR112022010019A2 BR 112022010019 A2 BR112022010019 A2 BR 112022010019A2 BR 112022010019 A BR112022010019 A BR 112022010019A BR 112022010019 A BR112022010019 A BR 112022010019A BR 112022010019 A2 BR112022010019 A2 BR 112022010019A2
Authority
BR
Brazil
Prior art keywords
difluoroacetamide
dioxopiperidin
chlorophenyl
methyl
processes
Prior art date
Application number
BR112022010019A
Other languages
English (en)
Inventor
G Beauchamps Marie
Feigelson Gregg
Han Jianxin
HANSEN Joshua
A Kothare Mohit
James Williams Michael
J Zacuto Michael
Zhan Weihong
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of BR112022010019A2 publication Critical patent/BR112022010019A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/04—Preparation of carboxylic acid nitriles by reaction of cyanogen halides, e.g. ClCN, with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/16—Preparation of carboxylic acid nitriles by reaction of cyanides with lactones or compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/55—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and esterified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

PROCESSOS PARA PREPARAR 2-(4-CLOROFENIL)-N-((2-(2,6-DIOXOPIPERIDIN-3-IL)-1- OXOISOINDOLIN-5-IL)METIL)-2,2-DIFLUOROACETAMIDA. A presente invenção refere-se a processos para a preparação de 2-(4-clorofenil)-N-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida.
BR112022010019A 2019-12-06 2020-12-04 Processos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida BR112022010019A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962945013P 2019-12-06 2019-12-06
PCT/US2020/063195 WO2021113566A1 (en) 2019-12-06 2020-12-04 Processes for preparing 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

Publications (1)

Publication Number Publication Date
BR112022010019A2 true BR112022010019A2 (pt) 2022-08-16

Family

ID=76209533

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022010019A BR112022010019A2 (pt) 2019-12-06 2020-12-04 Processos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida

Country Status (11)

Country Link
US (2) US11312699B2 (pt)
EP (1) EP4069228A4 (pt)
JP (1) JP2023505254A (pt)
KR (1) KR20220110795A (pt)
CN (1) CN114761004A (pt)
AU (1) AU2020396543A1 (pt)
BR (1) BR112022010019A2 (pt)
CA (1) CA3158942A1 (pt)
IL (1) IL293481A (pt)
MX (1) MX2022006133A (pt)
WO (1) WO2021113566A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023104155A1 (zh) * 2021-12-08 2023-06-15 标新生物医药科技(上海)有限公司 E3泛素连接酶配体化合物、基于该配体化合物开发的蛋白降解剂及它们的应用

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AU2019284608A1 (en) * 2018-06-13 2020-12-17 Biotheryx, Inc. Aminoamide compounds
CA3125189A1 (en) 2018-12-31 2020-07-09 Celgene Corporation Compositions and methods of use of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5yl) methyl)-2,2-difluoroacetamide
WO2020242960A1 (en) * 2019-05-24 2020-12-03 Biotheryx, Inc. Compounds targeting proteins and pharmaceutical compositions thereof, and their therapeutic applications
EP4054578A4 (en) 2019-11-05 2023-11-22 Celgene Corporation COMBINATION THERAPY WITH 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDINE-3-YL)-1-OXOISOINDOLINE-5-YL) METHYL)-2,2-DIFLUOROACETAMIDE
IL296557A (en) 2020-03-16 2022-11-01 Celgene Corp Combined treatment for acute myeloid leukemia

Also Published As

Publication number Publication date
IL293481A (en) 2022-08-01
EP4069228A4 (en) 2024-04-17
EP4069228A1 (en) 2022-10-12
WO2021113566A1 (en) 2021-06-10
US11312699B2 (en) 2022-04-26
MX2022006133A (es) 2022-06-17
AU2020396543A1 (en) 2022-06-16
CN114761004A (zh) 2022-07-15
US20220213056A1 (en) 2022-07-07
JP2023505254A (ja) 2023-02-08
US20210171493A1 (en) 2021-06-10
CA3158942A1 (en) 2021-06-10
KR20220110795A (ko) 2022-08-09

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]